Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | p450 reductase, putative | 0.0362 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0362 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0139 | 0 | 0.5 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0362 | 1 | 0.5 |
Brugia malayi | FAD binding domain containing protein | 0.0362 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0139 | 0 | 0.5 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0139 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0362 | 1 | 1 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0362 | 1 | 1 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.018 | 0.1841 | 0.5 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0362 | 1 | 1 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0321 | 0.8159 | 0.5 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0183 | 0.1964 | 0.0816 |
Treponema pallidum | flavodoxin | 0.0139 | 0 | 0.5 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0362 | 1 | 1 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0362 | 1 | 1 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0362 | 1 | 1 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0362 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0362 | 1 | 1 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0362 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0362 | 1 | 1 |
Leishmania major | cytochrome P450 reductase, putative | 0.0321 | 0.8159 | 0.8159 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0224 | 0.3805 | 0.292 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0362 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0139 | 0 | 0.5 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0362 | 1 | 1 |
Schistosoma mansoni | diflavin oxidoreductase | 0.018 | 0.1841 | 0.0675 |
Plasmodium vivax | flavodoxin domain containing protein | 0.0321 | 0.8159 | 0.8159 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0362 | 1 | 1 |
Brugia malayi | FAD binding domain containing protein | 0.0224 | 0.3805 | 0.3805 |
Giardia lamblia | Hypothetical protein | 0.0321 | 0.8159 | 0.5 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0224 | 0.3805 | 0.3805 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.018 | 0.1841 | 0.5 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0362 | 1 | 1 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0362 | 1 | 1 |
Trichomonas vaginalis | NADPH fad oxidoreductase, putative | 0.0321 | 0.8159 | 0.8159 |
Trypanosoma cruzi | p450 reductase, putative | 0.0362 | 1 | 1 |
Chlamydia trachomatis | sulfite reductase | 0.0224 | 0.3805 | 0.5 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0362 | 1 | 1 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0362 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0139 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | > 32 ug ml-1 | Antibacterial activity against Escherichia coli ATCC 25922 by M07-A9 CLSI method | ChEMBL. | 23791571 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.