Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | beta-site APP-cleaving enzyme 1 | Starlite/ChEMBL | References |
Homo sapiens | cathepsin D | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | plasmepsin X | cathepsin D | 412 aa | 339 aa | 28.9 % |
Plasmodium falciparum | plasmepsin VII | beta-site APP-cleaving enzyme 1 | 401 aa | 352 aa | 21.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.548 | 0.9733 | 0.9823 |
Brugia malayi | Cytochrome P450 family protein | 0.0251 | 0.0103 | 1 |
Schistosoma mansoni | neuropeptide F-like receptor | 0.021 | 0.0028 | 0.0028 |
Schistosoma mansoni | myosin xvIII | 0.021 | 0.0028 | 0.0028 |
Schistosoma mansoni | muscarinic acetylcholine (GAR) receptor | 0.021 | 0.0028 | 0.0028 |
Schistosoma mansoni | peptide (allatostatin)-like receptor | 0.021 | 0.0028 | 0.0028 |
Schistosoma mansoni | biogenic amine (dopamine) receptor | 0.021 | 0.0028 | 0.0028 |
Loa Loa (eye worm) | hypothetical protein | 0.548 | 0.9733 | 0.9825 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.2378 | 0.4021 | 0.3997 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.021 | 0.0028 | 0.0028 |
Schistosoma mansoni | opsin-like receptor | 0.021 | 0.0028 | 0.0028 |
Schistosoma mansoni | hypothetical protein | 0.021 | 0.0028 | 0.0028 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.021 | 0.0028 | 0.0028 |
Schistosoma mansoni | peptide (FMRFamide/somatostatin)-like receptor | 0.021 | 0.0028 | 0.0028 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.021 | 0.0028 | 0.0028 |
Onchocerca volvulus | 0.5574 | 0.9906 | 1 | |
Schistosoma mansoni | biogenic amine (dopamine) receptor | 0.021 | 0.0028 | 0.0028 |
Schistosoma mansoni | biogenic amine (octopamine/dopamine) receptor | 0.021 | 0.0028 | 0.0028 |
Schistosoma mansoni | memapsin-2 (A01 family) | 0.0535 | 0.0626 | 0.0626 |
Echinococcus multilocularis | 6 phosphofructo 2 kinase:fructose 2 | 0.5574 | 0.9906 | 0.9906 |
Schistosoma mansoni | opsin-like receptor | 0.021 | 0.0028 | 0.0028 |
Schistosoma mansoni | biogenic amine receptor | 0.021 | 0.0028 | 0.0028 |
Schistosoma mansoni | thyrotropin-releasing hormone receptor | 0.021 | 0.0028 | 0.0028 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.548 | 0.9733 | 0.9823 |
Schistosoma mansoni | amine GPCR | 0.021 | 0.0028 | 0.0028 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0251 | 0.0103 | 0.0076 |
Schistosoma mansoni | hypothetical protein | 0.021 | 0.0028 | 0.0028 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.5574 | 0.9906 | 1 |
Schistosoma mansoni | adenoreceptor | 0.021 | 0.0028 | 0.0028 |
Schistosoma mansoni | neuropeptide receptor | 0.021 | 0.0028 | 0.0028 |
Schistosoma mansoni | ancient conserved domain protein 2 (cyclin m2) | 0.021 | 0.0028 | 0.0028 |
Schistosoma mansoni | peptide (FMRFamide/somatostatin)-like receptor | 0.021 | 0.0028 | 0.0028 |
Schistosoma mansoni | peptide (FMRFamide/neurokinin-3)-like receptor | 0.021 | 0.0028 | 0.0028 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.021 | 0.0028 | 0.0028 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.021 | 0.0028 | 0.0028 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.021 | 0.0028 | 0.0028 |
Brugia malayi | Cytochrome P450 family protein | 0.0251 | 0.0103 | 1 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.021 | 0.0028 | 0.0028 |
Loa Loa (eye worm) | hypothetical protein | 0.3196 | 0.5526 | 0.5566 |
Schistosoma mansoni | neuropeptide receptor | 0.021 | 0.0028 | 0.0028 |
Schistosoma mansoni | 6-phosphofructokinase | 0.5574 | 0.9906 | 0.9906 |
Entamoeba histolytica | phosphoglycerate mutase family protein, putative | 0.329 | 0.5699 | 0.5 |
Schistosoma mansoni | peptide (allatostatin/somatostatin)-like receptor | 0.021 | 0.0028 | 0.0028 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.021 | 0.0028 | 0.0028 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.021 | 0.0028 | 0.0028 |
Schistosoma mansoni | amine GPCR | 0.021 | 0.0028 | 0.0028 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.5574 | 0.9906 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.2378 | 0.4021 | 0.3997 |
Mycobacterium ulcerans | hypothetical protein | 0.329 | 0.5699 | 1 |
Schistosoma mansoni | amine GPCR | 0.021 | 0.0028 | 0.0028 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0251 | 0.0103 | 0.0076 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.2378 | 0.4021 | 0.3997 |
Schistosoma mansoni | hypothetical protein | 0.021 | 0.0028 | 0.0028 |
Echinococcus multilocularis | G protein coupled receptor 139 | 0.5625 | 1 | 1 |
Schistosoma mansoni | neuropeptide f receptor 76f | 0.021 | 0.0028 | 0.0028 |
Loa Loa (eye worm) | hypothetical protein | 0.5574 | 0.9906 | 1 |
Schistosoma mansoni | amine GPCR | 0.021 | 0.0028 | 0.0028 |
Mycobacterium ulcerans | fructose-2,6-bisphosphatase GpmB | 0.329 | 0.5699 | 1 |
Schistosoma mansoni | growth hormone secretagogue receptor | 0.021 | 0.0028 | 0.0028 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.5574 | 0.9906 | 1 |
Schistosoma mansoni | amine GPCR | 0.021 | 0.0028 | 0.0028 |
Trypanosoma brucei | 6-phosphofructo-2-kinase 2 | 0.548 | 0.9733 | 0.9823 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-1-like protein | 0.2378 | 0.4021 | 0.3997 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0251 | 0.0103 | 0.0076 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.021 | 0.0028 | 0.0028 |
Giardia lamblia | Hypothetical protein | 0.329 | 0.5699 | 0.5 |
Schistosoma mansoni | neuropeptide F-like receptor | 0.021 | 0.0028 | 0.0028 |
Schistosoma mansoni | histamine-responsive GPCR (AAF21638) | 0.021 | 0.0028 | 0.0028 |
Schistosoma mansoni | biogenic amine receptor | 0.021 | 0.0028 | 0.0028 |
Schistosoma mansoni | neuropeptide receptor | 0.021 | 0.0028 | 0.0028 |
Schistosoma mansoni | biogenic amine receptor | 0.021 | 0.0028 | 0.0028 |
Schistosoma mansoni | hypothetical protein | 0.021 | 0.0028 | 0.0028 |
Schistosoma mansoni | opsin-like receptor | 0.021 | 0.0028 | 0.0028 |
Giardia lamblia | Hypothetical protein | 0.329 | 0.5699 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.548 | 0.9733 | 0.9823 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.5574 | 0.9906 | 1 |
Schistosoma mansoni | histamine h1 receptor | 0.021 | 0.0028 | 0.0028 |
Schistosoma mansoni | biogenic amine (dopamine) receptor | 0.021 | 0.0028 | 0.0028 |
Schistosoma mansoni | alpha-1 adrenergic receptor | 0.021 | 0.0028 | 0.0028 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.021 | 0.0028 | 0.0028 |
Echinococcus multilocularis | neuropeptide receptor | 0.5625 | 1 | 1 |
Echinococcus granulosus | 6 phosphofructo 2 kinase:fructose 2 | 0.5574 | 0.9906 | 0.9906 |
Schistosoma mansoni | neuropeptide receptor | 0.5625 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1 nM | Inhibition of cathepsin-D (unknown origin) using C-terminal biotinylated peptide substrate treated 30 mins before addition of peptide substrate measured after 110 mins by fluorescence polarization assay | ChEMBL. | 23856050 |
IC50 (binding) | = 6 nM | Inhibition of recombinant BACE-1 (unknown origin) expressed in Escherichia coli using biotinylated peptide substrate treated 20 mins before substrate addition measured after 3 hrs by fluorescence polarization assay | ChEMBL. | 23856050 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.