Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | beta-site APP-cleaving enzyme 1 | Starlite/ChEMBL | References |
Homo sapiens | cathepsin D | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | plasmepsin X | cathepsin D | 412 aa | 339 aa | 28.9 % |
Plasmodium falciparum | plasmepsin VII | beta-site APP-cleaving enzyme 1 | 401 aa | 352 aa | 21.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.021 | 0.0028 | 0.0028 |
Schistosoma mansoni | muscarinic acetylcholine (GAR) receptor | 0.021 | 0.0028 | 0.0028 |
Onchocerca volvulus | 0.5574 | 0.9906 | 1 | |
Schistosoma mansoni | opsin-like receptor | 0.021 | 0.0028 | 0.0028 |
Schistosoma mansoni | myosin xvIII | 0.021 | 0.0028 | 0.0028 |
Brugia malayi | Cytochrome P450 family protein | 0.0251 | 0.0103 | 1 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.021 | 0.0028 | 0.0028 |
Schistosoma mansoni | memapsin-2 (A01 family) | 0.0535 | 0.0626 | 0.0626 |
Echinococcus multilocularis | G protein coupled receptor 139 | 0.5625 | 1 | 1 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.5574 | 0.9906 | 1 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.021 | 0.0028 | 0.0028 |
Schistosoma mansoni | 6-phosphofructokinase | 0.5574 | 0.9906 | 0.9906 |
Schistosoma mansoni | hypothetical protein | 0.021 | 0.0028 | 0.0028 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.2378 | 0.4021 | 0.3997 |
Schistosoma mansoni | opsin-like receptor | 0.021 | 0.0028 | 0.0028 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.021 | 0.0028 | 0.0028 |
Schistosoma mansoni | hypothetical protein | 0.021 | 0.0028 | 0.0028 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.548 | 0.9733 | 0.9823 |
Brugia malayi | Cytochrome P450 family protein | 0.0251 | 0.0103 | 1 |
Schistosoma mansoni | peptide (FMRFamide/somatostatin)-like receptor | 0.021 | 0.0028 | 0.0028 |
Echinococcus multilocularis | 6 phosphofructo 2 kinase:fructose 2 | 0.5574 | 0.9906 | 0.9906 |
Schistosoma mansoni | neuropeptide receptor | 0.021 | 0.0028 | 0.0028 |
Entamoeba histolytica | phosphoglycerate mutase family protein, putative | 0.329 | 0.5699 | 0.5 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0251 | 0.0103 | 0.0076 |
Schistosoma mansoni | biogenic amine (dopamine) receptor | 0.021 | 0.0028 | 0.0028 |
Schistosoma mansoni | ancient conserved domain protein 2 (cyclin m2) | 0.021 | 0.0028 | 0.0028 |
Schistosoma mansoni | peptide (FMRFamide/neurokinin-3)-like receptor | 0.021 | 0.0028 | 0.0028 |
Loa Loa (eye worm) | hypothetical protein | 0.5574 | 0.9906 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.2378 | 0.4021 | 0.3997 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.021 | 0.0028 | 0.0028 |
Schistosoma mansoni | histamine h1 receptor | 0.021 | 0.0028 | 0.0028 |
Schistosoma mansoni | neuropeptide f receptor 76f | 0.021 | 0.0028 | 0.0028 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.021 | 0.0028 | 0.0028 |
Schistosoma mansoni | amine GPCR | 0.021 | 0.0028 | 0.0028 |
Schistosoma mansoni | neuropeptide receptor | 0.021 | 0.0028 | 0.0028 |
Trypanosoma brucei | 6-phosphofructo-2-kinase 2 | 0.548 | 0.9733 | 0.9823 |
Schistosoma mansoni | neuropeptide F-like receptor | 0.021 | 0.0028 | 0.0028 |
Schistosoma mansoni | peptide (FMRFamide/somatostatin)-like receptor | 0.021 | 0.0028 | 0.0028 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.5574 | 0.9906 | 1 |
Schistosoma mansoni | opsin-like receptor | 0.021 | 0.0028 | 0.0028 |
Schistosoma mansoni | hypothetical protein | 0.021 | 0.0028 | 0.0028 |
Loa Loa (eye worm) | hypothetical protein | 0.3196 | 0.5526 | 0.5566 |
Echinococcus multilocularis | neuropeptide receptor | 0.5625 | 1 | 1 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-1-like protein | 0.2378 | 0.4021 | 0.3997 |
Giardia lamblia | Hypothetical protein | 0.329 | 0.5699 | 0.5 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.5574 | 0.9906 | 1 |
Schistosoma mansoni | biogenic amine receptor | 0.021 | 0.0028 | 0.0028 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.548 | 0.9733 | 0.9823 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.5574 | 0.9906 | 1 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.021 | 0.0028 | 0.0028 |
Schistosoma mansoni | amine GPCR | 0.021 | 0.0028 | 0.0028 |
Schistosoma mansoni | biogenic amine receptor | 0.021 | 0.0028 | 0.0028 |
Mycobacterium ulcerans | hypothetical protein | 0.329 | 0.5699 | 1 |
Schistosoma mansoni | amine GPCR | 0.021 | 0.0028 | 0.0028 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0251 | 0.0103 | 0.0076 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.2378 | 0.4021 | 0.3997 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.021 | 0.0028 | 0.0028 |
Giardia lamblia | Hypothetical protein | 0.329 | 0.5699 | 0.5 |
Schistosoma mansoni | peptide (allatostatin)-like receptor | 0.021 | 0.0028 | 0.0028 |
Schistosoma mansoni | biogenic amine (octopamine/dopamine) receptor | 0.021 | 0.0028 | 0.0028 |
Schistosoma mansoni | histamine-responsive GPCR (AAF21638) | 0.021 | 0.0028 | 0.0028 |
Schistosoma mansoni | neuropeptide F-like receptor | 0.021 | 0.0028 | 0.0028 |
Schistosoma mansoni | growth hormone secretagogue receptor | 0.021 | 0.0028 | 0.0028 |
Schistosoma mansoni | biogenic amine receptor | 0.021 | 0.0028 | 0.0028 |
Schistosoma mansoni | thyrotropin-releasing hormone receptor | 0.021 | 0.0028 | 0.0028 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.548 | 0.9733 | 0.9823 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.021 | 0.0028 | 0.0028 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.021 | 0.0028 | 0.0028 |
Schistosoma mansoni | peptide (allatostatin/somatostatin)-like receptor | 0.021 | 0.0028 | 0.0028 |
Schistosoma mansoni | biogenic amine (dopamine) receptor | 0.021 | 0.0028 | 0.0028 |
Mycobacterium ulcerans | fructose-2,6-bisphosphatase GpmB | 0.329 | 0.5699 | 1 |
Schistosoma mansoni | neuropeptide receptor | 0.5625 | 1 | 1 |
Schistosoma mansoni | alpha-1 adrenergic receptor | 0.021 | 0.0028 | 0.0028 |
Schistosoma mansoni | neuropeptide receptor | 0.021 | 0.0028 | 0.0028 |
Echinococcus granulosus | 6 phosphofructo 2 kinase:fructose 2 | 0.5574 | 0.9906 | 0.9906 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.021 | 0.0028 | 0.0028 |
Schistosoma mansoni | adenoreceptor | 0.021 | 0.0028 | 0.0028 |
Schistosoma mansoni | amine GPCR | 0.021 | 0.0028 | 0.0028 |
Schistosoma mansoni | biogenic amine (dopamine) receptor | 0.021 | 0.0028 | 0.0028 |
Schistosoma mansoni | hypothetical protein | 0.021 | 0.0028 | 0.0028 |
Schistosoma mansoni | amine GPCR | 0.021 | 0.0028 | 0.0028 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0251 | 0.0103 | 0.0076 |
Loa Loa (eye worm) | hypothetical protein | 0.548 | 0.9733 | 0.9825 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 2 nM | Inhibition of cathepsin-D (unknown origin) using C-terminal biotinylated peptide substrate treated 30 mins before addition of peptide substrate measured after 110 mins by fluorescence polarization assay | ChEMBL. | 23856050 |
IC50 (binding) | = 15 nM | Inhibition of recombinant BACE-1 (unknown origin) expressed in Escherichia coli using biotinylated peptide substrate treated 20 mins before substrate addition measured after 3 hrs by fluorescence polarization assay | ChEMBL. | 23856050 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.