Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | Janus kinase 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0008 | 0.0031 | 0.0031 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0143 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0143 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0143 | 1 | 1 |
Entamoeba histolytica | SH2-protein kinase domain containing protein | 0.0008 | 0 | 0.5 |
Echinococcus granulosus | nuclear receptor subfamily 4 group A | 0.0068 | 0.4414 | 0.4414 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.5013 | 0.5013 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.4414 | 0.4414 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0012 | 0.0312 | 0.0312 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0143 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.4414 | 0.4414 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0012 | 0.0312 | 0.0312 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0143 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0068 | 0.4414 | 0.4414 |
Brugia malayi | tailless protein | 0.0068 | 0.4414 | 0.4414 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0143 | 1 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0143 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0068 | 0.4414 | 0.4414 |
Echinococcus multilocularis | nuclear receptor nhr 48 | 0.0068 | 0.4414 | 0.4414 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0008 | 0.0031 | 0.0031 |
Echinococcus multilocularis | potassium:sodium hyperpolarization activated | 0.0008 | 0.0031 | 0.0031 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.5013 | 0.5013 |
Onchocerca volvulus | 0.0068 | 0.4414 | 0.4414 | |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0076 | 0.5013 | 0.5013 |
Brugia malayi | hypothetical protein | 0.0076 | 0.5013 | 0.5013 |
Schistosoma mansoni | thyroid hormone receptor | 0.0143 | 1 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0143 | 1 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0039 | 0.228 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0068 | 0.4414 | 0.4414 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0068 | 0.4414 | 0.4414 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0076 | 0.5013 | 0.5013 |
Echinococcus multilocularis | hyperpolarization activated cyclic | 0.0008 | 0.0031 | 0.0031 |
Schistosoma mansoni | zinc finger protein | 0.0068 | 0.4414 | 0.4414 |
Brugia malayi | ecdysone receptor | 0.0068 | 0.4414 | 0.4414 |
Schistosoma mansoni | coup transcription factor | 0.0143 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.4414 | 0.4414 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0143 | 1 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0143 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 1 | 1 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0143 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.5013 | 0.5013 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0068 | 0.4414 | 0.4414 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0312 | 0.0312 |
Brugia malayi | steroid hormone receptor | 0.0143 | 1 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0039 | 0.228 | 1 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0008 | 0.0031 | 0.0031 |
Onchocerca volvulus | 0.0068 | 0.4414 | 0.4414 | |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0012 | 0.0312 | 0.0312 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0143 | 1 | 1 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0008 | 0.0031 | 0.0031 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0143 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 1 | 1 |
Schistosoma mansoni | nuclear receptor | 0.0068 | 0.4414 | 0.4414 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0076 | 0.5013 | 0.5013 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0143 | 1 | 1 |
Echinococcus granulosus | cyclic nucleotide gated cation channel alpha 3 | 0.0008 | 0.0031 | 0.0031 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0143 | 1 | 1 |
Brugia malayi | nuclear receptor RXR | 0.0076 | 0.5013 | 0.5013 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0143 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0076 | 0.5013 | 0.5013 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0143 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0143 | 1 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0012 | 0.0312 | 0.0312 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0008 | 0.0031 | 0.0031 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0143 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 1 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0068 | 0.4414 | 0.4414 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0143 | 1 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0143 | 1 | 1 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0041 | 0.2481 | 0.2481 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0143 | 1 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0143 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0068 | 0.4414 | 0.4414 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.0068 | 0.4414 | 0.4414 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0143 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.2077 | 0.2077 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0143 | 1 | 1 |
Loa Loa (eye worm) | DR-78 | 0.0068 | 0.4414 | 0.4414 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.5013 | 0.5013 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0143 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0143 | 1 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0143 | 1 | 1 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0068 | 0.4414 | 0.4414 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0143 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 1 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0143 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0143 | 1 | 1 |
Loa Loa (eye worm) | cyclic-nucleotide gated cation channel | 0.0008 | 0.0031 | 0.0031 |
Schistosoma mansoni | nuclear hormone receptor | 0.0143 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.4414 | 0.4414 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0012 | 0.0312 | 0.0312 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0045 | 0.2761 | 0.2761 |
Echinococcus multilocularis | cyclic nucleotide gated cation channel alpha 3 | 0.0008 | 0.0031 | 0.0031 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.4414 | 0.4414 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.0068 | 0.4414 | 0.4414 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.0068 | 0.4414 | 0.4414 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.4414 | 0.4414 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.0068 | 0.4414 | 0.4414 |
Brugia malayi | hypothetical protein | 0.0068 | 0.4414 | 0.4414 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.4414 | 0.4414 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0143 | 1 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0143 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0143 | 1 | 1 |
Echinococcus granulosus | cyclic nucleotide gated cation channel | 0.0008 | 0.0031 | 0.0031 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0008 | 0.0031 | 0.0031 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0143 | 1 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0076 | 0.5013 | 0.5013 |
Brugia malayi | nuclear hormone receptor | 0.0068 | 0.4414 | 0.4414 |
Brugia malayi | hypothetical protein | 0.0076 | 0.5013 | 0.5013 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0143 | 1 | 1 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.0068 | 0.4414 | 0.4414 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0143 | 1 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0143 | 1 | 1 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0041 | 0.2481 | 0.2481 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0068 | 0.4414 | 0.4414 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0068 | 0.4414 | 0.4414 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0008 | 0.0031 | 0.0031 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0143 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.4414 | 0.4414 |
Brugia malayi | nuclear receptor RXR | 0.0068 | 0.4414 | 0.4414 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0068 | 0.4414 | 0.4414 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0068 | 0.4414 | 0.4414 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.0068 | 0.4414 | 0.4414 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0143 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0143 | 1 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0045 | 0.2761 | 0.2761 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 1 | 1 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0012 | 0.0312 | 0.0312 |
Echinococcus granulosus | cyclic nucleotide gated cation channel | 0.0008 | 0.0031 | 0.0031 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.0068 | 0.4414 | 0.4414 |
Loa Loa (eye worm) | cyclic-nucleotide gated cation channel | 0.0008 | 0.0031 | 0.0031 |
Schistosoma mansoni | nuclear receptor | 0.0068 | 0.4414 | 0.4414 |
Schistosoma mansoni | thyroid hormone receptor | 0.0143 | 1 | 1 |
Echinococcus granulosus | potassium:sodium hyperpolarization activated | 0.0008 | 0.0031 | 0.0031 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0143 | 1 | 1 |
Brugia malayi | Cyclic-nucleotide gated cation channel | 0.0008 | 0.0031 | 0.0031 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0143 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0143 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.4414 | 0.4414 |
Echinococcus granulosus | FTZ F1 alpha | 0.0143 | 1 | 1 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0041 | 0.2481 | 0.2481 |
Echinococcus multilocularis | hyperpolarization activated cyclic | 0.0008 | 0.0031 | 0.0031 |
Brugia malayi | nuclear receptor NHR-67 | 0.0068 | 0.4414 | 0.4414 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0041 | 0.2481 | 0.2481 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0143 | 1 | 1 |
Onchocerca volvulus | 0.0143 | 1 | 1 | |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0143 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 1 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0068 | 0.4414 | 0.4414 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0143 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.4414 | 0.4414 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0143 | 1 | 1 |
Echinococcus granulosus | nuclear receptor nhr 48 | 0.0068 | 0.4414 | 0.4414 |
Schistosoma mansoni | nuclear hormone receptor | 0.0068 | 0.4414 | 0.4414 |
Echinococcus granulosus | voltage gated potassium channel | 0.0012 | 0.0312 | 0.0312 |
Echinococcus multilocularis | nuclear receptor subfamily 4 group A | 0.0068 | 0.4414 | 0.4414 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.0068 | 0.4414 | 0.4414 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0143 | 1 | 1 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0068 | 0.4414 | 0.4414 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0076 | 0.5013 | 0.5013 |
Echinococcus granulosus | hyperpolarization activated cyclic | 0.0008 | 0.0031 | 0.0031 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0143 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.5013 | 0.5013 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0068 | 0.4414 | 0.4414 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.4414 | 0.4414 |
Brugia malayi | nuclear hormone receptor | 0.0143 | 1 | 1 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0068 | 0.4414 | 0.4414 |
Brugia malayi | nuclear receptor NHR-88 | 0.0143 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0076 | 0.5013 | 0.5013 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0143 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.4414 | 0.4414 |
Echinococcus multilocularis | cyclic nucleotide gated cation channel | 0.0008 | 0.0031 | 0.0031 |
Echinococcus granulosus | hyperpolarization activated cyclic | 0.0008 | 0.0031 | 0.0031 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.0068 | 0.4414 | 0.4414 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0143 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0143 | 1 | 1 |
Brugia malayi | conserved hypotetical protein | 0.0068 | 0.4414 | 0.4414 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.4414 | 0.4414 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.