TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 333.238 | Formula: C10H16N5O6P
H donors: 7 H acceptors: 5 LogP: -6.07 Rotable bonds: 7
Rule of 5 violations (Lipinski): 2
SMILES: OC[C@@H](COP(=O)(O)O)NCc1c[nH]c2c1nc(N)[nH]c2=O
InChi: 1S/C10H16N5O6P/c11-10-14-7-5(2-13-8(7)9(17)15-10)1-12-6(3-16)4-21-22(18,19)20/h2,6,12-13,16H,1,3-4H2,(H2,18,19,20)(H3,11,14,15,17)/t6-/m0/s1
InChiKey: GLFXVOLQPODIIY-LURJTMIESA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	hypoxanthine phosphoribosyltransferase 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trypanosoma cruzi	hypoxanthine-guanine phosphoribosyltransferase, putative	Get druggable targets OG5_127374	All targets in OG5_127374
Trypanosoma congolense	hypoxanthine-guanine phosphoribosyltransferase, putative	Get druggable targets OG5_127374	All targets in OG5_127374
Plasmodium berghei	hypoxanthine-guanine phosphoribosyltransferase, putative	Get druggable targets OG5_127374	All targets in OG5_127374
Trypanosoma brucei gambiense	hypoxanthine-guanine phosphoribosyltransferase, putative	Get druggable targets OG5_127374	All targets in OG5_127374
Leishmania mexicana	xanthine phosphoribosyltransferase	Get druggable targets OG5_127374	All targets in OG5_127374
Leishmania major	hypoxanthine-guanine phosphoribosyltransferase	Get druggable targets OG5_127374	All targets in OG5_127374
Trypanosoma congolense	hypoxanthine-guanine phosphoribosyltransferase	Get druggable targets OG5_127374	All targets in OG5_127374
Brugia malayi	Phosphoribosyl transferase domain containing protein	Get druggable targets OG5_127374	All targets in OG5_127374
Trypanosoma brucei gambiense	hypoxanthine-guanine phosphoribosyltransferase, putative	Get druggable targets OG5_127374	All targets in OG5_127374
Leishmania donovani	hypoxanthine-guanine phosphoribosyltransferase	Get druggable targets OG5_127374	All targets in OG5_127374
Echinococcus granulosus	hypoxanthine guanine phosphoribosyltransferase	Get druggable targets OG5_127374	All targets in OG5_127374
Mycobacterium ulcerans	hypoxanthine-guanine phosphoribosyltransferase Hpt	Get druggable targets OG5_127374	All targets in OG5_127374
Trichomonas vaginalis	hypoxanthine-guanine phosphoribosyltransferase, putative	Get druggable targets OG5_127374	All targets in OG5_127374
Trypanosoma congolense	hypoxanthine-guanine phosphoribosyltransferase, putative	Get druggable targets OG5_127374	All targets in OG5_127374
Echinococcus multilocularis	hypoxanthine guanine phosphoribosyltransferase	Get druggable targets OG5_127374	All targets in OG5_127374
Mycobacterium tuberculosis	Hypoxanthine-guanine phosphoribosyltransferase Hpt (HGPRT) (HGPRTase) (hypoxanthine phosphoribosyltransferase) (imp pyrophosphor	Get druggable targets OG5_127374	All targets in OG5_127374
Trypanosoma brucei gambiense	hypoxanthine-guanine phosphoribosyltransferase, putative	Get druggable targets OG5_127374	All targets in OG5_127374
Trypanosoma cruzi	hypoxanthine-guanine phosphoribosyltransferase, putative	Get druggable targets OG5_127374	All targets in OG5_127374
Leishmania infantum	xanthine phosphoribosyltransferase	Get druggable targets OG5_127374	All targets in OG5_127374
Trypanosoma brucei	hypoxanthine-guanine phosphoribosyltransferase, putative	Get druggable targets OG5_127374	All targets in OG5_127374
Plasmodium knowlesi	hypoxanthine-guanine phosphoribosyltransferase, putative	Get druggable targets OG5_127374	All targets in OG5_127374
Neospora caninum	Hypoxanthine phosphoribosyltransferase (EC 2.4.2.8), related	Get druggable targets OG5_127374	All targets in OG5_127374
Schistosoma japonicum	Hypoxanthine-guanine phosphoribosyltransferase, putative	Get druggable targets OG5_127374	All targets in OG5_127374
Schistosoma mansoni	hypoxanthine-guanine phosphoribosyltransferase	Get druggable targets OG5_127374	All targets in OG5_127374
Toxoplasma gondii	hypoxanthine-xanthine-guanine phosphoribosyl transferase HXGPRT	Get druggable targets OG5_127374	All targets in OG5_127374
Leishmania braziliensis	xanthine phosphoribosyltransferase	Get druggable targets OG5_127374	All targets in OG5_127374
Leishmania mexicana	hypoxanthine-guanine phosphoribosyltransferase	Get druggable targets OG5_127374	All targets in OG5_127374
Mycobacterium leprae	Probable hypoxanthine-guanine phosphoribosyltransferase Hpt (HGPRT) (HGPRTase) (hypoxanthine phosphoribosyltransferase) (IMP pho	Get druggable targets OG5_127374	All targets in OG5_127374
Trypanosoma brucei	hypoxanthine-guanine phosphoribosyltransferase	Get druggable targets OG5_127374	All targets in OG5_127374
Plasmodium vivax	hypoxanthine-guanine phosphoribosyltransferase, putative	Get druggable targets OG5_127374	All targets in OG5_127374
Trypanosoma cruzi	hypoxanthine-guanine phosphoribosyltransferase, putative	Get druggable targets OG5_127374	All targets in OG5_127374
Plasmodium falciparum	hypoxanthine-guanine phosphoribosyltransferase	Get druggable targets OG5_127374	All targets in OG5_127374
Trypanosoma cruzi	hypoxanthine-guanine phosphoribosyltransferase, putative	Get druggable targets OG5_127374	All targets in OG5_127374
Schistosoma mansoni	hypoxanthine-guanine phosphoribosyltransferase	Get druggable targets OG5_127374	All targets in OG5_127374
Leishmania infantum	hypoxanthine-guanine phosphoribosyltransferase	Get druggable targets OG5_127374	All targets in OG5_127374
Schistosoma japonicum	ko:K00760 hypoxanthine phosphoribosyltransferase [EC2.4.2.8], putative	Get druggable targets OG5_127374	All targets in OG5_127374
Onchocerca volvulus		Get druggable targets OG5_127374	All targets in OG5_127374
Leishmania braziliensis	hypoxanthine-guanine phosphoribosyltransferase	Get druggable targets OG5_127374	All targets in OG5_127374
Leishmania major	xanthine phosphoribosyltransferase	Get druggable targets OG5_127374	All targets in OG5_127374
Echinococcus granulosus	hypoxanthine guanine phosphoribosyltransferase	Get druggable targets OG5_127374	All targets in OG5_127374
Trypanosoma brucei	hypoxanthine-guanine phosphoribosyltransferase	Get druggable targets OG5_127374	All targets in OG5_127374
Giardia lamblia	Guanine phosphoribosyltransferase	Get druggable targets OG5_127374	All targets in OG5_127374
Leishmania donovani	xanthine phosphoribosyltransferase	Get druggable targets OG5_127374	All targets in OG5_127374
Echinococcus multilocularis	hypoxanthine guanine phosphoribosyltransferase	Get druggable targets OG5_127374	All targets in OG5_127374

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	neuropeptides capa receptor	0.0027	0.0111	0.0111
Loa Loa (eye worm)	melatonin receptor type 1A	0.0027	0.0111	0.0231
Trypanosoma cruzi	hypoxanthine-guanine phosphoribosyltransferase, putative	0.0111	1	1
Echinococcus multilocularis	serotonin receptor	0.0027	0.0111	0.0111
Brugia malayi	RE15519p	0.0027	0.0111	0.0111
Onchocerca volvulus		0.0027	0.0111	0.0111
Echinococcus granulosus	neuropeptide Y receptor	0.0027	0.0111	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0111	0.0231
Schistosoma mansoni	growth hormone secretagogue receptor	0.0027	0.0111	0.0111
Echinococcus multilocularis	allatostatin A receptor	0.0027	0.0111	0.0111
Trichomonas vaginalis	hypoxanthine-guanine phosphoribosyltransferase, putative	0.0111	1	1
Leishmania major	xanthine phosphoribosyltransferase	0.0111	1	1
Toxoplasma gondii	ck2 beta subunit	0.0036	0.1218	0.1218
Brugia malayi	hypothetical protein	0.0027	0.0111	0.0111
Echinococcus granulosus	somatostatin receptor	0.0027	0.0111	0.0111
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0027	0.0111	0.0111
Onchocerca volvulus		0.0027	0.0111	0.0111
Plasmodium vivax	casein kinase II beta chain, putative	0.0036	0.1218	0.1218
Schistosoma mansoni	neuropeptide receptor	0.0027	0.0111	0.0111
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0027	0.0111	0.0111
Onchocerca volvulus		0.0027	0.0111	0.0111
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0027	0.0111	0.0111
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0027	0.0111	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0111	0.0231
Schistosoma mansoni	hypoxanthine-guanine phosphoribosyltransferase	0.0111	1	1
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0036	0.1218	0.1218
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0027	0.0111	0.0111
Schistosoma mansoni	neuropeptide F-like receptor	0.0027	0.0111	0.0111
Brugia malayi	Csnk2b protein	0.0036	0.1218	0.1218
Toxoplasma gondii	CMGC kinase, CK2 family	0.0067	0.4791	0.4791
Echinococcus granulosus	allatostatin A receptor	0.0027	0.0111	0.0111
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0027	0.0111	0.0111
Wolbachia endosymbiont of Brugia malayi	amidophosphoribosyltransferase	0.0026	0	0.5
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0027	0.0111	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0111	0.0231
Echinococcus multilocularis	casein kinase ii subunit alpha	0.0067	0.4791	0.4791
Brugia malayi	Dopamine receptor	0.0027	0.0111	0.0111
Schistosoma mansoni	amine GPCR	0.0027	0.0111	0.0111
Echinococcus multilocularis	casein kinase ii subunit beta	0.0036	0.1218	0.1218
Schistosoma mansoni	histamine h1 receptor	0.0027	0.0111	0.0111
Loa Loa (eye worm)	Csnk2b protein	0.0036	0.1218	0.2543
Echinococcus granulosus	tm gpcr rhodopsin	0.0027	0.0111	0.0111
Plasmodium falciparum	casein kinase 2, alpha subunit	0.0067	0.4791	0.4791
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0111	0.0231
Echinococcus granulosus	neuropeptide s receptor	0.0027	0.0111	0.0111
Brugia malayi	Dopamine receptor protein 1	0.0027	0.0111	0.0111
Trypanosoma cruzi	Casein kinase II subunit beta, putative	0.0036	0.1218	0.1218
Trichomonas vaginalis	CMGC family protein kinase	0.0067	0.4791	0.4791
Brugia malayi	Dopamine receptor protein 2	0.0027	0.0111	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0111	0.0231
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0111	0.0231
Brugia malayi	GnHR receptor homolog	0.0027	0.0111	0.0111
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0027	0.0111	0.0111
Loa Loa (eye worm)	TYRA-2 protein	0.0027	0.0111	0.0231
Brugia malayi	putative neuropeptide receptor NPR1	0.0027	0.0111	0.0111
Trypanosoma cruzi	hypoxanthine-guanine phosphoribosyltransferase, putative	0.0111	1	1
Schistosoma mansoni	amine GPCR	0.0027	0.0111	0.0111
Schistosoma mansoni	neuropeptide receptor	0.0027	0.0111	0.0111
Trichomonas vaginalis	CMGC family protein kinase	0.0067	0.4791	0.4791
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0111	0.0231
Echinococcus granulosus	rhodopsin orphan GPCR	0.0027	0.0111	0.0111
Brugia malayi	G-protein coupled receptor	0.0027	0.0111	0.0111
Trichomonas vaginalis	CMGC family protein kinase	0.0067	0.4791	0.4791
Echinococcus multilocularis	g protein coupled receptor	0.0027	0.0111	0.0111
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0027	0.0111	0.0111
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0027	0.0111	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0111	0.0231
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0111	0.0231
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0027	0.0111	0.0111
Onchocerca volvulus		0.0027	0.0111	0.0111
Onchocerca volvulus	Casein kinase II subunit beta homolog	0.0036	0.1218	0.1218
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0027	0.0111	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0111	0.0231
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0111	0.0231
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0036	0.1218	0.1218
Echinococcus granulosus	rhodopsin orphan GPCR	0.0027	0.0111	0.0111
Brugia malayi	AKH receptor	0.0027	0.0111	0.0111
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0027	0.0111	0.0111
Echinococcus multilocularis	neuropeptide s receptor	0.0027	0.0111	0.0111
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0027	0.0111	0.0111
Echinococcus granulosus	rhodopsin orphan GPCR	0.0027	0.0111	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0111	0.0231
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0111	0.0231
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0111	0.0231
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0027	0.0111	0.0111
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0027	0.0111	0.0111
Onchocerca volvulus		0.0027	0.0111	0.0111
Plasmodium vivax	hypoxanthine-guanine phosphoribosyltransferase, putative	0.0111	1	1
Trichomonas vaginalis	CMGC family protein kinase	0.0067	0.4791	0.4791
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0036	0.1218	0.1218
Echinococcus multilocularis	neuropeptide Y receptor	0.0027	0.0111	0.0111
Onchocerca volvulus		0.0027	0.0111	0.0111
Onchocerca volvulus		0.0027	0.0111	0.0111
Mycobacterium tuberculosis	Hypoxanthine-guanine phosphoribosyltransferase Hpt (HGPRT) (HGPRTase) (hypoxanthine phosphoribosyltransferase) (imp pyrophosphor	0.0085	0.6943	1
Schistosoma mansoni	hypothetical protein	0.0027	0.0111	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0111	0.0231
Plasmodium vivax	casein kinase II beta chain, putative	0.0036	0.1218	0.1218
Echinococcus multilocularis	neuropeptide receptor	0.0027	0.0111	0.0111
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0027	0.0111	0.0111
Mycobacterium ulcerans	hypoxanthine-guanine phosphoribosyltransferase Hpt	0.0111	1	1
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0027	0.0111	0.0111
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0036	0.1218	0.1218
Schistosoma mansoni	neuropeptide receptor	0.0027	0.0111	0.0111
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0027	0.0111	0.0111
Echinococcus granulosus	hypoxanthine guanine phosphoribosyltransferase	0.0111	1	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0027	0.0111	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0111	0.0231
Echinococcus granulosus	rhodopsin orphan GPCR	0.0027	0.0111	0.0111
Loa Loa (eye worm)	G-protein coupled receptor	0.0027	0.0111	0.0231
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0027	0.0111	0.0111
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0027	0.0111	0.0111
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0027	0.0111	0.0111
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0027	0.0111	0.0231
Schistosoma mansoni	hypoxanthine-guanine phosphoribosyltransferase	0.0111	1	1
Echinococcus granulosus	7tm_1 domain containing protein	0.0027	0.0111	0.0111
Echinococcus multilocularis	fmrfamide receptor	0.0027	0.0111	0.0111
Trypanosoma brucei	Casein kinase II subunit beta, putative	0.0036	0.1218	0.1218
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0027	0.0111	0.0231
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0111	0.0231
Echinococcus granulosus	dro:myosuppressin receptor	0.0027	0.0111	0.0111
Schistosoma mansoni	hypothetical protein	0.0027	0.0111	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0111	0.0231
Brugia malayi	G protein-coupled receptor F59B2.13	0.0027	0.0111	0.0111
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0027	0.0111	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0111	0.0231
Echinococcus multilocularis	neuropeptide receptor A26	0.0027	0.0111	0.0111
Entamoeba histolytica	casein kinase, putative	0.0067	0.4791	1
Trichomonas vaginalis	CMGC family protein kinase	0.0067	0.4791	0.4791
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0111	0.0231
Echinococcus multilocularis	orexin receptor type 2	0.0027	0.0111	0.0111
Giardia lamblia	Kinase, CMGC CK2	0.0067	0.4791	0.4791
Echinococcus granulosus	neuropeptide receptor	0.0027	0.0111	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0111	0.0231
Echinococcus granulosus	fmrfamide receptor	0.0027	0.0111	0.0111
Trypanosoma cruzi	Casein kinase II subunit beta, putative	0.0036	0.1218	0.1218
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0111	0.0231
Echinococcus granulosus	biogenic amine 5HT receptor	0.0027	0.0111	0.0111
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0027	0.0111	0.0111
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0027	0.0111	0.0111
Loa Loa (eye worm)	neuropeptide F receptor	0.0027	0.0111	0.0231
Brugia malayi	sulfakinin receptor protein	0.0027	0.0111	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0111	0.0231
Plasmodium falciparum	casein kinase II beta chain	0.0036	0.1218	0.1218
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0036	0.1218	0.1218
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0027	0.0111	0.0111
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0027	0.0111	0.0111
Brugia malayi	Casein kinase II, alpha chain	0.0067	0.4791	0.4791
Echinococcus multilocularis	G protein coupled receptor 139	0.0027	0.0111	0.0111
Brugia malayi	G protein-coupled receptor	0.0027	0.0111	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0111	0.0231
Brugia malayi	larval opioid receptor	0.0027	0.0111	0.0111
Schistosoma mansoni	neuropeptide receptor	0.0027	0.0111	0.0111
Schistosoma mansoni	amine GPCR	0.0027	0.0111	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0111	0.0231
Trichomonas vaginalis	CMGC family protein kinase	0.0067	0.4791	0.4791
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0111	0.0231
Brugia malayi	hypothetical protein	0.0027	0.0111	0.0111
Echinococcus granulosus	neuropeptide receptor A26	0.0027	0.0111	0.0111
Echinococcus multilocularis	serotonin receptor	0.0027	0.0111	0.0111
Echinococcus multilocularis	sex peptide receptor	0.0027	0.0111	0.0111
Echinococcus granulosus	G protein coupled receptor 139	0.0027	0.0111	0.0111
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0027	0.0111	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0111	0.0231
Schistosoma mansoni	opsin-like receptor	0.0027	0.0111	0.0111
Brugia malayi	hypothetical protein	0.0027	0.0111	0.0111
Schistosoma mansoni	amine GPCR	0.0027	0.0111	0.0111
Leishmania major	hypoxanthine-guanine phosphoribosyltransferase	0.0111	1	1
Toxoplasma gondii	hypoxanthine-xanthine-guanine phosphoribosyl transferase HXGPRT	0.0111	1	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0027	0.0111	0.0111
Brugia malayi	G-protein coupled receptor	0.0027	0.0111	0.0111
Onchocerca volvulus		0.0027	0.0111	0.0111
Echinococcus granulosus	g protein coupled receptor	0.0027	0.0111	0.0111
Brugia malayi	putative neuropeptide receptor	0.0027	0.0111	0.0111
Plasmodium falciparum	hypoxanthine-guanine phosphoribosyltransferase	0.0111	1	1
Echinococcus multilocularis	dro:myosuppressin receptor	0.0027	0.0111	0.0111
Echinococcus granulosus	hypothetical protein	0.0027	0.0111	0.0111
Entamoeba histolytica	protein kinase domain containing protein	0.0067	0.4791	1
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0027	0.0111	0.0111
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0027	0.0111	0.0231
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0111	0.0231
Treponema pallidum	phosphoribosylpyrophosphate synthetase	0.0026	0	0.5
Echinococcus granulosus	serotonin receptor	0.0027	0.0111	0.0111
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0027	0.0111	0.0111
Brugia malayi	hypothetical protein	0.0027	0.0111	0.0111
Echinococcus multilocularis	neuropeptide receptor	0.0027	0.0111	0.0111
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0027	0.0111	0.0111
Echinococcus multilocularis	g protein coupled receptor	0.0027	0.0111	0.0111
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0036	0.1218	0.1218
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0036	0.1218	0.1218
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0036	0.1218	0.1218
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0027	0.0111	0.0111
Trypanosoma brucei	hypoxanthine-guanine phosphoribosyltransferase	0.0111	1	1
Brugia malayi	follicle stimulating hormone receptor	0.0027	0.0111	0.0111
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0027	0.0111	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0111	0.0231
Trypanosoma cruzi	hypoxanthine-guanine phosphoribosyltransferase, putative	0.0111	1	1
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0036	0.1218	0.1218
Schistosoma mansoni	biogenic amine receptor	0.0027	0.0111	0.0111
Echinococcus multilocularis	g-protein coupled receptor	0.0027	0.0111	0.0111
Echinococcus multilocularis	fmrfamide receptor	0.0027	0.0111	0.0111
Echinococcus multilocularis	hypoxanthine guanine phosphoribosyltransferase	0.0111	1	1
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0111	0.0231
Echinococcus granulosus	neuropeptide Y receptor	0.0027	0.0111	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0111	0.0231
Trypanosoma brucei	hypoxanthine-guanine phosphoribosyltransferase, putative	0.0111	1	1
Echinococcus granulosus	neuropeptides capa receptor	0.0027	0.0111	0.0111
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0027	0.0111	0.0111
Echinococcus granulosus	neuropeptide receptor	0.0027	0.0111	0.0111
Giardia lamblia	Casein kinase II beta chain	0.0036	0.1218	0.1218
Trypanosoma cruzi	casein kinase II, putative	0.0067	0.4791	0.4791
Mycobacterium leprae	Probable hypoxanthine-guanine phosphoribosyltransferase Hpt (HGPRT) (HGPRTase) (hypoxanthine phosphoribosyltransferase) (IMP pho	0.0085	0.6943	1
Schistosoma mansoni	myosin xvIII	0.0027	0.0111	0.0111
Treponema pallidum	adenine phosphoribosyltransferase	0.0026	0	0.5
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0027	0.0111	0.0111
Schistosoma mansoni	opsin-like receptor	0.0027	0.0111	0.0111
Schistosoma mansoni	neuropeptide F-like receptor	0.0027	0.0111	0.0111
Echinococcus granulosus	g-protein coupled receptor	0.0027	0.0111	0.0111
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0027	0.0111	0.0111
Echinococcus granulosus	rhodopsin orphan GPCR	0.0027	0.0111	0.0111
Brugia malayi	hypothetical protein	0.0027	0.0111	0.0111
Schistosoma mansoni	hypothetical protein	0.0027	0.0111	0.0111
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0027	0.0111	0.0111
Echinococcus granulosus	sex peptide receptor	0.0027	0.0111	0.0111
Onchocerca volvulus		0.0027	0.0111	0.0111
Onchocerca volvulus		0.0027	0.0111	0.0111
Onchocerca volvulus		0.0111	1	1
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0111	0.0231
Echinococcus granulosus	rhodopsin orphan GPCR	0.0027	0.0111	0.0111
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0027	0.0111	0.0111
Onchocerca volvulus		0.0027	0.0111	0.0111
Echinococcus granulosus	rhodopsin orphan GPCR	0.0027	0.0111	0.0111
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0027	0.0111	0.0111
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0027	0.0111	0.0111
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0027	0.0111	0.0111
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0027	0.0111	0.0111
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0036	0.1218	0.1218
Leishmania major	casein kinase II, putative	0.0067	0.4791	0.4791
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0027	0.0111	0.0111
Plasmodium falciparum	casein kinase II beta chain	0.0036	0.1218	0.1218
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0027	0.0111	0.0231
Echinococcus granulosus	casein kinase ii subunit alpha	0.0067	0.4791	0.4791
Echinococcus multilocularis	hypoxanthine guanine phosphoribosyltransferase	0.0111	1	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0027	0.0111	0.0111
Brugia malayi	hypothetical protein	0.0027	0.0111	0.0111
Echinococcus granulosus	neuropeptide FF receptor 2	0.0027	0.0111	0.0111
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0036	0.1218	0.1218
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0027	0.0111	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0111	0.0231
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0036	0.1218	0.1218
Schistosoma mansoni	casein kinase II beta subunit	0.0036	0.1218	0.1218
Schistosoma mansoni	hypothetical protein	0.0027	0.0111	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0111	0.0231
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0027	0.0111	0.0111
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0027	0.0111	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0111	0.0231
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0027	0.0111	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0111	0.0231
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0111	0.0231
Echinococcus granulosus	tm gpcr rhodopsin	0.0027	0.0111	0.0111
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0027	0.0111	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0111	0.0231
Brugia malayi	hypothetical protein	0.0027	0.0111	0.0111
Brugia malayi	hypothetical protein	0.0027	0.0111	0.0111
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0027	0.0111	0.0111
Brugia malayi	Melatonin receptor type 1A	0.0027	0.0111	0.0111
Schistosoma mansoni	protein kinase	0.0067	0.4791	0.4791
Echinococcus multilocularis	g protein coupled receptor	0.0027	0.0111	0.0111
Echinococcus multilocularis	neuropeptides capa receptor	0.0027	0.0111	0.0111
Echinococcus granulosus	7TM GPCR rhodopsin	0.0027	0.0111	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0111	0.0231
Brugia malayi	hypothetical protein	0.0027	0.0111	0.0111
Plasmodium vivax	casein kinase 2, alpha subunit, putative	0.0067	0.4791	0.4791
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0027	0.0111	0.0111
Onchocerca volvulus	Casein kinase II subunit beta homolog	0.0036	0.1218	0.1218
Brugia malayi	Serotonin receptor	0.0027	0.0111	0.0111
Loa Loa (eye worm)	G-protein coupled receptor	0.0027	0.0111	0.0231
Brugia malayi	ORL1-like opioid receptor	0.0027	0.0111	0.0111
Schistosoma mansoni	opsin-like receptor	0.0027	0.0111	0.0111
Onchocerca volvulus		0.0027	0.0111	0.0111
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0027	0.0111	0.0111
Echinococcus granulosus	orexin receptor type 2	0.0027	0.0111	0.0111
Trypanosoma brucei	hypoxanthine-guanine phosphoribosyltransferase	0.0111	1	1
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0027	0.0111	0.0111
Loa Loa (eye worm)	CMGC/CK2 protein kinase	0.0067	0.4791	1
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0036	0.1218	0.1218
Echinococcus granulosus	g protein coupled receptor	0.0027	0.0111	0.0111
Brugia malayi	hypothetical protein	0.0027	0.0111	0.0111
Onchocerca volvulus		0.0027	0.0111	0.0111
Echinococcus granulosus	casein kinase ii subunit beta	0.0036	0.1218	0.1218
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0027	0.0111	0.0231
Brugia malayi	Serotonin receptor	0.0027	0.0111	0.0111
Echinococcus granulosus	g protein coupled receptor	0.0027	0.0111	0.0111
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0027	0.0111	0.0111
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0027	0.0111	0.0111
Trichomonas vaginalis	CMGC family protein kinase	0.0067	0.4791	0.4791
Giardia lamblia	Guanine phosphoribosyltransferase	0.0111	1	1
Onchocerca volvulus		0.0027	0.0111	0.0111
Trypanosoma cruzi	hypoxanthine-guanine phosphoribosyltransferase, putative	0.0111	1	1
Echinococcus granulosus	hypoxanthine guanine phosphoribosyltransferase	0.0111	1	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0027	0.0111	0.0111
Onchocerca volvulus		0.0027	0.0111	0.0111
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0036	0.1218	0.1218
Brugia malayi	neuropeptide F receptor	0.0027	0.0111	0.0111
Onchocerca volvulus		0.0027	0.0111	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0111	0.0231
Echinococcus multilocularis	somatostatin receptor	0.0027	0.0111	0.0111
Schistosoma mansoni	neuropeptide f receptor 76f	0.0027	0.0111	0.0111
Schistosoma mansoni	amine GPCR	0.0027	0.0111	0.0111
Leishmania major	protein kinase ck2 regulatory subunit, putative	0.0036	0.1218	0.1218
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0027	0.0111	0.0111
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0027	0.0111	0.0111
Brugia malayi	neuropeptide F receptor	0.0027	0.0111	0.0111
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0027	0.0111	0.0111
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0027	0.0111	0.0111
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0027	0.0111	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0111	0.0231
Loa Loa (eye worm)	neuropeptide F receptor	0.0027	0.0111	0.0231
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0036	0.1218	0.1218
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0027	0.0111	0.0111
Treponema pallidum	hypothetical protein	0.0026	0	0.5
Wolbachia endosymbiont of Brugia malayi	orotate phosphoribosyltransferase	0.0026	0	0.5
Echinococcus granulosus	tm gpcr rhodopsin	0.0027	0.0111	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0111	0.0231
Echinococcus granulosus	neuropeptides capa receptor	0.0027	0.0111	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0111	0.0231
Schistosoma mansoni	biogenic amine receptor	0.0027	0.0111	0.0111
Toxoplasma gondii	casein kinase ii regulatory subunit protein	0.0036	0.1218	0.1218
Plasmodium vivax	unspecified product	0.0067	0.4791	0.4791
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0027	0.0111	0.0111
Schistosoma mansoni	adenoreceptor	0.0027	0.0111	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0111	0.0231
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0111	0.0231
Trypanosoma brucei	Casein kinase II	0.0067	0.4791	0.4791
Onchocerca volvulus		0.0027	0.0111	0.0111
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0027	0.0111	0.0111
Schistosoma mansoni	biogenic amine receptor	0.0027	0.0111	0.0111
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0027	0.0111	0.0111
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0027	0.0111	0.0111

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	> 10000 nM	Inhibition of human HGPRT using xanthine/PRPP assessed as xanthine/guanine conversion to xanthosine-5'-monophosphate/guanosine-5'-monophosphate by spectrophotometry in presence of PRPP	ChEMBL.	23810424

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2414627

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1773604