Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | vitamin D (1,25- dihydroxyvitamin D3) receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | steroid hormone receptor | vitamin D (1,25- dihydroxyvitamin D3) receptor | 427 aa | 416 aa | 24.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.009 | 1 | 1 |
Echinococcus multilocularis | peroxidasin | 0.009 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 1 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.009 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.009 | 1 | 1 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.009 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 1 | 1 |
Schistosoma mansoni | peroxidasin | 0.009 | 1 | 1 |
Brugia malayi | Peroxidasin | 0.009 | 1 | 1 |
Onchocerca volvulus | Dual oxidase homolog | 0.009 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.009 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.009 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.009 | 1 | 1 |
Onchocerca volvulus | 0.009 | 1 | 1 | |
Onchocerca volvulus | Peroxidasin homolog | 0.009 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 1 | 1 |
Echinococcus granulosus | peroxidasin | 0.009 | 1 | 1 |
Schistosoma mansoni | peroxidasin | 0.009 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.009 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.009 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 1 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.009 | 1 | 1 |
Onchocerca volvulus | 0.009 | 1 | 1 | |
Loa Loa (eye worm) | animal heme peroxidase | 0.009 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 1 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.009 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.009 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.009 | 1 | 1 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.009 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 1 | 1 |
Onchocerca volvulus | 0.009 | 1 | 1 | |
Brugia malayi | Blistered cuticle protein 3 | 0.009 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | < 1 % | Binding affinity to human VDR after 2 hrs by fluorescence assay relative to 1alpha,25(OH)2D3 | ChEMBL. | 24900728 |
EC50 (binding) | = 0.21 nM | Transactivation of VDR-mediated osteocalcin promoter in human HOS/SF cells after 24 hrs by luciferase reporter gene assay | ChEMBL. | 24900728 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.