Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Oryctolagus cuniculus | Angiotensin-converting enzyme | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | Angiotensin-converting enzyme family protein | Get druggable targets OG5_131988 | All targets in OG5_131988 |
Loa Loa (eye worm) | angiotensin-converting enzyme family protein | Get druggable targets OG5_131988 | All targets in OG5_131988 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Hypothetical protein | 0.2815 | 0.5139 | 0.5 |
Echinococcus multilocularis | 6 phosphofructo 2 kinase:fructose 2 | 0.477 | 1 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.477 | 1 | 1 |
Trypanosoma brucei | 6-phosphofructo-2-kinase 2 | 0.469 | 0.98 | 0.9706 |
Onchocerca volvulus | 0.477 | 1 | 0.5 | |
Schistosoma mansoni | 6-phosphofructokinase | 0.477 | 1 | 0.5 |
Entamoeba histolytica | phosphoglycerate mutase family protein, putative | 0.2815 | 0.5139 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.469 | 0.98 | 0.98 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.477 | 1 | 1 |
Brugia malayi | Angiotensin-converting enzyme family protein | 0.0749 | 0 | 0.5 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.469 | 0.98 | 0.9706 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.477 | 1 | 1 |
Mycobacterium ulcerans | fructose-2,6-bisphosphatase GpmB | 0.2815 | 0.5139 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2735 | 0.4939 | 0.4939 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.469 | 0.98 | 0.9706 |
Loa Loa (eye worm) | hypothetical protein | 0.477 | 1 | 1 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.477 | 1 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.469 | 0.98 | 0.9706 |
Giardia lamblia | Hypothetical protein | 0.2815 | 0.5139 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.2815 | 0.5139 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.418 uM | Inhibition of rabbit lung ACE assessed as hydrolysis of hippuryl-histidyl-leucine to hippuric acid and histidyl-leucine after 30 mins | ChEMBL. | 23777825 |
IC50 (ADMET) | = 400.4 uM | Cytotoxicity against human A549 cells assessed as cell survival after 24 hrs by MTT assay | ChEMBL. | 23777825 |
Inhibition (binding) | = 86 % | Inhibition of rabbit lung ACE assessed as hydrolysis of hippuryl-histidyl-leucine to hippuric acid and histidyl-leucine at 1 uM after 30 mins relative to control | ChEMBL. | 23777825 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.