Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear receptor subfamily 3, group C, member 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.2941 | 0.5956 | 0.5956 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.2992 | 0.6136 | 0.6136 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.2992 | 0.6136 | 0.6136 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.2941 | 0.5956 | 0.5956 |
Plasmodium falciparum | carbonic anhydrase | 0.1512 | 0.0842 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.1766 | 0.175 | 0.5 |
Leishmania major | carbonic anhydrase-like protein | 0.4072 | 1 | 1 |
Schistosoma mansoni | 6-phosphofructokinase | 0.2992 | 0.6136 | 0.5781 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.4072 | 1 | 1 |
Entamoeba histolytica | phosphoglycerate mutase family protein, putative | 0.1766 | 0.175 | 0.5 |
Trypanosoma brucei | 6-phosphofructo-2-kinase 2 | 0.2941 | 0.5956 | 0.5956 |
Loa Loa (eye worm) | hypothetical protein | 0.2941 | 0.5956 | 0.5584 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.4072 | 1 | 1 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.4072 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2992 | 0.6136 | 0.5781 |
Echinococcus multilocularis | carbonic anhydrase II | 0.4072 | 1 | 1 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.2992 | 0.6136 | 0.6136 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.4072 | 1 | 1 |
Toxoplasma gondii | hypothetical protein | 0.1512 | 0.0842 | 0.5 |
Onchocerca volvulus | 0.2992 | 0.6136 | 0.5 | |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.4072 | 1 | 1 |
Echinococcus multilocularis | 6 phosphofructo 2 kinase:fructose 2 | 0.2992 | 0.6136 | 0.5781 |
Mycobacterium ulcerans | hypothetical protein | 0.1766 | 0.175 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.1766 | 0.175 | 0.5 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.4072 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.4072 | 1 | 1 |
Echinococcus granulosus | carbonic anhydrase II | 0.4072 | 1 | 1 |
Mycobacterium ulcerans | fructose-2,6-bisphosphatase GpmB | 0.1766 | 0.175 | 0.5 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.2941 | 0.5956 | 0.5956 |
Echinococcus granulosus | 6 phosphofructo 2 kinase:fructose 2 | 0.2992 | 0.6136 | 0.5781 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.2992 | 0.6136 | 0.6136 |
Loa Loa (eye worm) | hypothetical protein | 0.1715 | 0.1569 | 0.0794 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.4072 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.65 uM | Antagonist activity at human mineralocorticoid receptor assessed as inhibition of binding to coactivator peptide by NH Pro assay | ChEMBL. | 23777778 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.