Detailed information for compound 177404

Basic information

Technical information
  • TDR Targets ID: 177404
  • Name: 4-N-(2-chloro-6-methylphenyl)-7-N-(2-dimethyl aminoethyl)-8-methoxyimidazo[1,5-a]quinoxalin e-4,7-diamine
  • MW: 424.927 | Formula: C22H25ClN6O
  • H donors: 2 H acceptors: 2 LogP: 5.07 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc2c(cc1NCCN(C)C)nc(c1n2cnc1)Nc1c(C)cccc1Cl
  • InChi: 1S/C22H25ClN6O/c1-14-6-5-7-15(23)21(14)27-22-19-12-24-13-29(19)18-11-20(30-4)17(10-16(18)26-22)25-8-9-28(2)3/h5-7,10-13,25H,8-9H2,1-4H3,(H,26,27)
  • InChiKey: XZWDOPOZRGQDBO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N4-(2-chloro-6-methyl-phenyl)-N7-(2-dimethylaminoethyl)-8-methoxy-imidazo[1,5-a]quinoxaline-4,7-diamine
  • N4-(2-chloro-6-methylphenyl)-N7-(2-dimethylaminoethyl)-8-methoxyimidazo[1,5-a]quinoxaline-4,7-diamine
  • 2-[[4-(2-chloro-6-methyl-anilino)-8-methoxy-imidazo[1,5-a]quinoxalin-7-yl]amino]ethyl-dimethyl-amine
  • N-(2-chloro-6-methylphenyl)-N'-(2-dimethylaminoethyl)-8-methoxyimidazo[5,1-c]quinoxaline-4,7-diamine
  • N-(2-chloro-6-methyl-phenyl)-N'-(2-dimethylaminoethyl)-8-methoxy-imidazo[5,1-c]quinoxaline-4,7-diamine
  • [4-[(2-chloro-6-methyl-phenyl)amino]-8-methoxy-imidazo[1,5-a]quinoxalin-7-yl]-(2-dimethylaminoethyl)amine

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens LCK proto-oncogene, Src family tyrosine kinase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0038 0.0092
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0724 0.4117 1
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0383 0.215 0.5224
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0077 0.0392 0.5
Echinococcus granulosus nuclear receptor nhr 48 0.0342 0.1915 0.4651
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0724 0.4117 1
Echinococcus granulosus GPCR family 2 0.0016 0.0038 0.0092
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0724 0.4117 1
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0077 0.0392 0.5
Echinococcus multilocularis peptidase Clp (S14 family) 0.0051 0.0239 0.0581
Schistosoma mansoni coup transcription factor 0.0724 0.4117 0.4117
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0724 0.4117 1
Echinococcus multilocularis nuclear receptor nhr 48 0.0342 0.1915 0.4651
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0724 0.4117 1
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0077 0.0392 1
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.001 0.0007 0.0018
Brugia malayi ecdysone receptor 0.0342 0.1915 0.4651
Loa Loa (eye worm) hypothetical protein 0.0016 0.0038 0.0092
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0724 0.4117 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0724 0.4117 0.4117
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0038 0.0092
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0724 0.4117 1
Brugia malayi nuclear hormone receptor family member odr-7 0.0342 0.1915 0.4651
Loa Loa (eye worm) hypothetical protein 0.0342 0.1915 0.4651
Brugia malayi nuclear receptor NHR-88 0.0724 0.4117 1
Echinococcus multilocularis c src tyrosine kinase 0.001 0.0007 0.0018
Brugia malayi hypothetical protein 0.0342 0.1915 0.4651
Echinococcus granulosus tyrosine protein kinase Btk29A 0.001 0.0007 0.0018
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0724 0.4117 1
Schistosoma mansoni hypothetical protein 0.0016 0.0038 0.0038
Loa Loa (eye worm) nuclear receptor NHR-67 0.0342 0.1915 0.4651
Echinococcus multilocularis GPCR, family 2 0.0016 0.0038 0.0092
Schistosoma mansoni zinc finger protein 0.0342 0.1915 0.1915
Loa Loa (eye worm) hypothetical protein 0.0342 0.1915 0.4651
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0724 0.4117 1
Loa Loa (eye worm) hypothetical protein 0.0342 0.1915 0.4651
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0724 0.4117 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0724 0.4117 1
Brugia malayi Steroid receptor seven-up type 2 0.0724 0.4117 1
Brugia malayi Nuclear hormone receptor E75 0.0342 0.1915 0.4651
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0724 0.4117 1
Schistosoma mansoni nuclear receptor nhr-48 0.0342 0.1915 0.1915
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0724 0.4117 1
Loa Loa (eye worm) hypothetical protein 0.0724 0.4117 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0724 0.4117 0.4117
Schistosoma mansoni nuclear receptor 0.0342 0.1915 0.1915
Schistosoma mansoni RAR-like nuclear receptor 0.0724 0.4117 0.4117
Loa Loa (eye worm) hypothetical protein 0.0724 0.4117 1
Brugia malayi SRC-1 0.001 0.0007 0.0018
Loa Loa (eye worm) hypothetical protein 0.0034 0.0142 0.0344
Loa Loa (eye worm) hypothetical protein 0.0724 0.4117 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0231 0.0562
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0231 0.0562
Schistosoma mansoni tyrosine kinase 0.001 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0724 0.4117 1
Schistosoma mansoni tyrosine kinase 0.001 0.0007 0.0007
Onchocerca volvulus Protein ultraspiracle homolog 0.0724 0.4117 1
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0051 0.0239 0.4744
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0724 0.4117 1
Brugia malayi hypothetical protein 0.0383 0.215 0.5224
Brugia malayi nuclear receptor RXR 0.0383 0.215 0.5224
Echinococcus granulosus tyrosine protein kinase Fyn 0.001 0.0007 0.0018
Loa Loa (eye worm) hypothetical protein 0.0342 0.1915 0.4651
Loa Loa (eye worm) hypothetical protein 0.0383 0.215 0.5224
Brugia malayi nuclear receptor NHR-88 0.0342 0.1915 0.4651
Schistosoma mansoni nuclear hormone receptor 0.0724 0.4117 0.4117
Loa Loa (eye worm) hypothetical protein 0.0383 0.215 0.5224
Loa Loa (eye worm) hypothetical protein 0.0724 0.4117 1
Echinococcus granulosus thyroid hormone receptor alpha 0.0342 0.1915 0.4651
Schistosoma mansoni peptidase Clp (S14 family) 0.0077 0.0392 0.0392
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0724 0.4117 0.4117
Schistosoma mansoni hypothetical protein 0.0034 0.0142 0.0142
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0724 0.4117 1
Loa Loa (eye worm) hypothetical protein 0.0342 0.1915 0.4651
Echinococcus granulosus tyrosine protein kinase Fyn 0.001 0.0007 0.0018
Echinococcus granulosus tyrosine protein kinase Src64B 0.001 0.0007 0.0018
Onchocerca volvulus Bile acid receptor homolog 0.0724 0.4117 1
Schistosoma mansoni hypothetical protein 0.0016 0.0038 0.0038
Brugia malayi hypothetical protein 0.0342 0.1915 0.4651
Schistosoma mansoni hypothetical protein 0.0016 0.0038 0.0038
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0724 0.4117 1
Echinococcus granulosus peptidase Clp S14 family 0.0051 0.0239 0.0581
Loa Loa (eye worm) hypothetical protein 0.0342 0.1915 0.4651
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0383 0.215 0.215
Schistosoma mansoni tyrosine kinase 0.001 0.0007 0.0007
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0724 0.4117 1
Schistosoma mansoni tyrosine kinase 0.001 0.0007 0.0007
Echinococcus multilocularis ecdysone induced protein 78C 0.0724 0.4117 1
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0342 0.1915 0.4651
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0342 0.1915 0.4651
Loa Loa (eye worm) hypothetical protein 0.0049 0.0231 0.0562
Echinococcus multilocularis tyrosine protein kinase Fyn 0.001 0.0007 0.0018
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.001 0.0007 0.0018
Brugia malayi Nuclear hormone receptor-like 1 0.0724 0.4117 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0724 0.4117 1
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.001 0.0007 0.0018
Echinococcus granulosus Nuclear hormone receptor HR96 0.0342 0.1915 0.4651
Onchocerca volvulus 0.0724 0.4117 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0231 0.0562
Brugia malayi nuclear receptor RXR 0.0342 0.1915 0.4651
Echinococcus multilocularis tyrosine protein kinase Fgr 0.001 0.0007 0.0018
Loa Loa (eye worm) hypothetical protein 0.0342 0.1915 0.4651
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0724 0.4117 1
Schistosoma mansoni thyroid hormone receptor 0.0724 0.4117 0.4117
Loa Loa (eye worm) hypothetical protein 0.0724 0.4117 1
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0077 0.0392 0.5
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.001 0.0007 0.0018
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0077 0.0392 0.5
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0724 0.4117 0.4117
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0724 0.4117 0.4117
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0038 0.0092
Brugia malayi steroid hormone receptor 0.0724 0.4117 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0724 0.4117 1
Echinococcus granulosus tyrosine protein kinase Src42A 0.001 0.0007 0.0018
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0342 0.1915 0.4651
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0038 0.0092
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0724 0.4117 1
Brugia malayi nuclear hormone receptor 0.0724 0.4117 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0724 0.4117 1
Schistosoma mansoni nuclear hormone receptor 0.0342 0.1915 0.1915
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0724 0.4117 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0342 0.1915 0.4651
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0383 0.215 0.215
Brugia malayi ecdysteroid receptor 0.0724 0.4117 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0724 0.4117 1
Loa Loa (eye worm) hypothetical protein 0.0383 0.215 0.5224
Echinococcus multilocularis tyrosine protein kinase Fyn 0.001 0.0007 0.0018
Echinococcus multilocularis tyrosine protein kinase Src64B 0.001 0.0007 0.0018
Echinococcus multilocularis thyroid hormone receptor alpha 0.0724 0.4117 1
Loa Loa (eye worm) hypothetical protein 0.0342 0.1915 0.4651
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0383 0.215 0.5224
Brugia malayi hypothetical protein 0.0383 0.215 0.5224
Brugia malayi nuclear receptor NHR-67 0.0342 0.1915 0.4651
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0724 0.4117 1
Schistosoma mansoni nuclear receptor 0.0342 0.1915 0.1915
Brugia malayi nuclear hormone receptor family member nhr-6 0.0342 0.1915 0.4651
Schistosoma mansoni thyroid hormone receptor 0.0724 0.4117 0.4117
Echinococcus multilocularis tyrosine protein kinase Src42A 0.001 0.0007 0.0018
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0077 0.0392 0.0953
Brugia malayi conserved hypotetical protein 0.0342 0.1915 0.4651
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0142 0.0344
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0724 0.4117 1
Brugia malayi Nuclear hormone receptor E75 0.0342 0.1915 0.4651
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0724 0.4117 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0724 0.4117 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0038 0.0092
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0077 0.0392 1
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.001 0.0007 0.0018
Brugia malayi nuclear hormone receptor 0.0342 0.1915 0.4651
Echinococcus multilocularis FTZ F1 alpha 0.0724 0.4117 1
Loa Loa (eye worm) hypothetical protein 0.0383 0.215 0.5224
Loa Loa (eye worm) hypothetical protein 0.0077 0.0392 0.0953
Echinococcus multilocularis tyrosine protein kinase Abl 0.001 0.0007 0.0018
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0051 0.0239 0.5
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0724 0.4117 0.4117
Brugia malayi orphan nuclear receptor NR2E1 0.0342 0.1915 0.4651
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0724 0.4117 1
Loa Loa (eye worm) nuclear hormone receptor 0.0342 0.1915 0.4651
Loa Loa (eye worm) hypothetical protein 0.0342 0.1915 0.4651
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0724 0.4117 1
Echinococcus granulosus FTZ F1 alpha 0.0724 0.4117 1
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0077 0.0392 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0342 0.1915 0.4651
Loa Loa (eye worm) hypothetical protein 0.0342 0.1915 0.4651
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0077 0.0392 1
Schistosoma mansoni retinoic acid receptor RXR 0.0724 0.4117 0.4117
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0038 0.0092
Loa Loa (eye worm) SRC-1 0.001 0.0007 0.0018
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0077 0.0392 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0724 0.4117 1
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0077 0.0392 1
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0342 0.1915 0.4651
Loa Loa (eye worm) hypothetical protein 0.0383 0.215 0.5224
Echinococcus granulosus ecdysone induced protein 78C 0.0724 0.4117 1
Brugia malayi Probable ClpP-like protease 0.0077 0.0392 0.0953
Brugia malayi Nuclear hormone receptor-like 1 0.0383 0.215 0.5224
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0077 0.0392 0.0953
Echinococcus granulosus tyrosine protein kinase Fyn 0.001 0.0007 0.0018
Schistosoma mansoni hypothetical protein 0.0016 0.0038 0.0038
Brugia malayi Tyrosine-protein kinase abl-1 0.001 0.0007 0.0018
Echinococcus granulosus tyrosine protein kinase Lyn 0.001 0.0007 0.0018
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.001 0.0007 0.0018
Echinococcus multilocularis tyrosine protein kinase Fyn 0.001 0.0007 0.0018
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0342 0.1915 0.4651
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0724 0.4117 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0724 0.4117 1
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.001 0.0007 0.0007
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0383 0.215 0.5224
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0342 0.1915 0.4651
Loa Loa (eye worm) steroid hormone receptor 0.0724 0.4117 1
Loa Loa (eye worm) DR-78 0.0342 0.1915 0.4651
Loa Loa (eye worm) hypothetical protein 0.0342 0.1915 0.4651
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0342 0.1915 0.4651
Echinococcus granulosus Nuclear hormone receptor HR96 0.0342 0.1915 0.4651
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0342 0.1915 0.1915
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0077 0.0392 0.5
Loa Loa (eye worm) hypothetical protein 0.0342 0.1915 0.4651
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0724 0.4117 1
Loa Loa (eye worm) hypothetical protein 0.0724 0.4117 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0724 0.4117 0.4117
Brugia malayi Nuclear hormone receptor-like 1 0.0383 0.215 0.5224
Loa Loa (eye worm) hypothetical protein 0.0724 0.4117 1
Loa Loa (eye worm) hypothetical protein 0.0342 0.1915 0.4651
Brugia malayi tailless protein 0.0342 0.1915 0.4651
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0051 0.0239 0.5
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0038 0.0092
Echinococcus granulosus c src tyrosine kinase 0.001 0.0007 0.0018
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0724 0.4117 1
Schistosoma mansoni nuclear hormone receptor 0.0342 0.1915 0.1915

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 1.7 nM 50% inhibition of the phosphorylation of an exogenous substrate by human Lck enzyme. ChEMBL. 12372522
IC50 (binding) = 1.7 nM Inhibition of recombinant p56 Lck tyrosine kinase expressed in insect cells ChEMBL. 15317463
IC50 (binding) = 1.7 nM Inhibition of Lck (unknown origin) ChEMBL. 18271520
IC50 (binding) = 1.7 nM 50% inhibition of the phosphorylation of an exogenous substrate by human Lck enzyme. ChEMBL. 12372522
IC50 (binding) = 1.7 nM Inhibition of Lck (unknown origin) ChEMBL. 18271520
IC50 (functional) = 190 nM 50% inhibition of T-cell proliferation induced by anti-CD3/anti-CD28 co-stimulation in human peripheral blood leukocytes (PBLs). ChEMBL. 12372522
IC50 (functional) = 190 nM Inhibition of T cell proliferation (unknown origin) ChEMBL. 18271520
IC50 (functional) = 194 nM Inhibition of Human PBL (T cell) proliferation ChEMBL. 15317463

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

3 literature references were collected for this gene.

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