Detailed information for compound 1774062

Basic information

Technical information
  • TDR Targets ID: 1774062
  • Name: (2-nitrophenyl)-phenylmethanol
  • MW: 229.231 | Formula: C13H11NO3
  • H donors: 1 H acceptors: 3 LogP: 2.56 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: [O-][N+](=O)c1ccccc1C(c1ccccc1)O
  • InChi: 1S/C13H11NO3/c15-13(10-6-2-1-3-7-10)11-8-4-5-9-12(11)14(16)17/h1-9,13,15H
  • InChiKey: AIHHQWUKHCUKLJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2-nitrophenyl)-phenyl-methanol
  • (2-Nitrophenyl)(phenyl)methanol
  • Benzenemethanol, 2-nitro-.alpha.-phenyl-

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Pseudomonas aeruginosa 2-heptyl-4(1H)-quinolone synthase PqsD Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium ulcerans beta-ketoacyl synthase-like protein Get druggable targets OG5_129509 All targets in OG5_129509
Plasmodium vivax beta-ketoacyl-acyl carrier protein synthase III precursor, putative Get druggable targets OG5_129509 All targets in OG5_129509
Plasmodium falciparum beta-ketoacyl-ACP synthase III Get druggable targets OG5_129509 All targets in OG5_129509
Plasmodium berghei apicoplast beta-ketoacyl-acyl carrier protein synthase III precursor, putative Get druggable targets OG5_129509 All targets in OG5_129509
Chlamydia trachomatis oxoacyl-ACP synthase III Get druggable targets OG5_129509 All targets in OG5_129509
Plasmodium knowlesi beta-ketoacyl-acyl carrier protein synthase III precursor, putative Get druggable targets OG5_129509 All targets in OG5_129509
Mycobacterium ulcerans 3-oxoacyl-ACP synthase Get druggable targets OG5_129509 All targets in OG5_129509
Mycobacterium ulcerans 3-oxoacyl-ACP synthase Get druggable targets OG5_129509 All targets in OG5_129509
Mycobacterium tuberculosis 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) Get druggable targets OG5_129509 All targets in OG5_129509
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase Get druggable targets OG5_129509 All targets in OG5_129509
Neospora caninum 3-oxoacyl-(acyl-carrier-protein) synthase III family protein, putative Get druggable targets OG5_129509 All targets in OG5_129509
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium ulcerans chalcone/stilbene synthase 2-heptyl-4(1H)-quinolone synthase PqsD   337 aa 278 aa 25.5 %
Mycobacterium ulcerans chalcone synthase, Pks11 2-heptyl-4(1H)-quinolone synthase PqsD   337 aa 293 aa 27.3 %
Mycobacterium tuberculosis Conserved hypothetical protein 2-heptyl-4(1H)-quinolone synthase PqsD   337 aa 307 aa 24.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0074 0.0405 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0074 0.0405 1
Echinococcus granulosus tm gpcr rhodopsin 0.0074 0.0405 1
Echinococcus granulosus hypothetical protein 0.0074 0.0405 1
Echinococcus multilocularis g protein coupled receptor 0.0074 0.0405 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0074 0.0405 1
Brugia malayi follicle stimulating hormone receptor 0.0074 0.0405 0.4658
Loa Loa (eye worm) hypothetical protein 0.0074 0.0405 0.4658
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.007 0.0287 0.5
Onchocerca volvulus 0.0074 0.0405 0.5
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0074 0.0405 1
Plasmodium vivax beta-ketoacyl-acyl carrier protein synthase III precursor, putative 0.0383 1 1
Loa Loa (eye worm) neuropeptide F receptor 0.0074 0.0405 0.4658
Brugia malayi hypothetical protein 0.0074 0.0405 0.4658
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0089 0.0869 1
Echinococcus granulosus peptide allatostatin:somatostatin 0.0074 0.0405 1
Brugia malayi sulfakinin receptor protein 0.0074 0.0405 0.4658
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0074 0.0405 1
Schistosoma mansoni opsin-like receptor 0.0074 0.0405 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0074 0.0405 1
Loa Loa (eye worm) melatonin receptor type 1A 0.0074 0.0405 0.4658
Loa Loa (eye worm) hypothetical protein 0.0074 0.0405 0.4658
Echinococcus multilocularis G-protein coupled receptor, putative 0.0074 0.0405 1
Echinococcus granulosus neuropeptides capa receptor 0.0074 0.0405 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.0405 0.4658
Giardia lamblia DNA repair protein RAD52 0.0308 0.7659 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0074 0.0405 1
Brugia malayi larval opioid receptor 0.0074 0.0405 0.4658
Onchocerca volvulus 0.0074 0.0405 0.5
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0383 1 1
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0074 0.0405 1
Echinococcus multilocularis g protein coupled receptor 0.0074 0.0405 1
Brugia malayi AKH receptor 0.0074 0.0405 0.4658
Onchocerca volvulus 0.0074 0.0405 0.5
Brugia malayi hypothetical protein 0.0074 0.0405 0.4658
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0074 0.0405 1
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0074 0.0405 0.4658
Onchocerca volvulus 0.0074 0.0405 0.5
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0074 0.0405 1
Schistosoma mansoni adenoreceptor 0.0074 0.0405 1
Brugia malayi putative neuropeptide receptor NPR1 0.0074 0.0405 0.4658
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0074 0.0405 0.4658
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0074 0.0405 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.0405 0.4658
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.007 0.0287 0.5
Echinococcus granulosus neuropeptide receptor 0.0074 0.0405 1
Echinococcus granulosus neuropeptide FF receptor 2 0.0074 0.0405 1
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0074 0.0405 1
Schistosoma mansoni amine GPCR 0.0074 0.0405 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0074 0.0405 1
Echinococcus granulosus neuropeptide receptor A26 0.0074 0.0405 1
Brugia malayi hypothetical protein 0.0074 0.0405 0.4658
Mycobacterium ulcerans beta-ketoacyl synthase-like protein 0.0383 1 1
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0074 0.0405 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.0405 0.4658
Brugia malayi G-protein coupled receptor 0.0074 0.0405 0.4658
Loa Loa (eye worm) hypothetical protein 0.0074 0.0405 0.4658
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0089 0.0869 1
Echinococcus granulosus 7TM GPCR rhodopsin 0.0074 0.0405 1
Echinococcus granulosus fmrfamide receptor 0.0074 0.0405 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0074 0.0405 1
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0074 0.0405 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0074 0.0405 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0074 0.0405 0.4658
Echinococcus multilocularis somatostatin receptor 0.0074 0.0405 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0074 0.0405 1
Echinococcus multilocularis neuropeptide receptor 0.0074 0.0405 1
Echinococcus granulosus dro:myosuppressin receptor 0.0074 0.0405 1
Schistosoma mansoni hypothetical protein 0.0074 0.0405 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.0405 0.4658
Schistosoma mansoni amine GPCR 0.0074 0.0405 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.0405 0.4658
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0074 0.0405 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0074 0.0405 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.0405 0.4658
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0074 0.0405 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.0405 0.4658
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0074 0.0405 0.4658
Loa Loa (eye worm) hypothetical protein 0.0074 0.0405 0.4658
Schistosoma mansoni alpha-1 adrenergic receptor 0.0074 0.0405 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0074 0.0405 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0074 0.0405 1
Schistosoma mansoni opsin-like receptor 0.0074 0.0405 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0074 0.0405 1
Schistosoma mansoni biogenic amine receptor 0.0074 0.0405 1
Brugia malayi G protein-coupled receptor 0.0074 0.0405 0.4658
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0074 0.0405 1
Echinococcus multilocularis neuropeptide receptor A26 0.0074 0.0405 1
Onchocerca volvulus 0.0074 0.0405 0.5
Loa Loa (eye worm) hypothetical protein 0.0074 0.0405 0.4658
Onchocerca volvulus 0.0074 0.0405 0.5
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0074 0.0405 1
Echinococcus granulosus g protein coupled receptor 0.0074 0.0405 1
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0074 0.0405 0.4658
Loa Loa (eye worm) hypothetical protein 0.0074 0.0405 0.4658
Schistosoma mansoni amine GPCR 0.0074 0.0405 1
Schistosoma mansoni myosin xvIII 0.0074 0.0405 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0074 0.0405 1
Echinococcus multilocularis dro:myosuppressin receptor 0.0074 0.0405 1
Echinococcus multilocularis neuropeptide Y receptor 0.0074 0.0405 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0074 0.0405 1
Echinococcus granulosus orexin receptor type 2 0.0074 0.0405 1
Echinococcus granulosus neuropeptide receptor 0.0074 0.0405 1
Loa Loa (eye worm) hypothetical protein 0.007 0.0287 0.3298
Schistosoma mansoni opsin-like receptor 0.0074 0.0405 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0074 0.0405 1
Schistosoma mansoni neuropeptide receptor 0.0074 0.0405 1
Brugia malayi Dopamine receptor protein 2 0.0074 0.0405 0.4658
Loa Loa (eye worm) hypothetical protein 0.0074 0.0405 0.4658
Loa Loa (eye worm) hypothetical protein 0.0074 0.0405 0.4658
Onchocerca volvulus 0.0074 0.0405 0.5
Echinococcus multilocularis g protein coupled receptor 0.0074 0.0405 1
Echinococcus multilocularis neuropeptides capa receptor 0.0074 0.0405 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0074 0.0405 0.4658
Loa Loa (eye worm) hypothetical protein 0.0074 0.0405 0.4658
Echinococcus multilocularis orexin receptor type 2 0.0074 0.0405 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.0405 0.4658
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0074 0.0405 1
Brugia malayi neuropeptide F receptor 0.0074 0.0405 0.4658
Loa Loa (eye worm) hypothetical protein 0.0074 0.0405 0.4658
Schistosoma mansoni neuropeptide F-like receptor 0.0074 0.0405 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.0405 0.4658
Echinococcus multilocularis neuropeptide s receptor 0.0074 0.0405 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0074 0.0405 1
Brugia malayi GnHR receptor homolog 0.0074 0.0405 0.4658
Brugia malayi Calcitonin receptor-like protein seb-1 0.0089 0.0869 1
Loa Loa (eye worm) G-protein coupled receptor 0.0074 0.0405 0.4658
Echinococcus multilocularis serotonin receptor 0.0074 0.0405 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.0405 0.4658
Brugia malayi hypothetical protein 0.0074 0.0405 0.4658
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0074 0.0405 1
Brugia malayi hypothetical protein 0.0074 0.0405 0.4658
Echinococcus granulosus neuropeptides capa receptor 0.0074 0.0405 1
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0383 1 1
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0074 0.0405 1
Echinococcus granulosus neuropeptide Y receptor 0.0074 0.0405 1
Schistosoma mansoni neuropeptide F-like receptor 0.0074 0.0405 1
Echinococcus granulosus neuropeptide Y receptor 0.0074 0.0405 1
Brugia malayi neuropeptide F receptor 0.0074 0.0405 0.4658
Onchocerca volvulus 0.0074 0.0405 0.5
Loa Loa (eye worm) hypothetical protein 0.0074 0.0405 0.4658
Brugia malayi Probable ClpP-like protease 0.007 0.0287 0.3298
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0074 0.0405 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0074 0.0405 1
Schistosoma mansoni neuropeptide receptor 0.0074 0.0405 1
Brugia malayi Dopamine receptor 0.0074 0.0405 0.4658
Loa Loa (eye worm) hypothetical protein 0.0074 0.0405 0.4658
Loa Loa (eye worm) neuropeptide F receptor 0.0074 0.0405 0.4658
Echinococcus multilocularis neuropeptides capa receptor 0.0074 0.0405 1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0074 0.0405 0.4658
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0074 0.0405 0.4658
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0074 0.0405 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.0405 0.4658
Schistosoma mansoni hypothetical protein 0.0074 0.0405 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0074 0.0405 1
Echinococcus granulosus alpha 1A adrenergic receptor 0.0074 0.0405 1
Echinococcus granulosus tm gpcr rhodopsin 0.0074 0.0405 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.0405 0.4658
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0074 0.0405 1
Schistosoma mansoni neuropeptide receptor 0.0074 0.0405 1
Brugia malayi hypothetical protein 0.0074 0.0405 0.4658
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0074 0.0405 1
Brugia malayi hypothetical protein 0.0074 0.0405 0.4658
Echinococcus multilocularis sex peptide receptor 0.0074 0.0405 1
Schistosoma mansoni biogenic amine receptor 0.0074 0.0405 1
Echinococcus granulosus g protein coupled receptor 0.0074 0.0405 1
Brugia malayi Dopamine receptor protein 1 0.0074 0.0405 0.4658
Loa Loa (eye worm) hypothetical protein 0.0074 0.0405 0.4658
Echinococcus granulosus G protein coupled receptor 139 0.0074 0.0405 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0074 0.0405 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0074 0.0405 1
Plasmodium falciparum beta-ketoacyl-ACP synthase III 0.0383 1 1
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.007 0.0287 0.5
Echinococcus granulosus allatostatin A receptor 0.0074 0.0405 1
Echinococcus multilocularis serotonin receptor 0.0074 0.0405 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0074 0.0405 1
Echinococcus granulosus somatostatin receptor 0.0074 0.0405 1
Brugia malayi hypothetical protein 0.0074 0.0405 0.4658
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0074 0.0405 0.4658
Loa Loa (eye worm) hypothetical protein 0.0074 0.0405 0.4658
Schistosoma mansoni neuropeptide f receptor 76f 0.0074 0.0405 1
Echinococcus multilocularis neuropeptide receptor 0.0074 0.0405 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0074 0.0405 1
Echinococcus multilocularis fmrfamide receptor 0.0074 0.0405 1
Echinococcus multilocularis allatostatin A receptor 0.0074 0.0405 1
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0074 0.0405 1
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0074 0.0405 0.4658
Loa Loa (eye worm) hypothetical protein 0.0089 0.0869 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0074 0.0405 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0074 0.0405 1
Echinococcus granulosus g protein coupled receptor 0.0074 0.0405 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0074 0.0405 1
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.007 0.0287 0.5
Loa Loa (eye worm) hypothetical protein 0.0074 0.0405 0.4658
Loa Loa (eye worm) hypothetical protein 0.0074 0.0405 0.4658
Loa Loa (eye worm) hypothetical protein 0.0074 0.0405 0.4658
Loa Loa (eye worm) hypothetical protein 0.0074 0.0405 0.4658
Onchocerca volvulus 0.0074 0.0405 0.5
Echinococcus multilocularis neuropeptide FF receptor 2 0.0074 0.0405 1
Onchocerca volvulus 0.0074 0.0405 0.5
Schistosoma mansoni histamine h1 receptor 0.0074 0.0405 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.0074 0.0405 0.4658
Brugia malayi hypothetical protein 0.0074 0.0405 0.4658
Loa Loa (eye worm) hypothetical protein 0.0074 0.0405 0.4658
Onchocerca volvulus 0.0074 0.0405 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0074 0.0405 1
Onchocerca volvulus 0.0074 0.0405 0.5
Loa Loa (eye worm) hypothetical protein 0.0074 0.0405 0.4658
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.0383 1 1
Echinococcus multilocularis g-protein coupled receptor 0.0074 0.0405 1
Echinococcus granulosus neuropeptide s receptor 0.0074 0.0405 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.0405 0.4658
Echinococcus granulosus tachykinin peptides receptor 99D 0.0074 0.0405 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.0405 0.4658
Loa Loa (eye worm) hypothetical protein 0.0074 0.0405 0.4658
Echinococcus multilocularis neuropeptide Y receptor 0.0074 0.0405 1
Brugia malayi hypothetical protein 0.0074 0.0405 0.4658
Schistosoma mansoni hypothetical protein 0.0074 0.0405 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0074 0.0405 1
Schistosoma mansoni peptidase Clp (S14 family) 0.007 0.0287 0.7081
Brugia malayi RE15519p 0.0074 0.0405 0.4658
Echinococcus granulosus biogenic amine 5HT receptor 0.0074 0.0405 1
Echinococcus granulosus tm gpcr rhodopsin 0.0074 0.0405 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0074 0.0405 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.0405 0.4658
Onchocerca volvulus 0.0074 0.0405 0.5
Echinococcus multilocularis fmrfamide receptor 0.0074 0.0405 1
Loa Loa (eye worm) G-protein coupled receptor 0.0074 0.0405 0.4658
Schistosoma mansoni neuropeptide receptor 0.0074 0.0405 1
Schistosoma mansoni hypothetical protein 0.0074 0.0405 1
Schistosoma mansoni amine GPCR 0.0074 0.0405 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0074 0.0405 1
Echinococcus granulosus 7tm_1 domain containing protein 0.0074 0.0405 1
Echinococcus granulosus serotonin receptor 0.0074 0.0405 1
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0074 0.0405 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0074 0.0405 1
Mycobacterium tuberculosis 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) 0.0383 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0074 0.0405 0.4658
Schistosoma mansoni amine GPCR 0.0074 0.0405 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0074 0.0405 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.0405 0.4658
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0074 0.0405 1
Echinococcus granulosus g-protein coupled receptor 0.0074 0.0405 1
Schistosoma mansoni growth hormone secretagogue receptor 0.0074 0.0405 1
Onchocerca volvulus 0.0074 0.0405 0.5
Brugia malayi putative neuropeptide receptor 0.0074 0.0405 0.4658
Loa Loa (eye worm) hypothetical protein 0.0074 0.0405 0.4658
Echinococcus granulosus sex peptide receptor 0.0074 0.0405 1
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0074 0.0405 0.5
Brugia malayi G-protein coupled receptor 0.0074 0.0405 0.4658
Onchocerca volvulus 0.0074 0.0405 0.5
Loa Loa (eye worm) hypothetical protein 0.0074 0.0405 0.4658
Schistosoma mansoni biogenic amine receptor 0.0074 0.0405 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0074 0.0405 1
Brugia malayi Serotonin receptor 0.0074 0.0405 0.4658
Loa Loa (eye worm) TYRA-2 protein 0.0074 0.0405 0.4658
Echinococcus granulosus biogenic amine 5HT receptor 0.0074 0.0405 1
Echinococcus multilocularis G protein coupled receptor 139 0.0074 0.0405 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0074 0.0405 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.0405 0.4658
Echinococcus granulosus rhodopsin orphan GPCR 0.0074 0.0405 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0074 0.0405 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0074 0.0405 1
Onchocerca volvulus 0.0074 0.0405 0.5
Brugia malayi Melatonin receptor type 1A 0.0074 0.0405 0.4658
Loa Loa (eye worm) hypothetical protein 0.0074 0.0405 0.4658
Loa Loa (eye worm) hypothetical protein 0.0074 0.0405 0.4658
Loa Loa (eye worm) hypothetical protein 0.0074 0.0405 0.4658
Brugia malayi ORL1-like opioid receptor 0.0074 0.0405 0.4658
Loa Loa (eye worm) hypothetical protein 0.0074 0.0405 0.4658
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0308 0.7659 1
Brugia malayi G protein-coupled receptor F59B2.13 0.0074 0.0405 0.4658
Brugia malayi Serotonin receptor 0.0074 0.0405 0.4658
Onchocerca volvulus Neuropeptide F receptor homolog 0.0074 0.0405 0.5

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 1 uM Inhibition of recombinant His6-tagged Pseudomonas aeruginosa PqsD expressed in Escherichia coli BL21 (deltaDE3) using anthraniloyl-CoA/beta-ketodecanoic acid as substrate assessed as HHQ formation preincubated for 10 mins followed by substrate addition by HPLC/MS-MS analysis ChEMBL. 25874327

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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