TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 440.577 | Formula: C29H32N2O2
H donors: 2 H acceptors: 1 LogP: 5.63 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: CC(=CC[C@]12Cc3c4ccccc4[nH]c3[C@]3([C@]42CCN(C1Cc1c4c(O3)c(cc1)O)C)C)C
InChi: 1S/C29H32N2O2/c1-17(2)11-12-28-16-20-19-7-5-6-8-21(19)30-26(20)27(3)29(28)13-14-31(4)23(28)15-18-9-10-22(32)25(33-27)24(18)29/h5-11,23,30,32H,12-16H2,1-4H3/t23?,27-,28-,29-/m0/s1
InChiKey: MKCNXIXFBHSWPM-CAQJENOZSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	opioid receptor, kappa 1	Starlite/ChEMBL	References
Homo sapiens	opioid receptor, mu 1	Starlite/ChEMBL	References
Homo sapiens	opioid receptor, delta 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	Get druggable targets OG5_139759	All targets in OG5_139759
Echinococcus granulosus	tm gpcr rhodopsin	Get druggable targets OG5_139759	All targets in OG5_139759

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0187	0.262	1
Loa Loa (eye worm)	thioredoxin reductase	0.0046	0.029	0.1107
Giardia lamblia	PHD finger protein 15	0.0028	0	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0187	0.262	1
Brugia malayi	hypothetical protein	0.0099	0.1164	0.4443
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0989	0.3777
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0989	0.3777
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0187	0.262	0.262
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0099	0.1164	0.4443
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0104	0.1259	0.8342
Brugia malayi	hypothetical protein	0.0088	0.0989	0.3777
Brugia malayi	conserved hypotetical protein	0.0088	0.0989	0.3777
Schistosoma mansoni	coup transcription factor	0.0187	0.262	1
Loa Loa (eye worm)	hypothetical protein	0.0099	0.1164	0.4443
Loa Loa (eye worm)	glutathione reductase	0.0046	0.029	0.1107
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0187	0.262	1
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0088	0.0989	0.0989
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0048	0.0331	0.1263
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0104	0.1259	0.8342
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0088	0.0989	0.3777
Brugia malayi	nuclear receptor NHR-67	0.0088	0.0989	0.3777
Schistosoma mansoni	nuclear receptor	0.0088	0.0989	0.3777
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0989	0.3777
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0088	0.0989	0.0989
Plasmodium vivax	thioredoxin reductase, putative	0.0046	0.029	1
Brugia malayi	ecdysone receptor	0.0088	0.0989	0.3777
Brugia malayi	jmjC domain containing protein	0.0034	0.0098	0.0374
Entamoeba histolytica	hypothetical protein	0.0035	0.0109	0.5
Brugia malayi	ecdysteroid receptor	0.0187	0.262	1
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0088	0.0989	0.0989
Echinococcus granulosus	nuclear receptor nhr 48	0.0088	0.0989	0.0989
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0088	0.0989	0.3777
Loa Loa (eye worm)	steroid hormone receptor	0.0187	0.262	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0099	0.1164	0.4443
Echinococcus granulosus	ecdysone induced protein 78C	0.0187	0.262	0.262
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0099	0.1164	0.4443
Loa Loa (eye worm)	hypothetical protein	0.0187	0.262	1
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0187	0.262	0.262
Loa Loa (eye worm)	hypothetical protein	0.0187	0.262	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0187	0.262	0.262
Echinococcus multilocularis	FTZ F1 alpha	0.0187	0.262	0.262
Brugia malayi	Nuclear hormone receptor-like 1	0.0099	0.1164	0.4443
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0187	0.262	0.262
Echinococcus granulosus	FTZ F1 alpha	0.0187	0.262	0.262
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0092	0.1061	0.1061
Mycobacterium tuberculosis	Probable oxidoreductase	0.0116	0.1451	1
Loa Loa (eye worm)	hypothetical protein	0.0099	0.1164	0.4443
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0116	0.1451	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0187	0.262	1
Schistosoma mansoni	transcription factor LCR-F1	0.0035	0.0109	0.0417
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0187	0.262	0.262
Schistosoma mansoni	thyroid hormone receptor	0.0187	0.262	1
Brugia malayi	nuclear receptor NHR-88	0.0187	0.262	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0088	0.0989	0.0989
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0187	0.262	1
Brugia malayi	Nuclear hormone receptor E75	0.0088	0.0989	0.3777
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0989	0.3777
Loa Loa (eye worm)	hypothetical protein	0.0187	0.262	1
Loa Loa (eye worm)	DR-78	0.0088	0.0989	0.3777
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0099	0.1164	0.1164
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0989	0.3777
Loa Loa (eye worm)	hypothetical protein	0.0187	0.262	1
Brugia malayi	nuclear receptor NHR-88	0.0088	0.0989	0.3777
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0187	0.262	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0187	0.262	0.262
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0187	0.262	1
Plasmodium falciparum	glutathione reductase	0.0046	0.029	1
Mycobacterium tuberculosis	Probable dehydrogenase	0.0104	0.1259	0.8342
Brugia malayi	hypothetical protein	0.0099	0.1164	0.4443
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0187	0.262	1
Plasmodium falciparum	thioredoxin reductase	0.0046	0.029	1
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0088	0.0989	0.3777
Brugia malayi	jmjC domain containing protein	0.0092	0.1061	0.4049
Brugia malayi	hypothetical protein	0.0035	0.0109	0.0417
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0187	0.262	1
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0035	0.0109	0.0109
Brugia malayi	tailless protein	0.0088	0.0989	0.3777
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0187	0.262	1
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0088	0.0989	0.0989
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0187	0.262	0.262
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0331	0.1263
Brugia malayi	nuclear receptor RXR	0.0099	0.1164	0.4443
Onchocerca volvulus	Protein ultraspiracle homolog	0.0187	0.262	1
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0989	0.3777
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0187	0.262	1
Echinococcus multilocularis	ecdysone induced protein 78C	0.0187	0.262	0.262
Loa Loa (eye worm)	hypothetical protein	0.0187	0.262	1
Schistosoma mansoni	thyroid hormone receptor	0.0187	0.262	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0187	0.262	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0187	0.262	1
Brugia malayi	Steroid receptor seven-up type 2	0.0187	0.262	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0634	1	1
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0088	0.0989	0.0989
Onchocerca volvulus		0.0088	0.0989	0.3777
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0088	0.0989	0.0989
Schistosoma mansoni	nuclear hormone receptor	0.0088	0.0989	0.3777
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0989	0.3777
Schistosoma mansoni	nuclear receptor nhr-48	0.0088	0.0989	0.3777
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0088	0.0989	0.3777
Brugia malayi	nuclear hormone receptor	0.0187	0.262	1
Entamoeba histolytica	hypothetical protein	0.0035	0.0109	0.5
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0187	0.262	0.262
Echinococcus multilocularis	lysine specific demethylase 5A	0.0034	0.0098	0.0098
Schistosoma mansoni	jumonji domain containing protein	0.0073	0.0747	0.2851
Loa Loa (eye worm)	hypothetical protein	0.0187	0.262	1
Brugia malayi	nuclear hormone receptor	0.0088	0.0989	0.3777
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0187	0.262	1
Entamoeba histolytica	hypothetical protein	0.0035	0.0109	0.5
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0088	0.0989	0.3777
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0088	0.0989	0.0989
Brugia malayi	photoreceptor-specific nuclear receptor	0.0187	0.262	1
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0187	0.262	0.262
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0187	0.262	0.262
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0088	0.0989	0.3777
Schistosoma mansoni	nuclear receptor	0.0088	0.0989	0.3777
Schistosoma mansoni	nuclear hormone receptor	0.0088	0.0989	0.3777
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0989	0.3777
Trypanosoma brucei	trypanothione reductase	0.0046	0.029	0.5
Brugia malayi	Nuclear hormone receptor E75	0.0088	0.0989	0.3777
Brugia malayi	latrophilin 2 splice variant baaae	0.0033	0.0079	0.0301
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0989	0.3777
Loa Loa (eye worm)	hypothetical protein	0.0187	0.262	1
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0046	0.029	0.029
Loa Loa (eye worm)	nuclear hormone receptor	0.0088	0.0989	0.3777
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0187	0.262	1
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0035	0.0109	0.0109
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0092	0.1061	0.1061
Echinococcus granulosus	jumonji domain containing protein	0.0039	0.0183	0.0183
Brugia malayi	steroid hormone receptor	0.0187	0.262	1
Loa Loa (eye worm)	hypothetical protein	0.0099	0.1164	0.4443
Onchocerca volvulus	Bile acid receptor homolog	0.0187	0.262	1
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0088	0.0989	0.3777
Echinococcus granulosus	thioredoxin glutathione reductase	0.0046	0.029	0.029
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0187	0.262	1
Brugia malayi	nuclear hormone receptor family member odr-7	0.0088	0.0989	0.3777
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0187	0.262	1
Plasmodium vivax	glutathione reductase, putative	0.0046	0.029	1
Brugia malayi	glutathione reductase	0.0046	0.029	0.1107
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0989	0.3777
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0099	0.1164	0.1164
Onchocerca volvulus		0.0187	0.262	1
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0187	0.262	1
Toxoplasma gondii	thioredoxin reductase	0.0046	0.029	1
Trypanosoma cruzi	trypanothione reductase, putative	0.0046	0.029	0.5
Echinococcus multilocularis	jumonji domain containing protein	0.0039	0.0183	0.0183
Brugia malayi	Thioredoxin reductase	0.0046	0.029	0.1107
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0187	0.262	0.262
Entamoeba histolytica	hypothetical protein	0.0035	0.0109	0.5
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0088	0.0989	0.3777
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0989	0.3777
Schistosoma mansoni	zinc finger protein	0.0088	0.0989	0.3777
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0989	0.3777
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0187	0.262	1
Mycobacterium tuberculosis	Probable reductase	0.0104	0.1259	0.8342
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0187	0.262	1
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0104	0.1259	0.8342
Brugia malayi	nuclear receptor RXR	0.0088	0.0989	0.3777
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0187	0.262	1
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0104	0.1259	0.8342
Onchocerca volvulus		0.0088	0.0989	0.3777
Schistosoma mansoni	nuclear hormone receptor	0.0187	0.262	1
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0187	0.262	0.262
Schistosoma mansoni	RAR-like nuclear receptor	0.0187	0.262	1
Loa Loa (eye worm)	hypothetical protein	0.0187	0.262	1
Brugia malayi	hypothetical protein	0.0088	0.0989	0.3777
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0187	0.262	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0048	0.0331	0.1263
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0187	0.262	0.262
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0079	0.0301
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0187	0.262	1
Echinococcus granulosus	lysine specific demethylase 5A	0.0034	0.0098	0.0098
Echinococcus granulosus	thyroid hormone receptor alpha	0.0088	0.0989	0.0989
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0333	0.1271
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0034	0.0098	0.0374
Leishmania major	trypanothione reductase	0.0046	0.029	0.5
Loa Loa (eye worm)	hypothetical protein	0.0099	0.1164	0.4443
Echinococcus multilocularis	nuclear receptor nhr 48	0.0088	0.0989	0.0989
Loa Loa (eye worm)	hypothetical protein	0.0099	0.1164	0.4443
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0187	0.262	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0187	0.262	1
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0116	0.1451	1
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0187	0.262	1
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0099	0.1164	0.4443
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0034	0.0098	0.0374
Brugia malayi	orphan nuclear receptor NR2E1	0.0088	0.0989	0.3777
Schistosoma mansoni	hypothetical protein	0.0035	0.0109	0.0417
Brugia malayi	Nuclear hormone receptor-like 1	0.0187	0.262	1
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0088	0.0989	0.0989
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0187	0.262	0.262
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0187	0.262	1
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0989	0.3777
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0048	0.0331	0.1263
Loa Loa (eye worm)	jmjC domain-containing protein	0.0034	0.0098	0.0374
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0116	0.1451	1
Schistosoma mansoni	hypothetical protein	0.0033	0.0079	0.0301
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0187	0.262	1
Schistosoma mansoni	retinoic acid receptor RXR	0.0187	0.262	1
Loa Loa (eye worm)	jmjC domain-containing protein	0.0058	0.0496	0.1895

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (functional)	= 90.1 nM	Agonistic activity towards Opioid receptor delta 1	ChEMBL.	12825957
EC50 (functional)	= 90.1 nM	Agonistic activity towards Opioid receptor delta 1	ChEMBL.	12825957
EC50 (functional)	= 945 nM	Agonistic activity towards Opioid receptor kappa 1	ChEMBL.	12825957
EC50 (functional)	= 945 nM	Agonistic activity towards Opioid receptor kappa 1	ChEMBL.	12825957
EC50 (functional)	= 1201 nM	Effective concentration agonistic activity towards Opioid receptor mu 1	ChEMBL.	12825957
EC50 (functional)	= 1201 nM	Effective concentration agonistic activity towards Opioid receptor mu 1	ChEMBL.	12825957
Ki (binding)	= 4.9 nM	Ratio of mu/delta-opioid receptors Binding affinity	ChEMBL.	12825957
Ki (binding)	= 8.6 nM	Ratio of kappa/delta-opioid receptors Binding affinity	ChEMBL.	12825957
Ki (binding)	= 51.4 nM	Binding affinity for human Opioid receptor delta 1 transfected into chinese hamster ovary cells by displacing [3H]-CI-DPDPE radioligand	ChEMBL.	12825957
Ki (binding)	= 51.4 nM	Binding affinity for human Opioid receptor delta 1 transfected into chinese hamster ovary cells by displacing [3H]-CI-DPDPE radioligand	ChEMBL.	12825957
Ki (binding)	= 254 nM	Binding affinity for human Opioid receptor mu 1 transfected into chinese hamster ovary cells by displacing [3H]-DAMGO radioligand	ChEMBL.	12825957
Ki (binding)	= 254 nM	Binding affinity for human Opioid receptor mu 1 transfected into chinese hamster ovary cells by displacing [3H]-DAMGO radioligand	ChEMBL.	12825957
Ki (binding)	= 440 nM	Binding affinity in recombinant human Opioid receptor kappa 1 transfected into chinese hamster ovary cells by displacing [3H]-U-69,593 radioligand	ChEMBL.	12825957
Ki (binding)	= 440 nM	Binding affinity in recombinant human Opioid receptor kappa 1 transfected into chinese hamster ovary cells by displacing [3H]-U-69,593 radioligand	ChEMBL.	12825957
Stimulation (functional)	= 31 %	% stimulation of [35S]-GTP-gammaS, binding of compound in recombinant human Opioid receptor kappa 1 transfected into CHO cells	ChEMBL.	12825957
Stimulation (functional)	= 31 %	% stimulation of [35S]-GTP-gammaS, binding of compound in recombinant human Opioid receptor kappa 1 transfected into CHO cells	ChEMBL.	12825957
Stimulation (functional)	= 43 %	% stimulation of [35S]-GTP-gammaS, binding in recombinant human Opioid receptor delta 1 transfected into CHO cells	ChEMBL.	12825957
Stimulation (functional)	= 43 %	% stimulation of [35S]-GTP-gammaS, binding in recombinant human Opioid receptor delta 1 transfected into CHO cells	ChEMBL.	12825957
Stimulation (functional)	= 72 %	% stimulation of [35S]-GTP-gammaS, binding in recombinant human Opioid receptor mu 1 transfected into CHO cells	ChEMBL.	12825957
Stimulation (functional)	= 72 %	% stimulation of [35S]-GTP-gammaS, binding in recombinant human Opioid receptor mu 1 transfected into CHO cells	ChEMBL.	12825957

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL322875

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 177411