Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | adenosine A3 receptor | Starlite/ChEMBL | References |
Rattus norvegicus | Adenosine A1 receptor | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 2.11 uM | Displacement of [125I]-AB-MECA from adenosine A3 receptor from HEK-293 cell membranes | ChEMBL. | 9703464 |
Ki (binding) | = 2.11 uM | Displacement of [125I]-AB-MECA from adenosine A3 receptor from HEK-293 cell membranes | ChEMBL. | 9703464 |
Ki (binding) | = 17.4 uM | Binding affinity for adenosine A1 receptor as displacement of [3H]-R-PIA from rat brain membranes | ChEMBL. | 9703464 |
Ki (binding) | = 17.4 uM | Binding affinity for adenosine A1 receptor as displacement of [3H]-R-PIA from rat brain membranes | ChEMBL. | 9703464 |
Ki (binding) | = 28.9 uM | Binding affinity for adenosine A2A receptor as displacement of [3H]-CGS- 21680 from rat striatal membranes | ChEMBL. | 9703464 |
Ki (binding) | = 28.9 uM | Binding affinity for adenosine A2A receptor as displacement of [3H]-CGS- 21680 from rat striatal membranes | ChEMBL. | 9703464 |
Ratio (binding) | = 8.2 | Selectivity for binding affinity towards A1 adenosine receptor in rat brain membrane and human A3 receptor expressed in HEK cells | ChEMBL. | 9703464 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.