Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | poly (ADP-ribose) polymerase 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. | 0.03 | 1 | 0.5 |
Toxoplasma gondii | proteasome subunit beta type, putative | 0.03 | 1 | 1 |
Giardia lamblia | Proteasome subunit beta type 5 precursor | 0.03 | 1 | 0.5 |
Loa Loa (eye worm) | proteasome A-type and B-type family protein | 0.03 | 1 | 1 |
Echinococcus granulosus | proteasome prosome macropain | 0.03 | 1 | 1 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.03 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.2135 | 0.1164 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.03 | 1 | 0.5 |
Brugia malayi | WGR domain containing protein | 0.0174 | 0.5141 | 0.3823 |
Schistosoma mansoni | poly [ADP-ribose] polymerase | 0.0095 | 0.2135 | 0.0592 |
Mycobacterium ulcerans | proteasome PrcB | 0.03 | 1 | 0.5 |
Echinococcus granulosus | poly adp ribose polymerase 2 | 0.0095 | 0.2135 | 0.1684 |
Schistosoma mansoni | poly [ADP-ribose] polymerase | 0.0174 | 0.5141 | 0.4188 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.03 | 1 | 1 |
Echinococcus granulosus | poly ADP ribose polymerase 1 | 0.0174 | 0.5141 | 0.4863 |
Echinococcus multilocularis | poly (adp ribose) polymerase 2 | 0.0095 | 0.2135 | 0.2135 |
Plasmodium falciparum | proteasome subunit beta type-5 | 0.03 | 1 | 0.5 |
Trypanosoma brucei | proteasome subunit beta type-5, putative | 0.03 | 1 | 1 |
Echinococcus multilocularis | poly (ADP ribose) polymerase 1 | 0.0174 | 0.5141 | 0.5141 |
Mycobacterium leprae | proteasome (beta subunit) PrcB | 0.03 | 1 | 0.5 |
Entamoeba histolytica | proteasome subunit beta type 5 precursor, putative | 0.03 | 1 | 1 |
Echinococcus multilocularis | proteasome (prosome, macropain) | 0.03 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.3548 | 0.2752 |
Leishmania major | proteasome beta 5 subunit, putative | 0.03 | 1 | 0.5 |
Plasmodium vivax | proteasome subunit beta type-5, putative | 0.03 | 1 | 0.5 |
Schistosoma mansoni | proteasome catalytic subunit 3 (T01 family) | 0.03 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 9 uM | Inhibition of PARP1 in human Jurkat cells assessed as reduction of cell viability after 96 hrs by MTS assay in presence of 100 uM of temozolomide | ChEMBL. | 23850199 |
EC50 (binding) | = 55 uM | Inhibition of PARP1 in human Jurkat cells assessed as reduction of cell viability after 96 hrs by MTS assay | ChEMBL. | 23850199 |
IC50 (binding) | = 56 nM | Inhibition of human PARP1 catalytic activity after 10 mins by ELISA | ChEMBL. | 23850199 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.