TDR Targets

Basic information

Technical information

TDR Targets ID: 1774831
Name: 2-[4-[4-[(3-chloro-4-fluorophenyl)amino]-7-me thoxyquinazolin-6-yl]oxypiperidin-1-yl]-N-met hylacetamide
MW: 473.928 | Formula: C23H25ClFN5O3
H donors: 2 H acceptors: 3 LogP: 4.02 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: CNC(=O)CN1CCC(CC1)Oc1cc2c(ncnc2cc1OC)Nc1ccc(c(c1)Cl)F
InChi: 1S/C23H25ClFN5O3/c1-26-22(31)12-30-7-5-15(6-8-30)33-21-10-16-19(11-20(21)32-2)27-13-28-23(16)29-14-3-4-18(25)17(24)9-14/h3-4,9-11,13,15H,5-8,12H2,1-2H3,(H,26,31)(H,27,28,29)
InChiKey: UUHJZHSXOPNXJK-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-[4-[4-[(3-chloro-4-fluoro-phenyl)amino]-7-methoxy-quinazolin-6-yl]oxy-1-piperidyl]-N-methyl-acetamide
2-[4-[[4-[(3-chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]oxy]-1-piperidinyl]-N-methylacetamide
2-[4-[4-[(3-chloro-4-fluoro-phenyl)amino]-7-methoxy-quinazolin-6-yl]oxypiperidin-1-yl]-N-methyl-ethanamide

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	erb-b2 receptor tyrosine kinase 2	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	expressed protein	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	IPR006212,Furin-like repeat;IPR009030,Growth factor, receptor,domain-containing	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus multilocularis	epidermal growth factor receptor	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus multilocularis		Get druggable targets OG5_128597	All targets in OG5_128597
Loa Loa (eye worm)	TK/EGFR protein kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Brugia malayi	Furin-like cysteine rich region family protein	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Tyrosine-protein kinase transforming protein erbB, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Receptor tyrosine-protein kinase erbB-2 precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus granulosus	epidermal growth factor receptor	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Receptor tyrosine-protein kinase erbB-4 precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus granulosus	epidermal growth factor receptor	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus multilocularis	epidermal growth factor receptor	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	ko:K05085 receptor tyrosine-protein kinase erbB-4, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	IPR000494,EGF receptor, L domain,domain-containing	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_128597	All targets in OG5_128597

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	TKL family protein kinase	0.0453	0.3451	0.5
Loa Loa (eye worm)	SH2 domain-containing protein	0.0678	0.5623	0.3317
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0678	0.5623	0.3317
Toxoplasma gondii	STE kinase	0.0453	0.3451	0.5
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0678	0.5623	0.3317
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.113	1	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0678	0.5623	0.3317
Plasmodium falciparum	protein kinase, putative	0.0453	0.3451	0.5
Echinococcus granulosus	SHC transforming protein 3	0.0678	0.5623	0.3317
Echinococcus granulosus	signal transduction protein lnk realted	0.0678	0.5623	0.3317
Schistosoma mansoni	tyrosine kinase	0.0453	0.3451	0.3451
Echinococcus multilocularis	c src tyrosine kinase	0.113	1	1
Giardia lamblia	Kinase, NEK	0.0453	0.3451	0.5
Onchocerca volvulus		0.113	1	1
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0453	0.3451	0.5
Brugia malayi	SH2 domain containing protein	0.0678	0.5623	0.3317
Trichomonas vaginalis	TKL family protein kinase	0.0453	0.3451	0.5
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0453	0.3451	0.3451
Trichomonas vaginalis	TKL family protein kinase	0.0453	0.3451	0.5
Echinococcus granulosus	tyrosine kinase	0.113	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0453	0.3451	0.5
Loa Loa (eye worm)	hypothetical protein	0.0678	0.5623	0.3317
Schistosoma mansoni	protein kinase	0.0453	0.3451	0.3451
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0549	0.4377	0.1413
Schistosoma mansoni	SH2A	0.0678	0.5623	0.5623
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.113	1	1
Schistosoma mansoni	hypothetical protein	0.0678	0.5623	0.5623
Echinococcus granulosus	N chimaerin	0.0678	0.5623	0.3317
Brugia malayi	SH2 domain containing protein	0.0678	0.5623	0.3317
Trichomonas vaginalis	TKL family protein kinase	0.0453	0.3451	0.5
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0678	0.5623	0.5623
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0453	0.3451	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0453	0.3451	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0453	0.3451	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.113	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0453	0.3451	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.113	1	1
Trichomonas vaginalis	AGC family protein kinase	0.0453	0.3451	0.5
Echinococcus multilocularis	tensin	0.0678	0.5623	0.3317
Trichomonas vaginalis	TKL family protein kinase	0.0453	0.3451	0.5
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0453	0.3451	0.5
Echinococcus multilocularis	epidermal growth factor receptor	0.0549	0.4377	0.1413
Trichomonas vaginalis	TKL family protein kinase	0.0453	0.3451	0.5
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0678	0.5623	0.3317
Brugia malayi	Furin-like cysteine rich region family protein	0.0632	0.5182	0.2643
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.113	1	1
Schistosoma mansoni	tyrosine kinase	0.0453	0.3451	0.3451
Schistosoma mansoni	ephrin receptor	0.0453	0.3451	0.3451
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0678	0.5623	0.3317
Schistosoma mansoni	protein kinase	0.0453	0.3451	0.3451
Schistosoma mansoni	protein kinase	0.0453	0.3451	0.3451
Schistosoma mansoni	ephrin receptor	0.0453	0.3451	0.3451
Brugia malayi	Protein kinase domain containing protein	0.113	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0453	0.3451	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0453	0.3451	0.5
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0678	0.5623	0.3317
Trichomonas vaginalis	TKL family protein kinase	0.0453	0.3451	0.5
Schistosoma mansoni	tyrosine kinase	0.0453	0.3451	0.3451
Onchocerca volvulus		0.113	1	1
Echinococcus granulosus	tyrosine kinase	0.113	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0453	0.3451	0.5
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0678	0.5623	0.3317
Brugia malayi	SH2 domain containing protein	0.0678	0.5623	0.3317
Loa Loa (eye worm)	hypothetical protein	0.0678	0.5623	0.3317
Trichomonas vaginalis	TKL family protein kinase	0.0453	0.3451	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0453	0.3451	0.5
Giardia lamblia	Kinase, NEK	0.0453	0.3451	0.5
Schistosoma mansoni	protein kinase	0.0453	0.3451	0.3451
Trichomonas vaginalis	TKL family protein kinase	0.0453	0.3451	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0453	0.3451	0.5
Echinococcus granulosus	SH2 motif	0.0678	0.5623	0.3317
Plasmodium falciparum	protein kinase, putative	0.0453	0.3451	0.5
Schistosoma mansoni	tyrosine kinase	0.0453	0.3451	0.3451
Trichomonas vaginalis	TK family protein kinase	0.0453	0.3451	0.5
Plasmodium vivax	protein kinase, putative	0.0453	0.3451	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0453	0.3451	0.5
Schistosoma mansoni	tyrosine kinase	0.0453	0.3451	0.3451
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0678	0.5623	0.3317
Trichomonas vaginalis	TKL family protein kinase	0.0453	0.3451	0.5
Trichomonas vaginalis	CAMK family protein kinase	0.0453	0.3451	0.5
Echinococcus multilocularis	SHC transforming protein 3	0.0678	0.5623	0.3317
Trichomonas vaginalis	TKL family protein kinase	0.0453	0.3451	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0453	0.3451	0.5
Onchocerca volvulus		0.113	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.113	1	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.113	1	1
Brugia malayi	Protein kinase domain containing protein	0.113	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0453	0.3451	0.5
Echinococcus granulosus	tyrosine protein kinase Srms	0.113	1	1
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.113	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0453	0.3451	0.5
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0678	0.5623	0.3317
Trichomonas vaginalis	TKL family protein kinase	0.0453	0.3451	0.5
Schistosoma mansoni	protein tyrosine kinase	0.0453	0.3451	0.3451
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0453	0.3451	0.5
Schistosoma mansoni	protein kinase	0.0453	0.3451	0.3451
Trichomonas vaginalis	TKL family protein kinase	0.0453	0.3451	0.5
Schistosoma mansoni	tyrosine kinase	0.0632	0.5182	0.5182
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.113	1	1
Echinococcus granulosus	expressed conserved protein	0.0678	0.5623	0.3317
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0678	0.5623	0.3317
Loa Loa (eye worm)	hypothetical protein	0.0678	0.5623	0.3317
Trichomonas vaginalis	TKL family protein kinase	0.0453	0.3451	0.5
Onchocerca volvulus		0.0678	0.5623	0.3317
Schistosoma mansoni	tyrosine kinase	0.0453	0.3451	0.3451
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0678	0.5623	0.3317
Trichomonas vaginalis	TKL family protein kinase	0.0453	0.3451	0.5
Onchocerca volvulus		0.0678	0.5623	0.3317
Loa Loa (eye worm)	TK/FER protein kinase	0.113	1	1
Schistosoma mansoni	tyrosine kinase	0.0453	0.3451	0.3451
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0453	0.3451	0.3451
Echinococcus granulosus	tyrosine protein kinase Src64B	0.113	1	1
Brugia malayi	Protein kinase domain containing protein	0.0509	0.3998	0.0834
Echinococcus multilocularis	signal transduction protein lnk realted	0.0678	0.5623	0.3317
Brugia malayi	SH2 domain containing protein	0.113	1	1
Entamoeba histolytica	SH2 domain containing protein	0.0678	0.5623	0.3317
Trichomonas vaginalis	TKL family protein kinase	0.0453	0.3451	0.5
Schistosoma mansoni	signal transduction protein lnk-related	0.0678	0.5623	0.5623
Trichomonas vaginalis	TKL family protein kinase	0.0453	0.3451	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0453	0.3451	0.5
Leishmania major	hypothetical protein, conserved	0.0453	0.3451	0.5
Schistosoma mansoni	tyrosine kinase	0.0453	0.3451	0.3451
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.113	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0453	0.3451	0.5
Schistosoma mansoni	GTPase activating protein	0.0678	0.5623	0.5623
Trichomonas vaginalis	TKL family protein kinase	0.0453	0.3451	0.5
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0453	0.3451	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.113	1	1
Echinococcus granulosus	tyrosine protein kinase shark	0.113	1	1
Loa Loa (eye worm)	hypothetical protein	0.0678	0.5623	0.3317
Echinococcus granulosus	SH2 domain containing protein 7	0.0678	0.5623	0.3317
Echinococcus granulosus	tyrosine protein kinase Fyn	0.113	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0453	0.3451	0.5
Loa Loa (eye worm)	TK/INSR protein kinase	0.0509	0.3998	0.0834
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0678	0.5623	0.3317
Schistosoma mansoni	tyrosine kinase	0.0453	0.3451	0.3451
Schistosoma mansoni	tyrosine kinase	0.113	1	1
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0453	0.3451	0.5
Echinococcus granulosus	insulin receptor	0.0509	0.3998	0.0834
Trichomonas vaginalis	conserved hypothetical protein	0.0453	0.3451	0.5
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0453	0.3451	0.3451
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0678	0.5623	0.3317
Loa Loa (eye worm)	TK/FER protein kinase	0.113	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0453	0.3451	0.5
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0678	0.5623	0.5623
Trichomonas vaginalis	conserved hypothetical protein	0.0453	0.3451	0.5
Schistosoma mansoni	protein kinase	0.0453	0.3451	0.3451
Trypanosoma cruzi	protein kinase, putative	0.0453	0.3451	0.5
Toxoplasma gondii	protein kinase	0.0453	0.3451	0.5
Schistosoma mansoni	protein kinase	0.0453	0.3451	0.3451
Trypanosoma brucei	protein kinase, putative	0.0453	0.3451	0.5
Schistosoma mansoni	tyrosine kinase	0.0453	0.3451	0.3451
Brugia malayi	hypothetical protein	0.113	1	1
Schistosoma mansoni	serine/threonine protein kinase	0.0453	0.3451	0.3451
Echinococcus multilocularis	SH2 domain containing protein 7	0.0678	0.5623	0.3317
Loa Loa (eye worm)	hypothetical protein	0.0678	0.5623	0.3317
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.113	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0453	0.3451	0.5
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0678	0.5623	0.3317
Trichomonas vaginalis	TKL family protein kinase	0.0453	0.3451	0.5
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.0678	0.5623	0.3317
Brugia malayi	SH2 domain containing protein	0.0678	0.5623	0.3317
Echinococcus multilocularis	tyrosine protein kinase Blk	0.113	1	1
Schistosoma mansoni	tyrosine kinase	0.0453	0.3451	0.3451
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.113	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0453	0.3451	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0453	0.3451	0.5
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0453	0.3451	0.3451
Loa Loa (eye worm)	STAT protein	0.0678	0.5623	0.3317
Echinococcus granulosus	tensin	0.0678	0.5623	0.3317
Schistosoma mansoni	shc transforming protein	0.0678	0.5623	0.5623
Onchocerca volvulus		0.113	1	1
Schistosoma mansoni	serine/threonine RGC	0.0453	0.3451	0.3451
Echinococcus granulosus	hypothetical protein	0.0678	0.5623	0.3317
Trichomonas vaginalis	TKL family protein kinase	0.0453	0.3451	0.5
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0678	0.5623	0.5623
Trichomonas vaginalis	TKL family protein kinase	0.0453	0.3451	0.5
Onchocerca volvulus		0.113	1	1
Brugia malayi	RhoGAP domain containing protein	0.0678	0.5623	0.3317
Loa Loa (eye worm)	hypothetical protein	0.0678	0.5623	0.3317
Trichomonas vaginalis	TKL family protein kinase	0.0453	0.3451	0.5
Schistosoma mansoni	tyrosine kinase	0.0453	0.3451	0.3451
Trichomonas vaginalis	TKL family protein kinase	0.0453	0.3451	0.5
Toxoplasma gondii	protein kinase domain-containing protein	0.0453	0.3451	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0453	0.3451	0.5
Echinococcus granulosus	tyrosine protein kinase Lyn	0.113	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0453	0.3451	0.5
Schistosoma mansoni	tyrosine kinase	0.113	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0453	0.3451	0.5
Schistosoma mansoni	suppressor of cytokine signaling	0.0678	0.5623	0.5623
Schistosoma mansoni	growth factor receptor-bound protein	0.0678	0.5623	0.5623
Brugia malayi	Protein kinase domain containing protein	0.113	1	1
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0678	0.5623	0.3317
Echinococcus granulosus	tyrosine protein kinase Src42A	0.113	1	1
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.113	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.113	1	1
Trichomonas vaginalis	protein kinase atn1, putative	0.0453	0.3451	0.5
Giardia lamblia	Protein 21.1	0.0453	0.3451	0.5
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0678	0.5623	0.5623
Brugia malayi	protein-tyrosine kinase	0.113	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0453	0.3451	0.5
Schistosoma mansoni	hypothetical protein	0.0678	0.5623	0.5623
Schistosoma mansoni	tyrosine kinase	0.0453	0.3451	0.3451
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.113	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0453	0.3451	0.5
Echinococcus granulosus	SH2 motif	0.0678	0.5623	0.3317
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0678	0.5623	0.3317
Loa Loa (eye worm)	SRC-1	0.113	1	1
Echinococcus granulosus	NCK adaptor protein	0.0678	0.5623	0.3317
Loa Loa (eye worm)	hypothetical protein	0.0678	0.5623	0.3317
Schistosoma mansoni	tyrosine kinase	0.0453	0.3451	0.3451
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0509	0.3998	0.0834
Loa Loa (eye worm)	hypothetical protein	0.0678	0.5623	0.3317
Echinococcus multilocularis	insulin receptor	0.0509	0.3998	0.0834
Schistosoma mansoni	tyrosine kinase	0.0509	0.3998	0.3998
Schistosoma mansoni	tyrosine kinase	0.0549	0.4377	0.4377
Trypanosoma brucei	Pseudokinase, putative	0.0453	0.3451	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0453	0.3451	0.5
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0678	0.5623	0.3317
Loa Loa (eye worm)	TK/FER protein kinase	0.113	1	1
Loa Loa (eye worm)	TK/ABL protein kinase	0.113	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0453	0.3451	0.5
Echinococcus granulosus	epidermal growth factor receptor	0.0549	0.4377	0.1413
Brugia malayi	Tyrosine-protein kinase abl-1	0.113	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0453	0.3451	0.5
Echinococcus multilocularis		0.0678	0.5623	0.3317
Trichomonas vaginalis	TKL family protein kinase	0.0453	0.3451	0.5
Schistosoma mansoni	protein kinase	0.0453	0.3451	0.3451
Loa Loa (eye worm)	hypothetical protein	0.113	1	1
Echinococcus multilocularis	tyrosine protein kinase Srms	0.113	1	1
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.0678	0.5623	0.3317
Trichomonas vaginalis	TKL family protein kinase	0.0453	0.3451	0.5
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0678	0.5623	0.3317
Schistosoma mansoni	tyrosine protein kinase	0.0453	0.3451	0.3451
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.113	1	1
Schistosoma mansoni	tensin	0.0678	0.5623	0.5623
Onchocerca volvulus		0.0678	0.5623	0.3317
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0678	0.5623	0.3317
Echinococcus granulosus	epidermal growth factor receptor	0.0632	0.5182	0.2643
Loa Loa (eye worm)	TK/FER protein kinase	0.113	1	1
Echinococcus multilocularis	SH2 motif	0.0678	0.5623	0.3317
Echinococcus multilocularis	tensin	0.0678	0.5623	0.3317
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0453	0.3451	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0453	0.3451	0.5
Brugia malayi	Variant SH3 domain containing protein	0.0678	0.5623	0.3317
Schistosoma mansoni	tyrosine kinase	0.0453	0.3451	0.3451
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0453	0.3451	0.3451
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0678	0.5623	0.3317
Trichomonas vaginalis	conserved hypothetical protein	0.0453	0.3451	0.5
Schistosoma mansoni	tyrosine kinase	0.0549	0.4377	0.4377
Leishmania major	protein kinase, putative	0.0453	0.3451	0.5
Brugia malayi	Variant SH3 domain containing protein	0.0678	0.5623	0.3317
Onchocerca volvulus		0.0678	0.5623	0.3317
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.113	1	1
Brugia malayi	SH2 domain containing protein	0.0678	0.5623	0.3317
Echinococcus multilocularis	SH2 motif	0.0678	0.5623	0.3317
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0509	0.3998	0.0834
Schistosoma mansoni	suppressor of cytokine signaling	0.0678	0.5623	0.5623
Loa Loa (eye worm)	TK/FER protein kinase	0.113	1	1
Echinococcus granulosus	c src tyrosine kinase	0.113	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0453	0.3451	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0453	0.3451	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0453	0.3451	0.5
Leishmania major	protein kinase, putative	0.0453	0.3451	0.5
Onchocerca volvulus		0.0678	0.5623	0.3317
Plasmodium falciparum	tyrosine kinase-like protein	0.0453	0.3451	0.5
Schistosoma mansoni	hypothetical protein	0.0453	0.3451	0.3451
Schistosoma mansoni	tensin-related	0.0678	0.5623	0.5623
Schistosoma mansoni	tensin-related	0.0678	0.5623	0.5623
Loa Loa (eye worm)	hypothetical protein	0.0678	0.5623	0.3317
Loa Loa (eye worm)	SH2 domain-containing protein	0.0678	0.5623	0.3317
Brugia malayi	SH2 domain containing protein	0.113	1	1
Brugia malayi	SH2 domain containing protein	0.0678	0.5623	0.3317
Schistosoma mansoni	tyrosine kinase	0.0509	0.3998	0.3998
Schistosoma mansoni	tyrosine kinase	0.113	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0453	0.3451	0.5
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0453	0.3451	0.5
Giardia lamblia	Kinase	0.0453	0.3451	0.5
Loa Loa (eye worm)	TK protein kinase	0.113	1	1
Plasmodium falciparum	protein kinase, putative	0.0453	0.3451	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0453	0.3451	0.3451
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0453	0.3451	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0453	0.3451	0.5
Schistosoma mansoni	tyrosine kinase	0.0453	0.3451	0.3451
Brugia malayi	Variant SH3 domain containing protein	0.0678	0.5623	0.3317
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.113	1	1
Schistosoma mansoni	vav2	0.0678	0.5623	0.5623
Trichomonas vaginalis	TKL family protein kinase	0.0453	0.3451	0.5
Schistosoma mansoni	tyrosine kinase	0.0453	0.3451	0.3451
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0453	0.3451	0.5
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0678	0.5623	0.3317
Loa Loa (eye worm)	hypothetical protein	0.0678	0.5623	0.3317
Schistosoma mansoni	tyrosine kinase	0.113	1	1
Loa Loa (eye worm)	hypothetical protein	0.0678	0.5623	0.3317
Echinococcus multilocularis	tyrosine protein kinase shark	0.113	1	1
Echinococcus granulosus	tyrosine protein kinase Blk	0.113	1	1
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0678	0.5623	0.3317
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.113	1	1
Brugia malayi	Variant SH3 domain containing protein	0.0678	0.5623	0.3317
Echinococcus granulosus	tyrosine protein kinase ABL1	0.113	1	1
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0453	0.3451	0.5
Trypanosoma cruzi	protein kinase, putative	0.0453	0.3451	0.5
Loa Loa (eye worm)	hypothetical protein	0.0678	0.5623	0.3317
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0678	0.5623	0.3317
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.113	1	1
Echinococcus granulosus	growth factor receptor bound protein 2	0.0678	0.5623	0.3317
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0678	0.5623	0.3317
Schistosoma mansoni	serine/threonine protein kinase	0.0453	0.3451	0.3451
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0678	0.5623	0.3317
Trichomonas vaginalis	TKL family protein kinase	0.0453	0.3451	0.5
Brugia malayi	SH2 domain containing protein	0.0678	0.5623	0.3317
Schistosoma mansoni	tensin	0.0678	0.5623	0.5623
Loa Loa (eye worm)	hypothetical protein	0.0678	0.5623	0.3317
Loa Loa (eye worm)	SH2 domain-containing protein	0.0678	0.5623	0.3317
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0453	0.3451	0.5
Loa Loa (eye worm)	hypothetical protein	0.0678	0.5623	0.3317
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0678	0.5623	0.3317
Schistosoma mansoni	protein kinase	0.0453	0.3451	0.3451
Plasmodium falciparum	tyrosine kinase-like protein	0.0453	0.3451	0.5
Schistosoma mansoni	tensin	0.0678	0.5623	0.5623
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.113	1	1
Brugia malayi	Tensin	0.0678	0.5623	0.3317
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0453	0.3451	0.5
Schistosoma mansoni	tyrosine kinase	0.0453	0.3451	0.3451
Trichomonas vaginalis	TKL family protein kinase	0.0453	0.3451	0.5
Schistosoma mansoni	protein kinase	0.0453	0.3451	0.3451
Onchocerca volvulus		0.0678	0.5623	0.3317
Trichomonas vaginalis	TKL family protein kinase	0.0453	0.3451	0.5
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0632	0.5182	0.2643
Loa Loa (eye worm)	hypothetical protein	0.0678	0.5623	0.3317
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0453	0.3451	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0453	0.3451	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0453	0.3451	0.5
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0453	0.3451	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0453	0.3451	0.5
Schistosoma mansoni	tyrosine kinase	0.0453	0.3451	0.3451
Entamoeba histolytica	protein kinase, putative	0.0678	0.5623	0.3317
Echinococcus multilocularis	NCK adaptor protein	0.0678	0.5623	0.3317
Echinococcus multilocularis	SH2 motif	0.0678	0.5623	0.3317
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.113	1	1
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0678	0.5623	0.3317
Echinococcus multilocularis	tyrosine kinase	0.113	1	1
Schistosoma mansoni	tyrosine kinase	0.0453	0.3451	0.3451
Onchocerca volvulus		0.113	1	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0453	0.3451	0.3451
Schistosoma mansoni	tyrosine kinase	0.113	1	1
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0678	0.5623	0.3317
Trichomonas vaginalis	STE family protein kinase	0.0453	0.3451	0.5
Brugia malayi	Protein kinase domain containing protein	0.113	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0453	0.3451	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0453	0.3451	0.5
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0678	0.5623	0.3317
Schistosoma mansoni	growth factor receptor-bound protein	0.0678	0.5623	0.5623
Brugia malayi	hypothetical protein	0.0678	0.5623	0.3317
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.113	1	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.113	1	1
Brugia malayi	Sex muscle abnormal protein 5	0.0678	0.5623	0.3317
Trichomonas vaginalis	TKL family protein kinase	0.0453	0.3451	0.5
Schistosoma mansoni	tyrosine kinase	0.113	1	1
Echinococcus multilocularis	epidermal growth factor receptor	0.0632	0.5182	0.2643
Echinococcus multilocularis	tyrosine protein kinase Abl	0.113	1	1
Schistosoma mansoni	nck2/grb4	0.0678	0.5623	0.5623
Schistosoma mansoni	adapter molecule crk	0.0678	0.5623	0.5623
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0678	0.5623	0.3317
Schistosoma mansoni	serine/threonine protein kinase	0.0453	0.3451	0.3451
Loa Loa (eye worm)	TK/FER protein kinase	0.113	1	1
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0678	0.5623	0.5623
Brugia malayi	SRC-1	0.113	1	1
Echinococcus multilocularis	N chimaerin	0.0678	0.5623	0.3317
Trichomonas vaginalis	TKL family protein kinase	0.0453	0.3451	0.5
Echinococcus granulosus	tyrosine protein kinase Fyn	0.113	1	1
Schistosoma mansoni	protein kinase	0.0453	0.3451	0.3451

Activities

Activity type	Activity value	Assay description	Source	Reference
AUC (ADMET)	= 19 uM.hr	AUC in mouse at 50 mg/kg, po	ChEMBL.	24900741
IC50 (binding)	= 0.264 uM	Inhibition of full-length HER2 phosphorylation transfected in in human MCF-7 cl.24 cells after 4 hrs by laser scanning fluorescence microplate cytometry	ChEMBL.	24900741
TGI (functional)	= 28 %	Antitumor activity against human LoVo cells xenografted in mouse assessed as tumor growth inhibition at 100 mg/kg, po qd	ChEMBL.	24900741

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2408050

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1774831