Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0189 | 0 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0189 | 0 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0189 | 0 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0189 | 0 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0189 | 0 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0189 | 0 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0189 | 0 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0189 | 0 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0189 | 0 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0189 | 0 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0189 | 0 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0189 | 0 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0189 | 0 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0189 | 0 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0189 | 0 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0189 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.2077 | 0.9497 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0189 | 0 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0189 | 0 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0189 | 0 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0189 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1988 | 0.9048 | 0.9527 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0189 | 0 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0189 | 0 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0189 | 0 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0189 | 0 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.2077 | 0.9497 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0189 | 0 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0189 | 0 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0189 | 0 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0189 | 0 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0189 | 0 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0189 | 0 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0189 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IZ (functional) | = 0 mm | Antifungal activity against Candida albicans NRRLY 477 assessed as growth inhibition at 1 mg/mL after 24 hrs by agar well diffusion assay | ChEMBL. | 23871906 |
IZ (functional) | = 0 mm | Antifungal activity against Saccharomyces cerevisiae assessed as growth inhibition at 1 mg/mL after 24 hrs by agar well diffusion assay | ChEMBL. | 23871906 |
IZ (functional) | = 0 mm | Antibacterial activity against Escherichia coli ATCC 25922 assessed as growth inhibition at 1 mg/mL after 24 hrs by agar well diffusion assay | ChEMBL. | 23871906 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.