TDR Targets

Basic information

Technical information

TDR Targets ID: 1775572
Name: [4-[[(3R,4R)-4-[(3,4-dimethoxyphenyl)methyl]- 2-oxooxolan-3-yl]methyl]-2-methoxyphenyl] 4-f luorobenzoate
MW: 494.508 | Formula: C28H27FO7
H donors: 0 H acceptors: 2 LogP: 5.45 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: COc1cc(ccc1OC(=O)c1ccc(cc1)F)C[C@H]1C(=O)OC[C@@H]1Cc1ccc(c(c1)OC)OC
InChi: 1S/C28H27FO7/c1-32-23-10-4-17(14-25(23)33-2)12-20-16-35-28(31)22(20)13-18-5-11-24(26(15-18)34-3)36-27(30)19-6-8-21(29)9-7-19/h4-11,14-15,20,22H,12-13,16H2,1-3H3/t20-,22+/m0/s1
InChiKey: QYYUPPGLQWTHAW-RBBKRZOGSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

[4-[[(3R,4R)-4-[(3,4-dimethoxyphenyl)methyl]-2-oxo-tetrahydrofuran-3-yl]methyl]-2-methoxy-phenyl] 4-fluorobenzoate
4-fluorobenzoic acid [4-[[(3R,4R)-4-[(3,4-dimethoxyphenyl)methyl]-2-oxo-3-tetrahydrofuranyl]methyl]-2-methoxyphenyl] ester
4-fluorobenzoic acid [4-[[(3R,4R)-4-(3,4-dimethoxybenzyl)-2-keto-tetrahydrofuran-3-yl]methyl]-2-methoxy-phenyl] ester
[4-[[(3R,4R)-4-[(3,4-dimethoxyphenyl)methyl]-2-oxo-oxolan-3-yl]methyl]-2-methoxy-phenyl] 4-fluorobenzoate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	nuclear receptor NHR-88	0.0124	0.0521	0.0533
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0255	0.0261
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0059	0.0226	0.1319
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0124	0.0521	0.0535
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0124	0.0521	0.0533
Schistosoma mansoni	aldehyde dehydrogenase	0.0059	0.0226	0.1139
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0124	0.0521	0.3066
Schistosoma mansoni	thyroid hormone receptor	0.0124	0.0521	0.262
Loa Loa (eye worm)	steroid hormone receptor	0.0124	0.0521	0.0535
Schistosoma mansoni	retinoic acid receptor RXR	0.0446	0.1988	1
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0141	0.06	0.3537
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0065	0.0255	0.1282
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0141	0.06	0.302
Brugia malayi	nuclear receptor RXR	0.0065	0.0255	0.0259
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0124	0.0521	0.2605
Brugia malayi	Cytochrome P450 family protein	0.0048	0.0173	0.0175
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0223	0.0228
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0058	0.0223	0.1103
Schistosoma mansoni	hypothetical protein	0.001	0.0004	0.002
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0124	0.0521	0.0535
Echinococcus multilocularis	ATP dependent DNA helicase Q5	0.0019	0.0045	0.0242
Loa Loa (eye worm)	ATP-dependent DNA helicase	0.0019	0.0045	0.0044
Brugia malayi	tailless protein	0.0058	0.0223	0.0226
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0223	0.0228
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.0019	0.0045	0.0042
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.0226	1
Loa Loa (eye worm)	cytochrome P450 family protein	0.001	0.0004	0.0002
Brugia malayi	nuclear hormone receptor family member odr-7	0.0058	0.0223	0.0226
Schistosoma mansoni	nuclear receptor	0.0058	0.0223	0.1121
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0059	0.0226	0.1121
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0124	0.0521	0.3066
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0058	0.0223	0.1298
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.016	0.0786
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0124	0.0521	0.3066
Entamoeba histolytica	acetyltransferase, GNAT family	0.0038	0.013	1
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0255	0.0261
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0124	0.0521	0.2605
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0058	0.0223	0.1103
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0058	0.0223	0.1103
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0124	0.0521	0.0533
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.0226	1
Loa Loa (eye worm)	hypothetical protein	0.0124	0.0521	0.0535
Echinococcus granulosus	nuclear receptor nhr 48	0.0058	0.0223	0.1103
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0059	0.0226	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0065	0.0255	0.0259
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0124	0.0521	0.0533
Trypanosoma cruzi	cytochrome P450, putative	0.001	0.0004	0.053
Plasmodium falciparum	histone acetyltransferase GCN5	0.0038	0.013	1
Echinococcus multilocularis	ecdysone induced protein 78C	0.0124	0.0521	0.3066
Brugia malayi	photoreceptor-specific nuclear receptor	0.0124	0.0521	0.0533
Brugia malayi	acetyltransferase, GNAT family protein	0.0141	0.06	0.0615
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0124	0.0521	0.262
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.214	0.9702	1
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0124	0.0521	0.0533
Mycobacterium leprae	putative cytochrome p450	0.001	0.0004	0.5
Echinococcus granulosus	thyroid hormone receptor alpha	0.0058	0.0223	0.1103
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0124	0.0521	0.2605
Brugia malayi	Nuclear hormone receptor-like 1	0.0065	0.0255	0.0259
Loa Loa (eye worm)	cytochrome P450	0.001	0.0004	0.0002
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.016	0.0805
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0124	0.0521	0.0533
Brugia malayi	ecdysone receptor	0.0058	0.0223	0.0226
Schistosoma mansoni	coup transcription factor	0.0124	0.0521	0.262
Schistosoma mansoni	nuclear receptor nhr-48	0.0058	0.0223	0.1121
Trypanosoma cruzi	cytochrome p450-like protein, putative	0.001	0.0004	0.053
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.0019	0.0045	0.0042
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.0226	1
Echinococcus multilocularis	bloom syndrome protein	0.0019	0.0045	0.0242
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0124	0.0521	0.262
Schistosoma mansoni	nuclear receptor	0.0058	0.0223	0.1121
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0124	0.0521	0.262
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0042	0.0146	1
Loa Loa (eye worm)	CYP4Cod1	0.001	0.0004	0.0002
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0065	0.0255	0.1282
Brugia malayi	steroid hormone receptor	0.0124	0.0521	0.0533
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0042	0.0146	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0124	0.0521	0.0535
Loa Loa (eye worm)	hypothetical protein	0.0124	0.0521	0.0535
Onchocerca volvulus	Protein ultraspiracle homolog	0.0124	0.0521	0.0305
Brugia malayi	nuclear receptor RXR	0.0058	0.0223	0.0226
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0223	0.0228
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0124	0.0521	0.262
Entamoeba histolytica	recQ family DNA helicase	0.001	0.0002	0.0131
Mycobacterium leprae	Conserved hypothetical protein	0.001	0.0004	0.5
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0255	0.0261
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0058	0.0223	0.1298
Loa Loa (eye worm)	hypothetical protein	0.0124	0.0521	0.0535
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0223	0.0228
Schistosoma mansoni	nuclear hormone receptor	0.0058	0.0223	0.1121
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.001	0.0004	0.053
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0124	0.0521	0.0535
Loa Loa (eye worm)	cytochrome P450 family protein	0.0048	0.0173	0.0177
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0124	0.0521	0.0533
Loa Loa (eye worm)	hypothetical protein	0.0124	0.0521	0.0535
Toxoplasma gondii	cytochrome p450 superfamily protein	0.001	0.0004	0.0176
Brugia malayi	Nuclear hormone receptor-like 1	0.0124	0.0521	0.0533
Trypanosoma cruzi	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0019	0.0045	1
Loa Loa (eye worm)	acetyltransferase	0.0141	0.06	0.0617
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0124	0.0521	0.0533
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0255	0.0261
Echinococcus multilocularis	FTZ F1 alpha	0.0124	0.0521	0.3066
Echinococcus granulosus	ATP dependent DNA helicase Q5	0.0019	0.0045	0.0206
Schistosoma mansoni	aldehyde dehydrogenase	0.0059	0.0226	0.1139
Leishmania major	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0019	0.0045	0.1837
Loa Loa (eye worm)	hypothetical protein	0.0124	0.0521	0.0535
Loa Loa (eye worm)	nuclear hormone receptor	0.0058	0.0223	0.0228
Schistosoma mansoni	DNA helicase recq5	0.0019	0.0045	0.0226
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0124	0.0521	0.2605
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0223	0.0228
Trypanosoma cruzi	cytochrome P450, putative	0.001	0.0004	0.053
Brugia malayi	conserved hypotetical protein	0.0058	0.0223	0.0226
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0223	0.0228
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0042	0.0146	0.6452
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0058	0.0223	0.1121
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0058	0.0223	0.1121
Schistosoma mansoni	nuclear hormone receptor	0.0058	0.0223	0.1121
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0124	0.0521	0.0533
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.001	0.0002	0.0075
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0124	0.0521	0.3066
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0124	0.0521	0.0533
Loa Loa (eye worm)	DR-78	0.0058	0.0223	0.0228
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0223	0.0228
Echinococcus granulosus	FTZ F1 alpha	0.0124	0.0521	0.2605
Entamoeba histolytica	recQ family helicase, putative	0.0019	0.0045	0.3441
Brugia malayi	hypothetical protein	0.0058	0.0223	0.0226
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0124	0.0521	0.2605
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.016	0.0163
Onchocerca volvulus	Bile acid receptor homolog	0.0124	0.0521	0.0305
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0019	0.0045	0.1981
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.001	0.0004	0.053
Trypanosoma brucei	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0019	0.0045	1
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0058	0.0223	0.1298
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0124	0.0521	0.2605
Schistosoma mansoni	zinc finger protein	0.0058	0.0223	0.1121
Echinococcus multilocularis	nuclear receptor nhr 48	0.0058	0.0223	0.1298
Brugia malayi	hypothetical protein	0.0058	0.0223	0.0226
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0223	0.0228
Treponema pallidum	ATP-dependent DNA helicase	0.001	0.0002	0.5
Brugia malayi	nuclear hormone receptor	0.214	0.9702	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0058	0.0223	0.1298
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0223	0.0228
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0124	0.0521	0.262
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0124	0.0521	0.0535
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.016	0.0161
Schistosoma mansoni	nuclear hormone receptor	0.0124	0.0521	0.262
Loa Loa (eye worm)	hypothetical protein	0.0124	0.0521	0.0535
Loa Loa (eye worm)	cytochrome P450 family protein	0.001	0.0004	0.0002
Plasmodium vivax	ADP-dependent DNA helicase RecQ, putative	0.001	0.0002	0.0117
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0124	0.0521	0.3066
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.016	0.0925
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0223	0.0228
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0137	0.0582	0.2915
Brugia malayi	Steroid receptor seven-up type 2	0.0124	0.0521	0.0533
Schistosoma mansoni	RAR-like nuclear receptor	0.0124	0.0521	0.262
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0058	0.0223	0.0226
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0045	0.0044
Schistosoma mansoni	DNA helicase recq1	0.0019	0.0045	0.0226
Brugia malayi	Nuclear hormone receptor E75	0.0058	0.0223	0.0226
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0381	0.169	1
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0065	0.0255	0.1264
Brugia malayi	ecdysteroid receptor	0.0124	0.0521	0.0533
Schistosoma mansoni	blooms syndrome DNA helicase	0.001	0.0002	0.0009
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0124	0.0521	0.0533
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0124	0.0521	0.0533
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0223	0.0228
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0255	0.0261
Toxoplasma gondii	aldehyde dehydrogenase	0.0059	0.0226	1
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0042	0.0146	0.6452
Loa Loa (eye worm)	RecQ helicase	0.0019	0.0045	0.0044
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0058	0.0223	0.1103
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.016	0.0805
Brugia malayi	Bloom's syndrome protein homolog	0.0019	0.0045	0.0042
Echinococcus granulosus	ecdysone induced protein 78C	0.0124	0.0521	0.2605
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.016	0.0805
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0124	0.0521	0.0535
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0223	0.0228
Schistosoma mansoni	cytochrome P450	0.001	0.0004	0.002
Loa Loa (eye worm)	hypothetical protein	0.0124	0.0521	0.0535
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0124	0.0521	0.262
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0446	0.1988	1
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0124	0.0521	0.0533
Loa Loa (eye worm)	hypothetical protein	0.0124	0.0521	0.0535
Loa Loa (eye worm)	hypothetical protein	0.001	0.0002	0.000000000037402
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0058	0.0223	0.0228
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0065	0.0255	0.0261
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0124	0.0521	0.0533
Brugia malayi	Nuclear hormone receptor E75	0.0058	0.0223	0.0226
Brugia malayi	hypothetical protein	0.0065	0.0255	0.0259
Brugia malayi	hypothetical protein	0.0065	0.0255	0.0259
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0124	0.0521	0.3066
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0124	0.0521	0.262
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0223	0.0228
Brugia malayi	nuclear receptor NHR-88	0.0058	0.0223	0.0226
Brugia malayi	nuclear receptor NHR-67	0.0058	0.0223	0.0226
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0058	0.0223	0.0226
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0019	0.0045	0.1981
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0124	0.0521	0.0535
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.016	0.0786
Echinococcus granulosus	ATP dependent DNA helicase Q1	0.0019	0.0045	0.0206
Echinococcus multilocularis	ATP dependent DNA helicase Q1	0.0019	0.0045	0.0242
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0042	0.0146	1
Schistosoma mansoni	thyroid hormone receptor	0.0124	0.0521	0.262
Brugia malayi	nuclear hormone receptor	0.0124	0.0521	0.0533
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0065	0.0255	0.1488
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0059	0.0226	1
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0042	0.0146	0.0716
Onchocerca volvulus		0.0124	0.0521	0.0305
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.016	0.0925
Echinococcus granulosus	bloom syndrome protein	0.0019	0.0045	0.0206
Loa Loa (eye worm)	hypothetical protein	0.2082	0.9436	0.9726
Giardia lamblia	Histone acetyltransferase GCN5	0.0038	0.013	1
Brugia malayi	orphan nuclear receptor NR2E1	0.0058	0.0223	0.0226
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0124	0.0521	0.3066

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2393531

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1775572