Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0915 | 1 | 0.5 |
Chlamydia trachomatis | sulfite reductase | 0.0565 | 0.2407 | 0.5 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0915 | 1 | 1 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0915 | 1 | 1 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0454 | 0 | 0.5 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0915 | 1 | 0.5 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0915 | 1 | 1 |
Leishmania major | p450 reductase, putative | 0.0915 | 1 | 1 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0915 | 1 | 1 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0915 | 1 | 0.5 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0461 | 0.0151 | 0.0151 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0915 | 1 | 1 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0915 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0915 | 1 | 1 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0915 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0915 | 1 | 0.5 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0915 | 1 | 0.5 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0915 | 1 | 0.5 |
Trypanosoma cruzi | p450 reductase, putative | 0.0915 | 1 | 0.5 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0811 | 0.7743 | 0.5 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0915 | 1 | 0.5 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0565 | 0.2407 | 0.2407 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0915 | 1 | 0.5 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0915 | 1 | 0.5 |
Brugia malayi | FAD binding domain containing protein | 0.0915 | 1 | 1 |
Giardia lamblia | Hypothetical protein | 0.0811 | 0.7743 | 0.5 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0915 | 1 | 1 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0915 | 1 | 1 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0454 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 8 ug ml-1 | Antifungal activity against Candida albicans ATCC 10231 after 24 to 48 hrs by broth microdilution method | ChEMBL. | 23644218 |
MIC (functional) | > 512 ug ml-1 | Antibacterial activity against Escherichia coli ATCC 25922 after 24 hrs by broth microdilution method | ChEMBL. | 23644218 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.