Detailed information for compound 1775690

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 359.461 | Formula: C24H25NO2
  • H donors: 2 H acceptors: 1 LogP: 5.81 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: NCCOc1ccc(cc1)/C(=C(\c1ccccc1)/CC)/c1ccc(cc1)O
  • InChi: 1S/C24H25NO2/c1-2-23(18-6-4-3-5-7-18)24(19-8-12-21(26)13-9-19)20-10-14-22(15-11-20)27-17-16-25/h3-15,26H,2,16-17,25H2,1H3/b24-23-
  • InChiKey: YCQBLTPGQSYLHD-VHXPQNKSSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens estrogen receptor 1 Starlite/ChEMBL References
Homo sapiens estrogen receptor 2 (ER beta) Starlite/ChEMBL References
Homo sapiens cytochrome P450, family 19, subfamily A, polypeptide 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) hypothetical protein estrogen receptor 2 (ER beta) 495 aa 418 aa 25.8 %
Trypanosoma cruzi cytochrome P450, putative cytochrome P450, family 19, subfamily A, polypeptide 1 503 aa 425 aa 18.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium leprae Possible transporter protein 0.0104 0.0141 0.4138
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.1932 0.4215 0.4212
Echinococcus granulosus metabotropic glutamate receptor 2 0.0072 0.0069 0.0059
Mycobacterium ulcerans phosphoglyceromutase 0.0076 0.0079 0.0113
Echinococcus granulosus 7tm_1 domain containing protein 0.0145 0.0231 0.0222
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0225 0.0409 0.04
Echinococcus granulosus g protein coupled receptor 0.0145 0.0231 0.0222
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0225 0.0409 0.04
Echinococcus multilocularis cAMP dependent protein kinase type I beta 0.015 0.0243 0.0234
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0145 0.0231 0.0231
Leishmania major protein kinase, putative 0.0153 0.025 0.0237
Echinococcus granulosus biogenic amine 5HT receptor 0.0145 0.0231 0.0222
Echinococcus granulosus receptor type guanylyl cyclase 0.0072 0.0069 0.0059
Loa Loa (eye worm) hypothetical protein 0.0064 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0086 0.01 0.01
Echinococcus granulosus aurora kinase A 0.0087 0.0102 0.0093
Echinococcus granulosus tachykinin peptides receptor 99D 0.0145 0.0231 0.0222
Echinococcus granulosus SAM and MBT domain containing protein 0.005 0.002 0.0011
Echinococcus multilocularis glutamate receptor subunit protein glur 0.014 0.0221 0.0212
Trichomonas vaginalis adenylate cyclase, putative 0.0104 0.0141 0.04
Brugia malayi hypothetical protein 0.0072 0.0068 0.0244
Echinococcus multilocularis hyperpolarization activated cyclic 0.0225 0.0409 0.04
Schistosoma mansoni voltage-gated potassium channel 0.0075 0.0075 0.0066
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0057 0.0035 0.0107
Echinococcus granulosus neuropeptide Y receptor 0.0145 0.0231 0.0222
Onchocerca volvulus 0.0145 0.0231 0.0216
Loa Loa (eye worm) hypothetical protein 0.0145 0.0231 0.0231
Schistosoma mansoni transient receptor potential channel 0.0075 0.0075 0.0066
Trypanosoma brucei Histidine phosphatase superfamily (branch 1), putative 0.0076 0.0079 0.0074
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.0075 0.0075 0.0271
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.034 0.0666 0.0658
Echinococcus multilocularis transfer RNA-Gly 0.0075 0.0075 0.0066
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0075 0.0075 0.0066
Onchocerca volvulus Neuropeptide F receptor homolog 0.0145 0.0231 0.0216
Echinococcus granulosus potassium voltage gated channel protein 0.0075 0.0075 0.0066
Trypanosoma cruzi regulatory subunit of protein kinase a-like protein, putative 0.015 0.0243 0.0238
Echinococcus multilocularis transient receptor potential cation channel 0.0075 0.0075 0.0066
Loa Loa (eye worm) voltage-gated potassium channel 0.0075 0.0075 0.0075
Echinococcus multilocularis cyclin dependent kinase 9 0.0056 0.0034 0.0025
Schistosoma mansoni neuropeptide F-like receptor 0.0145 0.0231 0.0222
Echinococcus granulosus neuropeptide receptor 0.0145 0.0231 0.0222
Loa Loa (eye worm) hypothetical protein 0.0072 0.0069 0.0069
Echinococcus multilocularis phosphoglycerate mutase 0.0076 0.0079 0.007
Echinococcus multilocularis histone acetyltransferase MYST2 0.0057 0.0035 0.0026
Trichomonas vaginalis CMGC family protein kinase 0.014 0.0221 0.0758
Schistosoma mansoni voltage-gated potassium channel 0.0075 0.0075 0.0066
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.015 0.0243 0.0234
Loa Loa (eye worm) hypothetical protein 0.0145 0.0231 0.0231
Echinococcus granulosus potassium voltage gated channel protein 0.0075 0.0075 0.0066
Echinococcus multilocularis potassium voltage gated channel protein 0.0075 0.0075 0.0066
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.106 0.2271 1
Onchocerca volvulus 0.0145 0.0231 0.0216
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0359 0.0709 1
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0304 0.0585 0.0585
Trypanosoma cruzi Histidine phosphatase superfamily (branch 1), putative 0.0076 0.0079 0.0074
Giardia lamblia Kinase, CMGC CDK 0.014 0.0221 0.0289
Leishmania major glycerolphosphate mutase, putative 0.0076 0.0079 0.0066
Loa Loa (eye worm) hypothetical protein 0.015 0.0243 0.0243
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.106 0.2271 1
Echinococcus granulosus phosphoglycerate mutase 0.0076 0.0079 0.007
Leishmania major extracellular receptor, putative 0.0072 0.0069 0.0056
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.3093 0.68 0.6797
Schistosoma mansoni neuropeptide receptor 0.0145 0.0231 0.0222
Leishmania major phosphoglycerate mutase family member 5, putative 0.0076 0.0079 0.0066
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0225 0.0409 0.04
Schistosoma mansoni voltage-gated potassium channel 0.0075 0.0075 0.0066
Brugia malayi hypothetical protein 0.0145 0.0231 0.0913
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0145 0.0231 0.0222
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0072 0.0068 0.0059
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0412 0.0826 0.0818
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0145 0.0231 0.0222
Plasmodium falciparum phosphoglucomutase-2 0.0076 0.0079 0.228
Schistosoma mansoni 60S ribosomal protein L21 0.0179 0.0307 0.0298
Trichomonas vaginalis phosphoglycerate mutase, putative 0.0076 0.0079 0.0121
Toxoplasma gondii hypothetical protein 0.0049 0.0019 0.0579
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0145 0.0231 0.0222
Loa Loa (eye worm) CYP4Cod1 0.0047 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0145 0.0231 0.0231
Trichomonas vaginalis adenylate cyclase, putative 0.0104 0.0141 0.04
Schistosoma mansoni amine GPCR 0.0145 0.0231 0.0222
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0104 0.0141 0.04
Mycobacterium tuberculosis Probable transcriptional regulatory protein Cmr 0.015 0.0243 0.3212
Schistosoma mansoni growth hormone secretagogue receptor 0.0145 0.0231 0.0222
Trypanosoma cruzi cAMP response protein 1, putative 0.015 0.0243 0.0238
Echinococcus multilocularis transient receptor potential cation channel 0.0075 0.0075 0.0066
Leishmania major hypothetical protein, conserved 0.015 0.0243 0.023
Echinococcus multilocularis rhodopsin orphan GPCR 0.0145 0.0231 0.0222
Loa Loa (eye worm) hypothetical protein 0.0072 0.0069 0.0069
Loa Loa (eye worm) hypothetical protein 0.0076 0.0079 0.0079
Treponema pallidum cyclic nucleotide binding protein 0.015 0.0243 0.2598
Schistosoma mansoni voltage-gated potassium channel 0.0075 0.0075 0.0066
Loa Loa (eye worm) hypothetical protein 0.0145 0.0231 0.0231
Toxoplasma gondii phosphoglycerate mutase family protein 0.0076 0.0079 0.3031
Echinococcus granulosus nmda type glutamate receptor 0.0739 0.1555 0.1547
Leishmania major regulatory subunit of protein kinase a-like protein 0.015 0.0243 0.023
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0145 0.0231 0.0222
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0145 0.0232 0.0228
Schistosoma mansoni amine GPCR 0.0145 0.0231 0.0222
Echinococcus granulosus voltage dependent calcium channel 0.0075 0.0075 0.0066
Leishmania major 4-coumarate:coa ligase-like protein 0.0072 0.0069 0.0056
Loa Loa (eye worm) hypothetical protein 0.005 0.002 0.002
Trichomonas vaginalis adenylate cyclase, putative 0.0104 0.0141 0.04
Echinococcus granulosus orexin receptor type 2 0.0145 0.0231 0.0222
Trypanosoma cruzi cdc2-related kinase 3 0.014 0.0221 0.0216
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0145 0.0231 0.0222
Brugia malayi aryl hydrocarbon receptor nuclear translocator protein, putative 0.0104 0.0141 0.0542
Brugia malayi AMP-binding enzyme family protein 0.0072 0.0069 0.0247
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0075 0.0075 0.0066
Trichomonas vaginalis phosphoglycerate mutase, putative 0.0076 0.0079 0.0121
Schistosoma mansoni phosphoglycerate mutase 0.0076 0.0079 0.007
Toxoplasma gondii aurora kinase 0.0087 0.0102 0.3959
Leishmania major 4-coumarate:coa ligase-like protein 0.0072 0.0069 0.0056
Echinococcus multilocularis serine:threonine protein phosphatase PGAM5 0.0076 0.0079 0.007
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.015 0.0243 0.0234
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0145 0.0231 0.0231
Trypanosoma brucei protein kinase A regulatory subunit 0.015 0.0243 0.0238
Echinococcus multilocularis rhodopsin orphan GPCR 0.0145 0.0231 0.0222
Loa Loa (eye worm) RGC/RGC protein kinase 0.0072 0.0069 0.0069
Loa Loa (eye worm) voltage-dependent calcium channel 0.0075 0.0075 0.0075
Loa Loa (eye worm) cytochrome P450 family protein 0.0047 0.0013 0.0013
Mycobacterium leprae Probable phosphoglycerate mutase (phosphoglyceromutase) (phosphoglycerate phosphomutase) 0.0076 0.0079 0.0567
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0075 0.0075 0.0066
Echinococcus granulosus shaker cognate 0.0075 0.0075 0.0066
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.0075 0.0075 0.0271
Loa Loa (eye worm) hypothetical protein 0.0076 0.0079 0.0079
Echinococcus multilocularis transient receptor potential cation channel 0.0075 0.0075 0.0066
Schistosoma mansoni histamine h1 receptor 0.0145 0.0231 0.0222
Trichomonas vaginalis conserved hypothetical protein 0.0104 0.0141 0.04
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0075 0.0075 0.0066
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0075 0.0075 0.0066
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0203 0.0361 0.0352
Trichomonas vaginalis CMGC family protein kinase 0.014 0.0221 0.0758
Brugia malayi sulfakinin receptor protein 0.0145 0.0231 0.0913
Echinococcus granulosus voltage gated hydrogen channel 1 0.0075 0.0075 0.0066
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.005 0.002 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0104 0.0141 0.04
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0075 0.0075 0.0066
Echinococcus multilocularis transient receptor potential gamma protein 0.0075 0.0075 0.0066
Echinococcus granulosus cAMP dependent protein kinase type II regulatory 0.015 0.0243 0.0234
Brugia malayi hypothetical protein 0.0145 0.0231 0.0913
Onchocerca volvulus 0.0145 0.0231 0.0216
Toxoplasma gondii hypothetical protein 0.0075 0.0075 0.2868
Loa Loa (eye worm) melatonin receptor type 1A 0.0145 0.0231 0.0231
Schistosoma mansoni camp-dependent protein kinase type II-alpha regulatory subunit 0.015 0.0243 0.0234
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0412 0.0826 0.0818
Echinococcus multilocularis cAMP dependent protein kinase type II regulatory 0.015 0.0243 0.0234
Trichomonas vaginalis guanylate cyclase, putative 0.0104 0.0141 0.04
Echinococcus granulosus cyclin B 0.0064 0.0052 0.0043
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0145 0.0231 0.0222
Echinococcus granulosus single minded 2 0.0104 0.0141 0.0132
Trypanosoma brucei 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.4529 1 1
Leishmania major protein kinase A regulatory subunit, putative 0.015 0.0243 0.023
Entamoeba histolytica hypothetical protein 0.0072 0.0068 0.0059
Mycobacterium ulcerans hydrolase MutT1 0.0076 0.0079 0.0113
Loa Loa (eye worm) hypothetical protein 0.0075 0.0075 0.0075
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0048 0.0015 0.0006
Loa Loa (eye worm) hypothetical protein 0.0145 0.0231 0.0231
Echinococcus multilocularis fmrfamide receptor 0.0145 0.0231 0.0222
Leishmania major hypothetical protein, conserved 0.015 0.0243 0.023
Trichomonas vaginalis conserved hypothetical protein 0.015 0.0243 0.0858
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0145 0.0231 0.0222
Mycobacterium tuberculosis Possible hydrolase MutT1 0.0076 0.0079 0.083
Toxoplasma gondii transporter, cation channel family protein 0.0075 0.0075 0.2868
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0145 0.0231 0.0222
Loa Loa (eye worm) hypothetical protein 0.0075 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.0329 0.0641 0.0641
Trypanosoma brucei 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatas, putative 0.0076 0.0079 0.0074
Brugia malayi serine/threonine kinase 12 0.0087 0.0102 0.0381
Brugia malayi neuropeptide F receptor 0.0145 0.0231 0.0913
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.0075 0.0075 0.0271
Trichomonas vaginalis guanylate cyclase, putative 0.0104 0.0141 0.04
Treponema pallidum cyclic nucleotide binding protein 0.015 0.0243 0.2598
Echinococcus multilocularis orexin receptor type 2 0.0145 0.0231 0.0222
Plasmodium vivax phosphoglucomutase-2, putative 0.0076 0.0079 0.2356
Schistosoma mansoni hypothetical protein 0.0076 0.0079 0.007
Schistosoma mansoni dual specificity serine/threonine tyrosine kinase 0.011 0.0154 0.0145
Loa Loa (eye worm) hypothetical protein 0.0105 0.0143 0.0143
Brugia malayi Cytochrome P450 family protein 0.0047 0.0013 0.0015
Plasmodium falciparum cyclin 0.0064 0.0052 0.107
Echinococcus granulosus hyperpolarization activated cyclic 0.0225 0.0409 0.04
Echinococcus multilocularis cyclins 0.0064 0.0052 0.0043
Leishmania major cyclic nucleotide-binding protein-like protein 0.015 0.0243 0.023
Brugia malayi G protein-coupled receptor F59B2.13 0.0145 0.0231 0.0913
Mycobacterium ulcerans fructose-2,6-bisphosphatase GpmB 0.2673 0.5864 1
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0104 0.0141 0.04
Schistosoma mansoni hypothetical protein 0.0075 0.0075 0.0066
Echinococcus granulosus rhodopsin orphan GPCR 0.0145 0.0231 0.0222
Trichomonas vaginalis phosphoglycerate mutase, putative 0.0076 0.0079 0.0121
Trypanosoma brucei cytochrome P450, putative 0.0047 0.0013 0.0008
Brugia malayi Metabotropic glutamate receptor precursor. 0.0072 0.0069 0.0245
Trichomonas vaginalis guanylate cyclase, putative 0.0104 0.0141 0.04
Trypanosoma cruzi glycerolphosphate mutase, putative 0.0076 0.0079 0.0074
Echinococcus multilocularis rhodopsin orphan GPCR 0.0145 0.0231 0.0222
Leishmania major hypothetical protein, unknown function 0.0076 0.0079 0.0066
Echinococcus multilocularis nmda type glutamate receptor 0.0312 0.0603 0.0595
Trichomonas vaginalis adenylate cyclase, putative 0.0104 0.0141 0.04
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.014 0.0221 0.0212
Plasmodium vivax CAMP-dependent protein kinase regulatory subunit, putative 0.015 0.0243 1
Brugia malayi ion channel NompC 0.0075 0.0075 0.0271
Echinococcus granulosus neuropeptides capa receptor 0.0145 0.0231 0.0222
Trichomonas vaginalis adenylate cyclase, putative 0.0104 0.0141 0.04
Trichomonas vaginalis phosphoglycerate mutase, putative 0.0076 0.0079 0.0121
Schistosoma mansoni biogenic amine receptor 0.0145 0.0231 0.0222
Trichomonas vaginalis AGC family protein kinase 0.0087 0.0102 0.0223
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0075 0.0075 0.0271
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0307 0.0592 0.0588
Echinococcus multilocularis neuropeptide FF receptor 2 0.0145 0.0231 0.0222
Brugia malayi mbt repeat family protein 0.005 0.002 0.0044
Schistosoma mansoni serine/threonine protein kinase 0.014 0.0221 0.0211
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0072 0.0069 0.0245
Schistosoma mansoni metabotropic glutamate receptor 0.0072 0.0069 0.0059
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0104 0.0141 0.04
Echinococcus granulosus expressed conserved protein 0.0188 0.0327 0.0319
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0145 0.0231 0.0222
Echinococcus granulosus histone acetyltransferase MYST2 0.0057 0.0035 0.0026
Loa Loa (eye worm) hypothetical protein 0.0071 0.0067 0.0067
Schistosoma mansoni biogenic amine (5HT) receptor 0.0145 0.0231 0.0222
Brugia malayi hypothetical protein 0.0145 0.0231 0.0913
Trypanosoma brucei 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.1932 0.4215 0.4212
Schistosoma mansoni glutamate receptor AMPA 0.034 0.0666 0.0658
Toxoplasma gondii phosphoglycerate mutase family protein 0.0076 0.0079 0.3031
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0145 0.0231 0.0222
Brugia malayi olfactory channel protein osm-9 0.0075 0.0075 0.0271
Onchocerca volvulus 0.0145 0.0231 0.0216
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0072 0.0068 0.0059
Schistosoma mansoni hypothetical protein 0.0104 0.0141 0.0132
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.015 0.0243 0.3212
Trichomonas vaginalis adenylate cyclase type, putative 0.0104 0.0141 0.04
Entamoeba histolytica cell division protein kinase 2, putative 0.014 0.0221 0.032
Brugia malayi hypothetical protein 0.0145 0.0231 0.0913
Entamoeba histolytica protein kinase, putative 0.0087 0.0102 0.0116
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0145 0.0231 0.0222
Echinococcus granulosus alpha 1A adrenergic receptor 0.0145 0.0231 0.0222
Loa Loa (eye worm) hypothetical protein 0.0145 0.0231 0.0231
Trichomonas vaginalis guanylate cyclase, putative 0.0104 0.0141 0.04
Echinococcus granulosus tm gpcr rhodopsin 0.0145 0.0231 0.0222
Echinococcus granulosus glutamate receptor ionotropic kainate 0.014 0.0221 0.0212
Loa Loa (eye worm) neuropeptide F receptor 0.0145 0.0231 0.0231
Schistosoma mansoni voltage-gated potassium channel 0.0179 0.0307 0.0298
Echinococcus multilocularis rhodopsin orphan GPCR 0.0145 0.0231 0.0222
Echinococcus granulosus atrial natriuretic peptide receptor 0.0072 0.0069 0.0059
Trypanosoma cruzi regulatory subunit of protein kinase a-like protein, putative 0.015 0.0243 0.0238
Leishmania major 4-coumarate:coa ligase-like protein 0.0072 0.0069 0.0056
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0153 0.025 0.0241
Echinococcus granulosus glutamate receptor 2 0.0272 0.0514 0.0505
Echinococcus multilocularis voltage gated hydrogen channel 1 0.0075 0.0075 0.0066
Trypanosoma cruzi cdc2-related kinase 1 0.014 0.0221 0.0216
Onchocerca volvulus 0.0072 0.0069 0.0054
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0075 0.0075 0.0066
Echinococcus multilocularis serotonin receptor 0.0145 0.0231 0.0222
Echinococcus granulosus cyclin dependent kinase 9 0.0056 0.0034 0.0025
Echinococcus multilocularis somatostatin receptor 0.0145 0.0231 0.0222
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0145 0.0231 0.0222
Echinococcus granulosus neuropeptides capa receptor 0.0145 0.0231 0.0222
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0087 0.0102 0.0116
Echinococcus multilocularis rhodopsin orphan GPCR 0.0145 0.0231 0.0222
Echinococcus granulosus short transient receptor potential channel 6 0.0075 0.0075 0.0066
Loa Loa (eye worm) hypothetical protein 0.2596 0.5694 0.5694
Loa Loa (eye worm) hypothetical protein 0.4452 0.983 0.983
Echinococcus multilocularis cyclin B3 1 0.0064 0.0052 0.0043
Trichomonas vaginalis adenylate cyclase type IX, putative 0.0104 0.0141 0.04
Echinococcus granulosus Protein patched homolog 1 0.0086 0.01 0.0091
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.014 0.0221 0.0221
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0075 0.0075 0.0066
Echinococcus multilocularis phosphoglycerate mutase 0.0076 0.0079 0.007
Mycobacterium ulcerans hypothetical protein 0.0162 0.0269 0.0437
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.1135 0.2437 0.243
Schistosoma mansoni serine/threonine protein kinase 0.0153 0.025 0.0241
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0057 0.0035 0.0026
Schistosoma mansoni opsin-like receptor 0.0145 0.0231 0.0222
Echinococcus multilocularis g-protein coupled receptor 0.0145 0.0231 0.0222
Trichomonas vaginalis AGC family protein kinase 0.0087 0.0102 0.0223
Brugia malayi Receptor family ligand binding region containing protein 0.0072 0.0069 0.0245
Echinococcus granulosus fmrfamide receptor 0.0145 0.0231 0.0222
Echinococcus granulosus two pore calcium channel protein 2 0.0075 0.0075 0.0066
Loa Loa (eye worm) hypothetical protein 0.0075 0.0075 0.0075
Entamoeba histolytica protein kinase domain containing protein 0.0087 0.0102 0.0116
Echinococcus granulosus hypothetical protein 0.0145 0.0231 0.0222
Echinococcus granulosus transient receptor potential cation channel 0.0075 0.0075 0.0066
Onchocerca volvulus 0.0072 0.0069 0.0054
Echinococcus multilocularis voltage dependent calcium channel 0.0075 0.0075 0.0066
Trypanosoma brucei cyclic nucleotide-binding domain containing protein, putative 0.015 0.0243 0.0238
Entamoeba histolytica phosphoglycerate mutase family protein. putative 0.0076 0.0079 0.0077
Trichomonas vaginalis guanylate cyclase, putative 0.0104 0.0141 0.04
Mycobacterium ulcerans bifunctional RNase H/acid phosphatase 0.0076 0.0079 0.0113
Trypanosoma cruzi phosphoglycerate mutase protein, putative 0.0076 0.0079 0.0074
Trypanosoma cruzi phosphoglycerate mutase family member 5, putative 0.0076 0.0079 0.0074
Trichomonas vaginalis conserved hypothetical protein 0.0104 0.0141 0.04
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatas, putative 0.0076 0.0079 0.0074
Echinococcus multilocularis 6 phosphofructo 2 kinase:fructose 2 0.4529 1 1
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0104 0.0141 0.04
Schistosoma mansoni sex comb on midleg homolog 0.005 0.002 0.0011
Echinococcus granulosus cyclins 0.0064 0.0052 0.0043
Trypanosoma cruzi Histidine phosphatase superfamily (branch 1), putative 0.0076 0.0079 0.0074
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.014 0.0221 0.0212
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0225 0.0409 0.04
Echinococcus multilocularis phosphoglycerate mutase 0.0076 0.0079 0.007
Loa Loa (eye worm) hypothetical protein 0.0075 0.0075 0.0075
Schistosoma mansoni voltage-gated potassium channel 0.0075 0.0075 0.0066
Schistosoma mansoni serine/threonine protein kinase 0.0153 0.025 0.0241
Trichomonas vaginalis guanylate cyclase, putative 0.0104 0.0141 0.04
Plasmodium falciparum protein kinase 5 0.014 0.0221 0.8679
Echinococcus granulosus phosphoglycerate mutase 0.0076 0.0079 0.007
Echinococcus granulosus calcium activated potassium channel 0.0078 0.0082 0.0073
Echinococcus granulosus potassium voltage gated channel subfamily H 0.1135 0.2437 0.243
Trichomonas vaginalis guanylate cyclase, putative 0.0104 0.0141 0.04
Echinococcus granulosus neuropeptide FF receptor 2 0.0145 0.0231 0.0222
Echinococcus multilocularis potassium voltage gated channel protein 0.0075 0.0075 0.0066
Echinococcus granulosus allatostatin A receptor 0.0145 0.0231 0.0222
Echinococcus multilocularis cAMP dependent protein kinase regulatory 0.015 0.0243 0.0234
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0104 0.0141 0.04
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0075 0.0075 0.0066
Loa Loa (eye worm) hypothetical protein 0.0145 0.0231 0.0231
Brugia malayi N-terminal motif family protein 0.015 0.0243 0.0961
Giardia lamblia Hypothetical protein 0.2673 0.5864 1
Brugia malayi Glutamate receptor 2 precursor 0.034 0.0666 0.2706
Onchocerca volvulus 0.0145 0.0231 0.0216
Loa Loa (eye worm) hypothetical protein 0.0145 0.0231 0.0231
Onchocerca volvulus 0.0145 0.0231 0.0216
Brugia malayi hypothetical protein 0.012 0.0175 0.0684
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.002 0.0046
Loa Loa (eye worm) calcium channel 0.0075 0.0075 0.0075
Brugia malayi hypothetical protein 0.0472 0.0961 0.3919
Loa Loa (eye worm) hypothetical protein 0.0145 0.0231 0.0231
Schistosoma mansoni transient receptor potential channel 4 0.0075 0.0075 0.0066
Mycobacterium ulcerans acyl-CoA synthetase 0.0072 0.0069 0.0096
Brugia malayi hypothetical protein 0.0145 0.0231 0.0913
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0225 0.0409 0.04
Echinococcus multilocularis cyclin dependent kinase 1 0.014 0.0221 0.0211
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.0075 0.0075 0.007
Echinococcus granulosus cyclin dependent kinase 0.014 0.0221 0.0211
Echinococcus granulosus microtubule associated protein 2 0.0674 0.1411 0.1403
Loa Loa (eye worm) hypothetical protein 0.0145 0.0231 0.0231
Schistosoma mansoni sex comb on midleg homolog 0.005 0.002 0.0011
Echinococcus granulosus voltage dependent calcium channel 0.0075 0.0075 0.0066
Echinococcus granulosus Niemann Pick C1 protein 0.0286 0.0546 0.0537
Schistosoma mansoni hypothetical protein 0.0076 0.0079 0.007
Schistosoma mansoni serine/threonine protein kinase 0.0087 0.0102 0.0093
Trichomonas vaginalis adenylate cyclase, putative 0.0104 0.0141 0.04
Echinococcus multilocularis potassium large conductance calcium activated 0.0075 0.0075 0.0066
Trypanosoma cruzi Histidine phosphatase superfamily (branch 1), putative 0.0076 0.0079 0.0074
Onchocerca volvulus 0.0072 0.0069 0.0054
Brugia malayi mbt repeat family protein 0.005 0.002 0.0044
Trichomonas vaginalis guanylate cyclase, putative 0.0104 0.0141 0.04
Brugia malayi RE15519p 0.0145 0.0231 0.0913
Leishmania major cyclin 0.0064 0.0052 0.0039
Mycobacterium ulcerans hypothetical protein 0.015 0.0243 0.0392
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.0075 0.0075 0.007
Trichomonas vaginalis adenylate cyclase type III, putative 0.0104 0.0141 0.04
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0307 0.0592 0.0588
Echinococcus multilocularis Niemann Pick C1 protein 0.02 0.0354 0.0346
Echinococcus granulosus G protein coupled receptor 139 0.0145 0.0231 0.0222
Loa Loa (eye worm) hypothetical protein 0.0145 0.0231 0.0231
Schistosoma mansoni hypothetical protein 0.0167 0.0281 0.0272
Echinococcus multilocularis neuropeptide receptor 0.0145 0.0231 0.0222
Brugia malayi putative neuropeptide receptor NPR1 0.0145 0.0231 0.0913
Loa Loa (eye worm) hypothetical protein 0.0145 0.0231 0.0231
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0225 0.0409 0.1608
Trypanosoma cruzi cdc2-related kinase 3 0.014 0.0221 0.0216
Echinococcus granulosus sterol regulatory element binding protein 0.0086 0.01 0.0091
Loa Loa (eye worm) hypothetical protein 0.0145 0.0231 0.0231
Brugia malayi ORL1-like opioid receptor 0.0145 0.0231 0.0913
Echinococcus multilocularis neuropeptides capa receptor 0.0145 0.0231 0.0222
Onchocerca volvulus 0.0145 0.0231 0.0216
Leishmania major phosphoglycerate mutase, putative 0.0076 0.0079 0.0066
Echinococcus multilocularis phosphoglycerate mutase 0.0076 0.0079 0.007
Schistosoma mansoni hypothetical protein 0.0304 0.0585 0.0577
Brugia malayi cation channel family protein 0.0075 0.0075 0.0271
Onchocerca volvulus Heat shock factor protein 2 homolog 0.0318 0.0616 0.0603
Loa Loa (eye worm) hypothetical protein 0.0145 0.0231 0.0231
Echinococcus granulosus tyrosine kinase 0.0072 0.0069 0.0059
Schistosoma mansoni transient receptor potential channel 0.0075 0.0075 0.0066
Echinococcus granulosus nmda type glutamate receptor 0.0312 0.0603 0.0595
Onchocerca volvulus Dual specificity protein kinase TTK homolog 0.011 0.0154 0.0139
Entamoeba histolytica acyl-CoA synthetase, putative 0.0072 0.0069 0.006
Echinococcus multilocularis protein patched 0.0086 0.01 0.0091
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.015 0.0243 0.9708
Loa Loa (eye worm) hypothetical protein 0.012 0.0175 0.0175
Echinococcus granulosus rhodopsin orphan GPCR 0.0145 0.0231 0.0222
Schistosoma mansoni hypothetical protein 0.0076 0.0079 0.007
Trichomonas vaginalis guanylate cyclase, putative 0.0104 0.0141 0.04
Trichomonas vaginalis adenylate cyclase, putative 0.0104 0.0141 0.04
Giardia lamblia Kinase, TTK 0.011 0.0154 0.0175
Echinococcus granulosus tm gpcr rhodopsin 0.0145 0.0231 0.0222
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.4529 1 1
Echinococcus multilocularis expressed conserved protein 0.0153 0.025 0.0241
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.4529 1 1
Trichomonas vaginalis cAMP-dependent protein kinase type I-beta regulatory subunit, putative 0.015 0.0243 0.0858
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0412 0.0826 0.0818
Echinococcus multilocularis geminin 0.0167 0.0281 0.0272
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0087 0.0102 0.0093
Echinococcus multilocularis allatostatin A receptor 0.0145 0.0231 0.0222
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.006 0.0043 0.0033
Treponema pallidum catabolite gene activator 0.015 0.0243 0.2598
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0145 0.0232 0.022
Leishmania major hypothetical protein, conserved 0.0076 0.0079 0.0066
Schistosoma mansoni tyrosine kinase 0.0072 0.0069 0.0059
Brugia malayi G-protein coupled receptor 0.0145 0.0231 0.0913
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0145 0.0231 0.0222
Loa Loa (eye worm) hypothetical protein 0.005 0.002 0.002
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0087 0.0102 0.0116
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.006 0.0043 0.0033
Trypanosoma cruzi phosphoglycerate mutase, putative 0.0076 0.0079 0.0074
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0104 0.0141 0.04
Schistosoma mansoni transcription factor LCR-F1 0.0072 0.0068 0.0059
Toxoplasma gondii cAMP-dependent protein kinase regulatory subunit 0.015 0.0243 0.9708
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0072 0.0069 0.0054
Trichomonas vaginalis CAMK family protein kinase 0.011 0.0154 0.0459
Echinococcus granulosus transient receptor potential gamma protein 0.0075 0.0075 0.0066
Echinococcus multilocularis expressed conserved protein 0.0188 0.0327 0.0319
Schistosoma mansoni hypothetical protein 0.0076 0.0079 0.007
Schistosoma mansoni vesicular amine transporter 0.0075 0.0075 0.0066
Echinococcus granulosus cGMP dependent protein kinase 1 0.0153 0.025 0.0241
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0225 0.0409 0.0409
Echinococcus granulosus phosphoglycerate mutase 0.0076 0.0079 0.007
Leishmania major protein kinase, putative 0.0153 0.025 0.0237
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.014 0.0221 0.0208
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0072 0.0069 0.0096
Trypanosoma cruzi cyclin, putative 0.0064 0.0052 0.0047
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0145 0.0231 0.0222
Mycobacterium ulcerans transcriptional regulatory protein 0.015 0.0243 0.0392
Loa Loa (eye worm) hypothetical protein 0.0145 0.0231 0.0231
Echinococcus granulosus sodium leak channel non selective protein 0.0075 0.0075 0.0066
Echinococcus multilocularis sodium leak channel non selective protein 0.0075 0.0075 0.0066
Loa Loa (eye worm) AGC/PKG protein kinase 0.0153 0.025 0.025
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0075 0.0075 0.0271
Trypanosoma cruzi cyclin 6, putative 0.0064 0.0052 0.0047
Echinococcus multilocularis phosphoglycerate mutase 0.0076 0.0079 0.007
Echinococcus granulosus voltage gated potassium channel 0.0075 0.0075 0.0066
Echinococcus granulosus snurportin 1 0.0304 0.0585 0.0577
Echinococcus granulosus voltage gated potassium channel 0.0329 0.0641 0.0633
Mycobacterium leprae conserved hypothetical protein 0.0076 0.0079 0.0567
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0145 0.0231 0.0222
Mycobacterium tuberculosis Conserved hypothetical protein 0.015 0.0243 0.3212
Loa Loa (eye worm) ryanodine receptor 0.0075 0.0075 0.0075
Echinococcus granulosus sodium channel protein 0.0075 0.0075 0.0066
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0075 0.0075 0.007
Trichomonas vaginalis AGC family protein kinase 0.0087 0.0102 0.0223
Echinococcus granulosus cyclins 0.0064 0.0052 0.0043
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0145 0.0231 0.0222
Loa Loa (eye worm) hypothetical protein 0.0145 0.0231 0.0231
Echinococcus granulosus g protein coupled receptor 0.0145 0.0231 0.0222
Echinococcus granulosus cGMP dependent protein kinase 0.0153 0.025 0.0241
Trypanosoma cruzi cAMP response protein 1 0.015 0.0243 0.0238
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0104 0.0141 0.04
Loa Loa (eye worm) cyclin domain-containing protein 0.0778 0.1641 0.1641
Trichomonas vaginalis guanylate cyclase beta 2 subunit, putative 0.0104 0.0141 0.04
Trichomonas vaginalis cAMP-dependent protein kinase regulatory subunit, putative 0.015 0.0243 0.0858
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0072 0.0069 0.0069
Echinococcus multilocularis transient receptor potential cation channel 0.0075 0.0075 0.0066
Treponema pallidum catabolite gene activator (Crp) 0.015 0.0243 0.2598
Trichomonas vaginalis conserved hypothetical protein 0.0086 0.01 0.0215
Leishmania major protein kinase, putative 0.0087 0.0102 0.0089
Echinococcus granulosus g protein coupled receptor 0.0145 0.0231 0.0222
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0075 0.0075 0.0066
Entamoeba histolytica hypothetical protein 0.0072 0.0069 0.0059
Schistosoma mansoni voltage-gated cation channel 0.0075 0.0075 0.0066
Leishmania major 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-1-like protein 0.1932 0.4215 0.4207
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.015 0.0243 0.0858
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0064 0.0052 0.0043
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0075 0.0075 0.0066
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0145 0.0231 0.0222
Loa Loa (eye worm) hypothetical protein 0.0145 0.0231 0.0231
Brugia malayi hypothetical protein 0.0072 0.0069 0.0245
Loa Loa (eye worm) hypothetical protein 0.0225 0.0409 0.0409
Trypanosoma cruzi cyclin, putative 0.0064 0.0052 0.0047
Trichomonas vaginalis guanylate cyclase, putative 0.0104 0.0141 0.04
Brugia malayi larval opioid receptor 0.0145 0.0231 0.0913
Brugia malayi Transient-receptor-potential like protein 0.0075 0.0075 0.0271
Loa Loa (eye worm) hypothetical protein 0.4529 1 1
Echinococcus granulosus cyclic nucleotide gated cation channel 0.015 0.0243 0.0234
Echinococcus multilocularis two pore calcium channel protein 2 0.0075 0.0075 0.0066
Echinococcus granulosus neuropeptide Y receptor 0.0145 0.0231 0.0222
Onchocerca volvulus 0.0076 0.0079 0.0064
Echinococcus multilocularis rhodopsin orphan GPCR 0.0145 0.0231 0.0222
Schistosoma mansoni hypothetical protein 0.0167 0.0281 0.0272
Loa Loa (eye worm) hypothetical protein 0.0145 0.0231 0.0231
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0075 0.0075 0.006
Trichomonas vaginalis conserved hypothetical protein 0.0076 0.0079 0.0121
Echinococcus granulosus potassium voltage gated channel protein 0.0075 0.0075 0.0066
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0225 0.0409 0.04
Trichomonas vaginalis adenylate cyclase, putative 0.0104 0.0141 0.04
Trypanosoma cruzi Flagellar Member 6 0.015 0.0243 0.0238
Schistosoma mansoni hypothetical protein 0.0083 0.0093 0.0084
Echinococcus granulosus polycomb protein SCMH1 0.005 0.002 0.0011
Onchocerca volvulus 0.0076 0.0079 0.0064
Echinococcus granulosus hypothetical protein 0.0075 0.0075 0.0066
Brugia malayi AKH receptor 0.0145 0.0231 0.0913
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0075 0.0075 0.0066
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.015 0.0243 0.0234
Echinococcus granulosus neuropeptide receptor A26 0.0145 0.0231 0.0222
Mycobacterium leprae Possible phosphoglycerate mutase 0.0076 0.0079 0.0567
Echinococcus granulosus cAMP dependent protein kinase regulatory 0.015 0.0243 0.0234
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatas, putative 0.0076 0.0079 0.0074
Echinococcus multilocularis sodium channel protein 0.0075 0.0075 0.0066
Echinococcus granulosus cyclin B3 1 0.0064 0.0052 0.0043
Loa Loa (eye worm) hypothetical protein 0.0145 0.0231 0.0231
Loa Loa (eye worm) hypothetical protein 0.0072 0.0069 0.0069
Brugia malayi cell division control protein 2 homolog 0.014 0.0221 0.087
Loa Loa (eye worm) hypothetical protein 0.0054 0.0029 0.0029
Toxoplasma gondii transporter, cation channel family protein 0.0075 0.0075 0.2868
Schistosoma mansoni neuropeptide f receptor 76f 0.0145 0.0231 0.0222
Loa Loa (eye worm) hypothetical protein 0.0137 0.0213 0.0213
Echinococcus granulosus Niemann Pick C1 protein 0.02 0.0354 0.0346
Echinococcus granulosus transient receptor potential cation channel 0.0075 0.0075 0.0066
Loa Loa (eye worm) hypothetical protein 0.0145 0.0231 0.0231
Leishmania major mitochondrial DNA polymerase beta 0.0307 0.0592 0.058
Echinococcus multilocularis glutamate receptor NMDA 0.024 0.0443 0.0434
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0064 0.0052 0.0043
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0087 0.0102 0.0116
Schistosoma mansoni opsin-like receptor 0.0145 0.0231 0.0222
Schistosoma mansoni hypothetical protein 0.0076 0.0079 0.007
Echinococcus granulosus peptide allatostatin:somatostatin 0.0145 0.0231 0.0222
Trypanosoma brucei phosphoglycerate mutase protein, putative 0.0076 0.0079 0.0074
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0145 0.0231 0.0913
Brugia malayi Cyclic-nucleotide gated cation channel 0.0225 0.0409 0.1646
Mycobacterium tuberculosis Conserved hypothetical protein 0.0162 0.0269 0.3595
Loa Loa (eye worm) hypothetical protein 0.0075 0.0075 0.0075
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0075 0.0075 0.0066
Loa Loa (eye worm) hypothetical protein 0.0315 0.0611 0.0611
Loa Loa (eye worm) hypothetical protein 0.0075 0.0075 0.0075
Entamoeba histolytica heat shock transcription factor, putative 0.0318 0.0616 0.0999
Echinococcus multilocularis glutamate receptor 2 0.034 0.0666 0.0658
Mycobacterium ulcerans acid phosphatase 0.0076 0.0079 0.0113
Mycobacterium ulcerans acyl-CoA synthetase 0.0072 0.0069 0.0096
Loa Loa (eye worm) hypothetical protein 0.0145 0.0231 0.0231
Schistosoma mansoni protein kinase 0.0087 0.0102 0.0093
Echinococcus multilocularis NMDA receptor 0.014 0.0221 0.0212
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0075 0.0075 0.0066
Schistosoma mansoni voltage-gated potassium channel 0.0225 0.0409 0.04
Trypanosoma brucei Serine/threonine-protein phosphatase PGAM5, mitochondrial, putative 0.0076 0.0079 0.0074
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.015 0.0243 0.0228
Trichomonas vaginalis adenylate cyclase type IX, putative 0.0104 0.0141 0.04
Schistosoma mansoni hypothetical protein 0.0145 0.0231 0.0222
Trypanosoma brucei STE group serine/threonine-protein kinase, putative 0.0107 0.0148 0.0143
Brugia malayi Serotonin receptor 0.0145 0.0231 0.0913
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0145 0.0231 0.0222
Loa Loa (eye worm) hypothetical protein 0.0145 0.0231 0.0231
Echinococcus multilocularis rhodopsin orphan GPCR 0.0145 0.0231 0.0222
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0153 0.025 0.0241
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0145 0.0231 0.0222
Schistosoma mansoni voltage-gated potassium channel 0.0329 0.0641 0.0633
Echinococcus granulosus transient receptor potential cation channel 0.0075 0.0075 0.0066
Echinococcus multilocularis rhodopsin orphan GPCR 0.0145 0.0231 0.0222
Echinococcus granulosus rhodopsin orphan GPCR 0.0145 0.0231 0.0222
Loa Loa (eye worm) hypothetical protein 0.0075 0.0075 0.0075
Schistosoma mansoni serine/threonine protein kinase 0.014 0.0221 0.0211
Schistosoma mansoni voltage-gated potassium channel 0.0075 0.0075 0.0066
Trypanosoma cruzi cytochrome P450, putative 0.0047 0.0013 0.0008
Loa Loa (eye worm) hypothetical protein 0.0075 0.0075 0.0075
Schistosoma mansoni serine/threonine protein kinase 0.0056 0.0034 0.0025
Schistosoma mansoni cyclin B3 0.0064 0.0052 0.0043
Trichomonas vaginalis adenylate cyclase, putative 0.0104 0.0141 0.04
Brugia malayi CHE-14 protein 0.0086 0.01 0.0374
Schistosoma mansoni hypothetical protein 0.014 0.0221 0.0212
Echinococcus multilocularis transient receptor potential cation channel 0.0075 0.0075 0.0066
Onchocerca volvulus Huntingtin homolog 0.012 0.0175 0.0161
Giardia lamblia Kinase, CMGC CDK 0.014 0.0221 0.0289
Trypanosoma cruzi CYC2-like cyclin, putative 0.0064 0.0052 0.0047
Schistosoma mansoni cyclins 0.0064 0.0052 0.0043
Onchocerca volvulus 0.0145 0.0231 0.0216
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0064 0.0052 0.0039
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0075 0.0075 0.0066
Onchocerca volvulus 0.0064 0.0052 0.0038
Schistosoma mansoni camp-dependent protein kinase type II regulatory subunit 0.015 0.0243 0.0234
Schistosoma mansoni cyclin B 0.0064 0.0052 0.0043
Loa Loa (eye worm) cAMP-dependent protein kinase regulatory subunit 0.015 0.0243 0.0243
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0145 0.0231 0.0222
Brugia malayi cation channel family protein 0.0075 0.0075 0.0271
Onchocerca volvulus Protein UBASH3A homolog 0.0076 0.0079 0.0064
Schistosoma mansoni voltage-gated potassium channel 0.1239 0.2669 0.2663
Schistosoma mansoni voltage-gated potassium channel 0.0075 0.0075 0.0066
Toxoplasma gondii phosphoglycerate mutase family protein 0.0076 0.0079 0.3031
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0072 0.0069 0.0069
Echinococcus multilocularis neuropeptide receptor 0.0145 0.0231 0.0222
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0072 0.0069 0.0059
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0412 0.0826 0.0818
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0145 0.0231 0.0222
Schistosoma mansoni tyrosine kinase 0.0072 0.0069 0.0059
Echinococcus granulosus glutamate receptor 2 0.0412 0.0826 0.0818
Entamoeba histolytica protein kinase, putative 0.0087 0.0102 0.0116
Entamoeba histolytica cell division protein kinase 2, putative 0.0149 0.0241 0.0355
Brugia malayi hypothetical protein 0.0145 0.0231 0.0913
Schistosoma mansoni neuropeptide receptor 0.0145 0.0231 0.0222
Loa Loa (eye worm) hypothetical protein 0.0145 0.0231 0.0231
Schistosoma mansoni voltage-gated ion channel 0.0075 0.0075 0.0066
Brugia malayi Dopamine receptor protein 1 0.0145 0.0231 0.0913
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0048 0.0015 0.0006
Trichomonas vaginalis adenylate cyclase type vIII, putative 0.0104 0.0141 0.04
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0145 0.0231 0.0222
Echinococcus multilocularis cyclins 0.0064 0.0052 0.0043
Brugia malayi Dopamine receptor 0.0145 0.0231 0.0913
Echinococcus multilocularis cyclins 0.0064 0.0052 0.0043
Mycobacterium leprae conserved hypothetical protein 0.0076 0.0079 0.0567
Loa Loa (eye worm) hypothetical protein 0.0054 0.0029 0.0029
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0072 0.0069 0.0059
Trichomonas vaginalis adenylate cyclase type III, putative 0.0104 0.0141 0.04
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0075 0.0075 0.0271
Echinococcus multilocularis hyperpolarization activated cyclic 0.0225 0.0409 0.04
Loa Loa (eye worm) hypothetical protein 0.0054 0.0029 0.0029
Echinococcus granulosus biogenic amine 5HT receptor 0.0145 0.0231 0.0222
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0359 0.0709 1
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0104 0.0141 0.04
Schistosoma mansoni voltage-gated potassium channel 0.0075 0.0075 0.0066
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.015 0.0243 0.0234
Echinococcus granulosus cGMP dependent protein kinase 1 0.0153 0.025 0.0241
Schistosoma mansoni hypothetical protein 0.0145 0.0231 0.0222
Trypanosoma brucei cyclic nucleotide-binding domain containing protein, putative 0.015 0.0243 0.0238
Schistosoma mansoni hypothetical protein 0.0083 0.0093 0.0084
Entamoeba histolytica hypothetical protein 0.0072 0.0068 0.0059
Loa Loa (eye worm) phosphoglycerate mutase 0.0076 0.0079 0.0079
Loa Loa (eye worm) cytochrome P450 family protein 0.0047 0.0013 0.0013
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0145 0.0231 0.0222
Trypanosoma brucei cAMP binding protein, putative 0.015 0.0243 0.0238
Echinococcus granulosus potassium voltage gated channel protein 0.0075 0.0075 0.0066
Loa Loa (eye worm) hypothetical protein 0.0043 0.0004 0.0004
Trichomonas vaginalis adenylate cyclase, putative 0.0104 0.0141 0.04
Leishmania major hypothetical protein, conserved 0.0075 0.0075 0.0062
Loa Loa (eye worm) TTK protein kinase 0.011 0.0154 0.0154
Trypanosoma cruzi hypothetical protein, conserved 0.015 0.0243 0.0238
Mycobacterium ulcerans hypothetical protein 0.015 0.0243 0.0392
Echinococcus granulosus rhodopsin orphan GPCR 0.0145 0.0231 0.0222
Trichomonas vaginalis adenylate cyclase, putative 0.0104 0.0141 0.04
Schistosoma mansoni camp-dependent protein kinase regulatory chain 0.015 0.0243 0.0234
Leishmania major hypothetical protein, unknown function 0.015 0.0243 0.023
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0104 0.0141 0.04
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0075 0.0075 0.0066
Schistosoma mansoni patched 1 0.0086 0.01 0.0091
Echinococcus granulosus geminin 0.0167 0.0281 0.0272
Entamoeba histolytica phosphoglycerate mutase family protein, putative 0.0076 0.0079 0.0077
Echinococcus multilocularis cyclins 0.0064 0.0052 0.0043
Loa Loa (eye worm) hypothetical protein 0.0145 0.0231 0.0231
Brugia malayi Receptor family ligand binding region containing protein 0.0072 0.0069 0.0245
Loa Loa (eye worm) mbt repeat family protein 0.005 0.002 0.002
Trichomonas vaginalis guanylate cyclase, putative 0.0104 0.0141 0.04
Echinococcus multilocularis voltage gated potassium channel 0.0329 0.0641 0.0633
Schistosoma mansoni serine/threonine protein kinase 0.0153 0.025 0.0241
Chlamydia trachomatis cAMP-dependent protein kinase regulatory subunit 0.015 0.0243 0.3147
Trypanosoma cruzi protein kinase A regulatory subunit 0.015 0.0243 0.0238
Schistosoma mansoni voltage-dependent calcium channel 0.0075 0.0075 0.0066
Loa Loa (eye worm) hypothetical protein 0.0145 0.0231 0.0231
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.015 0.0243 0.9708
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0412 0.0826 0.0818
Mycobacterium tuberculosis Probable conserved lipoprotein LpqD 0.0076 0.0079 0.083
Loa Loa (eye worm) RGC/RGC protein kinase 0.0072 0.0069 0.0069
Echinococcus multilocularis microtubule associated protein 2 0.0674 0.1411 0.1403
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0329 0.0641 0.2603
Mycobacterium leprae Conserved hypothetical protein 0.015 0.0243 1
Schistosoma mansoni myosin xvIII 0.0145 0.0231 0.0222
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0086 0.01 0.01
Toxoplasma gondii phosphoglycerate mutase family protein 0.0076 0.0079 0.3031
Leishmania major hypothetical protein, unknown function 0.0075 0.0075 0.0062
Onchocerca volvulus 0.0145 0.0231 0.0216
Trypanosoma cruzi phosphoglycerate mutase family member 5, putative 0.0076 0.0079 0.0074
Trypanosoma brucei cdc2-related kinase 3 0.014 0.0221 0.0216
Loa Loa (eye worm) hypothetical protein 0.0145 0.0231 0.0231
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0412 0.0826 0.0818
Echinococcus multilocularis ryanodine receptor 44f 0.0075 0.0075 0.0066
Trichomonas vaginalis adenylate cyclase type VI, putative 0.0104 0.0141 0.04
Brugia malayi Cyclin, N-terminal domain containing protein 0.0064 0.0052 0.0177
Mycobacterium ulcerans acyl-CoA synthetase 0.0072 0.0069 0.0096
Trichomonas vaginalis guanylate cyclase, putative 0.0104 0.0141 0.04
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0104 0.0141 0.04
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.0075 0.0075 0.0271
Schistosoma mansoni hypothetical protein 0.0303 0.0584 0.0576
Trichomonas vaginalis phosphoglycerate mutase, putative 0.0076 0.0079 0.0121
Entamoeba histolytica acyl-CoA synthetase, putative 0.0072 0.0069 0.006
Trypanosoma cruzi Histidine phosphatase superfamily (branch 1), putative 0.0076 0.0079 0.0074
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0145 0.0231 0.0222
Trichomonas vaginalis CMGC family protein kinase 0.014 0.0221 0.0758
Loa Loa (eye worm) hypothetical protein 0.0145 0.0231 0.0231
Schistosoma mansoni glutamate receptor AMPA 0.034 0.0666 0.0658
Trichomonas vaginalis adenylate cyclase type, putative 0.0104 0.0141 0.04
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.002 0.002
Echinococcus multilocularis neuropeptide receptor A26 0.0145 0.0231 0.0222
Trypanosoma brucei Histidine phosphatase superfamily (branch 1), putative 0.0076 0.0079 0.0074
Onchocerca volvulus 0.0145 0.0231 0.0216
Trypanosoma cruzi phosphoglycerate mutase protein, putative 0.0076 0.0079 0.0074
Brugia malayi Cyclin, N-terminal domain containing protein 0.0778 0.1641 0.6722
Loa Loa (eye worm) hypothetical protein 0.0076 0.0079 0.0079
Schistosoma mansoni biogenic amine (5HT) receptor 0.0145 0.0231 0.0222
Brugia malayi serine/threonine protein kinase 6 0.0087 0.0102 0.0381
Echinococcus granulosus neuropeptide receptor 0.0145 0.0231 0.0222
Leishmania major hypothetical protein, conserved 0.0076 0.0079 0.0066
Echinococcus granulosus cyclins 0.0064 0.0052 0.0043
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0075 0.0075 0.0271
Brugia malayi GnHR receptor homolog 0.0145 0.0231 0.0913
Toxoplasma gondii transporter, cation channel family protein 0.0075 0.0075 0.2868
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0145 0.0231 0.0222
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0075 0.0075 0.0066
Schistosoma mansoni protein kinase 0.0072 0.0069 0.0059
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.014 0.0221 0.0221
Trypanosoma cruzi extracellular receptor, putative 0.0072 0.0069 0.0064
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0145 0.0231 0.0222
Loa Loa (eye worm) hypothetical protein 0.0072 0.0069 0.0069
Onchocerca volvulus 0.0145 0.0231 0.0216
Trichomonas vaginalis adenylate cyclase, putative 0.0104 0.0141 0.04
Loa Loa (eye worm) hypothetical protein 0.0072 0.0069 0.0069
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0225 0.0409 0.04
Trichomonas vaginalis guanylate cyclase, putative 0.0104 0.0141 0.04
Plasmodium falciparum phosphoglycerate mutase, putative 0.0076 0.0079 0.228
Trichomonas vaginalis conserved hypothetical protein 0.0104 0.0141 0.04
Brugia malayi hypothetical protein 0.0075 0.0075 0.0271
Loa Loa (eye worm) hypothetical protein 0.0075 0.0075 0.0075
Mycobacterium tuberculosis Conserved protein 0.0076 0.0079 0.083
Trichomonas vaginalis adenylate cyclase type, putative 0.0104 0.0141 0.04
Mycobacterium ulcerans phosphohistidine phosphatase SixA 0.0076 0.0079 0.0113
Onchocerca volvulus Protein UBASH3A homolog 0.0076 0.0079 0.0064
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.015 0.0243 0.0234
Echinococcus multilocularis serotonin receptor 0.0145 0.0231 0.0222
Brugia malayi metabotropic glutamate receptor type 2 0.0072 0.0069 0.0245
Brugia malayi Dopamine receptor protein 2 0.0145 0.0231 0.0913
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.005 0.002 0.0005
Echinococcus multilocularis cyclin dependent kinase 0.014 0.0221 0.0211
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0145 0.0231 0.0222
Echinococcus multilocularis tyrosine kinase 0.0072 0.0069 0.0059
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0153 0.025 1
Loa Loa (eye worm) hypothetical protein 0.0145 0.0231 0.0231
Brugia malayi neuropeptide F receptor 0.0145 0.0231 0.0913
Loa Loa (eye worm) hypothetical protein 0.0054 0.0029 0.0029
Schistosoma mansoni phosphoglycerate mutase 0.0076 0.0079 0.007
Brugia malayi cyclin-dependent kinase 9 0.0056 0.0034 0.0102
Loa Loa (eye worm) hypothetical protein 0.0145 0.0231 0.0231
Loa Loa (eye worm) hypothetical protein 0.0145 0.0231 0.0231
Brugia malayi G-protein coupled receptor 0.0145 0.0231 0.0913
Loa Loa (eye worm) hypothetical protein 0.0072 0.0069 0.0069
Onchocerca volvulus Protein UBASH3A homolog 0.0076 0.0079 0.0064
Trypanosoma brucei phosphoglycerate mutase, putative 0.0076 0.0079 0.0074
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.014 0.0221 0.0221
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0075 0.0075 0.0066
Plasmodium vivax protein kinase Crk2 0.014 0.0221 0.897
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0072 0.0069 0.0096
Loa Loa (eye worm) glutamate receptor 0.0072 0.0069 0.0069
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0359 0.0709 1
Entamoeba histolytica cyclin family protein 0.0064 0.0052 0.0031
Echinococcus multilocularis neuropeptide Y receptor 0.0145 0.0231 0.0222
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0145 0.0231 0.0222
Echinococcus multilocularis voltage gated potassium channel 0.0075 0.0075 0.0066
Trichomonas vaginalis intestinal guanylate cyclase, putative 0.0104 0.0141 0.04
Plasmodium vivax rap guanine nucleotide exchange factor, putative 0.015 0.0243 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.0145 0.0231 0.0222
Trypanosoma cruzi aurora B kinase, putative 0.0087 0.0102 0.0097
Echinococcus granulosus TRP transient receptor potential channel 0.0075 0.0075 0.0066
Echinococcus multilocularis short transient receptor potential channel 6 0.0075 0.0075 0.0066
Schistosoma mansoni hypothetical protein 0.0145 0.0231 0.0222
Echinococcus granulosus somatostatin receptor 0.0145 0.0231 0.0222
Mycobacterium ulcerans hypothetical protein 0.015 0.0243 0.0392
Echinococcus multilocularis potassium voltage gated channel protein 0.0075 0.0075 0.0066
Mycobacterium tuberculosis Possible phosphoglycerate mutase Gpm2 (phosphoglyceromutase) (PGAM) (BPG-dependent PGAM) 0.0076 0.0079 0.083
Trichomonas vaginalis conserved hypothetical protein 0.0104 0.0141 0.04
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.014 0.0221 0.0212
Loa Loa (eye worm) RGC/RGC protein kinase 0.0072 0.0069 0.0069
Trichomonas vaginalis conserved hypothetical protein 0.0104 0.0141 0.04
Schistosoma mansoni ATP-binding cassette transporter 0.034 0.0666 0.0658
Schistosoma mansoni microtubule-associated protein tau 0.0674 0.1411 0.1403
Trichomonas vaginalis adenylyl cyclase type V, putative 0.0104 0.0141 0.04
Trichomonas vaginalis conserved hypothetical protein 0.0104 0.0141 0.04
Leishmania major 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.4452 0.983 0.9829
Loa Loa (eye worm) glutamate receptor 2 0.034 0.0666 0.0666
Entamoeba histolytica protein kinase , putative 0.0087 0.0102 0.0116
Loa Loa (eye worm) AUR protein kinase 0.0087 0.0102 0.0102
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0412 0.0826 0.0818
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0075 0.0075 0.0066
Brugia malayi G protein-coupled receptor 0.0145 0.0231 0.0913
Leishmania major hypothetical protein, conserved 0.0076 0.0079 0.0066
Brugia malayi Cyclin, N-terminal domain containing protein 0.0064 0.0052 0.0177
Trypanosoma cruzi 6-phosphofructo-2-kinase 1 0.4452 0.983 0.983
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0072 0.0069 0.0686
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.015 0.0243 0.0234
Entamoeba histolytica phosphoglycerate mutase family protein, putative 0.0076 0.0079 0.0077
Echinococcus granulosus rhodopsin orphan GPCR 0.0145 0.0231 0.0222
Echinococcus granulosus potassium voltage gated channel protein 0.0075 0.0075 0.0066
Echinococcus granulosus 7TM GPCR rhodopsin 0.0145 0.0231 0.0222
Loa Loa (eye worm) hypothetical protein 0.0145 0.0231 0.0231
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0104 0.0141 0.04
Loa Loa (eye worm) hypothetical protein 0.0072 0.0069 0.0069
Schistosoma mansoni amine GPCR 0.0145 0.0231 0.0222
Trichomonas vaginalis CAMK family protein kinase 0.011 0.0154 0.0459
Echinococcus multilocularis two pore calcium channel protein 1 0.0075 0.0075 0.0066
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0072 0.0069 0.0059
Echinococcus multilocularis g protein coupled receptor 0.0145 0.0231 0.0222
Echinococcus multilocularis voltage dependent calcium channel 0.0075 0.0075 0.0066
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0225 0.0409 0.04
Schistosoma mansoni hypothetical protein 0.015 0.0243 0.0234
Echinococcus multilocularis G protein coupled receptor 139 0.0145 0.0231 0.0222
Brugia malayi Glutamate receptor 1 precursor 0.034 0.0666 0.2706
Schistosoma mansoni hypothetical protein 0.0076 0.0079 0.007
Mycobacterium ulcerans regulatory protein 0.015 0.0243 0.0392
Trichomonas vaginalis adenylate cyclase type IX, putative 0.0104 0.0141 0.04
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0075 0.0075 0.0066
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0145 0.0232 0.0228
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.1135 0.2437 1
Echinococcus multilocularis protein dispatched 1 0.0098 0.0127 0.0118
Echinococcus multilocularis fmrfamide receptor 0.0145 0.0231 0.0222
Leishmania major fructose-6-phosphate2-kinase/fructose-2,6-bisph os phatase-likeprotein 0.0076 0.0079 0.0066
Echinococcus multilocularis neuropeptide s receptor 0.0145 0.0231 0.0222
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0075 0.0075 0.0271
Loa Loa (eye worm) G-protein coupled receptor 0.0145 0.0231 0.0231
Echinococcus multilocularis cyclins 0.0064 0.0052 0.0043
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.015 0.0243 0.0234
Mycobacterium ulcerans lipoprotein LpqD 0.0076 0.0079 0.0113
Entamoeba histolytica phosphoglycerate mutase family protein, putative 0.2673 0.5864 1
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.015 0.0243 0.0234
Trypanosoma brucei Histidine phosphatase superfamily (branch 1), putative 0.0076 0.0079 0.0074
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0087 0.0102 0.0093
Schistosoma mansoni alpha-1 adrenergic receptor 0.0145 0.0231 0.0222
Trichomonas vaginalis AGC family protein kinase 0.0087 0.0102 0.0223
Brugia malayi Cyclin, N-terminal domain containing protein 0.0064 0.0052 0.0177
Echinococcus granulosus g-protein coupled receptor 0.0145 0.0231 0.0222
Loa Loa (eye worm) glutamate receptor 1 0.034 0.0666 0.0666
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0104 0.0141 0.04
Onchocerca volvulus 0.0145 0.0231 0.0216
Echinococcus granulosus dual specificity serine:threonine tyrosine 0.011 0.0154 0.0145
Onchocerca volvulus 0.0076 0.0079 0.0064
Onchocerca volvulus 0.4529 1 1
Onchocerca volvulus 0.015 0.0243 0.0228
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0145 0.0231 0.0222
Loa Loa (eye worm) voltage-gated potassium channel 0.0075 0.0075 0.0075
Echinococcus multilocularis aurora kinase A 0.0087 0.0102 0.0093
Mycobacterium tuberculosis Probable phosphoglycerate mutase (phosphoglyceromutase) (phosphoglycerate phosphomutase) 0.0076 0.0079 0.083
Trypanosoma cruzi cdc2-related kinase 1 0.014 0.0221 0.0216
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0075 0.0075 0.0271
Schistosoma mansoni biogenic amine receptor 0.0145 0.0231 0.0222
Schistosoma mansoni ryanodine receptor related 0.0075 0.0075 0.0066
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0225 0.0409 0.04
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.3256 0.7164 0.7162
Trichomonas vaginalis guanylate cyclase, putative 0.0104 0.0141 0.04
Loa Loa (eye worm) hypothetical protein 0.0145 0.0231 0.0231
Brugia malayi UBASH3A protein homolog 0.0076 0.0079 0.0287
Onchocerca volvulus 0.0145 0.0231 0.0216
Schistosoma mansoni voltage-gated potassium channel 0.0075 0.0075 0.0066
Brugia malayi RNA, U transporter 1 0.0081 0.0089 0.0328
Schistosoma mansoni amine GPCR 0.0145 0.0231 0.0222
Brugia malayi phosphoglycerate mutase family protein 0.0076 0.0079 0.0287
Echinococcus multilocularis nmda type glutamate receptor 0.0739 0.1555 0.1547
Echinococcus granulosus ryanodine receptor 44f 0.0075 0.0075 0.0066
Schistosoma mansoni neuropeptide receptor 0.0145 0.0231 0.0222
Brugia malayi Cation transporter family protein 0.0048 0.0015 0.0023
Mycobacterium ulcerans hypothetical protein 0.0076 0.0079 0.0113
Brugia malayi HSF-type DNA-binding domain containing protein 0.0318 0.0616 0.2501
Echinococcus multilocularis polycomb protein SCMH1 0.005 0.002 0.0011
Loa Loa (eye worm) hypothetical protein 0.012 0.0175 0.0175
Brugia malayi hypothetical protein 0.0145 0.0231 0.0913
Brugia malayi Cytochrome P450 family protein 0.0047 0.0013 0.0015
Echinococcus multilocularis dro:myosuppressin receptor 0.0145 0.0231 0.0222
Schistosoma mansoni 6-phosphofructokinase 0.4529 1 1
Schistosoma mansoni adenoreceptor 0.0145 0.0231 0.0222
Echinococcus granulosus transient receptor potential cation channel 0.0075 0.0075 0.0066
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0329 0.0641 0.0633
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.1932 0.4215 0.4212
Trypanosoma brucei glycerolphosphate mutase, putative 0.0076 0.0079 0.0074
Schistosoma mansoni hypothetical protein 0.0083 0.0093 0.0084
Onchocerca volvulus 0.0145 0.0231 0.0216
Brugia malayi putative neuropeptide receptor 0.0145 0.0231 0.0913
Chlamydia trachomatis glutamine binding protein 0.0359 0.0709 1
Echinococcus multilocularis glutamate receptor 2 0.0412 0.0826 0.0818
Echinococcus granulosus serine:threonine protein phosphatase PGAM5 0.0076 0.0079 0.007
Schistosoma mansoni opsin-like receptor 0.0145 0.0231 0.0222
Trichomonas vaginalis hypothetical protein 0.0104 0.0141 0.04
Trichomonas vaginalis guanylate cyclase beta 1 subunit, putative 0.0104 0.0141 0.04
Mycobacterium ulcerans hypothetical protein 0.2673 0.5864 1
Trichomonas vaginalis guanylate cyclase, putative 0.0104 0.0141 0.04
Brugia malayi AMP-binding enzyme family protein 0.0072 0.0069 0.0247
Echinococcus multilocularis Niemann Pick C1 protein 0.0286 0.0546 0.0537
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0145 0.0231 0.0222
Entamoeba histolytica cyclin family protein 0.0064 0.0052 0.0031
Loa Loa (eye worm) AUR protein kinase 0.0087 0.0102 0.0102
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0075 0.0075 0.0066
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0145 0.0231 0.0222
Trypanosoma brucei 6-phosphofructo-2-kinase 2 0.4452 0.983 0.983
Echinococcus multilocularis dual specificity serine:threonine tyrosine 0.011 0.0154 0.0145
Mycobacterium ulcerans phosphoglycerate mutase 0.0076 0.0079 0.0113
Trypanosoma brucei cdc2-related kinase 1 0.014 0.0221 0.0216
Loa Loa (eye worm) hypothetical protein 0.0145 0.0231 0.0231
Trichomonas vaginalis guanylate cyclase, putative 0.0104 0.0141 0.04
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.015 0.0243 0.9708
Loa Loa (eye worm) hypothetical protein 0.0075 0.0075 0.0075
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0145 0.0231 0.0913
Brugia malayi Hypothetical UPF0028 protein ZK370.4 in chromosome III, putative 0.015 0.0243 0.0961
Brugia malayi Cyclic-nucleotide gated cation channel, C. elegans tax-4 ortholog 0.015 0.0243 0.0961
Echinococcus multilocularis cyclin b3 0.0064 0.0052 0.0043
Loa Loa (eye worm) hypothetical protein 0.0075 0.0075 0.0075
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.015 0.0243 0.0234
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0075 0.0075 0.0066
Mycobacterium tuberculosis Glucosyl-3-phosphoglycerate phosphatase GpgP 0.0076 0.0079 0.083
Echinococcus multilocularis g protein coupled receptor 0.0145 0.0231 0.0222
Trypanosoma cruzi cytochrome P450, putative 0.0047 0.0013 0.0008
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0145 0.0231 0.0222
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0075 0.0075 0.0271
Loa Loa (eye worm) hypothetical protein 0.0472 0.0961 0.0961
Entamoeba histolytica heat shock transcription factor, putative 0.0318 0.0616 0.0999
Echinococcus multilocularis neuropeptide Y receptor 0.0145 0.0231 0.0222
Trypanosoma cruzi glycerolphosphate mutase, putative 0.0076 0.0079 0.0074
Brugia malayi AMP-binding enzyme family protein 0.0072 0.0069 0.0247
Mycobacterium tuberculosis Conserved hypothetical protein 0.0076 0.0079 0.083
Entamoeba histolytica acyl-coA synthetase, putative 0.0072 0.0069 0.006
Entamoeba histolytica cyclin, putative 0.0064 0.0052 0.0031
Trichomonas vaginalis guanylate cyclase, putative 0.0104 0.0141 0.04
Loa Loa (eye worm) hypothetical protein 0.0145 0.0231 0.0231
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0359 0.0709 1
Echinococcus granulosus patatin phospholipase domain containing protein 0.015 0.0243 0.0234
Loa Loa (eye worm) cyclin domain-containing protein 0.0064 0.0052 0.0052
Echinococcus granulosus serotonin receptor 0.0145 0.0231 0.0222
Echinococcus multilocularis receptor type guanylyl cyclase 0.0072 0.0069 0.0059
Onchocerca volvulus Huntingtin homolog 0.012 0.0175 0.0161
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.014 0.0221 0.8808
Onchocerca volvulus 0.0145 0.0231 0.0216
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0075 0.0075 0.0066
Schistosoma mansoni kinase 0.0056 0.0034 0.0025
Brugia malayi Egg laying defective protein 4 0.0153 0.025 0.0991
Schistosoma mansoni hypothetical protein 0.0072 0.0068 0.0059
Brugia malayi follicle stimulating hormone receptor 0.0145 0.0231 0.0913
Echinococcus multilocularis g protein coupled receptor 0.0145 0.0231 0.0222
Loa Loa (eye worm) hypothetical protein 0.0075 0.0075 0.0075
Echinococcus granulosus short transient receptor potential channel 6 0.0075 0.0075 0.0066
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0145 0.0231 0.0913
Brugia malayi voltage-dependent calcium channel 0.0075 0.0075 0.0271
Brugia malayi Bromodomain containing protein 0.0075 0.0077 0.0278
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0145 0.0231 0.0231
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0057 0.0035 0.0026
Echinococcus multilocularis phosphoglycerate mutase 0.0076 0.0079 0.007
Echinococcus granulosus two pore calcium channel protein 1 0.0075 0.0075 0.0066
Brugia malayi serine/threonine-protein kinase 6 0.0087 0.0102 0.0381
Loa Loa (eye worm) hypothetical protein 0.0075 0.0075 0.0075
Onchocerca volvulus 0.015 0.0243 0.0228
Brugia malayi hypothetical protein 0.0145 0.0231 0.0913
Brugia malayi Niemann-Pick C1 protein precursor 0.02 0.0354 0.1422
Trichomonas vaginalis conserved hypothetical protein 0.0104 0.0141 0.04
Toxoplasma gondii phosphoglycerate mutase PGMII 0.0076 0.0079 0.3031
Trichomonas vaginalis guanylate cyclase, putative 0.0104 0.0141 0.04
Echinococcus granulosus transient receptor potential cation channel 0.0075 0.0075 0.0066
Onchocerca volvulus 0.0145 0.0231 0.0216
Mycobacterium leprae conserved hypothetical protein 0.0076 0.0079 0.0567
Brugia malayi Serotonin receptor 0.0145 0.0231 0.0913
Echinococcus multilocularis patatin phospholipase domain containing protein 0.015 0.0243 0.0234
Schistosoma mansoni neuropeptide F-like receptor 0.0145 0.0231 0.0222
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0075 0.0075 0.0271
Toxoplasma gondii phosphoglycerate mutase 0.0076 0.0079 0.3031
Trichomonas vaginalis conserved hypothetical protein 0.0104 0.0141 0.04
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0145 0.0231 0.0222
Echinococcus multilocularis sterol regulatory element binding protein 0.0086 0.01 0.0091
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0197 0.0347 0.0338
Echinococcus granulosus cyclin b3 0.0064 0.0052 0.0043
Echinococcus multilocularis conserved hypothetical protein 0.0075 0.0075 0.0066
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0075 0.0075 0.0066
Echinococcus granulosus cAMP dependent protein kinase type I beta 0.015 0.0243 0.0234
Schistosoma mansoni voltage-gated potassium channel 0.0075 0.0075 0.0066
Loa Loa (eye worm) voltage-gated calcium channel 0.0075 0.0075 0.0075
Brugia malayi hypothetical protein 0.0145 0.0231 0.0913
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0145 0.0231 0.0222
Trichomonas vaginalis adenylate cyclase, putative 0.0104 0.0141 0.04
Trypanosoma cruzi Histidine phosphatase superfamily (branch 1), putative 0.0076 0.0079 0.0074
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0225 0.0409 0.0409
Toxoplasma gondii hypothetical protein 0.0075 0.0075 0.2868
Echinococcus multilocularis SAM and MBT domain containing protein 0.005 0.002 0.0011
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0329 0.0641 0.0633
Trypanosoma brucei cAMP response protein 1, putative 0.015 0.0243 0.0238
Plasmodium falciparum cGMP-dependent protein kinase 0.0153 0.025 1
Echinococcus granulosus cyclin dependent kinase 9 0.0066 0.0055 0.0046
Loa Loa (eye worm) hypothetical protein 0.0145 0.0231 0.0231
Echinococcus granulosus dro:myosuppressin receptor 0.0145 0.0231 0.0222
Echinococcus granulosus rhodopsin orphan GPCR 0.0145 0.0231 0.0222
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0075 0.0075 0.0066
Loa Loa (eye worm) hypothetical protein 0.0075 0.0075 0.0075
Loa Loa (eye worm) MBCTL1 0.0057 0.0035 0.0035
Schistosoma mansoni glutamate receptor kainate 0.034 0.0666 0.0658
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.014 0.0221 0.0212
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0104 0.0141 0.04
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0075 0.0075 0.0066
Schistosoma mansoni glutamate receptor NMDA 0.0652 0.1361 0.1353
Onchocerca volvulus 0.0145 0.0231 0.0216
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.02 0.0354 0.055
Mycobacterium tuberculosis PE-PGRS family protein PE_PGRS11 0.0076 0.0079 0.083
Plasmodium falciparum serine/threonine protein kinase, putative 0.0087 0.0102 0.3308
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0075 0.0075 0.007
Echinococcus multilocularis serine:threonine protein phosphatase PGAM5 0.0076 0.0079 0.007
Echinococcus multilocularis glutamate receptor 2 0.0272 0.0514 0.0505
Loa Loa (eye worm) hypothetical protein 0.0048 0.0015 0.0015
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0075 0.0075 0.0066
Schistosoma mansoni myelin transcription factor 1 myt1 0.0057 0.0035 0.0026
Onchocerca volvulus Protein UBASH3A homolog 0.0076 0.0079 0.0064
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0072 0.0069 0.0686
Schistosoma mansoni calcium-activated potassium channel 0.0075 0.0075 0.0066
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0499 0.1021 0.1012
Echinococcus multilocularis snurportin 1 0.0304 0.0585 0.0577
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0075 0.0075 0.006
Brugia malayi hypothetical protein 0.0145 0.0231 0.0913
Mycobacterium ulcerans hypothetical protein 0.0072 0.0069 0.0096
Mycobacterium leprae POSSIBLE HYDROLASE MUTT1 0.0076 0.0079 0.0567
Echinococcus multilocularis sex peptide receptor 0.0145 0.0231 0.0222
Brugia malayi Guanylyl cyclase protein 23 0.0072 0.0069 0.0245
Plasmodium falciparum cAMP-dependent protein kinase regulatory subunit 0.015 0.0243 0.9676
Schistosoma mansoni voltage-gated potassium channel 0.0075 0.0075 0.0066
Loa Loa (eye worm) hypothetical protein 0.0145 0.0231 0.0231
Echinococcus multilocularis cyclin dependent kinase 1 0.014 0.0221 0.0211
Chlamydia trachomatis 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase 0.0076 0.0079 0.0741
Trypanosoma cruzi phosphoglycerate mutase, putative 0.0076 0.0079 0.0074
Entamoeba histolytica cyclin, putative 0.0064 0.0052 0.0031
Brugia malayi phosphoglycerate mutase family protein 0.0076 0.0079 0.0287
Schistosoma mansoni neuropeptide receptor 0.0145 0.0231 0.0222
Mycobacterium tuberculosis Conserved protein 0.015 0.0243 0.3212
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0054 0.0029 0.0095
Echinococcus multilocularis cyclin dependent kinase 9 0.0066 0.0055 0.0046
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0075 0.0075 0.0066
Loa Loa (eye worm) hypothetical protein 0.0072 0.0069 0.0069
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0225 0.0409 0.04
Mycobacterium leprae PROBABLE PHOSPHOGLYCERATE MUTASE (PHOSPHOGLYCEROMUTASE) 0.0076 0.0079 0.0567
Trypanosoma cruzi cAMP binding protein, putative 0.015 0.0243 0.0238
Loa Loa (eye worm) hypothetical protein 0.0072 0.0069 0.0069
Plasmodium vivax phosphoglycerate mutase, putative 0.0076 0.0079 0.2356
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0145 0.0231 0.0913
Trypanosoma cruzi 6-phosphofructo-2-kinase 1 0.4452 0.983 0.983
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0145 0.0231 0.0231
Loa Loa (eye worm) hypothetical protein 0.0072 0.0069 0.0069
Schistosoma mansoni hypothetical protein 0.0083 0.0093 0.0084
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0072 0.0069 0.0096
Schistosoma mansoni glutamate receptor kainate 0.034 0.0666 0.0658
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.002 0.0046
Loa Loa (eye worm) hypothetical protein 0.0985 0.2103 0.2103
Trichomonas vaginalis guanylate cyclase, putative 0.0104 0.0141 0.04
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0087 0.0102 0.3419
Onchocerca volvulus 0.005 0.002 0.0005
Loa Loa (eye worm) hypothetical protein 0.0145 0.0231 0.0231
Brugia malayi Melatonin receptor type 1A 0.0145 0.0231 0.0913
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.0075 0.0075 0.0066
Loa Loa (eye worm) hypothetical protein 0.0145 0.0231 0.0231
Schistosoma mansoni voltage-gated potassium channel 0.0075 0.0075 0.0066
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0145 0.0231 0.0222
Echinococcus granulosus cyclin dependent kinase 5 0.014 0.0221 0.0211
Echinococcus granulosus metabotropic glutamate receptor 5 0.0072 0.0069 0.0059
Entamoeba histolytica hypothetical protein 0.0072 0.0068 0.0059
Echinococcus granulosus cyclin dependent kinase 1 0.014 0.0221 0.0211
Schistosoma mansoni two-pore calcium channel 0.0075 0.0075 0.0066
Schistosoma mansoni voltage-gated potassium channel 0.0329 0.0641 0.0633
Echinococcus granulosus neuropeptide s receptor 0.0145 0.0231 0.0222
Schistosoma mansoni glutamate receptor NMDA 0.034 0.0666 0.0658
Trypanosoma brucei Flagellar Member 6 0.015 0.0243 0.0238
Echinococcus granulosus sex peptide receptor 0.0145 0.0231 0.0222
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0075 0.0075 0.0066
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0075 0.0075 0.2868
Loa Loa (eye worm) hypothetical protein 0.0072 0.0069 0.0069
Mycobacterium tuberculosis Probable glutamine-transport ATP-binding protein ABC transporter GlnQ 0.015 0.0243 0.3212
Leishmania major phosphoglycerate mutase protein, putative 0.0076 0.0079 0.0066
Echinococcus granulosus cyclins 0.0064 0.0052 0.0043
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.014 0.0221 0.0211
Mycobacterium tuberculosis Conserved protein 0.0076 0.0079 0.083
Loa Loa (eye worm) hypothetical protein 0.0075 0.0075 0.0075
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0225 0.0409 0.1608
Mycobacterium leprae PROBABLE PHOSPHOGLYCERATE MUTASE 1 GPM1 (PHOSPHOGLYCEROMUTASE) (PGAM) (BPG-DEPENDENT PGAM) 0.0076 0.0079 0.0567
Schistosoma mansoni amine GPCR 0.0145 0.0231 0.0222
Mycobacterium ulcerans hypothetical protein 0.0076 0.0079 0.0113
Loa Loa (eye worm) hypothetical protein 0.0145 0.0231 0.0231
Echinococcus granulosus glutamate receptor subunit protein glur 0.014 0.0221 0.0212
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0197 0.0347 0.0338
Entamoeba histolytica heat shock transcription factor, putative 0.0318 0.0616 0.0999
Mycobacterium ulcerans transmembrane transport protein 0.015 0.0243 0.0392
Brugia malayi Protein kinase domain containing protein 0.011 0.0154 0.0596
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0075 0.0075 0.0066
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0145 0.0231 0.0913
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0145 0.0231 0.0222
Echinococcus granulosus tm gpcr rhodopsin 0.3093 0.68 0.6797
Echinococcus multilocularis cyclin B 0.0064 0.0052 0.0043
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0225 0.0409 0.04
Loa Loa (eye worm) hypothetical protein 0.0145 0.0231 0.0231
Echinococcus granulosus glutamate receptor NMDA 0.024 0.0443 0.0434
Echinococcus granulosus hyperpolarization activated cyclic 0.0225 0.0409 0.04
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0075 0.0075 0.0062
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0145 0.0231 0.0216
Trichomonas vaginalis guanylate cyclase, putative 0.0104 0.0141 0.04
Echinococcus granulosus rhodopsin orphan GPCR 0.0145 0.0231 0.0222
Echinococcus granulosus potassium large conductance calcium activated 0.0075 0.0075 0.0066
Mycobacterium tuberculosis Probable conserved transmembrane transport protein 0.015 0.0243 0.3212
Echinococcus multilocularis cyclins 0.0064 0.0052 0.0043
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0075 0.0075 0.2868
Trypanosoma cruzi cyclic nucleotide-binding domain containing protein, putative 0.015 0.0243 0.0238
Entamoeba histolytica hypothetical protein 0.0072 0.0068 0.0059
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.0075 0.0075 0.0271
Trypanosoma brucei aurora B kinase 0.0087 0.0102 0.0097
Trichomonas vaginalis conserved hypothetical protein 0.0104 0.0141 0.04
Loa Loa (eye worm) hypothetical protein 0.0072 0.0069 0.0069
Echinococcus granulosus serine:threonine protein phosphatase PGAM5 0.0076 0.0079 0.007
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0145 0.0231 0.0222
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0145 0.0231 0.0222
Trichomonas vaginalis adenylate cyclase type IX, putative 0.0104 0.0141 0.04
Schistosoma mansoni bromodomain containing protein 0.0064 0.0051 0.0041
Loa Loa (eye worm) hypothetical protein 0.0075 0.0075 0.0075
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0145 0.0231 0.0222
Loa Loa (eye worm) hypothetical protein 0.0145 0.0231 0.0231
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0075 0.0075 0.0066
Schistosoma mansoni cyclic nucleotide-gated ion channel 0.015 0.0243 0.0234
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0104 0.0141 0.04
Giardia lamblia Hypothetical protein 0.2673 0.5864 1
Schistosoma mansoni transient receptor potential channel 0.0075 0.0075 0.0066
Trypanosoma brucei mitotic cyclin 6 0.0064 0.0052 0.0047
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0145 0.0231 0.0222
Echinococcus granulosus transient receptor potential cation channel 0.0075 0.0075 0.0066
Loa Loa (eye worm) hypothetical protein 0.0076 0.0079 0.0079
Loa Loa (eye worm) ion channel NompC 0.0075 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.0145 0.0231 0.0231
Echinococcus multilocularis potassium voltage gated channel protein 0.0075 0.0075 0.0066
Loa Loa (eye worm) hypothetical protein 0.0145 0.0231 0.0231
Leishmania major 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.4529 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0076 0.0079 0.0121
Trichomonas vaginalis adenylate cyclase, putative 0.0104 0.0141 0.04
Schistosoma mansoni glutamate receptor kainate 0.034 0.0666 0.0658
Loa Loa (eye worm) hypothetical protein 0.0318 0.0616 0.0616
Schistosoma mansoni biogenic amine receptor 0.0145 0.0231 0.0222
Loa Loa (eye worm) CMGC/CDK/CDK9 protein kinase 0.0056 0.0034 0.0034
Echinococcus multilocularis cyclin dependent kinase 5 0.014 0.0221 0.0211
Echinococcus multilocularis cyclins 0.0064 0.0052 0.0043
Loa Loa (eye worm) TYRA-2 protein 0.0145 0.0231 0.0231
Schistosoma mansoni hypothetical protein 0.0145 0.0231 0.0222
Brugia malayi Protein kinase domain containing protein 0.014 0.0221 0.087
Mycobacterium ulcerans hypothetical protein 0.015 0.0243 0.0392
Loa Loa (eye worm) hypothetical protein 0.0075 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.0145 0.0231 0.0231
Loa Loa (eye worm) hypothetical protein 0.015 0.0243 0.0243
Echinococcus multilocularis transient receptor potential cation channel 0.0075 0.0075 0.0066
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.1135 0.2437 0.2437
Loa Loa (eye worm) hypothetical protein 0.0048 0.0015 0.0015
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0412 0.0826 0.0818
Echinococcus multilocularis short transient receptor potential channel 6 0.0075 0.0075 0.0066
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.015 0.0243 0.9708
Mycobacterium tuberculosis Conserved hypothetical protein 0.015 0.0243 0.3212
Schistosoma mansoni similar to Protein C20orf152 homolog 0.015 0.0243 0.0234
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0054 0.0029 0.0027
Brugia malayi Tachykinin-like peptides receptor 99D 0.0145 0.0231 0.0913
Giardia lamblia CAMP-dependent protein kinase regulatory chain 0.015 0.0243 0.0327
Leishmania major hypothetical protein, conserved 0.015 0.0243 0.023
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0307 0.0592 0.0588
Echinococcus granulosus cyclins 0.0064 0.0052 0.0043
Echinococcus multilocularis shaker cognate 0.0075 0.0075 0.0066
Loa Loa (eye worm) hypothetical protein 0.0075 0.0075 0.0075
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0145 0.0231 0.0231
Echinococcus multilocularis calcium activated potassium channel 0.0078 0.0082 0.0073
Mycobacterium leprae probable isochorismate synthase EntC 0.0076 0.0079 0.0567
Loa Loa (eye worm) hypothetical protein 0.0054 0.0029 0.0029
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0009 0.0009
Loa Loa (eye worm) G-protein coupled receptor 0.0145 0.0231 0.0231
Loa Loa (eye worm) hypothetical protein 0.0075 0.0075 0.0075
Loa Loa (eye worm) neuropeptide F receptor 0.0145 0.0231 0.0231
Loa Loa (eye worm) AUR protein kinase 0.0087 0.0102 0.0102
Echinococcus granulosus phosphoglycerate mutase 0.0076 0.0079 0.007
Schistosoma mansoni metabotropic glutamate receptor 0.0072 0.0069 0.0059
Loa Loa (eye worm) hypothetical protein 0.0064 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0044 0.0007 0.0007
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0053 0.0026 0.0021
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0072 0.0069 0.0096
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0075 0.0075 0.0066
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.015 0.0243 0.0858
Loa Loa (eye worm) hypothetical protein 0.02 0.0354 0.0354
Echinococcus granulosus glutamate NMDA receptor subunit 0.034 0.0666 0.0658
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0072 0.0069 0.0069
Onchocerca volvulus 0.0075 0.0075 0.006
Mycobacterium ulcerans phosphoglycerate mutase 0.0076 0.0079 0.0113
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0145 0.0231 0.0222
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0075 0.0075 0.0066
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0359 0.0709 0.1189
Giardia lamblia Aurora kinase 0.0087 0.0102 0.0085
Schistosoma mansoni voltage-gated potassium channel 0.1239 0.2669 0.2663
Echinococcus multilocularis neuropeptides capa receptor 0.0145 0.0231 0.0222
Loa Loa (eye worm) hypothetical protein 0.0145 0.0231 0.0231
Loa Loa (eye worm) hypothetical protein 0.0057 0.0035 0.0035
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0225 0.0409 0.04
Echinococcus granulosus phosphoglycerate mutase 0.0076 0.0079 0.007
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.014 0.0221 0.0208
Brugia malayi cAMP-dependent protein kinase regulatory chain, putative 0.015 0.0243 0.0961

Activities

Activity type Activity value Assay description Source Reference
CL/F (ADMET) = 0.016 L/hr Apparent oral clearance in NOD/SCID mouse at 100 mg/kg, po by LC-MS-MS analysis ChEMBL. 23731360
EC50 (binding) = 17 nM Displacement of fluorescent ES2 from human recombinant ERalpha after 2 hrs by fluorimetric analysis ChEMBL. 23731360
EC50 (binding) = 17 nM Displacement of fluorescent ES2 from recombinant human ERalpha after 2 hrs in absence of light by fluorometric analysis LITERATURE. 27647367
EC50 (binding) = 27.5 nM Displacement of fluorescent ES2 from human recombinant ERbeta after 2 hrs by fluorimetric analysis ChEMBL. 23731360
EC50 (binding) = 27.5 nM Displacement of fluorescent ES2 from recombinant human ERbeta after 2 hrs in absence of light by fluorometric analysis LITERATURE. 27647367
IC50 (binding) = 30 nM Inhibition of human placental microsomal aromatase using testosterone as substrate assessed as formation of estradiol after 10 mins ChEMBL. 26689671
IC50 (binding) = 1029 nM Inhibition of human recombinant microsomal aromatase-mediated 7-methoxy-4-trifluoromethylcoumarin conversion to 7-hydroxytrifluoromethylcoumarin preincubated for 10 mins measured after 30 mins by fluorescence assay ChEMBL. 23731360
IC50 (binding) = 1029 nM Inhibition of recombinant human microsomal CYP19 using MFC as substrate measured after 30 mins by fluorometric analysis LITERATURE. 27647367
Inhibition (binding) > 90 % Inhibition of recombinant human microsomal CYP19 at 50 uM using MFC as substrate measured after 30 mins by fluorometric analysis relative to control LITERATURE. 27647367
Ki (binding) = 442 nM Inhibition of human recombinant microsomal aromatase using 7-methoxy-4-trifluoromethylcoumarin as substrate by Lineweaver-Burk plot analysis ChEMBL. 23731360

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

3 literature references were collected for this gene.

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