Detailed information for compound 1775755

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 371.52 | Formula: C21H33N5O
  • H donors: 1 H acceptors: 1 LogP: 2.2 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN1CCN(CC1)C(=O)Nc1ccc(cc1)N1CCC(C1)N1CCCC1C
  • InChi: 1S/C21H33N5O/c1-17-4-3-10-26(17)20-9-11-25(16-20)19-7-5-18(6-8-19)22-21(27)24-14-12-23(2)13-15-24/h5-8,17,20H,3-4,9-16H2,1-2H3,(H,22,27)
  • InChiKey: WGDBSIUKEGGNAD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens histamine receptor H3 Starlite/ChEMBL References
Macaca mulatta Histamine receptor H3 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) hypothetical protein Histamine receptor H3   445 aa 385 aa 23.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis phosphoglycerate mutase, putative 0.0033 0.0102 0.0097
Plasmodium falciparum GPI-anchor transamidase, putative 0.0508 0.2284 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0056 0.0211 0.0234
Onchocerca volvulus 0.0033 0.0102 0.0097
Echinococcus granulosus phosphoglycerate mutase 0.0033 0.0102 0.0116
Onchocerca volvulus Legumain homolog 0.2191 1 1
Trichomonas vaginalis glucosylceramidase, putative 0.03 0.1328 0.1324
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.004 0.0039
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.003 0.009 0.1863
Echinococcus multilocularis phosphoglycerate mutase 0.0033 0.0102 0.0116
Echinococcus granulosus 6 phosphofructo 2 kinase:fructose 2 0.1927 0.8789 1
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.003 0.009 0.0163
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0007 0.0007
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.2191 1 1
Mycobacterium ulcerans hypothetical protein 0.1137 0.5168 1
Trichomonas vaginalis glucosylceramidase, putative 0.0207 0.0904 0.0899
Onchocerca volvulus Protein UBASH3A homolog 0.0033 0.0102 0.0097
Schistosoma mansoni DNA polymerase eta 0.0044 0.0154 0.0149
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.004 0.0039
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0011 0.0005 0.0005
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0007 0.0007
Trypanosoma brucei 6-phosphofructo-2-kinase 2 0.1894 0.864 0.983
Loa Loa (eye worm) hypothetical protein 0.0033 0.0102 0.0102
Echinococcus multilocularis dna polymerase eta 0.0044 0.0154 0.0175
Loa Loa (eye worm) hypothetical protein 0.0011 0.0005 0.0005
Brugia malayi phosphoglycerate mutase family protein 0.0033 0.0102 0.0102
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0162 0.0157
Brugia malayi ImpB/MucB/SamB family protein 0.0044 0.0154 0.0154
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0007 0.0007
Schistosoma mansoni hypothetical protein 0.0033 0.0102 0.0097
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0007 0.0007
Brugia malayi nuclear receptor NHR-88 0.0012 0.0007 0.0007
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0007 0.0002
Leishmania major hypothetical protein, conserved 0.0029 0.0088 0.0094
Brugia malayi 6-phosphofructokinase 0.011 0.0457 0.0457
Loa Loa (eye worm) transcription factor SMAD2 0.0139 0.0589 0.0588
Echinococcus granulosus 6 phosphofructokinase 0.011 0.0457 0.052
Brugia malayi RNA, U transporter 1 0.008 0.0321 0.0321
Schistosoma mansoni ap endonuclease 0.0056 0.0211 0.0206
Mycobacterium ulcerans fructose-2,6-bisphosphatase GpmB 0.1137 0.5168 1
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0031 0.0094 0.0391
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0058 0.006
Onchocerca volvulus Glucosylceramidase homolog 0.0197 0.0855 0.0851
Leishmania major hypothetical protein, conserved 0.0033 0.0102 0.0111
Trichomonas vaginalis glucosylceramidase, putative 0.0197 0.0855 0.0851
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0301 0.1334 0.1333
Schistosoma mansoni hypothetical protein 0.0033 0.0102 0.0097
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0056 0.0211 0.021
Entamoeba histolytica hypothetical protein 0.0023 0.0058 0.0102
Trypanosoma cruzi glycerolphosphate mutase, putative 0.0033 0.0102 0.0111
Brugia malayi Importin beta-1 subunit 0.0028 0.0083 0.0083
Trichomonas vaginalis glucosylceramidase, putative 0.0197 0.0855 0.0851
Trypanosoma brucei glycerolphosphate mutase, putative 0.0033 0.0102 0.0111
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0007 0.0002
Schistosoma mansoni 6-phosphofructokinase 0.011 0.0457 0.0452
Echinococcus multilocularis phosphoglycerate mutase 0.0033 0.0102 0.0116
Loa Loa (eye worm) hypothetical protein 0.1105 0.5019 0.5019
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0071 0.0278 0.0273
Trypanosoma brucei 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.0822 0.3724 0.4233
Schistosoma mansoni hypothetical protein 0.0034 0.0109 0.0104
Schistosoma mansoni hemoglobinase (C13 family) 0.2191 1 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0056 0.0211 0.0901
Plasmodium vivax ataxin-2 like protein, putative 0.0029 0.0088 0.0361
Echinococcus multilocularis synaptojanin 1 0.0011 0.0005 0.0005
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0011 0.0005 0.0005
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0109 0.0109
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.004 0.0039
Trichomonas vaginalis glucosylceramidase, putative 0.03 0.1328 0.1324
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0011 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0034 0.0109 0.0109
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0007 0.0007
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.011 0.0457 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0013 0.0009
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0007 0.0007
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.004 0.0039
Schistosoma mansoni hypothetical protein 0.0034 0.0109 0.0104
Leishmania major DNA polymerase eta, putative 0.0044 0.0154 0.0169
Mycobacterium tuberculosis Conserved hypothetical protein 0.0033 0.0102 0.215
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0109 0.0109
Echinococcus multilocularis serine:threonine protein phosphatase PGAM5 0.0033 0.0102 0.0116
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0109 0.0124
Leishmania major 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-1-like protein 0.0822 0.3724 0.4233
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0007 0.0007
Mycobacterium ulcerans 6-phosphofructokinase 0.011 0.0457 0.0814
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.004 0.0039
Trypanosoma brucei Histidine phosphatase superfamily (branch 1), putative 0.0033 0.0102 0.0111
Schistosoma mansoni hypothetical protein 0.1682 0.7669 0.7668
Loa Loa (eye worm) hypothetical protein 0.0033 0.0102 0.0102
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0007 0.0002
Echinococcus granulosus neutral sphingomyelinase 0.0011 0.0005 0.0005
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0109 0.0124
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0007 0.0007
Toxoplasma gondii phosphoglycerate mutase 0.0033 0.0102 0.0427
Echinococcus granulosus phosphoglycerate mutase 0.0033 0.0102 0.0116
Brugia malayi CCR4 0.0011 0.0005 0.0005
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.009 0.037
Trichomonas vaginalis glucosylceramidase, putative 0.03 0.1328 0.1324
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.004 0.0039
Echinococcus multilocularis snurportin 1 0.0301 0.1334 0.1517
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.004 0.0035
Trypanosoma cruzi phosphoglycerate mutase family member 5, putative 0.0033 0.0102 0.0111
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0056 0.0211 0.0333
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0011 0.0005 0.0005
Trypanosoma cruzi DNA polymerase eta, putative 0.0031 0.0094 0.0102
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0109 0.0124
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0007 0.0007
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0007 0.0007
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0007 0.0007
Toxoplasma gondii phosphoglycerate mutase PGMII 0.0033 0.0102 0.0427
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.011 0.0457 0.0515
Plasmodium vivax importin-beta 2, putative 0.0028 0.0083 0.0339
Trypanosoma cruzi Histidine phosphatase superfamily (branch 1), putative 0.0033 0.0102 0.0111
Mycobacterium ulcerans phosphoglycerate mutase 0.0033 0.0102 0.0122
Trypanosoma cruzi Histidine phosphatase superfamily (branch 1), putative 0.0033 0.0102 0.0111
Leishmania major 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.1927 0.8789 1
Schistosoma mansoni phosphoglycerate mutase 0.0033 0.0102 0.0097
Schistosoma mansoni hypothetical protein 0.0033 0.0102 0.0097
Brugia malayi steroid hormone receptor 0.0012 0.0007 0.0007
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0007 0.0007
Brugia malayi ecdysteroid receptor 0.0012 0.0007 0.0007
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.004 0.0039
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0007 0.0002
Brugia malayi nuclear hormone receptor 0.0012 0.0007 0.0007
Giardia lamblia Hypothetical protein 0.1137 0.5168 1
Toxoplasma gondii exonuclease III APE 0.0056 0.0211 0.0901
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0011 0.0005 0.0005
Brugia malayi 6-phosphofructokinase 0.011 0.0457 0.0457
Brugia malayi Calcitonin receptor-like protein seb-1 0.0107 0.0446 0.0446
Leishmania major hypothetical protein, unknown function 0.0033 0.0102 0.0111
Toxoplasma gondii phosphofructokinase domain-containing protein 0.003 0.009 0.037
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.1927 0.8789 1
Schistosoma mansoni hypothetical protein 0.0013 0.0013 0.0008
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.004 0.0045
Leishmania major phosphoglycerate mutase protein, putative 0.0033 0.0102 0.0111
Onchocerca volvulus Protein UBASH3A homolog 0.0033 0.0102 0.0097
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.2191 1 1
Loa Loa (eye worm) 6-phosphofructokinase 0.011 0.0457 0.0457
Plasmodium vivax phosphoglucomutase-2, putative 0.0033 0.0102 0.0427
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0088 0.0361
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0007 0.0007
Leishmania major glycerolphosphate mutase, putative 0.0033 0.0102 0.0111
Plasmodium falciparum phosphoglycerate mutase, putative 0.0033 0.0102 0.0427
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0056 0.0211 0.0239
Echinococcus granulosus traf and tnf receptor associated protein 0.0011 0.0005 0.0005
Trichomonas vaginalis ap endonuclease, putative 0.0056 0.0211 0.0206
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatas, putative 0.0033 0.0102 0.0111
Loa Loa (eye worm) hypothetical protein 0.0012 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0033 0.0102 0.0102
Toxoplasma gondii 6-phosphofructokinase 0.003 0.009 0.037
Echinococcus multilocularis 6 phosphofructokinase 0.011 0.0457 0.052
Trypanosoma cruzi phosphoglycerate mutase protein, putative 0.0033 0.0102 0.0111
Trypanosoma cruzi DNA polymerase eta, putative 0.0044 0.0154 0.0169
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0162 0.0157
Plasmodium vivax GPI-anchor transamidase, putative 0.0508 0.2284 1
Echinococcus multilocularis phosphoglycerate mutase 0.0033 0.0102 0.0116
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0083 0.0088
Echinococcus multilocularis dna polymerase kappa 0.0019 0.004 0.0045
Echinococcus granulosus CCR4 NOT transcription complex subunit 6 0.0011 0.0005 0.0005
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.2191 1 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0007 0.0007
Onchocerca volvulus 0.1927 0.8789 0.8789
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0007 0.0007
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0011 0.0005 0.0005
Echinococcus granulosus gamma secretase subunit aph 1 0.0479 0.2148 0.2443
Echinococcus granulosus inositol polyphosphate 5 phosphatase OCRL 1 0.0011 0.0005 0.0005
Leishmania major fructose-6-phosphate2-kinase/fructose-2,6-bisph os phatase-likeprotein 0.0033 0.0102 0.0111
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0007 0.0002
Leishmania major phosphoglycerate mutase, putative 0.0033 0.0102 0.0111
Brugia malayi MH2 domain containing protein 0.0139 0.0589 0.0589
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0007 0.0007
Schistosoma mansoni cpg binding protein 0.0035 0.0115 0.011
Mycobacterium ulcerans phosphohistidine phosphatase SixA 0.0033 0.0102 0.0122
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.004 0.0035
Brugia malayi exodeoxyribonuclease III family protein 0.0056 0.0211 0.0211
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.1927 0.8789 1
Schistosoma mansoni hypothetical protein 0.0034 0.0109 0.0104
Entamoeba histolytica phosphofructokinase, putative 0.011 0.0457 0.0876
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0007 0.0007
Trypanosoma cruzi phosphoglycerate mutase family member 5, putative 0.0033 0.0102 0.0111
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.004 0.0035
Echinococcus multilocularis deoxyribonuclease 1 2 0.0011 0.0005 0.0005
Leishmania major DNA polymerase kappa, putative 0.0019 0.004 0.0039
Trichomonas vaginalis ap endonuclease, putative 0.0056 0.0211 0.0206
Schistosoma mansoni coup transcription factor 0.0012 0.0007 0.0002
Echinococcus multilocularis phosphoglycerate mutase 0.0033 0.0102 0.0116
Loa Loa (eye worm) hypothetical protein 0.0107 0.0446 0.0445
Trypanosoma cruzi cysteine peptidase, Clan CD, family C13, putative 0.0508 0.2284 0.2595
Brugia malayi UBASH3A protein homolog 0.0033 0.0102 0.0102
Leishmania major importin beta-1 subunit, putative 0.0023 0.0058 0.006
Entamoeba histolytica Ran family GTPase 0.0021 0.0048 0.0084
Toxoplasma gondii peptidase c13 family protein 0.0508 0.2284 1
Mycobacterium ulcerans hypothetical protein 0.0033 0.0102 0.0122
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0048 0.0049
Loa Loa (eye worm) hypothetical protein 0.1894 0.864 0.864
Schistosoma mansoni hypothetical protein 0.0033 0.0102 0.0097
Schistosoma mansoni cpg binding protein 0.0035 0.0115 0.011
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0058 0.0053
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.2191 1 1
Trichomonas vaginalis glucosylceramidase, putative 0.0207 0.0904 0.0899
Onchocerca volvulus Protein UBASH3A homolog 0.0033 0.0102 0.0097
Trichomonas vaginalis phosphoglycerate mutase, putative 0.0033 0.0102 0.0097
Loa Loa (eye worm) hypothetical protein 0.0012 0.0007 0.0007
Echinococcus multilocularis dnaJ subfamily B 0.0475 0.2131 0.2424
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.004 0.0039
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0162 0.0184
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0011 0.0005 0.0005
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0013 0.0009
Mycobacterium tuberculosis Conserved protein 0.0033 0.0102 0.215
Plasmodium falciparum importin beta, putative 0.0028 0.0083 0.0339
Trichomonas vaginalis glucosylceramidase, putative 0.0197 0.0855 0.0851
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.004 0.0039
Loa Loa (eye worm) hypothetical protein 0.0148 0.0634 0.0634
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.009 0.0084
Mycobacterium ulcerans lipoprotein LpqD 0.0033 0.0102 0.0122
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.2191 1 1
Mycobacterium ulcerans acid phosphatase 0.0033 0.0102 0.0122
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0007 0.0007
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0007 0.0007
Echinococcus granulosus snurportin 1 0.0301 0.1334 0.1517
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.0508 0.2284 0.228
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.004 0.0039
Trypanosoma brucei Histidine phosphatase superfamily (branch 1), putative 0.0033 0.0102 0.0111
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.0457 0.0452
Trypanosoma cruzi Aph-1 protein, putative 0.0186 0.0808 0.0914
Echinococcus multilocularis inositol polyphosphate 5 phosphatase OCRL 1 0.0011 0.0005 0.0005
Trypanosoma brucei 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatas, putative 0.0033 0.0102 0.0111
Trypanosoma brucei Histidine phosphatase superfamily (branch 1), putative 0.0033 0.0102 0.0111
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0007 0.0007
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0088 0.0094
Entamoeba histolytica GPI-anchor transamidase, putative 0.0508 0.2284 0.4415
Loa Loa (eye worm) hypothetical protein 0.0012 0.0007 0.0007
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0013 0.0013 0.0015
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatas, putative 0.0033 0.0102 0.0111
Entamoeba histolytica phosphoglycerate mutase family protein, putative 0.1137 0.5168 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.004 0.0039
Brugia malayi latrophilin 2 splice variant baaae 0.0073 0.029 0.029
Toxoplasma gondii LsmAD domain-containing protein 0.0029 0.0088 0.0361
Echinococcus granulosus dna polymerase kappa 0.0019 0.004 0.0045
Echinococcus multilocularis GPCR, family 2 0.0034 0.0109 0.0124
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0007 0.0007
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0011 0.0005 0.0005
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0007 0.0007
Schistosoma mansoni hypothetical protein 0.0301 0.1334 0.1329
Trypanosoma brucei PAB1-binding protein , putative 0.0029 0.0088 0.0094
Brugia malayi phosphoglycerate mutase family protein 0.0033 0.0102 0.0102
Giardia lamblia DINP protein human, muc B family 0.0019 0.004 0.0067
Loa Loa (eye worm) hypothetical protein 0.0044 0.0154 0.0154
Leishmania major hypothetical protein, conserved 0.0033 0.0102 0.0111
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0007 0.0007
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0011 0.0005 0.0005
Trichomonas vaginalis glucosylceramidase, putative 0.0197 0.0855 0.0851
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0056 0.0211 0.0398
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.004 0.0039
Echinococcus granulosus GPCR family 2 0.0034 0.0109 0.0124
Echinococcus granulosus synaptojanin 1 0.0011 0.0005 0.0005
Mycobacterium tuberculosis Probable phosphoglycerate mutase (phosphoglyceromutase) (phosphoglycerate phosphomutase) 0.0033 0.0102 0.215
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0007 0.0007
Onchocerca volvulus 0.0033 0.0102 0.0097
Entamoeba histolytica phosphofructokinase, putative 0.011 0.0457 0.0876
Echinococcus multilocularis traf and tnf receptor associated protein 0.0011 0.0005 0.0005
Trypanosoma brucei Aph-1 protein, putative 0.0186 0.0808 0.0914
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0083 0.0339
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0162 0.0184
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0007 0.0007
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0007 0.0007
Echinococcus multilocularis serine:threonine protein phosphatase PGAM5 0.0033 0.0102 0.0116
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.0822 0.3724 0.4233
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0011 0.0005 0.0005
Brugia malayi phosphofructokinase 0.011 0.0457 0.0457
Loa Loa (eye worm) hypothetical protein 0.0011 0.0005 0.0005
Schistosoma mansoni cpg binding protein 0.0033 0.0106 0.0101
Trypanosoma brucei unspecified product 0.0019 0.004 0.0039
Schistosoma mansoni ap endonuclease 0.0056 0.0211 0.0206
Trypanosoma cruzi Histidine phosphatase superfamily (branch 1), putative 0.0033 0.0102 0.0111
Brugia malayi GPI-anchor transamidase 0.0508 0.2284 0.2284
Loa Loa (eye worm) gamma-secretase subunit aph-1 0.0479 0.2148 0.2147
Mycobacterium ulcerans hypothetical protein 0.0033 0.0102 0.0122
Schistosoma mansoni hypothetical protein 0.0033 0.0102 0.0097
Trichomonas vaginalis ran, putative 0.0021 0.0048 0.0043
Trypanosoma cruzi Aph-1 protein, putative 0.0186 0.0808 0.0914
Trypanosoma brucei unspecified product 0.0013 0.0013 0.0009
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.009 0.0084
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0048 0.0048
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0162 0.0184
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0048 0.0049
Loa Loa (eye worm) hypothetical protein 0.0029 0.0088 0.0087
Schistosoma mansoni phosphoglycerate mutase 0.0033 0.0102 0.0097
Loa Loa (eye worm) phosphofructokinase 0.011 0.0457 0.0457
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0007 0.0007
Trichomonas vaginalis phosphoglycerate mutase, putative 0.0033 0.0102 0.0097
Trypanosoma cruzi 6-phosphofructo-2-kinase 1 0.1894 0.864 0.983
Giardia lamblia Hypothetical protein 0.1137 0.5168 1
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0102 0.0097
Onchocerca volvulus 0.0033 0.0106 0.0101
Schistosoma mansoni ran 0.0021 0.0048 0.0043
Toxoplasma gondii phosphoglycerate mutase family protein 0.0033 0.0102 0.0427
Toxoplasma gondii phosphoglycerate mutase family protein 0.0033 0.0102 0.0427
Echinococcus multilocularis cpg binding protein 0.0035 0.0115 0.013
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0007 0.0002
Toxoplasma gondii phosphoglycerate mutase family protein 0.0033 0.0102 0.0427
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0058 0.0053
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0056 0.0211 0.0234
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0056 0.0211 0.0901
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0011 0.0005 0.0005
Brugia malayi CXXC zinc finger family protein 0.0033 0.0106 0.0106
Schistosoma mansoni hypothetical protein 0.0475 0.2131 0.2127
Mycobacterium ulcerans phosphoglycerate mutase 0.0033 0.0102 0.0122
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0007 0.0007
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.004 0.0039
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0048 0.0054
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.009 0.0084
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0011 0.0005 0.0005
Onchocerca volvulus Protein UBASH3A homolog 0.0033 0.0102 0.0097
Trypanosoma brucei DNA polymerase eta, putative 0.0044 0.0154 0.0169
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.2191 1 1
Chlamydia trachomatis 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase 0.0033 0.0102 1
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.0508 0.2284 0.228
Schistosoma mansoni hemoglobinase (C13 family) 0.2191 1 1
Schistosoma mansoni 6-phosphofructokinase 0.1927 0.8789 0.8789
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.03 0.1328 0.1328
Trypanosoma brucei Serine/threonine-protein phosphatase PGAM5, mitochondrial, putative 0.0033 0.0102 0.0111
Mycobacterium tuberculosis Probable conserved lipoprotein LpqD 0.0033 0.0102 0.215
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0162 0.0184
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0048 0.0049
Echinococcus multilocularis gamma secretase subunit aph 1 0.0479 0.2148 0.2443
Loa Loa (eye worm) hypothetical protein 0.0012 0.0007 0.0007
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.0457 0.0452
Echinococcus multilocularis CCR4 NOT transcription complex subunit 6 0.0011 0.0005 0.0005
Trypanosoma cruzi Histidine phosphatase superfamily (branch 1), putative 0.0033 0.0102 0.0111
Echinococcus granulosus cpg binding protein 0.0035 0.0115 0.013
Trypanosoma brucei 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.1927 0.8789 1
Toxoplasma gondii phosphoglycerate mutase family protein 0.0033 0.0102 0.0427
Loa Loa (eye worm) hypothetical protein 0.0508 0.2284 0.2284
Trypanosoma brucei unspecified product 0.0013 0.0013 0.0009
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0007 0.0007
Leishmania major GTP-binding protein, putative 0.0021 0.0048 0.0049
Schistosoma mansoni importin beta-1 0.0028 0.0083 0.0077
Leishmania major phosphoglycerate mutase family member 5, putative 0.0033 0.0102 0.0111
Trypanosoma cruzi phosphoglycerate mutase, putative 0.0033 0.0102 0.0111
Mycobacterium ulcerans bifunctional RNase H/acid phosphatase 0.0033 0.0102 0.0122
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0011 0.0005 0.0005
Schistosoma mansoni 6-phosphofructokinase 0.011 0.0457 0.0452
Onchocerca volvulus 0.0148 0.0634 0.0629
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.009 0.037
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.03 0.1328 0.1328
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0083 0.0093
Echinococcus granulosus dnaJ subfamily B 0.0475 0.2131 0.2424
Entamoeba histolytica phosphoglycerate mutase family protein, putative 0.0033 0.0102 0.0188
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0007 0.0002
Mycobacterium tuberculosis Glucosyl-3-phosphoglycerate phosphatase GpgP 0.0033 0.0102 0.215
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.004 0.0765
Treponema pallidum exodeoxyribonuclease (exoA) 0.0056 0.0211 0.4542
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0007 0.0007
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0056 0.0211 0.0398
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0056 0.0211 0.0234
Leishmania major ATP-dependent phosphofructokinase 0.011 0.0457 0.0515
Trichomonas vaginalis phosphoglycerate mutase, putative 0.0033 0.0102 0.0097
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.004 0.004
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0102 0.0097
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0048 0.019
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.009 0.037
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0011 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0012 0.0007 0.0007
Trypanosoma cruzi phosphoglycerate mutase, putative 0.0033 0.0102 0.0111
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.009 0.0084
Giardia lamblia GPI-anchor transamidase, putative 0.0508 0.2284 0.4415
Schistosoma mansoni hypothetical protein 0.0034 0.0109 0.0104
Echinococcus granulosus dna polymerase eta 0.0044 0.0154 0.0175
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.009 0.037
Echinococcus granulosus phosphoglycerate mutase 0.0033 0.0102 0.0116
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.0822 0.3724 0.4233
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0011 0.0005 0.0005
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0048 0.0054
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0048 0.0048
Treponema pallidum phosphoglyceromutase 0.0033 0.0102 0.215
Trichomonas vaginalis 6-phosphofructokinase, putative 0.003 0.009 0.0084
Schistosoma mansoni hypothetical protein 0.0073 0.029 0.0285
Brugia malayi hypothetical protein 0.0019 0.004 0.004
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.011 0.0457 0.0515
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0083 0.0088
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0007 0.0007
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0107 0.0446 0.0446
Loa Loa (eye worm) CXXC zinc finger family protein 0.0033 0.0106 0.0106
Echinococcus multilocularis GPI anchor transamidase 0.0508 0.2284 0.2599
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0007 0.0002
Loa Loa (eye worm) hypothetical protein 0.0033 0.0102 0.0102
Loa Loa (eye worm) MH2 domain-containing protein 0.0139 0.0589 0.0588
Schistosoma mansoni gamma-secretase subunit aph-1 0.0479 0.2148 0.2144
Loa Loa (eye worm) peptidase C13 family protein 0.2191 1 1
Entamoeba histolytica phosphoglycerate mutase family protein, putative 0.0033 0.0102 0.0188
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0007 0.0007
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.0007 0.0002
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.004 0.0035
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.004 0.0039
Loa Loa (eye worm) hypothetical protein 0.0012 0.0007 0.0007
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0007 0.0007
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.004 0.0039
Trichomonas vaginalis glucosylceramidase, putative 0.0197 0.0855 0.0851
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0048 0.019
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.009 0.0084
Echinococcus multilocularis 6 phosphofructo 2 kinase:fructose 2 0.1927 0.8789 1
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.004 0.0765
Plasmodium vivax phosphoglycerate mutase, putative 0.0033 0.0102 0.0427
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0056 0.0211 0.5
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0011 0.0005 0.0005
Loa Loa (eye worm) phosphoglycerate mutase 0.0033 0.0102 0.0102
Echinococcus multilocularis phosphoglycerate mutase 0.0033 0.0102 0.0116
Trichomonas vaginalis glucosylceramidase, putative 0.03 0.1328 0.1324
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.004 0.0039
Echinococcus granulosus GPI anchor transamidase 0.0508 0.2284 0.2599
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0007 0.0007
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.009 0.0084
Echinococcus multilocularis phosphoglycerate mutase 0.0033 0.0102 0.0116
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0013 0.0009
Loa Loa (eye worm) hypothetical protein 0.0028 0.0083 0.0082
Echinococcus granulosus serine:threonine protein phosphatase PGAM5 0.0033 0.0102 0.0116
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0013 0.0013 0.0015
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0162 0.0162
Trypanosoma brucei phosphoglycerate mutase protein, putative 0.0033 0.0102 0.0111
Leishmania major hypothetical protein, conserved 0.0033 0.0102 0.0111
Loa Loa (eye worm) hypothetical protein 0.0011 0.0005 0.0005
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.004 0.0067
Trypanosoma cruzi 6-phosphofructo-2-kinase 1 0.1894 0.864 0.983
Trichomonas vaginalis phosphoglycerate mutase, putative 0.0033 0.0102 0.0097
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0048 0.019
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.004 0.0045
Echinococcus granulosus importin subunit beta 1 0.0028 0.0083 0.0093
Leishmania major DNA polymerase eta, putative 0.0031 0.0094 0.0102
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0007 0.0007
Mycobacterium tuberculosis Possible phosphoglycerate mutase Gpm2 (phosphoglyceromutase) (PGAM) (BPG-dependent PGAM) 0.0033 0.0102 0.215
Brugia malayi hypothetical protein 0.0029 0.0088 0.0088
Trichomonas vaginalis glucosylceramidase, putative 0.03 0.1328 0.1324
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0007 0.0002
Schistosoma mansoni glycosylphosphatidylinositol:protein transamidase (C13 family) 0.0508 0.2284 0.228
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0007 0.0007
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0056 0.0211 0.0234
Onchocerca volvulus 0.0033 0.0102 0.0097
Loa Loa (eye worm) hypothetical protein 0.1927 0.8789 0.8789
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.0457 0.0452
Mycobacterium tuberculosis PE-PGRS family protein PE_PGRS11 0.0033 0.0102 0.215
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0107 0.0446 0.0445
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0007 0.0007
Leishmania major 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.1894 0.864 0.983
Loa Loa (eye worm) hypothetical protein 0.0012 0.0007 0.0007
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.0508 0.2284 0.228
Schistosoma mansoni family C13 non-peptidase homologue (C13 family) 0.2191 1 1
Trypanosoma cruzi phosphoglycerate mutase protein, putative 0.0033 0.0102 0.0111
Trypanosoma brucei phosphoglycerate mutase, putative 0.0033 0.0102 0.0111
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.0007 0.0002
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.004 0.0039
Echinococcus granulosus phosphoglycerate mutase 0.0033 0.0102 0.0116
Trypanosoma cruzi Histidine phosphatase superfamily (branch 1), putative 0.0033 0.0102 0.0111
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.004 0.0039
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0048 0.0084
Echinococcus granulosus phosphoglycerate mutase 0.0033 0.0102 0.0116
Trichomonas vaginalis glucosylceramidase, putative 0.03 0.1328 0.1324
Leishmania major GPI-anchor transamidase subunit 8 (GPI8), putative 0.0508 0.2284 0.2595
Trichomonas vaginalis glucosylceramidase, putative 0.0197 0.0855 0.0851
Entamoeba histolytica phosphofructokinase, putative 0.011 0.0457 0.0876
Trypanosoma cruzi glycerolphosphate mutase, putative 0.0033 0.0102 0.0111
Echinococcus granulosus serine:threonine protein phosphatase PGAM5 0.0033 0.0102 0.0116
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0056 0.0211 0.0239
Mycobacterium tuberculosis Conserved protein 0.0033 0.0102 0.215
Onchocerca volvulus 0.0012 0.0007 0.0002
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0007 0.0002
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0109 0.0124
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.003 0.009 0.0163
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0007 0.0007
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0007 0.0007
Toxoplasma gondii phosphofructokinase PFKII 0.003 0.009 0.037
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0011 0.0005 0.0005
Mycobacterium tuberculosis Possible hydrolase MutT1 0.0033 0.0102 0.215
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0088 0.0361
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0162 0.0157
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0162 0.0161
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.2191 1 1
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0058 0.0053
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.011 0.0457 1
Schistosoma mansoni ran 0.0021 0.0048 0.0043
Brugia malayi hypothetical protein 0.0148 0.0634 0.0634
Plasmodium falciparum phosphoglucomutase-2 0.0033 0.0102 0.0427
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0007 0.0002
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0007 0.0007
Schistosoma mansoni hypothetical protein 0.0033 0.0102 0.0097
Loa Loa (eye worm) 6-phosphofructokinase 0.011 0.0457 0.0457
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.011 0.0457 1
Mycobacterium ulcerans phosphoglyceromutase 0.0033 0.0102 0.0122
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0088 0.0094
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0056 0.0211 0.4542
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.0457 0.0452
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.004 0.0039
Entamoeba histolytica phosphoglycerate mutase family protein. putative 0.0033 0.0102 0.0188
Loa Loa (eye worm) hypothetical protein 0.0073 0.029 0.029
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0109 0.0109
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0007 0.0007
Brugia malayi gamma-secretase subunit aph-1 0.0479 0.2148 0.2148
Trypanosoma brucei GPI-anchor transamidase subunit 8 (GPI8) 0.0508 0.2284 0.2595
Loa Loa (eye worm) CCR4-NOT transcription complex subunit 6 family protein 0.0011 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0012 0.0007 0.0007
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0007 0.0002
Mycobacterium ulcerans hydrolase MutT1 0.0033 0.0102 0.0122
Trichomonas vaginalis glucosylceramidase, putative 0.0197 0.0855 0.0851
Echinococcus multilocularis neutral sphingomyelinase 0.0011 0.0005 0.0005
Toxoplasma gondii histone lysine methyltransferase SET1 0.0063 0.0243 0.1043
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.0007 0.0002

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 0.2 nM Antagonist activity at human histamine H3 receptor expressed in HEK293 cells assessed as inhibition of calcium mobilization by FLIPR assay ChEMBL. 23591110
Inhibition (functional) < 40 % Antagonist activity at human MCH1R assessed as inhibition of calcium mobilization at 10 uM by FLIPR assay relative to control ChEMBL. 23591110
Inhibition (functional) < 40 % Antagonist activity at human histamine H1 receptor assessed as inhibition of calcium mobilization at 10 uM by FLIPR assay relative to control ChEMBL. 23591110
Inhibition (functional) < 40 % Antagonist activity at human histamine H2 receptor assessed as inhibition of calcium mobilization at 10 uM by FLIPR assay relative to control ChEMBL. 23591110
Inhibition (functional) = 132 % Antagonist activity at human histamine H3 receptor in human T-REx-293 cells assessed as inhibition of basal GTPgammaS binding at 10 uM after 90 mins by scintillation counting analysis relative to control ChEMBL. 23591110
Ki (binding) = 25.7 nM Displacement of [3H]N-alpha-methylhistamine from cloned rhesus monkey histamine H3 receptor transfected in CHO cells after 1 hr by scintillation counting analysis ChEMBL. 23591110

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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