Detailed information for compound 1775755

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 371.52 | Formula: C21H33N5O
  • H donors: 1 H acceptors: 1 LogP: 2.2 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN1CCN(CC1)C(=O)Nc1ccc(cc1)N1CCC(C1)N1CCCC1C
  • InChi: 1S/C21H33N5O/c1-17-4-3-10-26(17)20-9-11-25(16-20)19-7-5-18(6-8-19)22-21(27)24-14-12-23(2)13-15-24/h5-8,17,20H,3-4,9-16H2,1-2H3,(H,22,27)
  • InChiKey: WGDBSIUKEGGNAD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens histamine receptor H3 Starlite/ChEMBL References
Macaca mulatta Histamine receptor H3 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) hypothetical protein Histamine receptor H3   445 aa 385 aa 23.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii LsmAD domain-containing protein 0.0029 0.0088 0.0361
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.0007 0.0002
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0048 0.019
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.009 0.037
Loa Loa (eye worm) hypothetical protein 0.0011 0.0005 0.0005
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.011 0.0457 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0102 0.0102
Mycobacterium tuberculosis PE-PGRS family protein PE_PGRS11 0.0033 0.0102 0.215
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.004 0.0039
Trichomonas vaginalis phosphoglycerate mutase, putative 0.0033 0.0102 0.0097
Brugia malayi 6-phosphofructokinase 0.011 0.0457 0.0457
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0007 0.0007
Echinococcus multilocularis serine:threonine protein phosphatase PGAM5 0.0033 0.0102 0.0116
Brugia malayi steroid hormone receptor 0.0012 0.0007 0.0007
Trypanosoma cruzi phosphoglycerate mutase, putative 0.0033 0.0102 0.0111
Echinococcus multilocularis 6 phosphofructokinase 0.011 0.0457 0.052
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0007 0.0007
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0007 0.0007
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0056 0.0211 0.0901
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.011 0.0457 0.0515
Brugia malayi Calcitonin receptor-like protein seb-1 0.0107 0.0446 0.0446
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.011 0.0457 1
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.004 0.0039
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.2191 1 1
Mycobacterium ulcerans 6-phosphofructokinase 0.011 0.0457 0.0814
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0011 0.0005 0.0005
Onchocerca volvulus Protein UBASH3A homolog 0.0033 0.0102 0.0097
Entamoeba histolytica phosphoglycerate mutase family protein. putative 0.0033 0.0102 0.0188
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0109 0.0124
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0048 0.0054
Giardia lamblia DINP protein human, muc B family 0.0019 0.004 0.0067
Echinococcus multilocularis serine:threonine protein phosphatase PGAM5 0.0033 0.0102 0.0116
Leishmania major fructose-6-phosphate2-kinase/fructose-2,6-bisph os phatase-likeprotein 0.0033 0.0102 0.0111
Mycobacterium ulcerans fructose-2,6-bisphosphatase GpmB 0.1137 0.5168 1
Leishmania major phosphoglycerate mutase family member 5, putative 0.0033 0.0102 0.0111
Plasmodium vivax ataxin-2 like protein, putative 0.0029 0.0088 0.0361
Schistosoma mansoni hypothetical protein 0.0013 0.0013 0.0008
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.03 0.1328 0.1328
Brugia malayi phosphofructokinase 0.011 0.0457 0.0457
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0013 0.0009
Trypanosoma brucei 6-phosphofructo-2-kinase 2 0.1894 0.864 0.983
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0007 0.0002
Loa Loa (eye worm) hypothetical protein 0.0012 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0011 0.0005 0.0005
Brugia malayi 6-phosphofructokinase 0.011 0.0457 0.0457
Echinococcus multilocularis 6 phosphofructo 2 kinase:fructose 2 0.1927 0.8789 1
Echinococcus multilocularis phosphoglycerate mutase 0.0033 0.0102 0.0116
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0007 0.0007
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0031 0.0094 0.0391
Loa Loa (eye worm) hypothetical protein 0.0033 0.0102 0.0102
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0083 0.0093
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0007 0.0007
Mycobacterium ulcerans phosphohistidine phosphatase SixA 0.0033 0.0102 0.0122
Echinococcus multilocularis dna polymerase kappa 0.0019 0.004 0.0045
Schistosoma mansoni hypothetical protein 0.0301 0.1334 0.1329
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0007 0.0007
Brugia malayi nuclear receptor NHR-88 0.0012 0.0007 0.0007
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.004 0.0035
Echinococcus multilocularis phosphoglycerate mutase 0.0033 0.0102 0.0116
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0088 0.0361
Trypanosoma cruzi phosphoglycerate mutase family member 5, putative 0.0033 0.0102 0.0111
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0056 0.0211 0.0234
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0056 0.0211 0.0333
Trypanosoma brucei Histidine phosphatase superfamily (branch 1), putative 0.0033 0.0102 0.0111
Toxoplasma gondii phosphofructokinase PFKII 0.003 0.009 0.037
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.1927 0.8789 1
Mycobacterium tuberculosis Possible hydrolase MutT1 0.0033 0.0102 0.215
Trichomonas vaginalis ran, putative 0.0021 0.0048 0.0043
Loa Loa (eye worm) hypothetical protein 0.0012 0.0007 0.0007
Trypanosoma cruzi Histidine phosphatase superfamily (branch 1), putative 0.0033 0.0102 0.0111
Onchocerca volvulus Glucosylceramidase homolog 0.0197 0.0855 0.0851
Trypanosoma cruzi 6-phosphofructo-2-kinase 1 0.1894 0.864 0.983
Echinococcus granulosus phosphoglycerate mutase 0.0033 0.0102 0.0116
Treponema pallidum phosphoglyceromutase 0.0033 0.0102 0.215
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0048 0.0049
Trypanosoma brucei glycerolphosphate mutase, putative 0.0033 0.0102 0.0111
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.004 0.004
Leishmania major hypothetical protein, conserved 0.0029 0.0088 0.0094
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0007 0.0007
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0011 0.0005 0.0005
Onchocerca volvulus 0.0033 0.0106 0.0101
Schistosoma mansoni hypothetical protein 0.0475 0.2131 0.2127
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0109 0.0109
Schistosoma mansoni DNA polymerase eta 0.0044 0.0154 0.0149
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0007 0.0002
Loa Loa (eye worm) CXXC zinc finger family protein 0.0033 0.0106 0.0106
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0083 0.0088
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.0822 0.3724 0.4233
Echinococcus multilocularis synaptojanin 1 0.0011 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0034 0.0109 0.0109
Leishmania major GTP-binding protein, putative 0.0021 0.0048 0.0049
Loa Loa (eye worm) hypothetical protein 0.0033 0.0102 0.0102
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.009 0.037
Trichomonas vaginalis glucosylceramidase, putative 0.03 0.1328 0.1324
Schistosoma mansoni ran 0.0021 0.0048 0.0043
Echinococcus granulosus phosphoglycerate mutase 0.0033 0.0102 0.0116
Schistosoma mansoni cpg binding protein 0.0035 0.0115 0.011
Onchocerca volvulus 0.0148 0.0634 0.0629
Trypanosoma cruzi glycerolphosphate mutase, putative 0.0033 0.0102 0.0111
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0056 0.0211 0.4542
Trichomonas vaginalis glucosylceramidase, putative 0.0207 0.0904 0.0899
Schistosoma mansoni family C13 non-peptidase homologue (C13 family) 0.2191 1 1
Plasmodium vivax phosphoglycerate mutase, putative 0.0033 0.0102 0.0427
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.004 0.0039
Plasmodium falciparum phosphoglucomutase-2 0.0033 0.0102 0.0427
Onchocerca volvulus Legumain homolog 0.2191 1 1
Mycobacterium ulcerans hypothetical protein 0.0033 0.0102 0.0122
Loa Loa (eye worm) hypothetical protein 0.0011 0.0005 0.0005
Echinococcus granulosus synaptojanin 1 0.0011 0.0005 0.0005
Echinococcus granulosus gamma secretase subunit aph 1 0.0479 0.2148 0.2443
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.1927 0.8789 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0107 0.0446 0.0446
Schistosoma mansoni hypothetical protein 0.0073 0.029 0.0285
Echinococcus granulosus importin subunit beta 1 0.0028 0.0083 0.0093
Onchocerca volvulus 0.1927 0.8789 0.8789
Trypanosoma cruzi glycerolphosphate mutase, putative 0.0033 0.0102 0.0111
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0071 0.0278 0.0273
Schistosoma mansoni hypothetical protein 0.0034 0.0109 0.0104
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.004 0.0039
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.004 0.0039
Brugia malayi GPI-anchor transamidase 0.0508 0.2284 0.2284
Trichomonas vaginalis glucosylceramidase, putative 0.03 0.1328 0.1324
Leishmania major 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.1927 0.8789 1
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.004 0.0039
Echinococcus multilocularis GPCR, family 2 0.0034 0.0109 0.0124
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.0457 0.0452
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0007 0.0007
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0007 0.0002
Loa Loa (eye worm) phosphoglycerate mutase 0.0033 0.0102 0.0102
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0007 0.0002
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0007 0.0007
Mycobacterium ulcerans hypothetical protein 0.1137 0.5168 1
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.2191 1 1
Mycobacterium ulcerans bifunctional RNase H/acid phosphatase 0.0033 0.0102 0.0122
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.003 0.009 0.0163
Trypanosoma cruzi phosphoglycerate mutase protein, putative 0.0033 0.0102 0.0111
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0109 0.0124
Echinococcus granulosus phosphoglycerate mutase 0.0033 0.0102 0.0116
Trichomonas vaginalis glucosylceramidase, putative 0.0197 0.0855 0.0851
Echinococcus granulosus dna polymerase eta 0.0044 0.0154 0.0175
Leishmania major hypothetical protein, conserved 0.0033 0.0102 0.0111
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0011 0.0005 0.0005
Trypanosoma cruzi 6-phosphofructo-2-kinase 1 0.1894 0.864 0.983
Echinococcus granulosus 6 phosphofructokinase 0.011 0.0457 0.052
Toxoplasma gondii peptidase c13 family protein 0.0508 0.2284 1
Echinococcus granulosus inositol polyphosphate 5 phosphatase OCRL 1 0.0011 0.0005 0.0005
Schistosoma mansoni importin beta-1 0.0028 0.0083 0.0077
Echinococcus multilocularis dnaJ subfamily B 0.0475 0.2131 0.2424
Echinococcus granulosus dna polymerase kappa 0.0019 0.004 0.0045
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.004 0.0039
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0058 0.0053
Schistosoma mansoni hypothetical protein 0.1682 0.7669 0.7668
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0007 0.0002
Brugia malayi nuclear hormone receptor 0.0012 0.0007 0.0007
Trypanosoma brucei phosphoglycerate mutase protein, putative 0.0033 0.0102 0.0111
Trypanosoma cruzi phosphoglycerate mutase, putative 0.0033 0.0102 0.0111
Plasmodium falciparum importin beta, putative 0.0028 0.0083 0.0339
Loa Loa (eye worm) 6-phosphofructokinase 0.011 0.0457 0.0457
Plasmodium vivax importin-beta 2, putative 0.0028 0.0083 0.0339
Loa Loa (eye worm) hypothetical protein 0.0012 0.0007 0.0007
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.0007 0.0002
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatas, putative 0.0033 0.0102 0.0111
Onchocerca volvulus Protein UBASH3A homolog 0.0033 0.0102 0.0097
Entamoeba histolytica phosphoglycerate mutase family protein, putative 0.1137 0.5168 1
Trypanosoma cruzi cysteine peptidase, Clan CD, family C13, putative 0.0508 0.2284 0.2595
Mycobacterium tuberculosis Conserved protein 0.0033 0.0102 0.215
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0011 0.0005 0.0005
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.004 0.0039
Trypanosoma cruzi Aph-1 protein, putative 0.0186 0.0808 0.0914
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.004 0.0765
Echinococcus granulosus CCR4 NOT transcription complex subunit 6 0.0011 0.0005 0.0005
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0007 0.0007
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.2191 1 1
Trichomonas vaginalis phosphoglycerate mutase, putative 0.0033 0.0102 0.0097
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0056 0.0211 0.0398
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0011 0.0005 0.0005
Trichomonas vaginalis phosphoglycerate mutase, putative 0.0033 0.0102 0.0097
Toxoplasma gondii phosphoglycerate mutase family protein 0.0033 0.0102 0.0427
Trichomonas vaginalis phosphoglycerate mutase, putative 0.0033 0.0102 0.0097
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.004 0.0039
Trichomonas vaginalis glucosylceramidase, putative 0.03 0.1328 0.1324
Trichomonas vaginalis phosphoglycerate mutase, putative 0.0033 0.0102 0.0097
Plasmodium falciparum GPI-anchor transamidase, putative 0.0508 0.2284 1
Loa Loa (eye worm) hypothetical protein 0.0107 0.0446 0.0445
Onchocerca volvulus Protein UBASH3A homolog 0.0033 0.0102 0.0097
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0083 0.0088
Echinococcus granulosus GPI anchor transamidase 0.0508 0.2284 0.2599
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0162 0.0184
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0301 0.1334 0.1333
Loa Loa (eye worm) hypothetical protein 0.0012 0.0007 0.0007
Echinococcus granulosus snurportin 1 0.0301 0.1334 0.1517
Toxoplasma gondii phosphoglycerate mutase family protein 0.0033 0.0102 0.0427
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0007 0.0007
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.2191 1 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0007 0.0002
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.009 0.037
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0056 0.0211 0.5
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0007 0.0007
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.004 0.0765
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0088 0.0094
Echinococcus granulosus 6 phosphofructo 2 kinase:fructose 2 0.1927 0.8789 1
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0102 0.0097
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0013 0.0013 0.0015
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0056 0.0211 0.0234
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.011 0.0457 0.0515
Loa Loa (eye worm) hypothetical protein 0.0148 0.0634 0.0634
Brugia malayi ecdysteroid receptor 0.0012 0.0007 0.0007
Toxoplasma gondii phosphoglycerate mutase PGMII 0.0033 0.0102 0.0427
Leishmania major DNA polymerase eta, putative 0.0044 0.0154 0.0169
Loa Loa (eye worm) phosphofructokinase 0.011 0.0457 0.0457
Trypanosoma brucei phosphoglycerate mutase, putative 0.0033 0.0102 0.0111
Trypanosoma brucei unspecified product 0.0019 0.004 0.0039
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0011 0.0005 0.0005
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.003 0.009 0.1863
Echinococcus granulosus cpg binding protein 0.0035 0.0115 0.013
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0162 0.0157
Schistosoma mansoni hypothetical protein 0.0033 0.0102 0.0097
Schistosoma mansoni 6-phosphofructokinase 0.011 0.0457 0.0452
Leishmania major importin beta-1 subunit, putative 0.0023 0.0058 0.006
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.004 0.0035
Brugia malayi MH2 domain containing protein 0.0139 0.0589 0.0589
Brugia malayi hypothetical protein 0.0148 0.0634 0.0634
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0048 0.019
Loa Loa (eye worm) peptidase C13 family protein 0.2191 1 1
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0007 0.0007
Trichomonas vaginalis glucosylceramidase, putative 0.0207 0.0904 0.0899
Trichomonas vaginalis glucosylceramidase, putative 0.03 0.1328 0.1324
Trypanosoma brucei Aph-1 protein, putative 0.0186 0.0808 0.0914
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0007 0.0007
Trypanosoma cruzi DNA polymerase eta, putative 0.0044 0.0154 0.0169
Loa Loa (eye worm) hypothetical protein 0.0012 0.0007 0.0007
Leishmania major 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.1894 0.864 0.983
Mycobacterium ulcerans lipoprotein LpqD 0.0033 0.0102 0.0122
Echinococcus multilocularis gamma secretase subunit aph 1 0.0479 0.2148 0.2443
Trichomonas vaginalis glucosylceramidase, putative 0.0197 0.0855 0.0851
Giardia lamblia Hypothetical protein 0.1137 0.5168 1
Loa Loa (eye worm) hypothetical protein 0.1927 0.8789 0.8789
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.009 0.0084
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.004 0.0039
Leishmania major phosphoglycerate mutase protein, putative 0.0033 0.0102 0.0111
Mycobacterium ulcerans phosphoglycerate mutase 0.0033 0.0102 0.0122
Leishmania major hypothetical protein, conserved 0.0033 0.0102 0.0111
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0162 0.0157
Echinococcus multilocularis phosphoglycerate mutase 0.0033 0.0102 0.0116
Giardia lamblia Hypothetical protein 0.1137 0.5168 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0058 0.0053
Schistosoma mansoni hemoglobinase (C13 family) 0.2191 1 1
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0007 0.0002
Loa Loa (eye worm) hypothetical protein 0.0028 0.0083 0.0082
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0011 0.0005 0.0005
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0007 0.0007
Schistosoma mansoni cpg binding protein 0.0033 0.0106 0.0101
Schistosoma mansoni coup transcription factor 0.0012 0.0007 0.0002
Loa Loa (eye worm) hypothetical protein 0.0012 0.0007 0.0007
Brugia malayi Importin beta-1 subunit 0.0028 0.0083 0.0083
Giardia lamblia GPI-anchor transamidase, putative 0.0508 0.2284 0.4415
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.009 0.0084
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0007 0.0007
Brugia malayi hypothetical protein 0.0029 0.0088 0.0088
Mycobacterium tuberculosis Glucosyl-3-phosphoglycerate phosphatase GpgP 0.0033 0.0102 0.215
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0011 0.0005 0.0005
Echinococcus multilocularis deoxyribonuclease 1 2 0.0011 0.0005 0.0005
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0007 0.0007
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0048 0.0048
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0048 0.019
Trypanosoma cruzi Aph-1 protein, putative 0.0186 0.0808 0.0914
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0162 0.0184
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0088 0.0361
Echinococcus multilocularis inositol polyphosphate 5 phosphatase OCRL 1 0.0011 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.1105 0.5019 0.5019
Schistosoma mansoni hypothetical protein 0.0033 0.0102 0.0097
Schistosoma mansoni gamma-secretase subunit aph-1 0.0479 0.2148 0.2144
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0102 0.0097
Entamoeba histolytica GPI-anchor transamidase, putative 0.0508 0.2284 0.4415
Schistosoma mansoni 6-phosphofructokinase 0.011 0.0457 0.0452
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0056 0.0211 0.0239
Echinococcus granulosus serine:threonine protein phosphatase PGAM5 0.0033 0.0102 0.0116
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0007 0.0007
Chlamydia trachomatis 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase 0.0033 0.0102 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0073 0.029 0.029
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0007 0.0002
Schistosoma mansoni hypothetical protein 0.0033 0.0102 0.0097
Mycobacterium tuberculosis Probable conserved lipoprotein LpqD 0.0033 0.0102 0.215
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0007 0.0007
Schistosoma mansoni hypothetical protein 0.0033 0.0102 0.0097
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.0457 0.0452
Trypanosoma brucei Serine/threonine-protein phosphatase PGAM5, mitochondrial, putative 0.0033 0.0102 0.0111
Trypanosoma cruzi Histidine phosphatase superfamily (branch 1), putative 0.0033 0.0102 0.0111
Trypanosoma cruzi DNA polymerase eta, putative 0.0031 0.0094 0.0102
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0007 0.0007
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0007 0.0007
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0056 0.0211 0.0398
Brugia malayi exodeoxyribonuclease III family protein 0.0056 0.0211 0.0211
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.004 0.0039
Toxoplasma gondii histone lysine methyltransferase SET1 0.0063 0.0243 0.1043
Loa Loa (eye worm) MH2 domain-containing protein 0.0139 0.0589 0.0588
Trypanosoma brucei unspecified product 0.0013 0.0013 0.0009
Entamoeba histolytica phosphofructokinase, putative 0.011 0.0457 0.0876
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0056 0.0211 0.0239
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0007 0.0002
Loa Loa (eye worm) transcription factor SMAD2 0.0139 0.0589 0.0588
Trypanosoma brucei PAB1-binding protein , putative 0.0029 0.0088 0.0094
Trichomonas vaginalis glucosylceramidase, putative 0.0197 0.0855 0.0851
Mycobacterium tuberculosis Possible phosphoglycerate mutase Gpm2 (phosphoglyceromutase) (PGAM) (BPG-dependent PGAM) 0.0033 0.0102 0.215
Onchocerca volvulus 0.0033 0.0102 0.0097
Schistosoma mansoni hypothetical protein 0.0034 0.0109 0.0104
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.0508 0.2284 0.228
Trichomonas vaginalis glucosylceramidase, putative 0.0197 0.0855 0.0851
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0007 0.0007
Schistosoma mansoni phosphoglycerate mutase 0.0033 0.0102 0.0097
Entamoeba histolytica phosphoglycerate mutase family protein, putative 0.0033 0.0102 0.0188
Loa Loa (eye worm) hypothetical protein 0.0029 0.0088 0.0087
Schistosoma mansoni hypothetical protein 0.0033 0.0102 0.0097
Leishmania major 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-1-like protein 0.0822 0.3724 0.4233
Trypanosoma brucei Histidine phosphatase superfamily (branch 1), putative 0.0033 0.0102 0.0111
Trypanosoma brucei 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.1927 0.8789 1
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.003 0.009 0.0163
Toxoplasma gondii phosphoglycerate mutase family protein 0.0033 0.0102 0.0427
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0011 0.0005 0.0005
Brugia malayi CCR4 0.0011 0.0005 0.0005
Echinococcus multilocularis traf and tnf receptor associated protein 0.0011 0.0005 0.0005
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0056 0.0211 0.0901
Toxoplasma gondii phosphoglycerate mutase family protein 0.0033 0.0102 0.0427
Plasmodium vivax GPI-anchor transamidase, putative 0.0508 0.2284 1
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.004 0.0035
Loa Loa (eye worm) gamma-secretase subunit aph-1 0.0479 0.2148 0.2147
Leishmania major DNA polymerase eta, putative 0.0031 0.0094 0.0102
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0088 0.0094
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0048 0.0048
Loa Loa (eye worm) CCR4-NOT transcription complex subunit 6 family protein 0.0011 0.0005 0.0005
Entamoeba histolytica phosphoglycerate mutase family protein, putative 0.0033 0.0102 0.0188
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0007 0.0007
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.004 0.0039
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.004 0.0039
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0011 0.0005 0.0005
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0109 0.0109
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0007 0.0007
Trypanosoma brucei DNA polymerase eta, putative 0.0044 0.0154 0.0169
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.0508 0.2284 0.228
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0056 0.0211 0.021
Toxoplasma gondii 6-phosphofructokinase 0.003 0.009 0.037
Toxoplasma gondii exonuclease III APE 0.0056 0.0211 0.0901
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0058 0.006
Echinococcus multilocularis CCR4 NOT transcription complex subunit 6 0.0011 0.0005 0.0005
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.004 0.0039
Mycobacterium tuberculosis Conserved protein 0.0033 0.0102 0.215
Loa Loa (eye worm) hypothetical protein 0.1894 0.864 0.864
Mycobacterium ulcerans hydrolase MutT1 0.0033 0.0102 0.0122
Schistosoma mansoni 6-phosphofructokinase 0.1927 0.8789 0.8789
Schistosoma mansoni ap endonuclease 0.0056 0.0211 0.0206
Echinococcus multilocularis snurportin 1 0.0301 0.1334 0.1517
Brugia malayi RNA, U transporter 1 0.008 0.0321 0.0321
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0048 0.0084
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0007 0.0007
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0048 0.0049
Schistosoma mansoni phosphoglycerate mutase 0.0033 0.0102 0.0097
Brugia malayi gamma-secretase subunit aph-1 0.0479 0.2148 0.2148
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.004 0.0039
Leishmania major ATP-dependent phosphofructokinase 0.011 0.0457 0.0515
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0011 0.0005 0.0005
Echinococcus granulosus dnaJ subfamily B 0.0475 0.2131 0.2424
Mycobacterium ulcerans phosphoglyceromutase 0.0033 0.0102 0.0122
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0162 0.0157
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0013 0.0009
Trypanosoma cruzi Histidine phosphatase superfamily (branch 1), putative 0.0033 0.0102 0.0111
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0007 0.0002
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.004 0.0035
Onchocerca volvulus Protein UBASH3A homolog 0.0033 0.0102 0.0097
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0007 0.0007
Mycobacterium ulcerans hypothetical protein 0.0033 0.0102 0.0122
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.004 0.0039
Loa Loa (eye worm) hypothetical protein 0.0033 0.0102 0.0102
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.0457 0.0452
Treponema pallidum exodeoxyribonuclease (exoA) 0.0056 0.0211 0.4542
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.004 0.0045
Toxoplasma gondii phosphofructokinase domain-containing protein 0.003 0.009 0.037
Brugia malayi phosphoglycerate mutase family protein 0.0033 0.0102 0.0102
Trypanosoma cruzi phosphoglycerate mutase protein, putative 0.0033 0.0102 0.0111
Trichomonas vaginalis ap endonuclease, putative 0.0056 0.0211 0.0206
Echinococcus granulosus GPCR family 2 0.0034 0.0109 0.0124
Trypanosoma brucei unspecified product 0.0013 0.0013 0.0009
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0162 0.0162
Leishmania major phosphoglycerate mutase, putative 0.0033 0.0102 0.0111
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0011 0.0005 0.0005
Echinococcus multilocularis phosphoglycerate mutase 0.0033 0.0102 0.0116
Toxoplasma gondii phosphoglycerate mutase 0.0033 0.0102 0.0427
Trypanosoma cruzi Histidine phosphatase superfamily (branch 1), putative 0.0033 0.0102 0.0111
Loa Loa (eye worm) hypothetical protein 0.0508 0.2284 0.2284
Trichomonas vaginalis glucosylceramidase, putative 0.0197 0.0855 0.0851
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0007 0.0007
Plasmodium vivax phosphoglucomutase-2, putative 0.0033 0.0102 0.0427
Trichomonas vaginalis 6-phosphofructokinase, putative 0.003 0.009 0.0084
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.004 0.0067
Loa Loa (eye worm) hypothetical protein 0.0012 0.0007 0.0007
Echinococcus multilocularis phosphoglycerate mutase 0.0033 0.0102 0.0116
Brugia malayi ImpB/MucB/SamB family protein 0.0044 0.0154 0.0154
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0011 0.0005 0.0005
Echinococcus granulosus neutral sphingomyelinase 0.0011 0.0005 0.0005
Leishmania major glycerolphosphate mutase, putative 0.0033 0.0102 0.0111
Trypanosoma cruzi phosphoglycerate mutase family member 5, putative 0.0033 0.0102 0.0111
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0107 0.0446 0.0445
Echinococcus multilocularis dna polymerase eta 0.0044 0.0154 0.0175
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0048 0.0054
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.009 0.0084
Brugia malayi latrophilin 2 splice variant baaae 0.0073 0.029 0.029
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0162 0.0184
Trichomonas vaginalis ap endonuclease, putative 0.0056 0.0211 0.0206
Echinococcus multilocularis neutral sphingomyelinase 0.0011 0.0005 0.0005
Echinococcus multilocularis phosphoglycerate mutase 0.0033 0.0102 0.0116
Loa Loa (eye worm) 6-phosphofructokinase 0.011 0.0457 0.0457
Schistosoma mansoni hypothetical protein 0.0033 0.0102 0.0097
Trypanosoma cruzi Histidine phosphatase superfamily (branch 1), putative 0.0033 0.0102 0.0111
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.2191 1 1
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.009 0.0084
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0007 0.0007
Brugia malayi CXXC zinc finger family protein 0.0033 0.0106 0.0106
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.004 0.0039
Trichomonas vaginalis glucosylceramidase, putative 0.0197 0.0855 0.0851
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0007 0.0002
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0007 0.0007
Brugia malayi hypothetical protein 0.0019 0.004 0.004
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.0007 0.0002
Mycobacterium ulcerans acid phosphatase 0.0033 0.0102 0.0122
Echinococcus multilocularis GPI anchor transamidase 0.0508 0.2284 0.2599
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatas, putative 0.0033 0.0102 0.0111
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0013 0.0013 0.0015
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0083 0.0339
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0162 0.0161
Entamoeba histolytica phosphofructokinase, putative 0.011 0.0457 0.0876
Leishmania major hypothetical protein, unknown function 0.0033 0.0102 0.0111
Trichomonas vaginalis glucosylceramidase, putative 0.03 0.1328 0.1324
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.2191 1 1
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.009 0.037
Trichomonas vaginalis glucosylceramidase, putative 0.0197 0.0855 0.0851
Loa Loa (eye worm) hypothetical protein 0.0012 0.0007 0.0007
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0007 0.0007
Leishmania major hypothetical protein, conserved 0.0033 0.0102 0.0111
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0007 0.0007
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0007 0.0007
Plasmodium falciparum phosphoglycerate mutase, putative 0.0033 0.0102 0.0427
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0007 0.0007
Schistosoma mansoni hypothetical protein 0.0034 0.0109 0.0104
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.0822 0.3724 0.4233
Mycobacterium tuberculosis Probable phosphoglycerate mutase (phosphoglyceromutase) (phosphoglycerate phosphomutase) 0.0033 0.0102 0.215
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.2191 1 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0048 0.0049
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0007 0.0007
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.004 0.0045
Trypanosoma brucei 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatas, putative 0.0033 0.0102 0.0111
Entamoeba histolytica hypothetical protein 0.0023 0.0058 0.0102
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.0457 0.0452
Echinococcus granulosus serine:threonine protein phosphatase PGAM5 0.0033 0.0102 0.0116
Trypanosoma brucei GPI-anchor transamidase subunit 8 (GPI8) 0.0508 0.2284 0.2595
Loa Loa (eye worm) hypothetical protein 0.0044 0.0154 0.0154
Leishmania major DNA polymerase kappa, putative 0.0019 0.004 0.0039
Schistosoma mansoni hemoglobinase (C13 family) 0.2191 1 1
Onchocerca volvulus 0.0012 0.0007 0.0002
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0007 0.0007
Trichomonas vaginalis glucosylceramidase, putative 0.03 0.1328 0.1324
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0056 0.0211 0.0234
Echinococcus granulosus phosphoglycerate mutase 0.0033 0.0102 0.0116
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0007 0.0002
Onchocerca volvulus 0.0033 0.0102 0.0097
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0013 0.0009
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0162 0.0184
Echinococcus multilocularis cpg binding protein 0.0035 0.0115 0.013
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.009 0.0084
Entamoeba histolytica phosphofructokinase, putative 0.011 0.0457 0.0876
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.004 0.0039
Schistosoma mansoni ran 0.0021 0.0048 0.0043
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0109 0.0124
Echinococcus granulosus traf and tnf receptor associated protein 0.0011 0.0005 0.0005
Echinococcus granulosus phosphoglycerate mutase 0.0033 0.0102 0.0116
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.03 0.1328 0.1328
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.004 0.0039
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0007 0.0007
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.0508 0.2284 0.228
Schistosoma mansoni glycosylphosphatidylinositol:protein transamidase (C13 family) 0.0508 0.2284 0.228
Loa Loa (eye worm) hypothetical protein 0.0011 0.0005 0.0005
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0056 0.0211 0.0234
Schistosoma mansoni hypothetical protein 0.0034 0.0109 0.0104
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0007 0.0007
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0007 0.0007
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0109 0.0124
Mycobacterium ulcerans phosphoglycerate mutase 0.0033 0.0102 0.0122
Entamoeba histolytica Ran family GTPase 0.0021 0.0048 0.0084
Onchocerca volvulus 0.0033 0.0102 0.0097
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.009 0.0084
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0007 0.0007
Mycobacterium tuberculosis Conserved hypothetical protein 0.0033 0.0102 0.215
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0109 0.0109
Schistosoma mansoni ap endonuclease 0.0056 0.0211 0.0206
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.011 0.0457 1
Leishmania major GPI-anchor transamidase subunit 8 (GPI8), putative 0.0508 0.2284 0.2595
Trypanosoma brucei Histidine phosphatase superfamily (branch 1), putative 0.0033 0.0102 0.0111
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0011 0.0005 0.0005
Brugia malayi UBASH3A protein homolog 0.0033 0.0102 0.0102
Trypanosoma brucei 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.0822 0.3724 0.4233
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0007 0.0007
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0011 0.0005 0.0005
Brugia malayi phosphoglycerate mutase family protein 0.0033 0.0102 0.0102
Schistosoma mansoni cpg binding protein 0.0035 0.0115 0.011
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0011 0.0005 0.0005
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0058 0.0053
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0007 0.0007

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 0.2 nM Antagonist activity at human histamine H3 receptor expressed in HEK293 cells assessed as inhibition of calcium mobilization by FLIPR assay ChEMBL. 23591110
Inhibition (functional) < 40 % Antagonist activity at human MCH1R assessed as inhibition of calcium mobilization at 10 uM by FLIPR assay relative to control ChEMBL. 23591110
Inhibition (functional) < 40 % Antagonist activity at human histamine H1 receptor assessed as inhibition of calcium mobilization at 10 uM by FLIPR assay relative to control ChEMBL. 23591110
Inhibition (functional) < 40 % Antagonist activity at human histamine H2 receptor assessed as inhibition of calcium mobilization at 10 uM by FLIPR assay relative to control ChEMBL. 23591110
Inhibition (functional) = 132 % Antagonist activity at human histamine H3 receptor in human T-REx-293 cells assessed as inhibition of basal GTPgammaS binding at 10 uM after 90 mins by scintillation counting analysis relative to control ChEMBL. 23591110
Ki (binding) = 25.7 nM Displacement of [3H]N-alpha-methylhistamine from cloned rhesus monkey histamine H3 receptor transfected in CHO cells after 1 hr by scintillation counting analysis ChEMBL. 23591110

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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