Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0223 | 1 | 1 |
Schistosoma mansoni | dihydropteridine reductase | 0.0015 | 0 | 0.5 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0015 | 0 | 0.5 |
Trypanosoma cruzi | beta-ketoacyl-ACP reductase | 0.0015 | 0 | 0.5 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0015 | 0 | 0.5 |
Trypanosoma brucei | pteridine reductase 1 | 0.0015 | 0 | 0.5 |
Trypanosoma cruzi | beta-ketoacyl-ACP reductase | 0.0015 | 0 | 0.5 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0015 | 0 | 0.5 |
Loa Loa (eye worm) | oxidoreductase | 0.0015 | 0 | 0.5 |
Leishmania major | dehydrogenase/oxidoreductase-like protein | 0.0015 | 0 | 0.5 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0223 | 1 | 1 |
Leishmania major | 3-oxoacyl-ACP reductase, putative | 0.0015 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0223 | 1 | 1 |
Leishmania major | oxidoreductase-like protein | 0.0015 | 0 | 0.5 |
Trypanosoma brucei | oxidoreductase-like protein | 0.0015 | 0 | 0.5 |
Loa Loa (eye worm) | retinol dehydrogenase 12 | 0.0015 | 0 | 0.5 |
Trypanosoma brucei | beta-ketoacyl-ACP reductase | 0.0015 | 0 | 0.5 |
Leishmania major | pteridine reductase 1 | 0.0015 | 0 | 0.5 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0223 | 1 | 1 |
Onchocerca volvulus | 0.0015 | 0 | 0.5 | |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0223 | 1 | 1 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0223 | 1 | 1 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0223 | 1 | 1 |
Trypanosoma cruzi | oxidoreductase-like protein, putative | 0.0015 | 0 | 0.5 |
Trichomonas vaginalis | hypothetical protein | 0.0223 | 1 | 0.5 |
Onchocerca volvulus | 0.0015 | 0 | 0.5 | |
Entamoeba histolytica | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0015 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0 | 0.5 |
Leishmania major | dehydrogenase/oxidoreductase-like protein | 0.0015 | 0 | 0.5 |
Echinococcus granulosus | 3 oxoacyl acyl carrier protein reductase | 0.0015 | 0 | 0.5 |
Echinococcus multilocularis | 3 oxoacyl acyl carrier protein reductase | 0.0015 | 0 | 0.5 |
Schistosoma mansoni | 3-oxoacyl-[ACP] reductase | 0.0015 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | > 2443 ng/ml | Antiplasmodial activity against blood stage of drug-sensitive Plasmodium falciparum D6 | ChEMBL. | 23664871 |
Activity (ADMET) | > 10 uM | Cytotoxicity against HFF after 72 hrs by WST-1 assay | ChEMBL. | 23664871 |
IC50 (binding) | = 29 nM | Inhibition of Toxoplasma gondii enoyl acyl-carrier protein reductase | ChEMBL. | 23664871 |
Inhibition (binding) | = 94 % | Inhibition of Toxoplasma gondii enoyl acyl-carrier protein reductase at 1 uM | ChEMBL. | 23664871 |
MIC50 (functional) | = 4 uM | Antiparasitic activity against tachyzoite of Toxoplasma gondii RH expressing yellow fluorescent protein infected in human foreskin fibroblasts after 72 hrs by bacterial beta-galactosidase reporter gene assay | ChEMBL. | 23664871 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.