Detailed information for compound 1776084

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 576.395 | Formula: C28H22BrN3O6
  • H donors: 0 H acceptors: 3 LogP: 4.49 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCOC(=O)c1ccc2c(c1)n1c(c3ccccc3)c3c(c1[C@H](O2)c1ccc(o1)Br)n(C)c(=O)n(c3=O)C
  • InChi: 1S/C28H22BrN3O6/c1-4-36-27(34)16-10-11-18-17(14-16)32-22(15-8-6-5-7-9-15)21-23(30(2)28(35)31(3)26(21)33)24(32)25(38-18)19-12-13-20(29)37-19/h5-14,25H,4H2,1-3H3/t25-/m1/s1
  • InChiKey: IQTUORHYHHBSMV-RUZDIDTESA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0022 0.0041 0.0041
Mycobacterium tuberculosis Conserved protein 0.0078 0.0469 0.0404
Echinococcus multilocularis neutral alpha glucosidase AB 0.004 0.0181 0.0181
Brugia malayi Pre-SET motif family protein 0.0179 0.1248 0.1248
Schistosoma mansoni kinase 0.0041 0.019 0.019
Trichomonas vaginalis D-aminoacylase, putative 0.0078 0.0469 0.3263
Brugia malayi Glycosyl hydrolases family 31 protein 0.0181 0.1261 0.1261
Echinococcus granulosus Polycystic kidney disease protein 0.0022 0.0041 0.0041
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0025 0.0068 0.0453
Echinococcus granulosus lysine specific demethylase 5A 0.0051 0.0262 0.0262
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0025 0.0068 0.0068
Mycobacterium tuberculosis Probable hydrolase 0.0078 0.0469 0.0404
Leishmania major hypothetical protein, conserved 0.0078 0.0469 0.9344
Echinococcus granulosus Excitatory amino acid transporter 0.1318 1 1
Mycobacterium tuberculosis Probable reductase 0.0167 0.1156 0.1095
Brugia malayi ImpB/MucB/SamB family protein 0.0033 0.0126 0.0126
Echinococcus granulosus microtubule associated protein 2 0.1177 0.8918 0.8918
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0033 0.0126 0.1356
Loa Loa (eye worm) hypothetical protein 0.0026 0.0071 0.0071
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0017 0.0002 0.0002
Mycobacterium ulcerans beta-lactamase 0.0078 0.0469 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.0126 0.1747
Mycobacterium ulcerans lipase LipD 0.0078 0.0469 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0495 0.3679 0.3636
Schistosoma mansoni hypothetical protein 0.0075 0.0451 0.0451
Loa Loa (eye worm) glutathione reductase 0.0073 0.0435 0.0435
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0025 0.0068 0.068
Echinococcus granulosus RUN 0.0022 0.0041 0.0041
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0041 0.0186 0.2936
Loa Loa (eye worm) hypothetical protein 0.0128 0.086 0.086
Echinococcus granulosus neuropeptide s receptor 0.0538 0.4006 0.4006
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.004 0.0181 0.3648
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.004 0.0181 0.2818
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0069 0.0404 0.0404
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0039 0.0171 0.0171
Entamoeba histolytica hypothetical protein 0.0075 0.0451 0.9077
Plasmodium falciparum thioredoxin reductase 0.0073 0.0435 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0078 0.0469 0.0404
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0039 0.0171 0.0171
Echinococcus granulosus transcription factor Dp 1 0.004 0.0181 0.0181
Trichomonas vaginalis DNA polymerase eta, putative 0.0033 0.0126 0.0879
Schistosoma mansoni polycystin 1-related 0.0022 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0078 0.0469 0.0469
Brugia malayi serine/threonine-protein kinase plk-2 0.0081 0.0497 0.0497
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0069 0.0404 0.0404
Schistosoma mansoni rab6-interacting 0.0022 0.0041 0.0041
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0041 0.0186 0.0118
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0404 0.7829
Mycobacterium leprae Probable lipase LipE 0.0078 0.0469 0.2785
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0017 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0078 0.0469 0.0469
Trypanosoma cruzi DNA polymerase kappa, putative 0.0033 0.0126 0.1356
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.004 0.0181 0.2818
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.004 0.0181 0.0114
Trypanosoma cruzi polo-like protein kinase, putative 0.0081 0.0497 1
Echinococcus multilocularis transcription factor Dp 1 0.004 0.0181 0.0181
Trypanosoma cruzi DNA polymerase kappa, putative 0.0033 0.0126 0.1356
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0039 0.0171 0.0171
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0078 0.0469 0.0469
Echinococcus multilocularis lysine specific demethylase 5A 0.0051 0.0262 0.0262
Trichomonas vaginalis CAMK family protein kinase 0.0081 0.0497 0.3458
Mycobacterium tuberculosis Probable lipase LipE 0.0078 0.0469 0.0404
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0069 0.0404 0.0404
Onchocerca volvulus 0.0204 0.1438 0.1402
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.004 0.0181 0.1262
Echinococcus granulosus lysosomal alpha glucosidase 0.0181 0.1261 0.1261
Trypanosoma cruzi DNA polymerase eta, putative 0.0033 0.0126 0.1356
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0584 0.4362 0.4362
Loa Loa (eye worm) hypothetical protein 0.0032 0.0117 0.0117
Loa Loa (eye worm) hypothetical protein 0.01 0.0644 0.0644
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0075 0.0451 0.0451
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0033 0.0126 0.0126
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0026 0.0071 0.0059
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0185 0.1299 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.0126 0.1747
Trichomonas vaginalis set domain proteins, putative 0.0204 0.1438 1
Trypanosoma cruzi hypothetical protein, conserved 0.0078 0.0469 0.9344
Trypanosoma cruzi DNA polymerase kappa, putative 0.0033 0.0126 0.1356
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0181 0.1262
Echinococcus multilocularis excitatory amino acid transporter 3 0.1318 1 1
Trypanosoma brucei DNA polymerase IV, putative 0.0033 0.0126 0.1747
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0181 0.126
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0584 0.4362 0.4362
Entamoeba histolytica myo-inositol monophosphatase, putative 0.004 0.0181 0.3644
Echinococcus multilocularis GPCR, family 2 0.0032 0.0117 0.0117
Brugia malayi exodeoxyribonuclease III family protein 0.0041 0.0186 0.0186
Trichomonas vaginalis maltase-glucoamylase, putative 0.004 0.0181 0.1262
Brugia malayi Muscleblind-like protein 0.0128 0.086 0.086
Echinococcus granulosus geminin 0.0538 0.4006 0.4006
Plasmodium vivax thioredoxin reductase, putative 0.0073 0.0435 0.153
Brugia malayi jmjC domain containing protein 0.0051 0.0262 0.0262
Trypanosoma cruzi DNA polymerase kappa, putative 0.0033 0.0126 0.1356
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.01 0.0644 0.0644
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0117 0.0117
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0081 0.0497 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0078 0.0469 0.0404
Trypanosoma brucei polo-like protein kinase 0.0081 0.0497 1
Trichomonas vaginalis CAMK family protein kinase 0.0081 0.0497 0.3458
Mycobacterium ulcerans esterase/lipase LipP 0.0078 0.0469 1
Loa Loa (eye worm) hypothetical protein 0.0069 0.04 0.04
Brugia malayi beta-lactamase family protein 0.0078 0.0469 0.0469
Schistosoma mansoni hypothetical protein 0.0538 0.4006 0.4006
Echinococcus granulosus neuropeptide receptor A26 0.0538 0.4006 0.4006
Schistosoma mansoni serine/threonine protein kinase 0.0017 0.0002 0.0002
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0041 0.0186 0.3667
Schistosoma mansoni alpha-glucosidase 0.0155 0.1068 0.1068
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0071 0.0419 0.8423
Loa Loa (eye worm) hypothetical protein 0.0022 0.0041 0.0041
Trichomonas vaginalis glutathione reductase, putative 0.0025 0.0068 0.0474
Trichomonas vaginalis CAMK family protein kinase 0.0081 0.0497 0.3458
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.0126 0.1747
Onchocerca volvulus 0.0078 0.0469 0.0429
Brugia malayi glutathione reductase 0.0073 0.0435 0.0435
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0069 0.0404 0.8127
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0041 0.0186 0.2743
Brugia malayi beta-lactamase 0.0078 0.0469 0.0469
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0167 0.1156 0.1095
Echinococcus granulosus excitatory amino acid transporter 3 0.1318 1 1
Brugia malayi hypothetical protein 0.0022 0.0041 0.0041
Echinococcus granulosus thioredoxin glutathione reductase 0.0074 0.0439 0.0439
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0185 0.1299 0.1239
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0181 0.1262
Loa Loa (eye worm) hypothetical protein 0.0078 0.0469 0.0469
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0026 0.0071 0.0071
Brugia malayi Doublecortin family protein 0.0022 0.0041 0.0041
Trypanosoma brucei glucosidase, putative 0.004 0.0181 0.2972
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0025 0.0068 0.0104
Onchocerca volvulus Excitatory amino acid transporter homolog 0.1318 1 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0026 0.0071 0.0071
Plasmodium vivax glutathione reductase, putative 0.0073 0.0435 0.153
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0181 0.1262
Treponema pallidum glutamate transporter 0.0584 0.4362 1
Echinococcus granulosus neutral alpha glucosidase AB 0.004 0.0181 0.0181
Echinococcus multilocularis neuropeptide s receptor 0.0538 0.4006 0.4006
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.004 0.0181 0.3648
Trichomonas vaginalis CAMK family protein kinase 0.0081 0.0497 0.3458
Loa Loa (eye worm) hypothetical protein 0.0078 0.0469 0.0469
Trypanosoma brucei trypanothione reductase 0.0073 0.0435 0.8626
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0033 0.0126 0.0126
Echinococcus multilocularis dna polymerase eta 0.0033 0.0126 0.0126
Brugia malayi jmjC domain containing protein 0.0051 0.0262 0.0262
Plasmodium falciparum glutathione reductase 0.0025 0.0068 0.068
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0041 0.0186 0.2743
Leishmania major trypanothione reductase 0.0073 0.0435 0.8561
Echinococcus multilocularis Excitatory amino acid transporter 0.1318 1 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0039 0.0171 0.0171
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0036 0.0149 0.0081
Trichomonas vaginalis esterase, putative 0.0078 0.0469 0.3263
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0069 0.0404 0.0404
Mycobacterium ulcerans hypothetical protein 0.0078 0.0469 1
Trypanosoma cruzi hypothetical protein, conserved 0.0078 0.0469 0.9344
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0078 0.0469 0.0469
Schistosoma mansoni DNA polymerase eta 0.0033 0.0126 0.0126
Entamoeba histolytica hypothetical protein 0.0075 0.0451 0.9077
Plasmodium vivax SET domain protein, putative 0.0026 0.0071 0.0113
Loa Loa (eye worm) hypothetical protein 0.0078 0.0469 0.0469
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.0126 0.1747
Schistosoma mansoni alpha glucosidase 0.004 0.0181 0.0181
Brugia malayi hypothetical protein 0.0075 0.0451 0.0451
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0041 0.0186 0.0118
Schistosoma mansoni serine/threonine protein kinase 0.0017 0.0002 0.0002
Echinococcus multilocularis dna polymerase kappa 0.0033 0.0126 0.0126
Loa Loa (eye worm) inositol-1 0.004 0.0181 0.0181
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.004 0.0181 0.1262
Chlamydia trachomatis neutral amino acid transporter 0.0584 0.4362 0.4323
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.0126 0.1747
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0404 0.7829
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0039 0.0171 0.0171
Loa Loa (eye worm) pigment dispersing factor receptor c 0.01 0.0644 0.0644
Echinococcus granulosus neutral amino acid transporter A 0.1318 1 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.0033 0.0126 0.2541
Schistosoma mansoni alpha-glucosidase 0.0155 0.1068 0.1068
Echinococcus multilocularis inositol monophosphatase 1 0.004 0.0181 0.0181
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0075 0.0451 0.0451
Entamoeba histolytica serine/threonine protein kinase, putative 0.0081 0.0497 1
Schistosoma mansoni hypothetical protein 0.0032 0.0117 0.0117
Mycobacterium tuberculosis Conserved hypothetical protein 0.0033 0.0126 0.0059
Echinococcus multilocularis expressed protein 0.0321 0.2338 0.2338
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0041 0.0186 0.2743
Schistosoma mansoni rab6-interacting 0.0022 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0128 0.086 0.086
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.0041 0.0041
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0182 0.1267
Leishmania major DNA polymerase kappa, putative 0.0033 0.0126 0.1356
Toxoplasma gondii thioredoxin reductase 0.0073 0.0435 0.9162
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0025 0.0068 0.0453
Mycobacterium tuberculosis Probable dehydrogenase 0.0167 0.1156 0.1095
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0182 0.1267
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0033 0.0126 0.0126
Leishmania major alpha glucosidase II subunit, putative 0.004 0.0181 0.2638
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0025 0.0068 0.0068
Trypanosoma cruzi trypanothione reductase, putative 0.0073 0.0435 0.8561
Echinococcus multilocularis geminin 0.0538 0.4006 0.4006
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0117 0.0117
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0181 0.2638
Schistosoma mansoni transcription factor LCR-F1 0.0075 0.0451 0.0451
Schistosoma mansoni hypothetical protein 0.0069 0.04 0.04
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0071 0.0419 0.8423
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0181 0.1261 0.1261
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0033 0.0126 0.0126
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.0041 0.0041
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0181 0.2633
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0025 0.0068 0.0453
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0181 0.1262
Toxoplasma gondii exonuclease III APE 0.0041 0.0186 0.2936
Echinococcus granulosus sodium:dicarboxylate symporter 0.1318 1 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.01 0.0644 0.0644
Mycobacterium ulcerans DNA polymerase IV 0.0033 0.0126 0.1451
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0025 0.0068 0.0453
Schistosoma mansoni jumonji/arid domain-containing protein 0.0051 0.0262 0.0262
Echinococcus multilocularis neuropeptide receptor A26 0.0538 0.4006 0.4006
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0167 0.1156 0.1095
Echinococcus multilocularis RUN 0.0022 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0071 0.0419 0.0419
Echinococcus multilocularis beta LACTamase domain containing family member 0.0078 0.0469 0.0469
Mycobacterium tuberculosis Probable C4-dicarboxylate-transport transmembrane protein DctA 0.1318 1 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0039 0.0171 0.0171
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0026 0.0071 0.0071
Mycobacterium tuberculosis Probable lipase LipD 0.0078 0.0469 0.0404
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0078 0.0469 0.0469
Echinococcus multilocularis neutral amino acid transporter A 0.1318 1 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0181 0.1261 0.1261
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0041 0.0186 0.0561
Echinococcus granulosus neutral amino acid transporter 0.1318 1 1
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0033 0.0126 0.0059
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.0041 0.0041
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.004 0.0181 0.2824
Echinococcus granulosus excitatory amino acid transporter 2 0.1318 1 1
Echinococcus multilocularis muscleblind protein 0.0128 0.086 0.086
Trichomonas vaginalis CAMK family protein kinase 0.0081 0.0497 0.3458
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.0126 0.1747
Onchocerca volvulus 0.0078 0.0469 0.0429
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.04 0.04
Echinococcus multilocularis Polycystic kidney disease protein 0.0022 0.0041 0.0041
Trichomonas vaginalis mercuric reductase, putative 0.0025 0.0068 0.0474
Loa Loa (eye worm) thioredoxin reductase 0.0073 0.0435 0.0435
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0041 0.0186 0.0186
Loa Loa (eye worm) jmjC domain-containing protein 0.0051 0.0262 0.0262
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0078 0.0469 0.0469
Echinococcus multilocularis sodium:dicarboxylate symporter 0.1318 1 1
Echinococcus multilocularis beta adrenergic receptor kinase 0.0017 0.0002 0.0002
Trichomonas vaginalis CAMK family protein kinase 0.0081 0.0497 0.3458
Onchocerca volvulus 0.0078 0.0469 0.0429
Loa Loa (eye worm) beta-lactamase 0.0078 0.0469 0.0469
Mycobacterium tuberculosis Conserved protein 0.0078 0.0469 0.0404
Trypanosoma brucei DNA polymerase IV, putative 0.0033 0.0126 0.1747
Loa Loa (eye worm) hypothetical protein 0.0078 0.0469 0.0469
Schistosoma mansoni ap endonuclease 0.0041 0.0186 0.0186
Trichomonas vaginalis penicillin-binding protein, putative 0.0078 0.0469 0.3263
Echinococcus granulosus beta-adrenergic receptor kinase 0.0017 0.0002 0.0002
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0041 0.0186 0.0186
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0069 0.0404 0.7829
Leishmania major DNA polymerase eta, putative 0.0033 0.0126 0.1356
Echinococcus granulosus dna polymerase eta 0.0033 0.0126 0.0126
Trichomonas vaginalis CAMK family protein kinase 0.0081 0.0497 0.3458
Schistosoma mansoni hypothetical protein 0.0032 0.0117 0.0117
Plasmodium falciparum thioredoxin reductase 0.0025 0.0068 0.068
Schistosoma mansoni terminal deoxycytidyl transferase 0.0033 0.0126 0.0126
Echinococcus granulosus Excitatory amino acid transporter 0.1318 1 1
Trichomonas vaginalis sucrase-isomaltase, putative 0.004 0.0181 0.1262
Brugia malayi beta-lactamase family protein 0.0078 0.0469 0.0469
Brugia malayi Inositol-1 0.004 0.0181 0.0181
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0078 0.0469 0.0404
Echinococcus granulosus GPCR family 2 0.0032 0.0117 0.0117
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0041 0.0186 0.3072
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.0041 0.0041
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0167 0.1156 0.1095
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0019 0.0016 0.0016
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0041 0.0186 0.3738
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0026 0.0071 0.0071
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.0126 0.1747
Treponema pallidum exodeoxyribonuclease (exoA) 0.0041 0.0186 0.0274
Wolbachia endosymbiont of Brugia malayi Na+/H+-dicarboxylate symporter 0.1318 1 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0041 0.0186 0.0186
Echinococcus granulosus beta LACTamase domain containing family member 0.0078 0.0469 0.0469
Echinococcus multilocularis neutral amino acid transporter A 0.1318 1 1
Giardia lamblia Kinase, PLK 0.0081 0.0497 1
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0131 0.0878 0.0878
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0117 0.0117
Trypanosoma brucei DNA polymerase eta, putative 0.0033 0.0126 0.1747
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0796 0.5991 0.5991
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0039 0.0171 0.0171
Schistosoma mansoni lipoxygenase 0.0131 0.0878 0.0878
Echinococcus multilocularis muscleblind protein 1 0.0128 0.086 0.086
Echinococcus multilocularis excitatory amino acid transporter 2 0.1318 1 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0025 0.0063 0.0063
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0081 0.0497 0.0497
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0081 0.0497 0.0497
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0017 0.0002 0.0002
Brugia malayi Pre-SET motif family protein 0.0026 0.0071 0.0071
Plasmodium vivax hypothetical protein, conserved 0.0078 0.0469 0.166
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.0126 0.1747
Brugia malayi Thioredoxin reductase 0.0073 0.0435 0.0435
Mycobacterium tuberculosis Probable esterase LipL 0.0078 0.0469 0.0404
Echinococcus granulosus dna polymerase kappa 0.0033 0.0126 0.0126
Loa Loa (eye worm) doublecortin family protein 0.0022 0.0041 0.0041
Echinococcus granulosus inositol monophosphatase 1 0.004 0.0181 0.0181
Mycobacterium tuberculosis Conserved protein 0.0078 0.0469 0.0404
Plasmodium falciparum glutathione reductase 0.0073 0.0435 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.004 0.0181 0.0181
Schistosoma mansoni serine/threonine protein kinase 0.0081 0.0497 0.0497
Trichomonas vaginalis D-aminoacylase, putative 0.0078 0.0469 0.3263
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0033 0.0126 0.0879
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.1318 1 1
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0404 0.7927
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0078 0.0469 1
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0025 0.0068 0.0104
Toxoplasma gondii ABC1 family protein 0.0078 0.0469 1
Trypanosoma brucei unspecified product 0.0033 0.0126 0.1747
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0181 0.1262
Echinococcus multilocularis excitatory amino acid transporter 2 0.1318 1 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0167 0.1156 0.1095
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0025 0.0068 0.068
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0026 0.0071 0.0071
Schistosoma mansoni hypothetical protein 0.0032 0.0117 0.0117
Brugia malayi Glycosyl hydrolases family 31 protein 0.004 0.0181 0.0181
Trypanosoma brucei DNA polymerase IV, putative 0.0033 0.0126 0.1747
Schistosoma mansoni hypothetical protein 0.0538 0.4006 0.4006
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0117 0.0117
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.0126 0.1747
Schistosoma mansoni hypothetical protein 0.0032 0.0117 0.0117
Schistosoma mansoni solute carrier family 1 (glial high affinity glutamate transporter 0.1318 1 1
Onchocerca volvulus 0.0026 0.0071 0.0029
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0584 0.4362 0.4362
Trypanosoma brucei hypothetical protein, conserved 0.0078 0.0469 0.9374
Trichomonas vaginalis ap endonuclease, putative 0.0041 0.0186 0.1293
Brugia malayi ImpB/MucB/SamB family protein 0.0033 0.0126 0.0126
Schistosoma mansoni ap endonuclease 0.0041 0.0186 0.0186
Trichomonas vaginalis inositol monophosphatase, putative 0.004 0.0181 0.126
Brugia malayi hypothetical protein 0.0022 0.0041 0.0041
Treponema pallidum glutamate/aspartate transporter 0.0584 0.4362 1
Giardia lamblia DINP protein human, muc B family 0.0033 0.0126 0.1356
Echinococcus granulosus muscleblind protein 0.0128 0.086 0.086
Echinococcus multilocularis lysosomal alpha glucosidase 0.0181 0.1261 0.1261
Echinococcus multilocularis Excitatory amino acid transporter 0.1318 1 1
Loa Loa (eye worm) excitatory amino acid transporter 0.1318 1 1
Schistosoma mansoni inositol monophosphatase 0.004 0.0181 0.0181
Echinococcus multilocularis thioredoxin glutathione reductase 0.0074 0.0439 0.0439
Schistosoma mansoni lipoxygenase 0.0091 0.0576 0.0576
Echinococcus granulosus histone lysine methyltransferase setb 0.0026 0.0071 0.0071
Schistosoma mansoni serine/threonine protein kinase 0.0017 0.0002 0.0002
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0025 0.0068 0.0068
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0117 0.0117
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0179 0.1248 0.1248
Mycobacterium tuberculosis Probable oxidoreductase 0.0185 0.1299 0.1239
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0081 0.0497 0.0497
Echinococcus granulosus excitatory amino acid transporter 2 0.1318 1 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0039 0.0171 0.0171
Entamoeba histolytica hypothetical protein 0.0075 0.0451 0.9077
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0069 0.0404 0.0404
Onchocerca volvulus 0.0104 0.0676 0.0637
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0181 0.126
Loa Loa (eye worm) hypothetical protein 0.0033 0.0126 0.0126
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.0126 0.1747
Schistosoma mansoni inositol monophosphatase 0.004 0.0181 0.0181
Echinococcus multilocularis neutral amino acid transporter A 0.1318 1 1
Schistosoma mansoni microtubule-associated protein tau 0.1177 0.8918 0.8918
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0041 0.0186 0.2743
Trypanosoma cruzi polo-like protein kinase, putative 0.0081 0.0497 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0073 0.0435 0.037
Chlamydia trachomatis glutamate symporter 0.1318 1 1
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0019 0.0016 0.0016
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0167 0.1156 0.8756
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0117 0.0117
Entamoeba histolytica hypothetical protein 0.0075 0.0451 0.9077
Echinococcus granulosus expressed protein 0.0321 0.2338 0.2338
Trichomonas vaginalis ap endonuclease, putative 0.0041 0.0186 0.1293
Trichomonas vaginalis D-aminoacylase, putative 0.0078 0.0469 0.3263
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0185 0.1299 0.1239
Schistosoma mansoni jumonji domain containing protein 0.0051 0.0262 0.0262
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0025 0.0068 0.0068
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0131 0.0878 0.0878
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0181 0.2967
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0181 0.2633
Schistosoma mansoni jumonji/arid domain-containing protein 0.0051 0.0262 0.0262
Mycobacterium leprae conserved hypothetical protein 0.0078 0.0469 0.2785
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0051 0.0262 0.0262
Echinococcus granulosus neutral amino acid transporter A 0.1318 1 1
Schistosoma mansoni hypothetical protein 0.0022 0.0041 0.0041
Schistosoma mansoni loxhd1 0.0022 0.0041 0.0041
Onchocerca volvulus Serine\/threonine kinase homolog 0.0081 0.0497 0.0458
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0181 0.2638
Plasmodium vivax multidrug resistance-associated protein 1, putative 0.0357 0.2617 1
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0584 0.4362 0.4362
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0051 0.0262 0.0262
Mycobacterium ulcerans DNA polymerase IV 0.0033 0.0126 0.1451
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0026 0.0071 0.0071
Trichomonas vaginalis penicillin-binding protein, putative 0.0078 0.0469 0.3263
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0117 0.0117
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0181 0.2633
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0039 0.0171 0.0171
Echinococcus multilocularis microtubule associated protein 2 0.1177 0.8918 0.8918

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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