Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.0321 | 0.0321 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0782 | 0.0782 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0017 | 0.0055 | 0.5 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0023 | 0.0321 | 1 |
Echinococcus multilocularis | geminin | 0.0164 | 0.6792 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0055 | 0.0055 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0055 | 0.0055 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0234 | 1 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0071 | 0.2503 | 0.3685 |
Entamoeba histolytica | hypothetical protein | 0.0071 | 0.2503 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0071 | 0.2503 | 1 |
Echinococcus granulosus | geminin | 0.0164 | 0.6792 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.0321 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.6792 | 1 |
Brugia malayi | hypothetical protein | 0.0071 | 0.2503 | 0.2503 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0321 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0071 | 0.2503 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0048 | 0.1482 | 0.1482 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0023 | 0.0321 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.0321 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0321 | 0.0321 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0023 | 0.0321 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0055 | 0.0055 |
Entamoeba histolytica | hypothetical protein | 0.0071 | 0.2503 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0321 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.6792 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0071 | 0.2503 | 0.3685 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0023 | 0.0321 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0048 | 0.1482 | 0.1482 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0017 | 0.0055 | 0.139 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.0321 | 0.0321 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0048 | 0.1482 | 0.1482 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.1482 | 0.1482 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0017 | 0.0055 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.0782 | 0.0782 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0023 | 0.0321 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0023 | 0.0321 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.0321 | 0.0321 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0023 | 0.0321 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0055 | 0.0055 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0782 | 0.1151 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.0321 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0234 | 1 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0071 | 0.2503 | 0.3685 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0071 | 0.2503 | 0.3685 |
Onchocerca volvulus | 0.0023 | 0.0321 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0321 | 0.0321 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0321 | 1 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0023 | 0.0321 | 1 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0017 | 0.0055 | 0.5 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0023 | 0.0321 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0055 | 0.0055 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0321 | 0.0321 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IZ (functional) | = 16 mm | Antibacterial activity against Escherichia coli at 150 mg/ml after 24 hrs by well diffusion assay | ChEMBL. | 23642965 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.