Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | CMGC family protein kinase | 0.0155 | 1 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0155 | 1 | 0.5 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0155 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0155 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0155 | 1 | 1 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0155 | 1 | 1 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0155 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0016 | 0 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0155 | 1 | 1 |
Trypanosoma brucei | protein kinase, putative | 0.0155 | 1 | 1 |
Echinococcus granulosus | ribosomal protein S6 kinase alpha 3 | 0.0102 | 0.6187 | 0.6187 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0155 | 1 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0016 | 0 | 0.5 |
Brugia malayi | ribosomal protein S6 kinase alpha 3 | 0.0088 | 0.5156 | 0.5156 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0155 | 1 | 1 |
Loa Loa (eye worm) | AGC/RSK/RSK protein kinase | 0.0102 | 0.6187 | 0.6187 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0155 | 1 | 1 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0155 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0155 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0016 | 0 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0155 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0155 | 1 | 1 |
Echinococcus multilocularis | ribosomal protein S6 kinase alpha 3 | 0.0102 | 0.6187 | 0.6187 |
Entamoeba histolytica | protein kinase, putative | 0.0016 | 0 | 0.5 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0155 | 1 | 1 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0155 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0102 | 0.6187 | 0.6187 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0155 | 1 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0155 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Antibacterial activity against Escherichia coli NCTC 8192 assessed as growth inhibition at 1 to 600 ug/mL after 18 hrs by broth microdilution method | ChEMBL. | 23648974 | |
Activity (functional) | Antifungal activity against Candida albicans ATCC 10231 assessed as growth inhibition at 1 to 600 ug/mL after 18 hrs by broth microdilution method | ChEMBL. | 23648974 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.