Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | Pim-2 proto-oncogene, serine/threonine kinase | Starlite/ChEMBL | References |
Homo sapiens | Pim-1 proto-oncogene, serine/threonine kinase | Starlite/ChEMBL | References |
Homo sapiens | Pim-3 proto-oncogene, serine/threonine kinase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | protein lipid droplet kinase (LDK) | Pim-2 proto-oncogene, serine/threonine kinase | 311 aa | 278 aa | 28.8 % |
Trypanosoma brucei | protein lipid droplet kinase (LDK) | Pim-3 proto-oncogene, serine/threonine kinase | 326 aa | 296 aa | 29.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | fructose-2,6-bisphosphatase GpmB | 0.1377 | 0.2852 | 0.5 |
Trypanosoma brucei | 6-phosphofructo-2-kinase 2 | 0.2294 | 0.9706 | 0.9706 |
Giardia lamblia | Hypothetical protein | 0.1377 | 0.2852 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.2333 | 1 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.2294 | 0.9706 | 0.9706 |
Giardia lamblia | Hypothetical protein | 0.1377 | 0.2852 | 0.5 |
Echinococcus multilocularis | 6 phosphofructo 2 kinase:fructose 2 | 0.2333 | 1 | 0.5 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.2294 | 0.9706 | 0.9706 |
Mycobacterium ulcerans | hypothetical protein | 0.1377 | 0.2852 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2333 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2294 | 0.9706 | 0.9604 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.2294 | 0.9706 | 0.9706 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.2333 | 1 | 1 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.2333 | 1 | 1 |
Onchocerca volvulus | 0.2333 | 1 | 0.5 | |
Entamoeba histolytica | phosphoglycerate mutase family protein, putative | 0.1377 | 0.2852 | 0.5 |
Schistosoma mansoni | 6-phosphofructokinase | 0.2333 | 1 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.2333 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 0.007 nM | Inhibition of PIM1 (unknown origin) using FAM-pimtide as substrate after 90 mins by spectrophotometry in presence of ATP | ChEMBL. | 23623490 |
Ki (binding) | = 0.022 nM | Inhibition of PIM3 (unknown origin) using FAM-pimtide as substrate after 90 mins by spectrophotometry in presence of ATP | ChEMBL. | 23623490 |
Ki (binding) | = 0.094 nM | Inhibition of PIM2 (unknown origin) using FAM-pimtide as substrate after 90 mins by spectrophotometry in presence of ATP | ChEMBL. | 23623490 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.