Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | Pim-2 proto-oncogene, serine/threonine kinase | Starlite/ChEMBL | References |
Homo sapiens | Pim-1 proto-oncogene, serine/threonine kinase | Starlite/ChEMBL | References |
Homo sapiens | Pim-3 proto-oncogene, serine/threonine kinase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | protein lipid droplet kinase (LDK) | Pim-2 proto-oncogene, serine/threonine kinase | 311 aa | 278 aa | 28.8 % |
Trypanosoma brucei | protein lipid droplet kinase (LDK) | Pim-3 proto-oncogene, serine/threonine kinase | 326 aa | 296 aa | 29.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | phosphoglycerate mutase family protein, putative | 0.0307 | 0.2852 | 0.5 |
Schistosoma mansoni | 6-phosphofructokinase | 0.052 | 1 | 1 |
Giardia lamblia | Hypothetical protein | 0.0307 | 0.2852 | 0.5 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0512 | 0.9706 | 0.9706 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.0512 | 0.9706 | 0.9706 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.052 | 1 | 1 |
Echinococcus multilocularis | 6 phosphofructo 2 kinase:fructose 2 | 0.052 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.052 | 1 | 1 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.052 | 1 | 1 |
Trypanosoma brucei | 6-phosphofructo-2-kinase 2 | 0.0512 | 0.9706 | 0.9706 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.0512 | 0.9706 | 0.9706 |
Giardia lamblia | Hypothetical protein | 0.0307 | 0.2852 | 0.5 |
Loa Loa (eye worm) | CAMK/PIM protein kinase | 0.0385 | 0.5481 | 0.3929 |
Brugia malayi | Serine/threonine-protein kinase Pim-3 | 0.0385 | 0.5481 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.052 | 1 | 1 |
Mycobacterium ulcerans | fructose-2,6-bisphosphatase GpmB | 0.0307 | 0.2852 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0307 | 0.2852 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0385 | 0.5481 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0512 | 0.9706 | 0.9604 |
Onchocerca volvulus | 0.052 | 1 | 1 | |
Loa Loa (eye worm) | CAMK/PIM protein kinase | 0.0385 | 0.5481 | 0.3929 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.052 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 0.036 nM | Inhibition of PIM1 (unknown origin) using FAM-pimtide as substrate after 90 mins by spectrophotometry in presence of ATP | ChEMBL. | 23623490 |
Ki (binding) | = 0.053 nM | Inhibition of PIM3 (unknown origin) using FAM-pimtide as substrate after 90 mins by spectrophotometry in presence of ATP | ChEMBL. | 23623490 |
Ki (binding) | = 7.8 nM | Inhibition of PIM2 (unknown origin) using FAM-pimtide as substrate after 90 mins by spectrophotometry in presence of ATP | ChEMBL. | 23623490 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.