TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 205.341 | Formula: C8H15NOS2
H donors: 1 H acceptors: 1 LogP: 3.29 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: S=C=NCCCC[S+](C(C)C)[O-]
InChi: 1S/C8H15NOS2/c1-8(2)12(10)6-4-3-5-9-7-11/h8H,3-6H2,1-2H3
InChiKey: BAXOKRWCEZXWMX-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma brucei	Histidine phosphatase superfamily (branch 1), putative	0.0055	0.0127	0.0108
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0048	0.0107	0.0107
Loa Loa (eye worm)	hypothetical protein	0.005	0.0111	0.0111
Plasmodium vivax	phosphoglucomutase-2, putative	0.0055	0.0127	1
Schistosoma mansoni	transcription factor LCR-F1	0.0022	0.0025	0.0025
Trypanosoma cruzi	PAB1-binding protein , putative	0.0031	0.0053	0.0034
Treponema pallidum	phosphoglyceromutase	0.0055	0.0127	0.5
Leishmania major	glycerolphosphate mutase, putative	0.0055	0.0127	0.0108
Trypanosoma cruzi	6-phosphofructo-2-kinase 1	0.3185	0.983	0.983
Echinococcus multilocularis	phosphoglycerate mutase	0.0055	0.0127	0.0127
Mycobacterium leprae	PROBABLE PHOSPHOGLYCERATE MUTASE 1 GPM1 (PHOSPHOGLYCEROMUTASE) (PGAM) (BPG-DEPENDENT PGAM)	0.0055	0.0127	0.5
Leishmania major	phosphoglycerate mutase family member 5, putative	0.0055	0.0127	0.0108
Mycobacterium tuberculosis	Conserved protein	0.0055	0.0127	1
Leishmania major	hypothetical protein, conserved	0.0055	0.0127	0.0108
Brugia malayi	hypothetical protein	0.002	0.0019	0.0145
Trypanosoma cruzi	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatas, putative	0.0055	0.0127	0.0108
Leishmania major	hypothetical protein, conserved	0.0055	0.0127	0.0108
Schistosoma mansoni	jumonji domain containing protein	0.0036	0.0068	0.0068
Mycobacterium leprae	POSSIBLE HYDROLASE MUTT1	0.0055	0.0127	0.5
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0045	0.0098	0.7716
Trypanosoma cruzi	Histidine phosphatase superfamily (branch 1), putative	0.0055	0.0127	0.0108
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0241	0.0241
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0018	0.0012	0.0012
Plasmodium vivax	ataxin-2 like protein, putative	0.0031	0.0053	0.3111
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0086	0.0224	0.0224
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0048	0.0107	0.0807
Echinococcus granulosus	serine:threonine protein phosphatase PGAM5	0.0055	0.0127	0.0127
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0499	0.1505	0.1505
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0127	0.0127
Toxoplasma gondii	phosphoglycerate mutase family protein	0.0055	0.0127	0.0715
Mycobacterium ulcerans	fructose-2,6-bisphosphatase GpmB	0.1912	0.5884	1
Brugia malayi	phosphoglycerate mutase family protein	0.0055	0.0127	0.096
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0086	0.0224	0.0224
Schistosoma mansoni	hypothetical protein	0.0107	0.0289	0.0289
Trypanosoma cruzi	phosphoglycerate mutase, putative	0.0055	0.0127	0.0108
Toxoplasma gondii	phosphoglycerate mutase PGMII	0.0055	0.0127	0.0715
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0022	0.0025	0.0025
Giardia lamblia	Hypothetical protein	0.1912	0.5884	0.5
Loa Loa (eye worm)	angiotensin-converting enzyme family protein	0.0441	0.1326	0.1326
Loa Loa (eye worm)	transcription factor SMAD2	0.0074	0.0186	0.0186
Brugia malayi	isocitrate dehydrogenase	0.002	0.002	0.0147
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0053	0.0053
Schistosoma mansoni	hypothetical protein	0.0055	0.0127	0.0127
Loa Loa (eye worm)	hypothetical protein	0.0243	0.0712	0.0712
Brugia malayi	hypothetical protein	0.0031	0.0053	0.04
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.005	0.0111	0.0111
Plasmodium falciparum	ataxin-2 like protein, putative	0.0031	0.0053	0.3111
Entamoeba histolytica	phosphoglycerate mutase family protein, putative	0.1912	0.5884	1
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0036	0.0068	0.0068
Trypanosoma cruzi	Histidine phosphatase superfamily (branch 1), putative	0.0055	0.0127	0.0108
Loa Loa (eye worm)	phosphoglycerate mutase	0.0055	0.0127	0.0127
Trypanosoma cruzi	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.1382	0.4243	0.4232
Echinococcus granulosus	phosphoglycerate mutase	0.0055	0.0127	0.0127
Trichomonas vaginalis	phosphoglycerate mutase, putative	0.0055	0.0127	1
Echinococcus granulosus	phosphoglycerate mutase	0.0055	0.0127	0.0127
Mycobacterium tuberculosis	Glucosyl-3-phosphoglycerate phosphatase GpgP	0.0055	0.0127	1
Echinococcus granulosus	microsomal glutathione S transferase 3	0.0506	0.1525	0.1525
Entamoeba histolytica	phosphoglycerate mutase family protein, putative	0.0055	0.0127	0.0174
Echinococcus multilocularis	phosphoglycerate mutase	0.0055	0.0127	0.0127
Trypanosoma cruzi	phosphoglycerate mutase family member 5, putative	0.0055	0.0127	0.0108
Mycobacterium tuberculosis	Possible phosphoglycerate mutase Gpm2 (phosphoglyceromutase) (PGAM) (BPG-dependent PGAM)	0.0055	0.0127	1
Toxoplasma gondii	phosphoglycerate mutase	0.0055	0.0127	0.0715
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.002	0.002	0.002
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0086	0.0224	0.0224
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0018	0.0012	0.0092
Schistosoma mansoni	hypothetical protein	0.0055	0.0127	0.0127
Leishmania major	hypothetical protein, unknown function	0.0055	0.0127	0.0108
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.002	0.002	0.002
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0086	0.0224	0.0224
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.005	0.0111	0.0839
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0036	0.0068	0.0068
Echinococcus multilocularis	geminin	0.0318	0.0944	0.0944
Loa Loa (eye worm)	MH2 domain-containing protein	0.0074	0.0186	0.0186
Leishmania major	phosphoglycerate mutase, putative	0.0055	0.0127	0.0108
Giardia lamblia	Hypothetical protein	0.1912	0.5884	0.5
Trypanosoma cruzi	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatas, putative	0.0055	0.0127	0.0108
Schistosoma mansoni	voltage-gated potassium channel	0.0018	0.0012	0.0012
Echinococcus granulosus	neuropeptide receptor A26	0.1173	0.3593	0.3593
Trypanosoma brucei	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatas, putative	0.0055	0.0127	0.0108
Echinococcus multilocularis	lysine specific demethylase 5A	0.0036	0.0068	0.0068
Schistosoma mansoni	hypothetical protein	0.005	0.0111	0.0111
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0086	0.0224	0.0224
Plasmodium falciparum	phosphoglycerate mutase, putative	0.0055	0.0127	1
Trypanosoma cruzi	glycerolphosphate mutase, putative	0.0055	0.0127	0.0108
Mycobacterium leprae	conserved hypothetical protein	0.0055	0.0127	0.5
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0157	0.0443	0.0443
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.002	0.002	0.002
Loa Loa (eye worm)	latrophilin receptor protein 2	0.005	0.0111	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0012	0.0012
Trypanosoma brucei	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.1382	0.4243	0.4232
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0127	0.0127
Trypanosoma cruzi	PAB1-binding protein , putative	0.0031	0.0053	0.0034
Leishmania major	hypothetical protein, conserved	0.0031	0.0053	0.0034
Brugia malayi	N-terminal motif family protein	0.0243	0.0712	0.5365
Schistosoma mansoni	hypothetical protein	0.0055	0.0127	0.0127
Echinococcus granulosus	serine:threonine protein phosphatase PGAM5	0.0055	0.0127	0.0127
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.005	0.0111	0.0111
Trypanosoma cruzi	phosphoglycerate mutase protein, putative	0.0055	0.0127	0.0108
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0243	0.0712	0.0592
Leishmania major	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-1-like protein	0.1382	0.4243	0.4232
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0045	0.0098	0.7716
Trypanosoma cruzi	Histidine phosphatase superfamily (branch 1), putative	0.0055	0.0127	0.0108
Plasmodium falciparum	phosphoglucomutase-2	0.0055	0.0127	1
Echinococcus granulosus	GPCR family 2	0.005	0.0111	0.0111
Mycobacterium leprae	conserved hypothetical protein	0.0055	0.0127	0.5
Mycobacterium ulcerans	hypothetical protein	0.1912	0.5884	1
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0086	0.0224	0.1689
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0055	0.0127	1
Trypanosoma brucei	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.324	1	1
Echinococcus multilocularis	isocitrate dehydrogenase	0.002	0.002	0.002
Trypanosoma cruzi	Histidine phosphatase superfamily (branch 1), putative	0.0055	0.0127	0.0108
Trichomonas vaginalis	conserved hypothetical protein	0.0055	0.0127	1
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0048	0.0107	0.0107
Trypanosoma cruzi	6-phosphofructo-2-kinase 1	0.3185	0.983	0.983
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0127	0.0127
Schistosoma mansoni	hypothetical protein	0.005	0.0111	0.0111
Echinococcus multilocularis	phosphoglycerate mutase	0.0055	0.0127	0.0127
Mycobacterium leprae	probable isochorismate synthase EntC	0.0055	0.0127	0.5
Schistosoma mansoni	hypothetical protein	0.0022	0.0025	0.0025
Leishmania major	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.3185	0.983	0.983
Leishmania major	phosphoglycerate mutase protein, putative	0.0055	0.0127	0.0108
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0086	0.0224	0.0224
Onchocerca volvulus		0.0091	0.0241	0.0115
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0048	0.0107	0.0107
Entamoeba histolytica	phosphoglycerate mutase family protein, putative	0.0055	0.0127	0.0174
Echinococcus granulosus	neuropeptide s receptor	0.1173	0.3593	0.3593
Trypanosoma cruzi	phosphoglycerate mutase protein, putative	0.0055	0.0127	0.0108
Trypanosoma cruzi	phosphoglycerate mutase family member 5, putative	0.0055	0.0127	0.0108
Mycobacterium tuberculosis	Probable conserved lipoprotein LpqD	0.0055	0.0127	1
Trypanosoma brucei	Serine/threonine-protein phosphatase PGAM5, mitochondrial, putative	0.0055	0.0127	0.0108
Chlamydia trachomatis	2,3-bisphosphoglycerate-dependent phosphoglycerate mutase	0.0055	0.0127	0.5
Mycobacterium leprae	Probable phosphoglycerate mutase (phosphoglyceromutase) (phosphoglycerate phosphomutase)	0.0055	0.0127	0.5
Brugia malayi	Isocitrate dehydrogenase	0.002	0.002	0.0147
Echinococcus multilocularis	GPCR, family 2	0.005	0.0111	0.0111
Mycobacterium leprae	PROBABLE PHOSPHOGLYCERATE MUTASE (PHOSPHOGLYCEROMUTASE)	0.0055	0.0127	0.5
Loa Loa (eye worm)	isocitrate dehydrogenase	0.002	0.002	0.002
Toxoplasma gondii	phosphoglycerate mutase family protein	0.0055	0.0127	0.0715
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0018	0.0012	0.0012
Echinococcus multilocularis	neuropeptide receptor A26	0.1173	0.3593	0.3593
Trypanosoma brucei	6-phosphofructo-2-kinase 2	0.3185	0.983	0.983
Trypanosoma brucei	PAB1-binding protein , putative	0.0031	0.0053	0.0034
Trichomonas vaginalis	phosphoglycerate mutase, putative	0.0055	0.0127	1
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.005	0.0111	0.0111
Loa Loa (eye worm)	hypothetical protein	0.1857	0.5715	0.5715
Brugia malayi	Angiotensin-converting enzyme family protein	0.0441	0.1326	1
Schistosoma mansoni	hypothetical protein	0.005	0.0111	0.0111
Brugia malayi	MH2 domain containing protein	0.0074	0.0186	0.1399
Mycobacterium leprae	Possible phosphoglycerate mutase	0.0055	0.0127	0.5
Loa Loa (eye worm)	hypothetical protein	0.0107	0.0289	0.0289
Toxoplasma gondii	LsmAD domain-containing protein	0.0031	0.0053	0.0223
Brugia malayi	hypothetical protein	0.0091	0.0241	0.1816
Trypanosoma brucei	phosphoglycerate mutase, putative	0.0055	0.0127	0.0108
Brugia malayi	jmjC domain containing protein	0.0036	0.0068	0.0512
Echinococcus multilocularis	serine:threonine protein phosphatase PGAM5	0.0055	0.0127	0.0127
Trypanosoma cruzi	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.324	1	1
Schistosoma mansoni	phosphoglycerate mutase	0.0055	0.0127	0.0127
Mycobacterium leprae	conserved hypothetical protein	0.0055	0.0127	0.5
Echinococcus multilocularis	voltage gated potassium channel	0.0018	0.0012	0.0012
Loa Loa (eye worm)	jmjC domain-containing protein	0.0036	0.0068	0.0068
Brugia malayi	UBASH3A protein homolog	0.0055	0.0127	0.096
Trypanosoma brucei	phosphoglycerate mutase protein, putative	0.0055	0.0127	0.0108
Entamoeba histolytica	phosphoglycerate mutase family protein. putative	0.0055	0.0127	0.0174
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0036	0.0068	0.0068
Brugia malayi	latrophilin 2 splice variant baaae	0.0107	0.0289	0.2182
Trypanosoma cruzi	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.324	1	1
Brugia malayi	hypothetical protein	0.0022	0.0025	0.0189
Echinococcus multilocularis	serine:threonine protein phosphatase PGAM5	0.0055	0.0127	0.0127
Schistosoma mansoni	microsomal glutathione s-transferase	0.0506	0.1525	0.1525
Loa Loa (eye worm)	hypothetical protein	0.0157	0.0443	0.0443
Echinococcus granulosus	lysine specific demethylase 5A	0.0036	0.0068	0.0068
Trichomonas vaginalis	phosphoglycerate mutase, putative	0.0055	0.0127	1
Leishmania major	fructose-6-phosphate2-kinase/fructose-2,6-bisph os phatase-likeprotein	0.0055	0.0127	0.0108
Echinococcus multilocularis	neuropeptide s receptor	0.1173	0.3593	0.3593
Echinococcus granulosus	phosphoglycerate mutase	0.0055	0.0127	0.0127
Schistosoma mansoni	hypothetical protein	0.005	0.0111	0.0111
Schistosoma mansoni	phosphoglycerate mutase	0.0055	0.0127	0.0127
Trypanosoma cruzi	glycerolphosphate mutase, putative	0.0055	0.0127	0.0108
Schistosoma mansoni	hypothetical protein	0.0318	0.0944	0.0944
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0157	0.0443	0.334
Onchocerca volvulus		0.324	1	1
Echinococcus granulosus	phosphoglycerate mutase	0.0055	0.0127	0.0127
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.002	0.002	0.002
Echinococcus multilocularis	phosphoglycerate mutase	0.0055	0.0127	0.0127
Trichomonas vaginalis	phosphoglycerate mutase, putative	0.0055	0.0127	1
Leishmania major	hypothetical protein, conserved	0.0055	0.0127	0.0108
Brugia malayi	Latrophilin receptor protein 2	0.005	0.0111	0.0839
Schistosoma mansoni	voltage-gated potassium channel	0.0052	0.0119	0.0119
Schistosoma mansoni	hypothetical protein	0.0055	0.0127	0.0127
Trichomonas vaginalis	phosphoglycerate mutase, putative	0.0055	0.0127	1
Mycobacterium tuberculosis	PE-PGRS family protein PE_PGRS11	0.0055	0.0127	1
Toxoplasma gondii	phosphoglycerate mutase family protein	0.0055	0.0127	0.0715
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0036	0.0068	0.0068
Echinococcus multilocularis	phosphoglycerate mutase	0.0055	0.0127	0.0127
Toxoplasma gondii	phosphoglycerate mutase family protein	0.0055	0.0127	0.0715
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.002	0.002	0.002
Schistosoma mansoni	hypothetical protein	0.0055	0.0127	0.0127
Mycobacterium tuberculosis	Conserved protein	0.0055	0.0127	1
Echinococcus multilocularis	phosphoglycerate mutase	0.0055	0.0127	0.0127
Brugia malayi	phosphoglycerate mutase family protein	0.0055	0.0127	0.096
Trypanosoma cruzi	Histidine phosphatase superfamily (branch 1), putative	0.0055	0.0127	0.0108
Schistosoma mansoni	membrane associated proteins in eicosanoid and glutathione metabolism family member	0.2207	0.6798	0.6798
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0073	0.0073
Leishmania major	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.324	1	1
Trypanosoma brucei	Histidine phosphatase superfamily (branch 1), putative	0.0055	0.0127	0.0108
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0086	0.0224	0.0224
Plasmodium vivax	phosphoglycerate mutase, putative	0.0055	0.0127	1
Echinococcus granulosus	voltage gated potassium channel	0.0018	0.0012	0.0012
Trypanosoma cruzi	phosphoglycerate mutase, putative	0.0055	0.0127	0.0108
Loa Loa (eye worm)	hypothetical protein	0.324	1	1
Mycobacterium tuberculosis	Possible hydrolase MutT1	0.0055	0.0127	1
Schistosoma mansoni	6-phosphofructokinase	0.324	1	1
Trypanosoma brucei	glycerolphosphate mutase, putative	0.0055	0.0127	0.0108
Schistosoma mansoni	hypothetical protein	0.0318	0.0944	0.0944
Echinococcus granulosus	geminin	0.0318	0.0944	0.0944
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0157	0.0443	0.334
Trichomonas vaginalis	conserved hypothetical protein	0.0055	0.0127	1
Echinococcus multilocularis	6 phosphofructo 2 kinase:fructose 2	0.324	1	1
Mycobacterium tuberculosis	Probable phosphoglycerate mutase (phosphoglyceromutase) (phosphoglycerate phosphomutase)	0.0055	0.0127	1
Schistosoma mansoni	voltage-gated potassium channel	0.0052	0.0119	0.0119
Echinococcus multilocularis	microsomal glutathione S transferase 3	0.0506	0.1525	0.1525
Schistosoma mansoni	hypothetical protein	0.0055	0.0127	0.0127
Plasmodium falciparum	ataxin-2 like protein, putative	0.0031	0.0053	0.3111
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.002	0.002	0.002
Loa Loa (eye worm)	hypothetical protein	0.3185	0.983	0.983
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0086	0.0224	0.0224
Toxoplasma gondii	MAPEG family protein	0.0506	0.1525	1
Echinococcus granulosus	phosphoglycerate mutase	0.0055	0.0127	0.0127
Brugia malayi	jmjC domain containing protein	0.0036	0.0068	0.0512
Trypanosoma cruzi	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.1382	0.4243	0.4232
Schistosoma mansoni	voltage-gated potassium channel	0.0018	0.0012	0.0012
Trypanosoma brucei	Histidine phosphatase superfamily (branch 1), putative	0.0055	0.0127	0.0108
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0022	0.0025	0.0025
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.005	0.0111	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0127	0.0127

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 3.74 uM	Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay	ChEMBL.	23685571

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23	23685571

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2391457

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1776655