Detailed information for compound 1776710

Basic information

Technical information
  • TDR Targets ID: 1776710
  • Name: ethyl 5-[(4-chloro-3-nitrobenzoyl)amino]-4-cy ano-3-methylthiophene-2-carboxylate
  • MW: 393.802 | Formula: C16H12ClN3O5S
  • H donors: 1 H acceptors: 5 LogP: 4.42 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)c1sc(c(c1C)C#N)NC(=O)c1ccc(c(c1)[N+](=O)[O-])Cl
  • InChi: 1S/C16H12ClN3O5S/c1-3-25-16(22)13-8(2)10(7-18)15(26-13)19-14(21)9-4-5-11(17)12(6-9)20(23)24/h4-6H,3H2,1-2H3,(H,19,21)
  • InChiKey: DWPRWCSXSQQBHP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ethyl 5-[(4-chloro-3-nitro-benzoyl)amino]-4-cyano-3-methyl-thiophene-2-carboxylate
  • 5-[[(4-chloro-3-nitrophenyl)-oxomethyl]amino]-4-cyano-3-methyl-2-thiophenecarboxylic acid ethyl ester
  • 5-[(4-chloro-3-nitro-benzoyl)amino]-4-cyano-3-methyl-thiophene-2-carboxylic acid ethyl ester
  • ethyl 5-[(4-chloro-3-nitro-phenyl)carbonylamino]-4-cyano-3-methyl-thiophene-2-carboxylate
  • IVK/8065443
  • ZINC01965039
  • AK-968/12117046

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0094 0.1102 0.2534
Echinococcus granulosus potassium voltage gated channel protein 0.0014 0.0002 0.0002
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0025 0.0151 0.3154
Echinococcus granulosus Smad4 0.0031 0.0233 0.0233
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0014 0.0002 0.0002
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0303 0.399 0.9184
Plasmodium vivax SET domain protein, putative 0.0035 0.0299 0.4009
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0014 0.0002 0.0002
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0113 0.1366 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0004
Schistosoma mansoni retinoic acid receptor RXR 0.0027 0.019 0.019
Toxoplasma gondii histone lysine methyltransferase SET1 0.01 0.1185 1
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0014 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0014 0.0012 0.002
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0027 0.0181 0.3912
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0027 0.019 0.019
Mycobacterium ulcerans acyl-CoA synthetase 0.0017 0.0048 0.0108
Leishmania major cathepsin L-like protease 0.0025 0.0151 0.0342
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0027 0.019 0.0318
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0101 0.121 0.8817
Loa Loa (eye worm) hypothetical protein 0.0017 0.0048 0.008
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0151 0.0372
Toxoplasma gondii ABC1 family protein 0.0065 0.0709 0.5976
Echinococcus granulosus beta LACTamase domain containing family member 0.0065 0.0709 0.0709
Echinococcus granulosus mixed lineage leukemia protein mll 0.0014 0.0007 0.0007
Schistosoma mansoni eyes absent homolog 0.0066 0.0718 0.0718
Trichomonas vaginalis D-aminoacylase, putative 0.0065 0.0709 0.1772
Schistosoma mansoni hypothetical protein 0.0031 0.0236 0.0236
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0004
Loa Loa (eye worm) MH2 domain-containing protein 0.0448 0.5984 1
Onchocerca volvulus 0.0052 0.0527 0.0981
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0081 0.0107
Loa Loa (eye worm) hypothetical protein 0.0014 0.0012 0.002
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0151 0.0372
Plasmodium falciparum cysteine proteinase falcipain 3 0.0025 0.0151 0.3154
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0041 0.0376 0.5144
Onchocerca volvulus Bile acid receptor homolog 0.0027 0.019 0.0354
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.0014 0.0002 0.0004
Mycobacterium tuberculosis Conserved protein 0.0065 0.0709 0.1241
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0035 0.0299 0.0299
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0139 0.0314
Loa Loa (eye worm) hypothetical protein 0.0035 0.0299 0.0499
Trypanosoma cruzi cruzipain precursor, putative 0.0094 0.1102 0.2534
Brugia malayi Pre-SET motif family protein 0.0239 0.3112 0.5201
Brugia malayi Pre-SET motif family protein 0.0035 0.0299 0.0499
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0014 0.0002 0.0004
Brugia malayi Cyclic-nucleotide gated cation channel 0.0014 0.0002 0.0004
Brugia malayi Cathepsin L-like precursor 0.0016 0.0039 0.0065
Echinococcus multilocularis cathepsin L cysteine protease 0.0025 0.0151 0.0151
Mycobacterium leprae Probable lipase LipE 0.0065 0.0709 0.5014
Loa Loa (eye worm) ion channel NompC 0.0014 0.0002 0.0004
Echinococcus multilocularis potassium voltage gated channel protein 0.0014 0.0002 0.0002
Leishmania major DNA polymerase eta, putative 0.002 0.0081 0.0181
Onchocerca volvulus 0.0052 0.0527 0.098
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0014 0.0002 0.0002
Echinococcus granulosus transient receptor potential cation channel 0.0014 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0004
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.0014 0.0002 0.0002
Mycobacterium tuberculosis Probable lipase LipD 0.0065 0.0709 0.1241
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0065 0.0709 0.1241
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0027 0.019 0.019
Loa Loa (eye worm) voltage-gated potassium channel 0.0014 0.0002 0.0004
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0015 0.0024 0.0041
Brugia malayi Steroid receptor seven-up type 2 0.0027 0.019 0.0318
Brugia malayi Cathepsin L-like cysteine proteinase 0.0016 0.0039 0.0065
Brugia malayi nuclear hormone receptor 0.0027 0.019 0.0318
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0025 0.0151 0.0372
Plasmodium vivax hypothetical protein, conserved 0.0065 0.0709 1
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0015 0.0024 0.0051
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0239 0.3112 0.5201
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0065 0.0709 0.0709
Echinococcus multilocularis dna polymerase kappa 0.002 0.0081 0.0081
Schistosoma mansoni calcium-activated potassium channel 0.0014 0.0002 0.0002
Echinococcus multilocularis short transient receptor potential channel 6 0.0014 0.0002 0.0002
Schistosoma mansoni voltage-gated potassium channel 0.0014 0.0002 0.0002
Echinococcus multilocularis short transient receptor potential channel 6 0.0014 0.0002 0.0002
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0113 0.1366 0.2432
Loa Loa (eye worm) hypothetical protein 0.0016 0.0039 0.0065
Onchocerca volvulus Cathepsin L homolog 0.0025 0.0151 0.028
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0086 0.0991 0.2276
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0191 0.245 0.245
Loa Loa (eye worm) thioredoxin reductase 0.0044 0.0425 0.071
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0014 0.0002 0.0002
Mycobacterium ulcerans hypothetical protein 0.0065 0.0709 0.3147
Echinococcus granulosus geminin 0.0629 0.8475 0.8475
Schistosoma mansoni hypothetical protein 0.0629 0.8475 0.8475
Echinococcus granulosus voltage gated potassium channel 0.0014 0.0002 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0027 0.019 0.0318
Echinococcus multilocularis transient receptor potential cation channel 0.0014 0.0002 0.0002
Plasmodium falciparum glutathione reductase 0.0044 0.0425 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0025 0.0151 0.0151
Schistosoma mansoni voltage-gated potassium channel 0.0014 0.0002 0.0002
Echinococcus multilocularis potassium voltage gated channel protein 0.0014 0.0002 0.0002
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0065 0.0709 0.1185
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.0266 0.0266
Echinococcus multilocularis transient receptor potential cation channel 0.0014 0.0002 0.0002
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0025 0.0157 0.0157
Echinococcus granulosus thioredoxin glutathione reductase 0.0044 0.0425 0.0425
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0081 0.026
Trichomonas vaginalis mercuric reductase, putative 0.0015 0.0024 0.0055
Echinococcus granulosus TRP transient receptor potential channel 0.0014 0.0002 0.0002
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0014 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0027 0.019 0.0318
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0081 0.0181
Echinococcus granulosus dna polymerase kappa 0.002 0.0081 0.0081
Loa Loa (eye worm) Smad1 0.0031 0.0233 0.0389
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0094 0.1102 0.2534
Mycobacterium ulcerans esterase/lipase LipP 0.0065 0.0709 0.3147
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0014 0.0002 0.0004
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0094 0.1102 0.2534
Brugia malayi Cathepsin L-like precursor 0.0025 0.0151 0.0252
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0094 0.1102 0.2534
Brugia malayi CXXC zinc finger family protein 0.0052 0.0527 0.0881
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0014 0.0007 0.0007
Schistosoma mansoni cpg binding protein 0.0055 0.0568 0.0568
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0095 0.1124 0.1879
Toxoplasma gondii NADPH-glutathione reductase 0.0015 0.0024 0.0187
Echinococcus multilocularis voltage dependent calcium channel 0.0014 0.0002 0.0002
Echinococcus multilocularis Smad4 0.0031 0.0233 0.0233
Entamoeba histolytica hypothetical protein 0.0032 0.0259 0.0558
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0014 0.0002 0.0004
Echinococcus granulosus short transient receptor potential channel 6 0.0014 0.0002 0.0002
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0014 0.0002 0.0004
Schistosoma mansoni DNA polymerase eta 0.002 0.0081 0.0081
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0025 0.0151 0.0372
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0151 0.0372
Mycobacterium ulcerans lipase LipD 0.0065 0.0709 0.3147
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0014 0.0008 0.0014
Onchocerca volvulus 0.0065 0.0709 0.1319
Loa Loa (eye worm) ctsf protein 0.0025 0.0151 0.0252
Echinococcus multilocularis voltage gated hydrogen channel 1 0.0014 0.0002 0.0002
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0094 0.1102 0.2534
Trichomonas vaginalis ap endonuclease, putative 0.0041 0.0376 0.0938
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0041 0.0376 1
Schistosoma mansoni coup transcription factor 0.0027 0.019 0.019
Echinococcus multilocularis ryanodine receptor 44f 0.0014 0.0002 0.0002
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0031 0.0233 0.0233
Echinococcus multilocularis GPCR, family 2 0.0014 0.0008 0.0008
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0027 0.019 0.0318
Plasmodium vivax vivapain-2 0.0025 0.0151 0.1846
Trypanosoma brucei hypothetical protein, conserved 0.0065 0.0709 0.1627
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0065 0.0709 0.1241
Echinococcus multilocularis mothers against decapentaplegic 5 0.0031 0.0233 0.0233
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0081 0.0197
Loa Loa (eye worm) hypothetical protein 0.0017 0.0045 0.0075
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0004
Trichomonas vaginalis penicillin-binding protein, putative 0.0065 0.0709 0.1772
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0025 0.0151 0.0372
Schistosoma mansoni transcription factor LCR-F1 0.0032 0.0259 0.0259
Echinococcus granulosus survival motor neuron protein 1 0.0271 0.3544 0.3544
Trypanosoma cruzi cysteine peptidase, putative 0.0094 0.1102 0.2534
Brugia malayi Nuclear hormone receptor-like 1 0.0014 0.0012 0.002
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0014 0.0002 0.0002
Schistosoma mansoni two-pore calcium channel 0.0014 0.0002 0.0002
Onchocerca volvulus 0.0025 0.0151 0.028
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0065 0.0709 0.1185
Schistosoma mansoni voltage-gated potassium channel 0.0014 0.0002 0.0002
Echinococcus multilocularis potassium large conductance calcium activated 0.0014 0.0002 0.0002
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0299 0.0299
Echinococcus granulosus mothers against decapentaplegic 5 0.0031 0.0233 0.0233
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0014 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0147 0.1834 0.3065
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0329 0.4344 1
Entamoeba histolytica cysteine protease, putative 0.0025 0.0151 0.0283
Schistosoma mansoni lamin 0.0052 0.0527 0.0527
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0004
Schistosoma mansoni voltage-gated potassium channel 0.0014 0.0002 0.0002
Echinococcus multilocularis thioredoxin glutathione reductase 0.0044 0.0425 0.0425
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0156 0.1957 0.4502
Plasmodium vivax vivapain-2 0.0025 0.0151 0.1846
Schistosoma mansoni voltage-gated potassium channel 0.0014 0.0002 0.0002
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0081 0.0102
Loa Loa (eye worm) hypothetical protein 0.0017 0.0048 0.008
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0081 0.0181
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0039 0.0091
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0039 0.0091
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0081 0.0181
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0027 0.019 0.0318
Onchocerca volvulus Cathepsin L homolog 0.0025 0.0151 0.028
Loa Loa (eye worm) hypothetical protein 0.0016 0.0039 0.0065
Brugia malayi beta-lactamase family protein 0.0065 0.0709 0.1185
Brugia malayi MH1 domain containing protein 0.0031 0.0233 0.0389
Onchocerca volvulus Cathepsin F homolog 0.0025 0.0151 0.028
Echinococcus multilocularis sodium channel protein 0.0213 0.2754 0.2754
Loa Loa (eye worm) hypothetical protein 0.0065 0.0709 0.1185
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0081 0.0181
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0041 0.0376 0.0888
Brugia malayi Transient-receptor-potential like protein 0.0014 0.0002 0.0004
Echinococcus granulosus sodium channel protein 0.0213 0.2754 0.2754
Loa Loa (eye worm) voltage-gated potassium channel 0.0014 0.0002 0.0004
Echinococcus multilocularis ecdysone induced protein 78C 0.0027 0.019 0.019
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0156 0.1957 0.4502
Schistosoma mansoni RAR-like nuclear receptor 0.0027 0.019 0.019
Mycobacterium tuberculosis Probable oxidoreductase 0.0113 0.1366 0.2432
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0191 0.245 0.245
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0076 0.0854 0.2063
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0014 0.0002 0.0002
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0151 0.0372
Onchocerca volvulus 0.0025 0.0151 0.028
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0303 0.399 0.9184
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0025 0.0157 0.0157
Onchocerca volvulus 0.0035 0.0299 0.0556
Entamoeba histolytica hypothetical protein 0.0032 0.0259 0.0558
Schistosoma mansoni transient receptor potential channel 0.0014 0.0002 0.0002
Schistosoma mansoni voltage-gated potassium channel 0.0014 0.0002 0.0002
Onchocerca volvulus 0.0027 0.019 0.0354
Schistosoma mansoni transient receptor potential channel 0.0014 0.0002 0.0002
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0081 0.0135
Brugia malayi Smad1 0.0031 0.0233 0.0389
Echinococcus granulosus lamin 0.0052 0.0527 0.0527
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0081 0.0081
Schistosoma mansoni 60S ribosomal protein L21 0.0014 0.0002 0.0002
Onchocerca volvulus 0.0017 0.0048 0.0089
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0094 0.1102 0.2534
Echinococcus granulosus voltage dependent calcium channel 0.0014 0.0002 0.0002
Echinococcus granulosus smad 0.0031 0.0233 0.0233
Schistosoma mansoni cpg binding protein 0.0052 0.0527 0.0527
Leishmania major trypanothione reductase 0.0044 0.0425 0.0973
Loa Loa (eye worm) hypothetical protein 0.0025 0.0157 0.0262
Leishmania major 4-coumarate:coa ligase-like protein 0.0017 0.0048 0.0105
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0081 0.0181
Loa Loa (eye worm) hypothetical protein 0.0016 0.0039 0.0065
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0025 0.0151 0.0372
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0046 0.0449 0.1029
Echinococcus granulosus voltage dependent calcium channel 0.0014 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0004
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0014 0.0002 0.0002
Echinococcus multilocularis potassium voltage gated channel protein 0.0014 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0014 0.0008 0.0014
Trypanosoma cruzi cysteine peptidase, putative 0.0025 0.0151 0.0342
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0303 0.399 0.9184
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0041 0.0376 0.0855
Schistosoma mansoni thyroid hormone receptor 0.0027 0.019 0.019
Schistosoma mansoni Smad4 0.0031 0.0233 0.0233
Leishmania major cysteine peptidase A (CPA) 0.0025 0.0151 0.0342
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0027 0.019 0.019
Brugia malayi hypothetical protein 0.0015 0.0023 0.0038
Schistosoma mansoni voltage-gated potassium channel 0.0014 0.0002 0.0002
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0041 0.0376 0.0862
Trypanosoma brucei unspecified product 0.002 0.0081 0.0181
Loa Loa (eye worm) nuclear factor I 0.0017 0.0045 0.0075
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0027 0.019 0.019
Loa Loa (eye worm) cysteine protease 0.0025 0.0151 0.0252
Onchocerca volvulus Protein ultraspiracle homolog 0.0027 0.019 0.0354
Leishmania major hypothetical protein, conserved 0.0024 0.0139 0.0314
Schistosoma mansoni ap endonuclease 0.0041 0.0376 0.0376
Echinococcus multilocularis ATP dependent DNA helicase PIF1 0.0303 0.399 0.399
Mycobacterium tuberculosis Probable reductase 0.0101 0.121 0.2149
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0027 0.0181 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0191 0.245 0.4095
Onchocerca volvulus 0.0065 0.0709 0.1319
Echinococcus multilocularis cysteine protease 0.0025 0.0151 0.0151
Onchocerca volvulus 0.0045 0.0427 0.0794
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0017 0.0048 0.0042
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0027 0.019 0.0318
Toxoplasma gondii thioredoxin reductase 0.0044 0.0425 0.3574
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0299 0.0299
Leishmania major hypothetical protein, conserved 0.0065 0.0709 0.1627
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0076 0.0854 0.1427
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.0014 0.0002 0.0004
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0032 0.0259 0.0259
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0027 0.019 0.0318
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0101 0.121 0.2149
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0014 0.0002 0.0002
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0094 0.1102 0.2534
Loa Loa (eye worm) hypothetical protein 0.0095 0.1124 0.1879
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0024 0.0051
Schistosoma mansoni hypothetical protein 0.0739 1 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.0025 0.0151 0.0151
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0017 0.0048 0.0108
Schistosoma mansoni voltage-gated potassium channel 0.0014 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0025 0.0151 0.0252
Loa Loa (eye worm) hypothetical protein 0.0147 0.1834 0.3065
Brugia malayi hypothetical protein 0.0014 0.0012 0.002
Echinococcus granulosus histone lysine methyltransferase setb 0.0035 0.0299 0.0299
Echinococcus granulosus GPCR family 2 0.0014 0.0008 0.0008
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0017 0.0051 0.0051
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0027 0.019 0.0318
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0076 0.0854 0.1961
Trypanosoma cruzi cysteine peptidase, putative 0.0094 0.1102 0.2534
Leishmania major cathepsin L-like protease 0.0025 0.0151 0.0342
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0025 0.0151 0.0151
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0027 0.019 0.0318
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0027 0.019 0.019
Schistosoma mansoni voltage-gated potassium channel 0.0014 0.0002 0.0002
Echinococcus granulosus potassium voltage gated channel protein 0.0014 0.0002 0.0002
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0151 0.0372
Brugia malayi Cathepsin L-like precursor 0.0016 0.0039 0.0065
Onchocerca volvulus 0.0065 0.0709 0.1319
Leishmania major mitochondrial DNA polymerase beta 0.0329 0.4344 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0027 0.019 0.0354
Brugia malayi Calcitonin receptor-like protein seb-1 0.0045 0.0432 0.0722
Schistosoma mansoni voltage-gated potassium channel 0.0014 0.0002 0.0002
Brugia malayi MH1 domain containing protein 0.0017 0.0045 0.0075
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0025 0.0151 0.0372
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0094 0.1102 0.2534
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0151 0.0372
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0014 0.0002 0.0002
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0028 0.0195 0.0326
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0014 0.0002 0.0002
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0014 0.0002 0.0002
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0027 0.019 0.019
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0076 0.0854 0.1961
Loa Loa (eye worm) hypothetical protein 0.0066 0.0718 0.12
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0014 0.0002 0.0002
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0025 0.0151 0.0372
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0076 0.0854 0.1961
Toxoplasma gondii cathepsin CPL 0.0025 0.0151 0.1255
Trichomonas vaginalis D-aminoacylase, putative 0.0065 0.0709 0.1772
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0076 0.0854 0.1427
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0056 0.0589 0.135
Echinococcus multilocularis lamin 0.0052 0.0527 0.0527
Echinococcus granulosus calcium activated potassium channel 0.0014 0.0002 0.0002
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0151 0.0372
Schistosoma mansoni voltage-gated cation channel 0.0014 0.0002 0.0002
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0076 0.0854 0.1961
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0081 0.0181
Echinococcus granulosus voltage gated potassium channel 0.0014 0.0002 0.0002
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0014 0.0002 0.0004
Loa Loa (eye worm) MH1 domain-containing protein 0.0031 0.0233 0.0389
Schistosoma mansoni hypothetical protein 0.0014 0.0002 0.0002
Echinococcus granulosus intermediate filament protein 0.0052 0.0527 0.0527
Onchocerca volvulus 0.0025 0.0151 0.028
Loa Loa (eye worm) hypothetical protein 0.0045 0.0427 0.0714
Echinococcus multilocularis transient receptor potential gamma protein 0.0014 0.0002 0.0002
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0014 0.0002 0.0002
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0015 0.0024 0.0024
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0044 0.0425 0.0726
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0014 0.0002 0.0002
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0027 0.019 0.019
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0014 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0065 0.0709 0.1185
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0151 0.0372
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0065 0.0709 0.1185
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0041 0.0376 0.0862
Brugia malayi cathepsin L-like precursor 0.0016 0.0039 0.0065
Schistosoma mansoni smad 0.0031 0.0233 0.0233
Mycobacterium tuberculosis Probable lipase LipE 0.0065 0.0709 0.1241
Leishmania major cathepsin L-like protease 0.0094 0.1102 0.2534
Onchocerca volvulus 0.0014 0.0002 0.0004
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.0048 0.0108
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0081 0.0181
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0004
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0081 0.0181
Loa Loa (eye worm) hypothetical protein 0.0404 0.5375 0.8982
Brugia malayi photoreceptor-specific nuclear receptor 0.0027 0.019 0.0318
Schistosoma mansoni smad1 5 8 and 0.0031 0.0233 0.0233
Echinococcus multilocularis geminin 0.0629 0.8475 0.8475
Echinococcus multilocularis transcription factor Dp 1 0.0044 0.0415 0.0415
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0014 0.0002 0.0002
Trichomonas vaginalis set domain proteins, putative 0.0272 0.3566 0.8937
Brugia malayi intermediate filament protein 0.0052 0.0527 0.088
Trichomonas vaginalis glutathione reductase, putative 0.0015 0.0024 0.0055
Mycobacterium ulcerans beta-lactamase 0.0065 0.0709 0.3147
Mycobacterium tuberculosis Conserved protein 0.0065 0.0709 0.1241
Echinococcus multilocularis two pore calcium channel protein 2 0.0014 0.0002 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0027 0.019 0.0318
Echinococcus multilocularis cpg binding protein 0.0055 0.0568 0.0568
Brugia malayi Thioredoxin reductase 0.0044 0.0425 0.071
Brugia malayi Muscleblind-like protein 0.0147 0.1834 0.3065
Loa Loa (eye worm) glutathione reductase 0.0044 0.0425 0.071
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0027 0.0181 0.445
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0303 0.399 1
Mycobacterium ulcerans hypothetical protein 0.0017 0.0048 0.0108
Loa Loa (eye worm) hypothetical protein 0.0014 0.0012 0.002
Brugia malayi ecdysteroid receptor 0.0027 0.019 0.0318
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0014 0.0002 0.0004
Echinococcus granulosus cathepsin L cysteine proteinase 0.0025 0.0151 0.0151
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0041 0.0376 0.0862
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0027 0.0181 0.2289
Loa Loa (eye worm) hypothetical protein 0.0027 0.019 0.0318
Brugia malayi beta-lactamase family protein 0.0065 0.0709 0.1185
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0014 0.0007 0.0007
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0041 0.0376 0.879
Entamoeba histolytica acyl-CoA synthetase, putative 0.0017 0.0048 0.0023
Plasmodium vivax glutathione reductase, putative 0.0044 0.0425 0.5852
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0213 0.2754 0.6338
Brugia malayi Cathepsin L-like precursor 0.0025 0.0151 0.0252
Loa Loa (eye worm) hypothetical protein 0.0031 0.0236 0.0394
Schistosoma mansoni lamin 0.0052 0.0527 0.0527
Brugia malayi Cathepsin L-like precursor 0.0025 0.0151 0.0252
Leishmania major cathepsin L-like protease 0.0025 0.0151 0.0342
Schistosoma mansoni voltage-gated potassium channel 0.0014 0.0002 0.0002
Echinococcus multilocularis dnaJ subfamily B 0.0739 1 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0024 0.0051
Brugia malayi hypothetical protein 0.0032 0.0259 0.0433
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0025 0.0151 0.0372
Entamoeba histolytica cysteine proteinase, putative 0.0025 0.0151 0.0283
Entamoeba histolytica acyl-CoA synthetase, putative 0.0017 0.0048 0.0023
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0004
Schistosoma mansoni hypothetical protein 0.0014 0.0008 0.0008
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0032 0.0259 0.0259
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0151 0.0372
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0025 0.0151 0.0252
Brugia malayi MH1 domain containing protein 0.0017 0.0045 0.0075
Loa Loa (eye worm) hypothetical protein 0.0065 0.0709 0.1185
Schistosoma mansoni voltage-dependent calcium channel 0.0014 0.0002 0.0002
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0081 0.0181
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0014 0.0002 0.0002
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0027 0.019 0.0318
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0027 0.019 0.019
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0076 0.0854 0.0854
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0015 0.0024 0.0051
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0014 0.0002 0.0002
Schistosoma mansoni smad1 5 8 and 0.0031 0.0233 0.0233
Brugia malayi F/Y-rich N-terminus family protein 0.0017 0.0048 0.008
Echinococcus multilocularis voltage gated potassium channel 0.0014 0.0002 0.0002
Echinococcus granulosus hyperpolarization activated cyclic 0.0014 0.0002 0.0002
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.0014 0.0002 0.0004
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0015 0.0024 0.0051
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0081 0.0181
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0081 0.0197
Schistosoma mansoni voltage-gated ion channel 0.0014 0.0002 0.0002
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0041 0.0376 0.0862
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0031 0.0233 0.0233
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0014 0.0002 0.0002
Trypanosoma brucei trypanothione reductase 0.0044 0.0425 0.0973
Loa Loa (eye worm) calcium channel 0.0014 0.0002 0.0004
Trypanosoma brucei DNA repair and recombination helicase protein PIF7 0.0303 0.399 0.9184
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0081 0.0181
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0014 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0004
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0081 0.0181
Echinococcus multilocularis FTZ F1 alpha 0.0027 0.019 0.019
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0014 0.0002 0.0002
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0014 0.0002 0.0002
Echinococcus granulosus potassium large conductance calcium activated 0.0014 0.0002 0.0002
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0027 0.0181 0.1512
Brugia malayi olfactory channel protein osm-9 0.0014 0.0002 0.0004
Brugia malayi cation channel family protein 0.0014 0.0002 0.0004
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0139 0.2855
Plasmodium vivax thioredoxin reductase, putative 0.0044 0.0425 0.5852
Brugia malayi Cathepsin L-like precursor 0.0025 0.0151 0.0252
Schistosoma mansoni hypothetical protein 0.0055 0.0573 0.0573
Schistosoma mansoni voltage-gated potassium channel 0.0014 0.0002 0.0002
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0014 0.0002 0.0002
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0014 0.0002 0.0004
Loa Loa (eye worm) histone methyltransferase 0.0017 0.0051 0.0085
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0025 0.0151 0.0151
Brugia malayi latrophilin 2 splice variant baaae 0.0031 0.0236 0.0394
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0014 0.0002 0.0002
Trypanosoma cruzi cysteine peptidase, putative 0.0094 0.1102 0.2534
Toxoplasma gondii hypothetical protein 0.0053 0.0543 0.4573
Echinococcus multilocularis calcium activated potassium channel 0.0014 0.0002 0.0002
Schistosoma mansoni ryanodine receptor related 0.0014 0.0002 0.0002
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0081 0.0135
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0052 0.0527 0.088
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0027 0.019 0.019
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0065 0.0709 0.0709
Loa Loa (eye worm) voltage-gated calcium channel 0.0014 0.0002 0.0004
Onchocerca volvulus 0.0272 0.3566 0.6635
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0025 0.0151 0.0372
Loa Loa (eye worm) hypothetical protein 0.0052 0.0527 0.088
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0004
Brugia malayi glutathione reductase 0.0044 0.0425 0.071
Echinococcus multilocularis hyperpolarization activated cyclic 0.0014 0.0002 0.0002
Brugia malayi AMP-binding enzyme family protein 0.0017 0.0048 0.008
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0027 0.0181 0.1512
Echinococcus granulosus potassium voltage gated channel protein 0.0014 0.0002 0.0002
Brugia malayi steroid hormone receptor 0.0027 0.019 0.0318
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0035 0.0299 0.2507
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0151 0.0372
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0027 0.019 0.019
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0015 0.0024 0.0051
Echinococcus granulosus transient receptor potential cation channel 0.0014 0.0002 0.0002
Entamoeba histolytica cysteine proteinase, putative 0.0025 0.0151 0.0283
Leishmania major 4-coumarate:coa ligase-like protein 0.0017 0.0048 0.0105
Brugia malayi Papain family cysteine protease containing protein 0.0025 0.0151 0.0252
Echinococcus multilocularis muscleblind protein 0.0147 0.1834 0.1834
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.0014 0.0002 0.0004
Loa Loa (eye worm) steroid hormone receptor 0.0027 0.019 0.0318
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0014 0.0002 0.0004
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0303 0.399 0.9184
Trichomonas vaginalis ap endonuclease, putative 0.0041 0.0376 0.0938
Echinococcus granulosus two pore calcium channel protein 2 0.0014 0.0002 0.0002
Echinococcus granulosus ryanodine receptor 44f 0.0014 0.0002 0.0002
Onchocerca volvulus 0.0404 0.5375 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.019 0.0318
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0101 0.121 0.2149
Loa Loa (eye worm) hypothetical protein 0.0271 0.3544 0.5922
Toxoplasma gondii exonuclease III APE 0.0041 0.0376 0.3164
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0191 0.245 0.4095
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0151 0.0372
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0191 0.245 0.245
Brugia malayi cytoplasmic intermediate filament protein 0.0028 0.0195 0.0326
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0027 0.019 0.019
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0081 0.0081
Brugia malayi cation channel family protein 0.0014 0.0002 0.0004
Schistosoma mansoni hypothetical protein 0.0032 0.0259 0.0259
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0081 0.0181
Echinococcus granulosus hypothetical protein 0.0014 0.0002 0.0002
Loa Loa (eye worm) beta-lactamase 0.0065 0.0709 0.1185
Brugia malayi Cathepsin L-like precursor 0.0025 0.0151 0.0252
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0027 0.0181 0.072
Schistosoma mansoni vesicular amine transporter 0.0014 0.0002 0.0002
Loa Loa (eye worm) ryanodine receptor 0.0014 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0004
Mycobacterium tuberculosis Conserved protein 0.0065 0.0709 0.1241
Echinococcus granulosus potassium voltage gated channel protein 0.0014 0.0002 0.0002
Brugia malayi MH2 domain containing protein 0.0031 0.0233 0.0389
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0014 0.0012 0.0012
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0025 0.0151 0.3154
Brugia malayi exodeoxyribonuclease III family protein 0.0041 0.0376 0.0629
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0151 0.0372
Loa Loa (eye worm) hypothetical protein 0.0017 0.0048 0.008
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0014 0.0002 0.0002
Mycobacterium ulcerans hypothetical protein 0.0173 0.2199 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0041 0.0376 0.0376
Echinococcus multilocularis L aminoadipate semialdehyde 0.0095 0.1124 0.1124
Trypanosoma cruzi hypothetical protein, conserved 0.0065 0.0709 0.1627
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0081 0.0181
Entamoeba histolytica hypothetical protein, conserved 0.0303 0.399 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0191 0.245 0.245
Loa Loa (eye worm) latrophilin receptor protein 2 0.0014 0.0008 0.0014
Echinococcus granulosus transient receptor potential cation channel 0.0014 0.0002 0.0002
Leishmania major 4-coumarate:coa ligase-like protein 0.0017 0.0048 0.0105
Leishmania major cathepsin L-like protease 0.0094 0.1102 0.2534
Echinococcus multilocularis lamin dm0 0.0052 0.0527 0.0527
Leishmania major cathepsin L-like protease 0.0025 0.0151 0.0342
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0014 0.0002 0.0002
Loa Loa (eye worm) intermediate filament protein 0.0052 0.0527 0.088
Schistosoma mansoni survival motor neuron protein 0.0055 0.0573 0.0573
Onchocerca volvulus 0.0025 0.0151 0.028
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0101 0.121 0.2149
Schistosoma mansoni intermediate filament proteins 0.0052 0.0527 0.0527
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0015 0.0024 0.0051
Echinococcus granulosus transient receptor potential gamma protein 0.0014 0.0002 0.0002
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0041 0.0376 0.0376
Schistosoma mansoni voltage-gated potassium channel 0.0014 0.0002 0.0002
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0014 0.0002 0.0002
Echinococcus multilocularis musashi 0.0052 0.0527 0.0527
Loa Loa (eye worm) hypothetical protein 0.002 0.0081 0.0135
Echinococcus multilocularis sodium leak channel non selective protein 0.0014 0.0002 0.0002
Trypanosoma cruzi trypanothione reductase, putative 0.0044 0.0425 0.0973
Echinococcus granulosus lamin dm0 0.0052 0.0527 0.0527
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0014 0.0002 0.0002
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0027 0.019 0.0318
Trichomonas vaginalis penicillin-binding protein, putative 0.0065 0.0709 0.1772
Schistosoma mansoni transient receptor potential channel 0.0014 0.0002 0.0002
Schistosoma mansoni voltage-gated potassium channel 0.0014 0.0002 0.0002
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0027 0.0181 0.0284
Loa Loa (eye worm) hypothetical protein 0.0027 0.019 0.0318
Schistosoma mansoni voltage-gated potassium channel 0.0014 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0065 0.0709 0.1185
Brugia malayi hypothetical protein 0.0066 0.0718 0.12
Brugia malayi Nuclear hormone receptor-like 1 0.0027 0.019 0.0318
Schistosoma mansoni steroid hormone receptor ad4bp 0.0027 0.019 0.019
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0024 0.0051
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0014 0.0002 0.0004
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0014 0.0008 0.0008
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0015 0.0024 0.0024
Schistosoma mansoni hypothetical protein 0.0303 0.399 0.399
Brugia malayi MH2 domain containing protein 0.0031 0.0233 0.0389
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0041 0.0376 0.1619
Trichomonas vaginalis D-aminoacylase, putative 0.0065 0.0709 0.1772
Brugia malayi Cathepsin L-like precursor 0.0025 0.0151 0.0252
Brugia malayi nuclear receptor NHR-88 0.0027 0.019 0.0318
Echinococcus multilocularis transient receptor potential cation channel 0.0014 0.0002 0.0002
Schistosoma mansoni nuclear hormone receptor 0.0027 0.019 0.019
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0191 0.245 0.245
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0076 0.0854 0.0854
Schistosoma mansoni transient receptor potential channel 4 0.0014 0.0002 0.0002
Brugia malayi AMP-binding enzyme family protein 0.0017 0.0048 0.008
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0027 0.019 0.0318
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0014 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0045 0.0432 0.0722
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0025 0.0151 0.0372
Echinococcus multilocularis thyroid hormone receptor alpha 0.0027 0.019 0.019
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0081 0.0181
Echinococcus granulosus cpg binding protein 0.0055 0.0568 0.0568
Echinococcus multilocularis voltage dependent calcium channel 0.0014 0.0002 0.0002
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0014 0.0008 0.0008
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0065 0.0709 0.3147
Echinococcus multilocularis potassium voltage gated channel protein 0.0014 0.0002 0.0002
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0027 0.019 0.019
Brugia malayi beta-lactamase 0.0065 0.0709 0.1185
Onchocerca volvulus 0.0052 0.0527 0.098
Loa Loa (eye worm) hypothetical protein 0.0051 0.0514 0.0858
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0299 0.0299
Onchocerca volvulus 0.0025 0.0151 0.028
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0014 0.0012 0.002
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0015 0.0024 0.0024
Echinococcus multilocularis microtubule associated protein 2 0.0498 0.6676 0.6676
Echinococcus granulosus two pore calcium channel protein 1 0.0014 0.0002 0.0002
Echinococcus multilocularis transfer RNA-Gly 0.0014 0.0002 0.0002
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0046 0.0449 0.1029
Trypanosoma cruzi hypothetical protein, conserved 0.0065 0.0709 0.1627
Brugia malayi Latrophilin receptor protein 2 0.0014 0.0008 0.0014
Loa Loa (eye worm) CXXC zinc finger family protein 0.0052 0.0527 0.0881
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0004
Mycobacterium ulcerans acyl-CoA synthetase 0.0017 0.0048 0.0108
Trypanosoma cruzi major cysteine proteinase, putative 0.0074 0.0826 0.1898
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0014 0.0007 0.0007
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0014 0.0002 0.0002
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0027 0.019 0.019
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0081 0.0135
Echinococcus granulosus short transient receptor potential channel 6 0.0014 0.0002 0.0002
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0139 0.0314
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0014 0.0002 0.0002
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0041 0.0376 0.0629
Schistosoma mansoni thyroid hormone receptor 0.0027 0.019 0.019
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0027 0.019 0.0318
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0081 0.0181
Onchocerca volvulus 0.0095 0.1124 0.2092
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0213 0.2754 0.2754
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0014 0.0002 0.0002
Echinococcus granulosus ATP dependent DNA helicase PIF1 0.0303 0.399 0.399
Entamoeba histolytica hypothetical protein 0.0032 0.0259 0.0558
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0081 0.0081
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0014 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0004
Giardia lamblia Rrm3p helicase 0.0303 0.399 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0101 0.121 0.2149
Echinococcus multilocularis beta LACTamase domain containing family member 0.0065 0.0709 0.0709
Trypanosoma brucei hypothetical protein, conserved 0.0027 0.0181 0.0412
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0014 0.0002 0.0002
Echinococcus granulosus transient receptor potential cation channel 0.0014 0.0002 0.0002
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0027 0.0181 0.445
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0014 0.0002 0.0002
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0191 0.245 0.245
Giardia lamblia DINP protein human, muc B family 0.002 0.0081 0.0142
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0156 0.1957 0.4502
Echinococcus granulosus ecdysone induced protein 78C 0.0027 0.019 0.019
Schistosoma mansoni cpg binding protein 0.0055 0.0568 0.0568
Schistosoma mansoni hypothetical protein 0.0014 0.0008 0.0008
Echinococcus granulosus potassium voltage gated channel protein 0.0014 0.0002 0.0002
Leishmania major cathepsin L-like protease 0.0094 0.1102 0.2534
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0139 0.1154
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0014 0.0002 0.0002
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0015 0.0024 0.0051
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0027 0.019 0.019
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0329 0.4344 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0024 0.0051
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0081 0.0181
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0015 0.0024 0.0187
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0004
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.0014 0.0002 0.0004
Brugia malayi hypothetical protein 0.0014 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0024 0.0139 0.0232
Echinococcus granulosus microtubule associated protein 2 0.0498 0.6676 0.6676
Loa Loa (eye worm) hypothetical protein 0.0014 0.0012 0.002
Echinococcus multilocularis shaker cognate 0.0014 0.0002 0.0002
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0151 0.0372
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0004
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0025 0.0151 0.0252
Echinococcus multilocularis survival motor neuron protein 1 0.0271 0.3544 0.3544
Loa Loa (eye worm) hypothetical protein 0.0027 0.019 0.0318
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0081 0.0181
Echinococcus multilocularis conserved hypothetical protein 0.0014 0.0002 0.0002
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0081 0.026
Loa Loa (eye worm) hypothetical protein 0.0027 0.019 0.0318
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0081 0.0102
Echinococcus granulosus hyperpolarization activated cyclic 0.0014 0.0002 0.0002
Entamoeba histolytica hypothetical protein 0.0027 0.0181 0.036
Schistosoma mansoni cathepsin F (C01 family) 0.0025 0.0151 0.0151
Echinococcus granulosus tumor protein p63 0.0305 0.4013 0.4013
Echinococcus granulosus cathepsin l1 0.0016 0.0039 0.0039
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0416 0.5542 1
Echinococcus granulosus L aminoadipate semialdehyde 0.0095 0.1124 0.1124
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0004
Mycobacterium leprae conserved hypothetical protein 0.0065 0.0709 0.5014
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0027 0.019 0.019
Entamoeba histolytica DNA repair and recombination protein, putative 0.0303 0.399 1
Schistosoma mansoni hypothetical protein 0.0629 0.8475 0.8475
Echinococcus granulosus cathepsin l1 0.0025 0.0151 0.0151
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0014 0.0002 0.0004
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0014 0.0002 0.0002
Loa Loa (eye worm) MH2 domain-containing protein 0.0031 0.0233 0.0389
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0014 0.0002 0.0002
Entamoeba histolytica acyl-coA synthetase, putative 0.0017 0.0048 0.0023
Echinococcus multilocularis transient receptor potential cation channel 0.0014 0.0002 0.0002
Mycobacterium tuberculosis Probable hydrolase 0.0065 0.0709 0.1241
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0017 0.0048 0.0108
Brugia malayi MH1 domain containing protein 0.0031 0.0233 0.0389
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0015 0.0024 0.0051
Echinococcus granulosus FTZ F1 alpha 0.0027 0.019 0.019
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0081 0.0181
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0014 0.0012 0.0012
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0039 0.0039
Echinococcus multilocularis dna polymerase eta 0.002 0.0081 0.0081
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0111 0.1347 0.1347
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0015 0.0024 0.0051
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0027 0.019 0.019
Loa Loa (eye worm) fibroinase 0.0025 0.0151 0.0252
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0027 0.019 0.0318
Echinococcus multilocularis two pore calcium channel protein 1 0.0014 0.0002 0.0002
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0027 0.0181 0.072
Onchocerca volvulus 0.0025 0.0151 0.028
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0065 0.0709 0.1185
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0017 0.0051 0.0051
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0014 0.0012 0.0012
Mycobacterium leprae conserved hypothetical protein 0.0027 0.0181 0.1011
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0017 0.0048 0.0108
Echinococcus granulosus shaker cognate 0.0014 0.0002 0.0002
Leishmania major cathepsin L-like protease 0.0025 0.0151 0.0342
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0014 0.0002 0.0002
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0035 0.0299 0.0299
Brugia malayi Nuclear hormone receptor-like 1 0.0014 0.0012 0.002
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0139 0.167
Schistosoma mansoni microtubule-associated protein tau 0.0498 0.6676 0.6676
Mycobacterium tuberculosis Probable esterase LipL 0.0065 0.0709 0.1241
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0094 0.1102 0.2534
Brugia malayi hypothetical protein 0.0404 0.5375 0.8982
Brugia malayi Intermediate filament tail domain containing protein 0.0052 0.0527 0.088
Trichomonas vaginalis esterase, putative 0.0065 0.0709 0.1772
Trypanosoma cruzi trypanothione reductase, putative 0.0015 0.0024 0.0051
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0151 0.0372
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0014 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0024 0.0144 0.024
Echinococcus granulosus muscleblind protein 0.0147 0.1834 0.1834
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0014 0.0002 0.0002
Schistosoma mansoni cellular tumor antigen P53 0.0045 0.0427 0.0427
Brugia malayi hypothetical protein 0.0024 0.0139 0.0232
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0035 0.0299 0.0299
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0014 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0027 0.019 0.0318
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0065 0.0709 0.1241
Treponema pallidum exodeoxyribonuclease (exoA) 0.0041 0.0376 1
Echinococcus granulosus voltage gated hydrogen channel 1 0.0014 0.0002 0.0002
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0113 0.1366 0.2432
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0014 0.0002 0.0004
Loa Loa (eye worm) voltage-dependent calcium channel 0.0014 0.0002 0.0004
Trypanosoma brucei DNA repair and recombination helicase protein PIF6 0.0303 0.399 0.9184
Entamoeba histolytica hypothetical protein 0.0032 0.0259 0.0558
Trypanosoma cruzi DNA repair and recombination helicase protein PIF6, putative 0.0303 0.399 0.9184
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0027 0.019 0.0318
Echinococcus granulosus transient receptor potential cation channel 0.0014 0.0002 0.0002
Schistosoma mansoni voltage-gated potassium channel 0.0014 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0014 0.0012 0.002
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0045 0.0432 0.0722
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0329 0.4344 1
Onchocerca volvulus 0.0025 0.0151 0.028
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0045 0.0432 0.0722
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0025 0.0151 0.0372
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0139 0.0314
Brugia malayi hypothetical protein 0.0014 0.0012 0.002
Leishmania major DNA polymerase kappa, putative 0.002 0.0081 0.0181
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0024 0.0051
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0014 0.0002 0.0004
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0094 0.1102 0.2534
Echinococcus multilocularis smad 0.0031 0.0233 0.0233
Echinococcus multilocularis cysteine protease 0.0025 0.0151 0.0151
Brugia malayi voltage-dependent calcium channel 0.0014 0.0002 0.0004
Echinococcus multilocularis transient receptor potential cation channel 0.0014 0.0002 0.0002
Plasmodium falciparum thioredoxin reductase 0.0044 0.0425 1
Brugia malayi ion channel NompC 0.0014 0.0002 0.0004
Leishmania major phosphopantetheinyl transferase-like protein 0.0027 0.0181 0.0412
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0027 0.019 0.0318
Loa Loa (eye worm) transcription factor SMAD2 0.0448 0.5984 1
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0046 0.0449 0.1029
Mycobacterium ulcerans acyl-CoA synthetase 0.0017 0.0048 0.0108
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0094 0.1102 0.2534
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0027 0.019 0.019
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0081 0.0181
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0015 0.0024 0.0051
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0014 0.0012 0.0012
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0027 0.019 0.0318
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0014 0.0002 0.0002
Echinococcus granulosus transient receptor potential cation channel 0.0014 0.0002 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0027 0.019 0.0318
Schistosoma mansoni cathepsin F (C01 family) 0.0025 0.0151 0.0151
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0076 0.0854 0.0854
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0048 0.0042
Loa Loa (eye worm) hypothetical protein 0.0024 0.0144 0.024
Brugia malayi AMP-binding enzyme family protein 0.0017 0.0048 0.008
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0014 0.0002 0.0002
Brugia malayi nuclear receptor RXR 0.0014 0.0012 0.002
Loa Loa (eye worm) hypothetical protein 0.0066 0.0718 0.12
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0024 0.0051
Onchocerca volvulus 0.0016 0.0039 0.0072
Echinococcus multilocularis voltage gated potassium channel 0.0014 0.0002 0.0002
Schistosoma mansoni hypothetical protein 0.0014 0.0008 0.0008
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0027 0.019 0.0318
Brugia malayi hypothetical protein 0.0271 0.3544 0.5922
Echinococcus multilocularis muscleblind protein 1 0.0147 0.1834 0.1834
Schistosoma mansoni voltage-gated potassium channel 0.0014 0.0002 0.0002
Schistosoma mansoni smad1 5 8 and 0.0031 0.0233 0.0233
Echinococcus multilocularis tumor protein p63 0.0305 0.4013 0.4013
Echinococcus multilocularis hyperpolarization activated cyclic 0.0014 0.0002 0.0002
Echinococcus granulosus sodium leak channel non selective protein 0.0014 0.0002 0.0002
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0055 0.0573 0.0958
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0014 0.0008 0.0008
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0101 0.121 0.2149
Schistosoma mansoni voltage-gated potassium channel 0.0014 0.0002 0.0002
Brugia malayi MH2 domain containing protein 0.0448 0.5984 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0014 0.0008 0.0008
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0191 0.245 0.245
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0014 0.0002 0.0002
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0015 0.0024 0.0051
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0041 0.0376 0.0638
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0025 0.0151 0.0372
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0027 0.019 0.019
Mycobacterium tuberculosis Conserved hypothetical protein 0.0173 0.2199 0.3942
Onchocerca volvulus 0.0055 0.0573 0.1067
Echinococcus multilocularis transient receptor potential cation channel 0.0014 0.0002 0.0002
Echinococcus granulosus dna polymerase eta 0.002 0.0081 0.0081
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0014 0.0002 0.0002
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0027 0.019 0.0318
Echinococcus granulosus TGF beta signal transducer SmadC 0.0031 0.0233 0.0233
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0004
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0095 0.1124 0.1124
Schistosoma mansoni hypothetical protein 0.0014 0.0008 0.0008
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0014 0.0002 0.0002
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0046 0.0449 0.1029
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0139 0.2855
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0014 0.0002 0.0004
Schistosoma mansoni ap endonuclease 0.0041 0.0376 0.0376
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0027 0.019 0.019
Loa Loa (eye worm) hypothetical protein 0.0027 0.019 0.0318
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0081 0.0081
Echinococcus granulosus transcription factor Dp 1 0.0044 0.0415 0.0415
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0014 0.0002 0.0002

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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