Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | p21 protein (Cdc42/Rac)-activated kinase 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0138 | 0.1415 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 0.1415 | 0.1411 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0239 | 0.0234 |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 0.1415 | 0.1411 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0045 | 0.0239 | 0.1659 |
Trypanosoma cruzi | p21-activated kinase 3, putative | 0.0026 | 0.0005 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0815 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0138 | 0.1415 | 0.1411 |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 0.1415 | 0.1411 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0138 | 0.1415 | 0.1411 |
Brugia malayi | Carboxylesterase family protein | 0.0138 | 0.1415 | 0.1411 |
Trypanosoma cruzi | STE/STE20 serine/threonine-protein kinase, putative | 0.0026 | 0.0005 | 0.5 |
Onchocerca volvulus | 0.0138 | 0.1415 | 0.5 | |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0138 | 0.1415 | 0.1201 |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 0.1415 | 0.1411 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0138 | 0.1415 | 0.1411 |
Loa Loa (eye worm) | carboxylesterase | 0.0815 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0815 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0815 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0815 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0815 | 1 | 1 |
Trichomonas vaginalis | STE family protein kinase | 0.0045 | 0.0243 | 0.1692 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0138 | 0.1415 | 0.5 |
Schistosoma mansoni | protein kinase | 0.0045 | 0.0243 | 0.0239 |
Entamoeba histolytica | p21-activated kinase | 0.0045 | 0.0243 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0138 | 0.1415 | 0.1411 |
Echinococcus granulosus | carboxylesterase 5A | 0.0815 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0138 | 0.1415 | 0.1411 |
Echinococcus granulosus | neuroligin | 0.0138 | 0.1415 | 0.1415 |
Entamoeba histolytica | protein kinase, putative | 0.0045 | 0.0243 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0138 | 0.1415 | 0.5 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0138 | 0.1415 | 0.1201 |
Trichomonas vaginalis | STE family protein kinase | 0.0045 | 0.0243 | 0.1692 |
Onchocerca volvulus | 0.0138 | 0.1415 | 0.5 | |
Brugia malayi | Carboxylesterase family protein | 0.0138 | 0.1415 | 0.1411 |
Loa Loa (eye worm) | carboxylesterase | 0.0138 | 0.1415 | 0.1411 |
Schistosoma mansoni | protein kinase | 0.0045 | 0.0243 | 0.0239 |
Brugia malayi | Protein kinase domain | 0.0045 | 0.0243 | 0.0239 |
Schistosoma mansoni | gliotactin | 0.0138 | 0.1415 | 0.1411 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0138 | 0.1415 | 0.5 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0138 | 0.1415 | 0.1415 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0138 | 0.1415 | 0.1411 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0138 | 0.1415 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 0.1415 | 0.1411 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0138 | 0.1415 | 0.1201 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0138 | 0.1415 | 0.1415 |
Onchocerca volvulus | 0.0138 | 0.1415 | 0.5 | |
Echinococcus multilocularis | acetylcholinesterase | 0.0815 | 1 | 1 |
Echinococcus granulosus | serine:threonine protein kinase PAK 3 | 0.0045 | 0.0243 | 0.0243 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0138 | 0.1415 | 0.1411 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0138 | 0.1415 | 0.1415 |
Echinococcus granulosus | p21 activated protein kinase 1 Dpak1 | 0.0045 | 0.0243 | 0.0243 |
Schistosoma mansoni | acetylcholinesterase | 0.0138 | 0.1415 | 0.1411 |
Trichomonas vaginalis | STE family protein kinase | 0.0045 | 0.0243 | 0.1692 |
Echinococcus granulosus | serine:threonine protein kinase PAK 3 | 0.0045 | 0.0243 | 0.0243 |
Brugia malayi | hypothetical protein | 0.0138 | 0.1415 | 0.1411 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0815 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 0.1415 | 0.1411 |
Giardia lamblia | Kinase, STE STE20 | 0.0045 | 0.0243 | 0.5 |
Onchocerca volvulus | 0.0138 | 0.1415 | 0.5 | |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0138 | 0.1415 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0815 | 1 | 1 |
Echinococcus multilocularis | neuroligin | 0.0138 | 0.1415 | 0.1201 |
Loa Loa (eye worm) | hypothetical protein | 0.0815 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0815 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0138 | 0.1415 | 0.5 |
Trichomonas vaginalis | STE family protein kinase | 0.0045 | 0.0243 | 0.1692 |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 0.1415 | 0.1411 |
Brugia malayi | Carboxylesterase family protein | 0.0138 | 0.1415 | 0.1411 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 7.99 uM | Inhibition of PAK1 in human OVCAR3 cells assessed as MEK phosphorylation by TR-FRET assay | ChEMBL. | 23756368 |
IC50 (binding) | = 0.674 uM | Inhibition of human recombinant PAK1 using MBP as substrate by scintillation counting analysis in presence of [gamma-32P]ATP | ChEMBL. | 23756368 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.