Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | UDP-galactopyranose mutase | 0.0088 | 0.0425 | 0.5 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0036 | 0.0096 | 0.0084 |
Onchocerca volvulus | 0.027 | 0.1582 | 1 | |
Plasmodium falciparum | lysine-specific histone demethylase 1, putative | 0.0088 | 0.0425 | 1 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0066 | 0.0291 | 0.0279 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.0088 | 0.0425 | 0.0425 |
Schistosoma mansoni | Lysine-specific histone demethylase 1 | 0.0088 | 0.0425 | 0.0425 |
Echinococcus multilocularis | 0.0088 | 0.0425 | 0.0413 | |
Loa Loa (eye worm) | hypothetical protein | 0.0088 | 0.0425 | 0.0425 |
Brugia malayi | amine oxidase, flavin-containing family protein | 0.0088 | 0.0425 | 0.0356 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0087 | 0.0422 | 0.041 |
Brugia malayi | Carboxylesterase family protein | 0.027 | 0.1582 | 0.1521 |
Brugia malayi | Carboxylesterase family protein | 0.027 | 0.1582 | 0.1521 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.027 | 0.1582 | 0.1572 |
Loa Loa (eye worm) | carboxylesterase | 0.1599 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0088 | 0.0425 | 0.0425 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0171 | 0.0171 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0088 | 0.0425 | 0.0413 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0183 | 0.0183 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.029 | 0.1709 | 0.165 |
Onchocerca volvulus | 0.027 | 0.1582 | 1 | |
Echinococcus granulosus | acetylcholinesterase | 0.1599 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.1599 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.1599 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.1599 | 1 | 1 |
Echinococcus granulosus | zinc finger protein | 0.0027 | 0.0038 | 0.0026 |
Echinococcus granulosus | acetylcholinesterase | 0.1599 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.027 | 0.1582 | 0.1582 |
Echinococcus multilocularis | geminin | 0.0164 | 0.0909 | 0.0898 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0078 | 0.0362 | 0.5 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.028 | 0.1643 | 0.1633 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.027 | 0.1582 | 0.158 |
Plasmodium vivax | hypothetical protein, conserved | 0.0088 | 0.0425 | 1 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0078 | 0.0362 | 0.5 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0088 | 0.0425 | 0.0413 |
Schistosoma mansoni | amine oxidase | 0.0088 | 0.0425 | 0.0425 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0088 | 0.0425 | 0.5 |
Brugia malayi | Bromodomain containing protein | 0.0045 | 0.0156 | 0.0085 |
Loa Loa (eye worm) | hypothetical protein | 0.0088 | 0.0425 | 0.0425 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0036 | 0.0096 | 0.0084 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0066 | 0.0291 | 0.0279 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0459 | 0.2781 | 0.2772 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.029 | 0.1709 | 0.1709 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.0909 | 0.0909 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0112 | 0.0112 |
Echinococcus granulosus | neuropeptide s receptor | 0.0459 | 0.2781 | 0.2772 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.027 | 0.1582 | 0.1582 |
Loa Loa (eye worm) | hypothetical protein | 0.0088 | 0.0425 | 0.0425 |
Echinococcus multilocularis | acetylcholinesterase | 0.1599 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0088 | 0.0425 | 0.0425 |
Plasmodium vivax | protoporphyrinogen oxidase, putative | 0.0088 | 0.0425 | 1 |
Onchocerca volvulus | 0.027 | 0.1582 | 1 | |
Loa Loa (eye worm) | acetyltransferase | 0.029 | 0.1709 | 0.1709 |
Loa Loa (eye worm) | hypothetical protein | 0.027 | 0.1582 | 0.1582 |
Echinococcus granulosus | BC026374 protein S09 family | 0.027 | 0.1582 | 0.1572 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0459 | 0.2781 | 0.2772 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.0909 | 0.0909 |
Schistosoma mansoni | amine oxidase | 0.0088 | 0.0425 | 0.0425 |
Schistosoma mansoni | zinc finger protein | 0.0027 | 0.0038 | 0.0038 |
Plasmodium falciparum | protoporphyrinogen oxidase | 0.0088 | 0.0425 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.027 | 0.1582 | 0.1582 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.1243 | 0.7746 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1599 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0088 | 0.0425 | 0.0356 |
Onchocerca volvulus | 0.027 | 0.1582 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.1599 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.1599 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0088 | 0.0425 | 0.0425 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.027 | 0.1582 | 1 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.027 | 0.1582 | 0.1572 |
Brugia malayi | Bromodomain containing protein | 0.0082 | 0.0387 | 0.0318 |
Echinococcus granulosus | neuroligin | 0.027 | 0.1582 | 0.1572 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.0088 | 0.0425 | 0.5 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.027 | 0.1582 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.1599 | 1 | 1 |
Echinococcus granulosus | geminin | 0.0164 | 0.0909 | 0.0898 |
Plasmodium vivax | lysine-specific histone demethylase 1, putative | 0.0088 | 0.0425 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.027 | 0.1582 | 0.1582 |
Schistosoma mansoni | bromodomain containing protein | 0.007 | 0.0313 | 0.0313 |
Brugia malayi | hypothetical protein | 0.027 | 0.1582 | 0.1521 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0022 | 0.0012 | 0.0012 |
Echinococcus multilocularis | neuroligin | 0.027 | 0.1582 | 0.1572 |
Loa Loa (eye worm) | hypothetical protein | 0.027 | 0.1582 | 0.1582 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0315 | 0.0315 |
Brugia malayi | Carboxylesterase family protein | 0.027 | 0.1582 | 0.1521 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.027 | 0.1582 | 0.171 |
Brugia malayi | Carboxylesterase family protein | 0.027 | 0.1582 | 0.1521 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1599 | 1 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0088 | 0.0425 | 1 |
Schistosoma mansoni | gliotactin | 0.027 | 0.1582 | 0.1582 |
Toxoplasma gondii | histone lysine-specific demethylase | 0.0088 | 0.0425 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.027 | 0.1582 | 0.1582 |
Echinococcus multilocularis | lysine specific histone demethylase 1A | 0.0088 | 0.0425 | 0.0413 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.1243 | 0.7746 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.027 | 0.1582 | 0.1582 |
Loa Loa (eye worm) | hypothetical protein | 0.027 | 0.1582 | 0.1582 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.027 | 0.1582 | 0.1572 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.029 | 0.1709 | 0.1699 |
Brugia malayi | SWIRM domain containing protein | 0.0088 | 0.0425 | 0.0356 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0459 | 0.2781 | 0.2772 |
Echinococcus multilocularis | zinc finger protein | 0.0027 | 0.0038 | 0.0026 |
Loa Loa (eye worm) | carboxylesterase | 0.027 | 0.1582 | 0.1582 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.027 | 0.1582 | 0.1572 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.027 | 0.1582 | 0.1582 |
Onchocerca volvulus | 0.027 | 0.1582 | 1 | |
Schistosoma mansoni | acetylcholinesterase | 0.027 | 0.1582 | 0.1582 |
Chlamydia trachomatis | protoporphyrinogen oxidase | 0.0088 | 0.0425 | 0.5 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0088 | 0.0425 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.027 | 0.1582 | 0.171 |
Toxoplasma gondii | histone lysine-specific demethylase LSD1/BHC110/KDMA1A | 0.0088 | 0.0425 | 1 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.027 | 0.1582 | 0.1582 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.0088 | 0.0425 | 0.0413 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.1156 | 0.7191 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.027 | 0.1582 | 0.1582 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.027 | 0.1582 | 0.1572 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.027 | 0.1582 | 0.171 |
Loa Loa (eye worm) | hypothetical protein | 0.027 | 0.1582 | 0.1582 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0088 | 0.0425 | 0.5 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0025 | 0.0026 | 0.0026 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.