TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 438.403 | Formula: C24H28BrN3
H donors: 1 H acceptors: 1 LogP: 5.59 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: Brc1ccc2c(c1)C[C@H](C2)CN[C@@H]1CC[C@@H](C1)n1c(C)nc2c1ccc(c2)C
InChi: 1S/C24H28BrN3/c1-15-3-8-24-23(9-15)27-16(2)28(24)22-7-6-21(13-22)26-14-17-10-18-4-5-20(25)12-19(18)11-17/h3-5,8-9,12,17,21-22,26H,6-7,10-11,13-14H2,1-2H3/t17-,21+,22-/m0/s1
InChiKey: NCGVYISELWIBPB-WTOYTKOKSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	melanin-concentrating hormone receptor 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	TK/ALK protein kinase	0.0896	0.2537	0.2537
Schistosoma mansoni	tyrosine kinase	0.0896	0.2537	0.2537
Entamoeba histolytica	tyrosin kinase, putative	0.0896	0.2537	0.2537
Schistosoma mansoni	tyrosine kinase	0.2232	1	1
Schistosoma mansoni	serine/threonine protein kinase	0.0896	0.2537	0.2537
Entamoeba histolytica	tyrosine kinase, putative	0.0896	0.2537	0.2537
Entamoeba histolytica	tyrosine kinase, putative	0.0896	0.2537	0.2537
Echinococcus granulosus	activated cdc42 kinase 1	0.0896	0.2537	0.2537
Echinococcus granulosus	expressed conserved protein	0.1337	0.4999	0.4999
Schistosoma mansoni	hypothetical protein	0.1337	0.4999	0.4999
Loa Loa (eye worm)	hypothetical protein	0.1337	0.4999	0.4999
Schistosoma mansoni	hypothetical protein	0.1337	0.4999	0.4999
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0896	0.2537	0.2537
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.2232	1	1
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.2232	1	1
Giardia lamblia	Kinase, NEK	0.0896	0.2537	1
Echinococcus multilocularis	integrin linked protein kinase	0.0896	0.2537	0.2537
Toxoplasma gondii	protein kinase	0.0896	0.2537	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0896	0.2537	0.2537
Entamoeba histolytica	tyrosine kinase, putative	0.0896	0.2537	0.2537
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0896	0.2537	1
Entamoeba histolytica	receptor protein kinase, putative	0.0896	0.2537	0.2537
Schistosoma mansoni	ephrin receptor	0.0896	0.2537	0.2537
Schistosoma mansoni	protein kinase	0.0896	0.2537	0.2537
Trichomonas vaginalis	TKL family protein kinase	0.0896	0.2537	1
Trichomonas vaginalis	TKL family protein kinase	0.0896	0.2537	1
Schistosoma mansoni	protein kinase	0.0896	0.2537	0.2537
Loa Loa (eye worm)	hypothetical protein	0.0896	0.2537	0.2537
Loa Loa (eye worm)	TK protein kinase	0.0896	0.2537	0.2537
Entamoeba histolytica	protein kinase domain containing protein	0.0896	0.2537	0.2537
Entamoeba histolytica	serine/threonine kinase, putative	0.0896	0.2537	0.2537
Entamoeba histolytica	tyrosin kinase, putative	0.0896	0.2537	0.2537
Entamoeba histolytica	protein kinase domain containing protein	0.0896	0.2537	0.2537
Entamoeba histolytica	hypothetical protein	0.0896	0.2537	0.2537
Trichomonas vaginalis	TKL family protein kinase	0.0896	0.2537	1
Entamoeba histolytica	tyrosine kinase, putative	0.0896	0.2537	0.2537
Entamoeba histolytica	cysteine surface protein, putative	0.0896	0.2537	0.2537
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0896	0.2537	0.2537
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0896	0.2537	0.2537
Trichomonas vaginalis	protein kinase atn1, putative	0.0896	0.2537	1
Entamoeba histolytica	hypothetical protein	0.0896	0.2537	0.2537
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.1337	0.4999	0.4999
Loa Loa (eye worm)	SH2 domain-containing protein	0.1337	0.4999	0.4999
Loa Loa (eye worm)	TK/CSK protein kinase	0.0896	0.2537	0.2537
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0896	0.2537	0.2537
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0896	0.2537	0.2537
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0896	0.2537	0.2537
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0896	0.2537	0.2537
Trichomonas vaginalis	TKL family protein kinase	0.0896	0.2537	1
Brugia malayi	Protein kinase domain containing protein	0.0896	0.2537	0.2537
Loa Loa (eye worm)	hypothetical protein	0.2232	1	1
Echinococcus granulosus	suppressor of cytokine signaling 6	0.1337	0.4999	0.4999
Echinococcus multilocularis	tyrosine protein kinase Blk	0.2232	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0896	0.2537	1
Entamoeba histolytica	serine/threonine kinase, putative	0.0896	0.2537	0.2537
Schistosoma mansoni	tyrosine kinase	0.2232	1	1
Brugia malayi	Protein kinase domain containing protein	0.0896	0.2537	0.2537
Echinococcus granulosus	insulin receptor	0.0896	0.2537	0.2537
Loa Loa (eye worm)	TK/EPH protein kinase	0.0896	0.2537	0.2537
Trichomonas vaginalis	TKL family protein kinase	0.0896	0.2537	1
Echinococcus multilocularis	SH2 motif	0.1337	0.4999	0.4999
Trichomonas vaginalis	TKL family protein kinase	0.0896	0.2537	1
Echinococcus granulosus	tyrosine kinase	0.2232	1	1
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0896	0.2537	0.2537
Loa Loa (eye worm)	TK protein kinase	0.0896	0.2537	0.2537
Entamoeba histolytica	protein kinase, putative	0.0896	0.2537	0.2537
Trichomonas vaginalis	TKL family protein kinase	0.0896	0.2537	1
Trichomonas vaginalis	conserved hypothetical protein	0.0896	0.2537	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.2232	1	1
Loa Loa (eye worm)	hypothetical protein	0.0671	0.1285	0.1285
Loa Loa (eye worm)	TK protein kinase	0.0896	0.2537	0.2537
Brugia malayi	Tyrosine-protein kinase abl-1	0.2232	1	1
Loa Loa (eye worm)	TK protein kinase	0.2232	1	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0896	0.2537	0.2537
Echinococcus granulosus	kinase suppressor of Ras 1	0.0896	0.2537	0.2537
Brugia malayi	ephrin receptor 1 precursor	0.0896	0.2537	0.2537
Loa Loa (eye worm)	hypothetical protein	0.1337	0.4999	0.4999
Entamoeba histolytica	protein kinase domain containing protein	0.0896	0.2537	0.2537
Trichomonas vaginalis	TKL family protein kinase	0.0896	0.2537	1
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0896	0.2537	1
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0896	0.2537	0.2537
Brugia malayi	SRC-1	0.2232	1	1
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0896	0.2537	0.2537
Schistosoma mansoni	tensin	0.1337	0.4999	0.4999
Echinococcus multilocularis	transfer RNA-Thr	0.0896	0.2537	0.2537
Echinococcus multilocularis	tyrosine kinase	0.2232	1	1
Echinococcus granulosus	hypothetical protein	0.1337	0.4999	0.4999
Schistosoma mansoni	tyrosine kinase	0.0896	0.2537	0.2537
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.1337	0.4999	0.4999
Loa Loa (eye worm)	TK/FER protein kinase	0.0896	0.2537	0.2537
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0896	0.2537	0.2537
Schistosoma mansoni	growth factor receptor-bound protein	0.1337	0.4999	0.4999
Entamoeba histolytica	protein farnesyltransferase alpha subunit, putative	0.0671	0.1285	0.1285
Schistosoma mansoni	nck2/grb4	0.1337	0.4999	0.4999
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.2232	1	1
Brugia malayi	Protein kinase domain containing protein	0.2232	1	1
Schistosoma mansoni	signal transduction protein lnk-related	0.1337	0.4999	0.4999
Entamoeba histolytica	hypothetical protein	0.0896	0.2537	0.2537
Brugia malayi	SH2 domain containing protein	0.1337	0.4999	0.4999
Loa Loa (eye worm)	TK/FER protein kinase	0.2232	1	1
Brugia malayi	protein-tyrosine kinase	0.2232	1	1
Echinococcus multilocularis		0.1337	0.4999	0.4999
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0896	0.2537	0.2537
Onchocerca volvulus		0.2232	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0896	0.2537	1
Trichomonas vaginalis	TKL family protein kinase	0.0896	0.2537	1
Brugia malayi	SH2 domain containing protein	0.1337	0.4999	0.4999
Trichomonas vaginalis	TKL family protein kinase	0.0896	0.2537	1
Loa Loa (eye worm)	TK protein kinase	0.0896	0.2537	0.2537
Plasmodium falciparum	tyrosine kinase-like protein	0.0896	0.2537	1
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.1337	0.4999	0.4999
Entamoeba histolytica	protein kinase domain containing protein	0.0896	0.2537	0.2537
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.1337	0.4999	0.4999
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.2232	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0896	0.2537	1
Trichomonas vaginalis	TKL family protein kinase	0.0896	0.2537	1
Entamoeba histolytica	protein kinase domain containing protein	0.0896	0.2537	0.2537
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0896	0.2537	0.2537
Entamoeba histolytica	hypothetical protein	0.0896	0.2537	0.2537
Loa Loa (eye worm)	TK/FER protein kinase	0.2232	1	1
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0896	0.2537	0.2537
Brugia malayi	Guanylyl cyclase protein 23	0.0896	0.2537	0.2537
Brugia malayi	Raf kinase	0.0896	0.2537	0.2537
Echinococcus granulosus	signal transduction protein lnk realted	0.1337	0.4999	0.4999
Trichomonas vaginalis	TKL family protein kinase	0.0896	0.2537	1
Entamoeba histolytica	protein kinase, putative	0.0896	0.2537	0.2537
Trichomonas vaginalis	TKL family protein kinase	0.0896	0.2537	1
Trichomonas vaginalis	TKL family protein kinase	0.0896	0.2537	1
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0896	0.2537	1
Onchocerca volvulus		0.1337	0.4999	0.3299
Trichomonas vaginalis	TKL family protein kinase	0.0896	0.2537	1
Trichomonas vaginalis	TKL family protein kinase	0.0896	0.2537	1
Loa Loa (eye worm)	hypothetical protein	0.1337	0.4999	0.4999
Echinococcus granulosus	tyrosine kinase	0.0896	0.2537	0.2537
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.2232	1	1
Brugia malayi	Protein kinase domain containing protein	0.0896	0.2537	0.2537
Brugia malayi	SH2 domain containing protein	0.1337	0.4999	0.4999
Schistosoma mansoni	tyrosine kinase	0.0896	0.2537	0.2537
Trichomonas vaginalis	conserved hypothetical protein	0.0896	0.2537	1
Schistosoma mansoni	tyrosine kinase	0.0896	0.2537	0.2537
Echinococcus multilocularis	activin receptor type	0.0896	0.2537	0.2537
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0896	0.2537	0.2537
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.2232	1	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0896	0.2537	0.2537
Echinococcus multilocularis	SH2 motif	0.1337	0.4999	0.4999
Brugia malayi	Furin-like cysteine rich region family protein	0.0896	0.2537	0.2537
Schistosoma mansoni	tyrosine kinase	0.0896	0.2537	0.2537
Brugia malayi	Variant SH3 domain containing protein	0.1337	0.4999	0.4999
Loa Loa (eye worm)	TK/FER protein kinase	0.0896	0.2537	0.2537
Onchocerca volvulus		0.2232	1	1
Entamoeba histolytica	tyrosine kinase, putative	0.0896	0.2537	0.2537
Entamoeba histolytica	ankyrin repeat protein	0.0896	0.2537	0.2537
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0896	0.2537	0.2537
Entamoeba histolytica	protein kinase, putative	0.0896	0.2537	0.2537
Echinococcus multilocularis	growth factor receptor bound protein 2	0.1337	0.4999	0.4999
Entamoeba histolytica	protein kinase, putative	0.0896	0.2537	0.2537
Echinococcus multilocularis	N chimaerin	0.1337	0.4999	0.4999
Schistosoma mansoni	tyrosine kinase	0.0896	0.2537	0.2537
Entamoeba histolytica	protein kinase, putative	0.0896	0.2537	0.2537
Echinococcus multilocularis	tyrosine protein kinase csk	0.0896	0.2537	0.2537
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0896	0.2537	0.2537
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.1337	0.4999	0.4999
Entamoeba histolytica	tyrosin kinase, putative	0.0896	0.2537	0.2537
Brugia malayi	Protein kinase domain containing protein	0.0896	0.2537	0.2537
Entamoeba histolytica	tyrosine kinase, putative	0.0896	0.2537	0.2537
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.2232	1	1
Echinococcus granulosus	SHC transforming protein 3	0.1337	0.4999	0.4999
Schistosoma mansoni	tyrosine kinase	0.2232	1	1
Entamoeba histolytica	protein kinase with ankyrin repeats, putative	0.0896	0.2537	0.2537
Entamoeba histolytica	protein kinase, putative	0.0896	0.2537	0.2537
Brugia malayi	STAT protein, DNA binding domain containing protein	0.1337	0.4999	0.4999
Trichomonas vaginalis	protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative	0.0671	0.1285	0.5065
Echinococcus granulosus	tyrosine protein kinase Fyn	0.2232	1	1
Brugia malayi	integrin-linked kinase	0.0896	0.2537	0.2537
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0896	0.2537	0.2537
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0896	0.2537	0.2537
Schistosoma mansoni	tyrosine kinase	0.0896	0.2537	0.2537
Schistosoma mansoni	tyrosine kinase	0.0896	0.2537	0.2537
Trichomonas vaginalis	TKL family protein kinase	0.0896	0.2537	1
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	0.0671	0.1285	0.5065
Entamoeba histolytica	tyrosine kinase, putative	0.0896	0.2537	0.2537
Leishmania major	hypothetical protein, conserved	0.0896	0.2537	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.2232	1	1
Schistosoma mansoni	protein kinase	0.0896	0.2537	0.2537
Loa Loa (eye worm)	hypothetical protein	0.1337	0.4999	0.4999
Trichomonas vaginalis	TKL family protein kinase	0.0896	0.2537	1
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0896	0.2537	0.2537
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.1337	0.4999	0.4999
Echinococcus multilocularis	insulin receptor	0.0896	0.2537	0.2537
Entamoeba histolytica	protein kinase domain containing protein	0.0896	0.2537	0.2537
Echinococcus granulosus	SH2 domain containing protein 7	0.1337	0.4999	0.4999
Entamoeba histolytica	protein kinase domain containing protein	0.0896	0.2537	0.2537
Entamoeba histolytica	tyrosine kinase, putative	0.0896	0.2537	0.2537
Trichomonas vaginalis	TKL family protein kinase	0.0896	0.2537	1
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.1337	0.4999	0.4999
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0896	0.2537	0.2537
Loa Loa (eye worm)	hypothetical protein	0.1337	0.4999	0.4999
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.1337	0.4999	0.4999
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.1337	0.4999	0.4999
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.1337	0.4999	0.4999
Entamoeba histolytica	tyrosine kinase, putative	0.0896	0.2537	0.2537
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.1337	0.4999	0.3299
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0896	0.2537	0.2537
Entamoeba histolytica	ankyrin repeat protein	0.0896	0.2537	0.2537
Trichomonas vaginalis	TKL family protein kinase	0.0896	0.2537	1
Trichomonas vaginalis	TKL family protein kinase	0.0896	0.2537	1
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.1337	0.4999	0.4999
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0896	0.2537	0.2537
Loa Loa (eye worm)	TK protein kinase	0.0896	0.2537	0.2537
Trichomonas vaginalis	TKL family protein kinase	0.0896	0.2537	1
Schistosoma mansoni	tyrosine kinase	0.2232	1	1
Schistosoma mansoni	tensin-related	0.1337	0.4999	0.4999
Loa Loa (eye worm)	hypothetical protein	0.1337	0.4999	0.4999
Brugia malayi	Tensin	0.1337	0.4999	0.4999
Schistosoma mansoni	tyrosine kinase	0.0896	0.2537	0.2537
Onchocerca volvulus		0.1337	0.4999	0.3299
Trichomonas vaginalis	TKL family protein kinase	0.0896	0.2537	1
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.1337	0.4999	0.4999
Echinococcus multilocularis	tyrosine protein kinase csk	0.0896	0.2537	0.2537
Loa Loa (eye worm)	hypothetical protein	0.0896	0.2537	0.2537
Loa Loa (eye worm)	TK/FER protein kinase	0.2232	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0896	0.2537	1
Loa Loa (eye worm)	TK/DDR protein kinase	0.0896	0.2537	0.2537
Brugia malayi	Protein kinase domain containing protein	0.2232	1	1
Brugia malayi	SH2 domain containing protein	0.2232	1	1
Schistosoma mansoni	tensin-related	0.1337	0.4999	0.4999
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.2232	1	1
Echinococcus multilocularis	protein kinase	0.0896	0.2537	0.2537
Loa Loa (eye worm)	TK/INSR protein kinase	0.0896	0.2537	0.2537
Trichomonas vaginalis	TKL family protein kinase	0.0896	0.2537	1
Toxoplasma gondii	STE kinase	0.0896	0.2537	1
Echinococcus granulosus	natriuretic peptide receptor 1	0.0896	0.2537	0.2537
Trichomonas vaginalis	TKL family protein kinase	0.0896	0.2537	1
Echinococcus multilocularis	tensin	0.1337	0.4999	0.4999
Echinococcus granulosus	ephrin type A receptor 4 A	0.0896	0.2537	0.2537
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0896	0.2537	0.5
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.1337	0.4999	0.4999
Echinococcus multilocularis	NCK adaptor protein	0.1337	0.4999	0.4999
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0896	0.2537	0.2537
Trichomonas vaginalis	TKL family protein kinase	0.0896	0.2537	1
Trichomonas vaginalis	TKL family protein kinase	0.0896	0.2537	1
Entamoeba histolytica	hypothetical protein, conserved	0.0896	0.2537	0.2537
Echinococcus granulosus	tyrosine protein kinase Srms	0.2232	1	1
Onchocerca volvulus		0.2232	1	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0896	0.2537	0.2537
Entamoeba histolytica	tyrosine kinase, putative	0.0896	0.2537	0.2537
Leishmania major	protein kinase, putative	0.0896	0.2537	0.5
Schistosoma mansoni	tyrosine kinase	0.0896	0.2537	0.2537
Entamoeba histolytica	tyrosin kinase, putative	0.0896	0.2537	0.2537
Echinococcus granulosus	tyrosine protein kinase Fyn	0.2232	1	1
Echinococcus multilocularis	tyrosine protein kinase Srms	0.2232	1	1
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0896	0.2537	0.2537
Entamoeba histolytica	protein kinase, putative	0.0896	0.2537	0.2537
Loa Loa (eye worm)	serine/threonine protein kinase	0.0896	0.2537	0.2537
Entamoeba histolytica	protein kinase, putative	0.0896	0.2537	0.2537
Entamoeba histolytica	protein kinase domain containing protein	0.0896	0.2537	0.2537
Brugia malayi	SH2 domain containing protein	0.1337	0.4999	0.4999
Entamoeba histolytica	serine/threonine kinase, putative	0.0896	0.2537	0.2537
Brugia malayi	Protein kinase domain containing protein	0.0896	0.2537	0.2537
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0896	0.2537	0.2537
Trichomonas vaginalis	protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative	0.0497	0.0313	0.1234
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0896	0.2537	0.2537
Trichomonas vaginalis	conserved hypothetical protein	0.0896	0.2537	1
Brugia malayi	Tyrosine-protein kinase PR2	0.0896	0.2537	0.2537
Entamoeba histolytica	protein kinase, putative	0.0896	0.2537	0.2537
Echinococcus granulosus	tyrosine protein kinase ABL1	0.2232	1	1
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0896	0.2537	0.2537
Echinococcus granulosus	tyrosine protein kinase	0.0896	0.2537	0.2537
Loa Loa (eye worm)	TK protein kinase	0.0896	0.2537	0.2537
Schistosoma mansoni	tyrosine kinase	0.0896	0.2537	0.2537
Entamoeba histolytica	receptor protein kinase, putative	0.0896	0.2537	0.2537
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0896	0.2537	0.2537
Giardia lamblia	Kinase	0.0896	0.2537	1
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0896	0.2537	0.2537
Loa Loa (eye worm)	TK protein kinase	0.0896	0.2537	0.2537
Brugia malayi	Receptor family ligand binding region containing protein	0.0896	0.2537	0.2537
Loa Loa (eye worm)	TK/FER protein kinase	0.2232	1	1
Loa Loa (eye worm)	hypothetical protein	0.1337	0.4999	0.4999
Loa Loa (eye worm)	TK/FER protein kinase	0.0896	0.2537	0.2537
Echinococcus granulosus	tyrosine protein kinase Lyn	0.2232	1	1
Brugia malayi	Protein kinase domain containing protein	0.0896	0.2537	0.2537
Loa Loa (eye worm)	STAT protein	0.1337	0.4999	0.4999
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.2232	1	1
Echinococcus multilocularis	tyrosine protein kinase csk	0.0896	0.2537	0.2537
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0896	0.2537	0.2537
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.2232	1	1
Onchocerca volvulus		0.1337	0.4999	0.3299
Schistosoma mansoni	protein kinase	0.0896	0.2537	0.2537
Echinococcus granulosus	tyrosine protein kinase Src42A	0.2232	1	1
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0896	0.2537	0.2537
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0896	0.2537	0.2537
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.2232	1	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0896	0.2537	0.2537
Echinococcus multilocularis	SH2 motif	0.1337	0.4999	0.4999
Loa Loa (eye worm)	hypothetical protein	0.0896	0.2537	0.2537
Echinococcus granulosus	tyrosine protein kinase csk	0.0896	0.2537	0.2537
Schistosoma mansoni	ephrin receptor	0.0896	0.2537	0.2537
Entamoeba histolytica	protein kinase, putative	0.0896	0.2537	0.2537
Echinococcus granulosus	SH2 motif	0.1337	0.4999	0.4999
Entamoeba histolytica	protein kinase domain containing protein	0.0896	0.2537	0.2537
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.2232	1	1
Brugia malayi	Protein kinase domain containing protein	0.0896	0.2537	0.2537
Loa Loa (eye worm)	TK/FER protein kinase	0.2232	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0896	0.2537	1
Brugia malayi	Protein kinase domain containing protein	0.0896	0.2537	0.2537
Schistosoma mansoni	suppressor of cytokine signaling	0.1337	0.4999	0.4999
Trichomonas vaginalis	TKL family protein kinase	0.0896	0.2537	1
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0896	0.2537	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0896	0.2537	0.2537
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0896	0.2537	0.5
Brugia malayi	C-terminal src kinase protein 1	0.0896	0.2537	0.2537
Schistosoma mansoni	serine/threonine RGC	0.0896	0.2537	0.2537
Plasmodium falciparum	protein kinase, putative	0.0896	0.2537	1
Loa Loa (eye worm)	TK/ACK protein kinase	0.0896	0.2537	0.2537
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0896	0.2537	0.2537
Brugia malayi	hypothetical protein	0.0896	0.2537	0.2537
Brugia malayi	Protein kinase domain containing protein	0.0896	0.2537	0.2537
Brugia malayi	Variant SH3 domain containing protein	0.1337	0.4999	0.4999
Brugia malayi	Protein kinase domain containing protein	0.2232	1	1
Echinococcus granulosus	tyrosine protein kinase csk	0.0896	0.2537	0.2537
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0896	0.2537	0.2537
Echinococcus granulosus	c src tyrosine kinase	0.2232	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0896	0.2537	1
Echinococcus multilocularis	activated cdc42 kinase 1	0.0896	0.2537	0.2537
Trichomonas vaginalis	TKL family protein kinase	0.0896	0.2537	1
Loa Loa (eye worm)	SRC-1	0.2232	1	1
Trichomonas vaginalis	AGC family protein kinase	0.0896	0.2537	1
Loa Loa (eye worm)	TK/FER protein kinase	0.2232	1	1
Onchocerca volvulus		0.2232	1	1
Entamoeba histolytica	protein kinase domain containing protein	0.0896	0.2537	0.2537
Trichomonas vaginalis	TKL family protein kinase	0.0896	0.2537	1
Trichomonas vaginalis	TKL family protein kinase	0.0896	0.2537	1
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.2232	1	1
Loa Loa (eye worm)	TK/ABL protein kinase	0.2232	1	1
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0896	0.2537	0.2537
Trypanosoma brucei	Pseudokinase, putative	0.0896	0.2537	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0896	0.2537	0.2537
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0896	0.2537	0.2537
Giardia lamblia	Kinase, NEK	0.0896	0.2537	1
Schistosoma mansoni	protein kinase	0.0896	0.2537	0.2537
Loa Loa (eye worm)	hypothetical protein	0.1337	0.4999	0.4999
Entamoeba histolytica	hypothetical protein	0.0896	0.2537	0.2537
Echinococcus granulosus	raf serine:threonine protein kinase	0.0896	0.2537	0.2537
Schistosoma mansoni	tyrosine kinase	0.0896	0.2537	0.2537
Loa Loa (eye worm)	SH2 domain-containing protein	0.1337	0.4999	0.4999
Trichomonas vaginalis	TKL family protein kinase	0.0896	0.2537	1
Loa Loa (eye worm)	TK/RYK protein kinase	0.0896	0.2537	0.2537
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0896	0.2537	0.2537
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0896	0.2537	0.2537
Entamoeba histolytica	protein kinase, putative	0.0896	0.2537	0.2537
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.1337	0.4999	0.4999
Toxoplasma gondii	protein kinase domain-containing protein	0.0896	0.2537	1
Entamoeba histolytica	protein kinase domain containing protein	0.0896	0.2537	0.2537
Brugia malayi	SH2 domain containing protein	0.1337	0.4999	0.4999
Loa Loa (eye worm)	TK/FER protein kinase	0.2232	1	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0896	0.2537	0.2537
Schistosoma mansoni	tyrosine kinase	0.2232	1	1
Onchocerca volvulus		0.2232	1	1
Schistosoma mansoni	SH2A	0.1337	0.4999	0.4999
Loa Loa (eye worm)	hypothetical protein	0.1337	0.4999	0.4999
Echinococcus granulosus	receptor type guanylyl cyclase	0.0896	0.2537	0.2537
Loa Loa (eye worm)	hypothetical protein	0.1337	0.4999	0.4999
Echinococcus multilocularis	FL cytokine receptor	0.0896	0.2537	0.2537
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0896	0.2537	1
Loa Loa (eye worm)	hypothetical protein	0.1337	0.4999	0.4999
Entamoeba histolytica	serine/threonine kinase, putative	0.0896	0.2537	0.2537
Schistosoma mansoni	vav2	0.1337	0.4999	0.4999
Entamoeba histolytica	serine/threonine kinase, putative	0.0896	0.2537	0.2537
Trichomonas vaginalis	TKL family protein kinase	0.0896	0.2537	1
Entamoeba histolytica	hypothetical protein	0.0896	0.2537	0.2537
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0896	0.2537	0.2537
Loa Loa (eye worm)	hypothetical protein	0.0896	0.2537	0.2537
Echinococcus granulosus	tyrosine kinase	0.2232	1	1
Entamoeba histolytica	protein kinase, putative	0.0896	0.2537	0.2537
Echinococcus multilocularis	epidermal growth factor receptor	0.0896	0.2537	0.2537
Entamoeba histolytica	SH2 domain containing protein	0.1337	0.4999	0.4999
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0896	0.2537	0.2537
Echinococcus granulosus	integrin linked protein kinase	0.0896	0.2537	0.2537
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0896	0.2537	0.2537
Entamoeba histolytica	hypothetical protein	0.0896	0.2537	0.2537
Loa Loa (eye worm)	TK/FER protein kinase	0.2232	1	1
Brugia malayi	Protein kinase domain containing protein	0.0896	0.2537	0.2537
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0896	0.2537	0.2537
Entamoeba histolytica	hypothetical protein	0.0896	0.2537	0.2537
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.1337	0.4999	0.3299
Trichomonas vaginalis	conserved hypothetical protein	0.0896	0.2537	1
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.1337	0.4999	0.4999
Schistosoma mansoni	growth factor receptor-bound protein	0.1337	0.4999	0.4999
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0896	0.2537	0.2537
Echinococcus multilocularis	protein kinase	0.0896	0.2537	0.2537
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0896	0.2537	0.2537
Brugia malayi	Protein kinase domain containing protein	0.0896	0.2537	0.2537
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.2232	1	1
Loa Loa (eye worm)	TK protein kinase	0.0896	0.2537	0.2537
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0896	0.2537	0.2537
Schistosoma mansoni	tyrosine kinase	0.0896	0.2537	0.2537
Loa Loa (eye worm)	SH2 domain-containing protein	0.1337	0.4999	0.4999
Onchocerca volvulus		0.1337	0.4999	0.3299
Plasmodium falciparum	tyrosine kinase-like protein	0.0896	0.2537	1
Trichomonas vaginalis	TKL family protein kinase	0.0896	0.2537	1
Brugia malayi	Protein kinase domain containing protein	0.0896	0.2537	0.2537
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0896	0.2537	0.2537
Echinococcus multilocularis	protein farnesyltransferase alpha subunit	0.0671	0.1285	0.1285
Schistosoma mansoni	tyrosine kinase	0.0896	0.2537	0.2537
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0896	0.2537	1
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	0.0671	0.1285	0.5065
Brugia malayi	Sex muscle abnormal protein 5	0.1337	0.4999	0.4999
Trypanosoma brucei	protein kinase, putative	0.0896	0.2537	0.5
Brugia malayi	hypothetical protein	0.2232	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0896	0.2537	1
Echinococcus granulosus	epidermal growth factor receptor	0.0896	0.2537	0.2537
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0896	0.2537	1
Loa Loa (eye worm)	hypothetical protein	0.0896	0.2537	0.2537
Trichomonas vaginalis	TKL family protein kinase	0.0896	0.2537	1
Trichomonas vaginalis	TKL family protein kinase	0.0896	0.2537	1
Loa Loa (eye worm)	hypothetical protein	0.1337	0.4999	0.4999
Echinococcus granulosus	tyrosine protein kinase Src64B	0.2232	1	1
Loa Loa (eye worm)	hypothetical protein	0.0896	0.2537	0.2537
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0896	0.2537	0.5
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.1337	0.4999	0.4999
Schistosoma mansoni	tyrosine protein kinase	0.0896	0.2537	0.2537
Schistosoma mansoni	tensin	0.1337	0.4999	0.4999
Entamoeba histolytica	protein kinase domain containing protein	0.0896	0.2537	0.2537
Entamoeba histolytica	protein kinase, putative	0.0896	0.2537	0.2537
Schistosoma mansoni	tensin	0.1337	0.4999	0.4999
Schistosoma mansoni	serine/threonine protein kinase	0.0896	0.2537	0.2537
Entamoeba histolytica	protein kinase domain containing protein	0.0896	0.2537	0.2537
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0896	0.2537	0.5
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0896	0.2537	0.2537
Trichomonas vaginalis	TKL family protein kinase	0.0896	0.2537	1
Brugia malayi	Protein kinase domain containing protein	0.0896	0.2537	0.2537
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.2232	1	1
Loa Loa (eye worm)	hypothetical protein	0.1337	0.4999	0.4999
Entamoeba histolytica	hypothetical protein	0.0896	0.2537	0.2537
Brugia malayi	Protein prenyltransferase alpha subunit repeat containing protein	0.0671	0.1285	0.1285
Loa Loa (eye worm)	TK/FER protein kinase	0.0896	0.2537	0.2537
Brugia malayi	Protein kinase domain containing protein	0.0896	0.2537	0.2537
Trichomonas vaginalis	TKL family protein kinase	0.0896	0.2537	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0896	0.2537	0.2537
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.1337	0.4999	0.4999
Brugia malayi	Protein kinase domain containing protein	0.0896	0.2537	0.2537
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0896	0.2537	0.2537
Plasmodium falciparum	protein kinase, putative	0.0896	0.2537	1
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0896	0.2537	0.2537
Brugia malayi	Protein kinase domain containing protein	0.0896	0.2537	0.2537
Entamoeba histolytica	tyrosine kinase, putative	0.0896	0.2537	0.2537
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0896	0.2537	0.2537
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0896	0.2537	0.2537
Onchocerca volvulus		0.1337	0.4999	0.3299
Echinococcus multilocularis	heat shock protein 70	0.0896	0.2537	0.2537
Echinococcus granulosus	tensin	0.1337	0.4999	0.4999
Echinococcus granulosus	NCK adaptor protein	0.1337	0.4999	0.4999
Echinococcus granulosus	tyrosine protein kinase Src42A	0.1337	0.4999	0.4999
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0896	0.2537	1
Brugia malayi	Protein kinase domain containing protein	0.0896	0.2537	0.2537
Trichomonas vaginalis	TKL family protein kinase	0.0896	0.2537	1
Trichomonas vaginalis	conserved hypothetical protein	0.0896	0.2537	1
Echinococcus granulosus	N chimaerin	0.1337	0.4999	0.4999
Loa Loa (eye worm)	prenyltransferase alpha subunit repeat containing protein	0.0671	0.1285	0.1285
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0896	0.2537	1
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0896	0.2537	0.2537
Trichomonas vaginalis	TKL family protein kinase	0.0896	0.2537	1
Brugia malayi	Protein kinase domain containing protein	0.2232	1	1
Echinococcus granulosus	tyrosine protein kinase csk	0.0896	0.2537	0.2537
Trichomonas vaginalis	TKL family protein kinase	0.0896	0.2537	1
Brugia malayi	SH2 domain containing protein	0.1337	0.4999	0.4999
Loa Loa (eye worm)	hypothetical protein	0.1337	0.4999	0.4999
Entamoeba histolytica	protein kinase domain containing protein	0.0896	0.2537	0.2537
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.1337	0.4999	0.4999
Schistosoma mansoni	tyrosine kinase	0.0896	0.2537	0.2537
Echinococcus multilocularis	SHC transforming protein 3	0.1337	0.4999	0.4999
Entamoeba histolytica	tyrosine kinase, putative	0.0896	0.2537	0.2537
Schistosoma mansoni	tyrosine kinase	0.0896	0.2537	0.2537
Trichomonas vaginalis	conserved hypothetical protein	0.0896	0.2537	1
Entamoeba histolytica	protein kinase domain containing protein	0.0896	0.2537	0.2537
Entamoeba histolytica	protein kinase domain containing protein	0.0896	0.2537	0.2537
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.1337	0.4999	0.4999
Trichomonas vaginalis	TKL family protein kinase	0.0896	0.2537	1
Schistosoma mansoni	tyrosine kinase	0.0896	0.2537	0.2537
Echinococcus granulosus	SH2 motif	0.1337	0.4999	0.4999
Schistosoma mansoni	protein kinase	0.0896	0.2537	0.2537
Loa Loa (eye worm)	hypothetical protein	0.0896	0.2537	0.2537
Entamoeba histolytica	protein kinase, putative	0.0896	0.2537	0.2537
Brugia malayi	hypothetical protein	0.1337	0.4999	0.4999
Entamoeba histolytica	tyrosine kinase, putative	0.0896	0.2537	0.2537
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0896	0.2537	0.2537
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.0896	0.2537	0.2537
Brugia malayi	cytokine inducible SH2-containing protein 5	0.1337	0.4999	0.4999
Schistosoma mansoni	protein kinase	0.0896	0.2537	0.2537
Schistosoma mansoni	tyrosine kinase	0.2232	1	1
Schistosoma mansoni	protein kinase	0.0896	0.2537	0.2537
Entamoeba histolytica	protein kinase, putative	0.0896	0.2537	0.2537
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0896	0.2537	0.2537
Schistosoma mansoni	protein kinase	0.0896	0.2537	0.2537
Schistosoma mansoni	tyrosine kinase	0.0896	0.2537	0.2537
Loa Loa (eye worm)	TK/ROR protein kinase	0.0896	0.2537	0.2537
Entamoeba histolytica	protein kinase, putative	0.0896	0.2537	0.2537
Entamoeba histolytica	hypothetical protein	0.0896	0.2537	0.2537
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0896	0.2537	0.2537
Schistosoma mansoni	GTPase activating protein	0.1337	0.4999	0.4999
Echinococcus multilocularis	tyrosine protein kinase	0.0896	0.2537	0.2537
Echinococcus granulosus	protein tyrosine kinase	0.0896	0.2537	0.2537
Trichomonas vaginalis	TKL family protein kinase	0.0896	0.2537	1
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0896	0.2537	1
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0896	0.2537	0.2537
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0896	0.2537	0.2537
Echinococcus granulosus	protein farnesyltransferase alpha subunit	0.0671	0.1285	0.1285
Echinococcus granulosus	protein kinase	0.0896	0.2537	0.2537
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.2232	1	1
Leishmania major	protein kinase, putative	0.0896	0.2537	0.5
Brugia malayi	SH2 domain containing protein	0.1337	0.4999	0.4999
Echinococcus multilocularis	SH2 domain containing protein 7	0.1337	0.4999	0.4999
Onchocerca volvulus		0.1337	0.4999	0.3299
Entamoeba histolytica	protein kinase, putative	0.0896	0.2537	0.2537
Loa Loa (eye worm)	TK/FER protein kinase	0.0896	0.2537	0.2537
Echinococcus granulosus	activated cdc42 kinase 1	0.0896	0.2537	0.2537
Loa Loa (eye worm)	hypothetical protein	0.0896	0.2537	0.2537
Entamoeba histolytica	protein kinase domain containing protein	0.0896	0.2537	0.2537
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.1337	0.4999	0.4999
Schistosoma mansoni	protein kinase	0.0896	0.2537	0.2537
Trichomonas vaginalis	TKL family protein kinase	0.0896	0.2537	1
Echinococcus granulosus	growth factor receptor bound protein 2	0.1337	0.4999	0.4999
Trichomonas vaginalis	TKL family protein kinase	0.0896	0.2537	1
Echinococcus granulosus	activin receptor type	0.0896	0.2537	0.2537
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0896	0.2537	0.2537
Trichomonas vaginalis	TKL family protein kinase	0.0896	0.2537	1
Schistosoma mansoni	tyrosine kinase	0.0896	0.2537	0.2537
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.1337	0.4999	0.4999
Trichomonas vaginalis	TKL family protein kinase	0.0896	0.2537	1
Brugia malayi	hypothetical protein	0.0896	0.2537	0.2537
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.1337	0.4999	0.4999
Entamoeba histolytica	serine/threonine kinase, putative	0.0896	0.2537	0.2537
Schistosoma mansoni	tyrosine kinase	0.0896	0.2537	0.2537
Echinococcus granulosus	epidermal growth factor receptor	0.0896	0.2537	0.2537
Loa Loa (eye worm)	TK protein kinase	0.0896	0.2537	0.2537
Trichomonas vaginalis	TKL family protein kinase	0.0896	0.2537	1
Trypanosoma cruzi	protein kinase, putative	0.0896	0.2537	0.5
Schistosoma mansoni	tyrosine kinase	0.0896	0.2537	0.2537
Brugia malayi	Protein kinase domain containing protein	0.0896	0.2537	0.2537
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0896	0.2537	0.2537
Entamoeba histolytica	protein kinase domain containing protein	0.0896	0.2537	0.2537
Loa Loa (eye worm)	hypothetical protein	0.0896	0.2537	0.2537
Schistosoma mansoni	tyrosine kinase	0.0896	0.2537	0.2537
Schistosoma mansoni	protein kinase	0.0896	0.2537	0.2537
Echinococcus multilocularis	protein tyrosine kinase	0.0896	0.2537	0.2537
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.1337	0.4999	0.4999
Brugia malayi	Protein kinase domain containing protein	0.0896	0.2537	0.2537
Trichomonas vaginalis	TKL family protein kinase	0.0896	0.2537	1
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0896	0.2537	0.2537
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0896	0.2537	0.2537
Trichomonas vaginalis	TK family protein kinase	0.0896	0.2537	1
Entamoeba histolytica	tyrosine kinase, putative	0.0896	0.2537	0.2537
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0896	0.2537	0.2537
Plasmodium falciparum	protein kinase, putative	0.0896	0.2537	1
Loa Loa (eye worm)	TK/FER protein kinase	0.2232	1	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.1337	0.4999	0.4999
Trichomonas vaginalis	TKL family protein kinase	0.0896	0.2537	1
Trypanosoma cruzi	protein kinase, putative	0.0896	0.2537	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0896	0.2537	0.2537
Echinococcus granulosus	suppressor of cytokine signaling 7	0.1337	0.4999	0.4999
Schistosoma mansoni	tyrosine kinase	0.0896	0.2537	0.2537
Echinococcus multilocularis	tyrosine protein kinase Abl	0.2232	1	1
Echinococcus granulosus	tyrosine protein kinase shark	0.2232	1	1
Schistosoma mansoni	shc transforming protein	0.1337	0.4999	0.4999
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.1337	0.4999	0.4999
Entamoeba histolytica	protein kinase domain containing protein	0.0896	0.2537	0.2537
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.2232	1	1
Entamoeba histolytica	protein kinase, putative	0.1337	0.4999	0.4999
Trichomonas vaginalis	CAMK family protein kinase	0.0896	0.2537	1
Loa Loa (eye worm)	hypothetical protein	0.0896	0.2537	0.2537
Schistosoma mansoni	protein farnesyltransferase alpha subunit	0.0671	0.1285	0.1285
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.2232	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0896	0.2537	1
Trichomonas vaginalis	TKL family protein kinase	0.0896	0.2537	1
Entamoeba histolytica	tyrosine- protein kinase 2, putative	0.0896	0.2537	0.2537
Trichomonas vaginalis	conserved hypothetical protein	0.0896	0.2537	1
Entamoeba histolytica	protein kinase domain containing protein	0.0896	0.2537	0.2537
Brugia malayi	RhoGAP domain containing protein	0.1337	0.4999	0.4999
Schistosoma mansoni	hypothetical protein	0.0896	0.2537	0.2537
Brugia malayi	Protein kinase domain containing protein	0.0896	0.2537	0.2537
Onchocerca volvulus		0.2232	1	1
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0896	0.2537	0.2537
Echinococcus multilocularis	signal transduction protein lnk realted	0.1337	0.4999	0.4999
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0896	0.2537	0.2537
Trichomonas vaginalis	TKL family protein kinase	0.0896	0.2537	1
Echinococcus multilocularis	tensin	0.1337	0.4999	0.4999
Echinococcus multilocularis	tyrosine protein kinase shark	0.2232	1	1
Brugia malayi	Protein kinase domain containing protein	0.0896	0.2537	0.2537
Schistosoma mansoni	protein tyrosine kinase	0.0896	0.2537	0.2537
Trichomonas vaginalis	TKL family protein kinase	0.0896	0.2537	1
Trichomonas vaginalis	TKL family protein kinase	0.0896	0.2537	1
Echinococcus multilocularis	c src tyrosine kinase	0.2232	1	1
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.2232	1	1
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0896	0.2537	0.2537
Brugia malayi	tRNA modification GTPase TrmE family protein	0.1337	0.4999	0.4999
Entamoeba histolytica	tyrosine kinase, putative	0.0896	0.2537	0.2537
Brugia malayi	Protein kinase domain containing protein	0.0896	0.2537	0.2537
Entamoeba histolytica	hypothetical protein	0.0896	0.2537	0.2537
Schistosoma mansoni	adapter molecule crk	0.1337	0.4999	0.4999
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0896	0.2537	1
Brugia malayi	Variant SH3 domain containing protein	0.1337	0.4999	0.4999
Brugia malayi	Protein kinase domain containing protein	0.0896	0.2537	0.2537
Schistosoma mansoni	suppressor of cytokine signaling	0.1337	0.4999	0.4999
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.1337	0.4999	0.4999
Loa Loa (eye worm)	hypothetical protein	0.0896	0.2537	0.2537
Trichomonas vaginalis	TKL family protein kinase	0.0896	0.2537	1
Entamoeba histolytica	tyrosine kinase, putative	0.0896	0.2537	0.2537
Echinococcus multilocularis	tyrosine kinase	0.0896	0.2537	0.2537
Schistosoma mansoni	tyrosine kinase	0.0896	0.2537	0.2537
Echinococcus granulosus	tyrosine protein kinase Fyn	0.2232	1	1
Loa Loa (eye worm)	TK/FAK protein kinase	0.0896	0.2537	0.2537
Echinococcus multilocularis	epidermal growth factor receptor	0.0896	0.2537	0.2537
Entamoeba histolytica	protein kinase domain containing protein	0.0896	0.2537	0.2537
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0896	0.2537	0.2537
Trichomonas vaginalis	TKL family protein kinase	0.0896	0.2537	1
Echinococcus granulosus	tyrosine protein kinase Blk	0.2232	1	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0896	0.2537	0.2537
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0896	0.2537	0.2537
Entamoeba histolytica	protein kinase domain containing protein	0.0896	0.2537	0.2537
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0896	0.2537	0.2537
Trichomonas vaginalis	TKL family protein kinase	0.0896	0.2537	1
Loa Loa (eye worm)	hypothetical protein	0.1337	0.4999	0.4999
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0896	0.2537	0.2537
Brugia malayi	Protein kinase domain containing protein	0.0896	0.2537	0.2537
Echinococcus granulosus	tyrosine protein kinase pr2	0.0896	0.2537	0.2537
Brugia malayi	Variant SH3 domain containing protein	0.1337	0.4999	0.4999
Giardia lamblia	Protein 21.1	0.0896	0.2537	1
Brugia malayi	Protein kinase domain containing protein	0.0896	0.2537	0.2537
Trichomonas vaginalis	STE family protein kinase	0.0896	0.2537	1
Entamoeba histolytica	protein kinase, putative	0.0896	0.2537	0.2537
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.1337	0.4999	0.4999
Schistosoma mansoni	serine/threonine protein kinase	0.0896	0.2537	0.2537
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0896	0.2537	0.2537
Schistosoma mansoni	tyrosine kinase	0.0896	0.2537	0.2537
Loa Loa (eye worm)	TK/FER protein kinase	0.0896	0.2537	0.2537
Loa Loa (eye worm)	TK/Met protein kinase	0.0896	0.2537	0.2537
Echinococcus granulosus	SH2 domain containing adapter protein F	0.1337	0.4999	0.4999
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0896	0.2537	0.2537
Brugia malayi	SH2 domain containing protein	0.2232	1	1
Entamoeba histolytica	protein kinase, putative	0.0896	0.2537	0.2537
Trichomonas vaginalis	TKL family protein kinase	0.0896	0.2537	1
Loa Loa (eye worm)	hypothetical protein	0.0896	0.2537	0.2537
Plasmodium vivax	protein kinase, putative	0.0896	0.2537	1
Echinococcus multilocularis	tyrosine protein kinase csk	0.0896	0.2537	0.2537
Echinococcus granulosus	tyrosine protein kinase HCK	0.0896	0.2537	0.2537
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0896	0.2537	0.2537

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.23 uM	Displacement of [125I]MCH peptide from human MCHR1 expressed in CHOK1 cells	ChEMBL.	23743277

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2403870

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1777006