Detailed information for compound 1777097

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 206.198 | Formula: C10H10N2O3
  • H donors: 0 H acceptors: 3 LogP: 0.68 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC1=CC(=O)c2c(C1=O)c(C)nn2C
  • InChi: 1S/C10H10N2O3/c1-5-8-9(12(2)11-5)6(13)4-7(15-3)10(8)14/h4H,1-3H3
  • InChiKey: LJIRSFJVQOYBJK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica glycogen phosphorylase, putative 0.0404 0.2621 1
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0188 0.0568
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0077 0.0396 0.1376
Brugia malayi metabotropic glutamate receptor type 2 0.0207 0.1278 0.1278
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0024 0.0036 0.0033
Echinococcus multilocularis glutamate receptor 2 0.0412 0.2673 0.2671
Schistosoma mansoni hypothetical protein 0.0275 0.1746 0.1744
Loa Loa (eye worm) MH2 domain-containing protein 0.0064 0.0308 0.0308
Mycobacterium tuberculosis Probable glycogen phosphorylase GlgP 0.0175 0.1063 0.1063
Echinococcus granulosus neuropeptide receptor A26 0.1022 0.6818 0.6817
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0052 0.023 0.0733
Schistosoma mansoni glutamate receptor NMDA 0.0618 0.4076 0.4074
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0024 0.0036 0.0033
Loa Loa (eye worm) hypothetical protein 0.0207 0.1278 0.1278
Loa Loa (eye worm) hypothetical protein 0.0207 0.1278 0.1278
Brugia malayi Glutamate receptor 2 precursor 0.0412 0.2673 0.2673
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0074 0.038 0.0377
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0097 0.0532 0.0532
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0024 0.0036 0.0033
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0056 0.0034
Loa Loa (eye worm) hypothetical protein 0.0045 0.018 0.018
Echinococcus multilocularis ATP dependent DNA helicase PIF1 0.0103 0.0574 0.0571
Trichomonas vaginalis conserved hypothetical protein 0.0103 0.0574 0.2064
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0618 0.4076 0.4074
Brugia malayi N-terminal motif family protein 0.0206 0.1272 0.1272
Echinococcus multilocularis nmda type glutamate receptor 0.1422 0.9536 0.9536
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.1019 0.6799 0.6799
Echinococcus granulosus dihydrofolate reductase 0.149 1 1
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0667 0.4403 1
Echinococcus multilocularis carbonic anhydrase 0.0144 0.0851 0.0848
Schistosoma mansoni cercarial elastase (S01 family) 0.0024 0.0036 0.0033
Plasmodium falciparum carbonic anhydrase 0.0144 0.0851 0.1856
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0074 0.038 0.038
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0074 0.038 0.0377
Schistosoma mansoni glycogen phosphorylase 0.0175 0.1063 0.106
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0396 0.1376
Loa Loa (eye worm) jmjC domain-containing protein 0.0031 0.0084 0.0084
Brugia malayi Glutamate receptor 1 precursor 0.0412 0.2673 0.2673
Onchocerca volvulus 0.0097 0.0532 0.2031
Echinococcus multilocularis transmembrane protease serine 3 0.0024 0.0036 0.0033
Leishmania major carbonic anhydrase-like protein 0.0306 0.1952 0.4433
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0077 0.0396 0.0783
Brugia malayi hypothetical protein 0.0024 0.0036 0.0036
Loa Loa (eye worm) DOMON domain-containing protein 0.0045 0.018 0.018
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0056 0.0034
Trypanosoma cruzi extracellular receptor, putative 0.0207 0.1278 0.2812
Loa Loa (eye worm) hypothetical protein 0.0024 0.0036 0.0036
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0034 0.0105 0.0248
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0077 0.0396 0.1376
Echinococcus multilocularis geminin 0.0275 0.1746 0.1744
Echinococcus multilocularis histone lysine N methyltransferase E(z) 0.094 0.6259 0.6258
Entamoeba histolytica DNA repair and recombination protein, putative 0.0103 0.0574 0.2189
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0636 0.4196 0.4194
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0024 0.0036 0.0033
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0056 0.0034
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0077 0.0396 0.1376
Onchocerca volvulus 0.0045 0.018 0.0686
Onchocerca volvulus 0.0207 0.1278 0.4878
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0024 0.0036 0.0036
Onchocerca volvulus 0.0207 0.1278 0.4878
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0032 0.0093 0.009
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0207 0.1278 0.1276
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0077 0.0396 0.1376
Echinococcus multilocularis NMDA receptor 0.042 0.2732 0.2729
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0074 0.038 0.038
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0043 0.0167 0.0163
Echinococcus multilocularis carbonic anhydrase 0.0144 0.0851 0.0848
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0636 0.4196 0.4194
Brugia malayi hypothetical protein 0.0207 0.1278 0.1278
Schistosoma mansoni hypothetical protein 0.0043 0.0167 0.0163
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0077 0.0396 0.1376
Echinococcus granulosus glutamate NMDA receptor subunit 0.0412 0.2673 0.2671
Trypanosoma cruzi DNA repair and recombination helicase protein PIF6, putative 0.0103 0.0574 0.1191
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0077 0.0396 0.1376
Onchocerca volvulus 0.0024 0.0036 0.0138
Loa Loa (eye worm) hypothetical protein 0.0207 0.1278 0.1278
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0207 0.1278 0.1278
Brugia malayi Metabotropic glutamate receptor precursor. 0.0207 0.1278 0.1278
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0207 0.1278 0.1276
Brugia malayi Calcitonin receptor-like protein seb-1 0.0135 0.0796 0.0796
Brugia malayi Trypsin family protein 0.0024 0.0036 0.0036
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0077 0.0396 0.1376
Schistosoma mansoni cercarial elastase (S01 family) 0.0024 0.0036 0.0033
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0043 0.0167 0.0163
Schistosoma mansoni hypothetical protein 0.0024 0.0036 0.0033
Schistosoma mansoni jumonji/arid domain-containing protein 0.0031 0.0084 0.0081
Brugia malayi SEA domain containing protein 0.0045 0.018 0.018
Loa Loa (eye worm) hypothetical protein 0.0048 0.0203 0.0203
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0077 0.0396 0.0783
Onchocerca volvulus 0.0287 0.1828 0.6974
Loa Loa (eye worm) carbonic anhydrase 3 0.0306 0.1952 0.1952
Entamoeba histolytica glycogen phosphorylase, putative 0.0404 0.2621 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0043 0.0167 0.0167
Schistosoma mansoni jumonji domain containing protein 0.0031 0.0084 0.0081
Onchocerca volvulus 0.0045 0.018 0.0686
Brugia malayi Muscle positioning protein 4 0.0045 0.018 0.018
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0034 0.0105 0.0105
Schistosoma mansoni glycogen phosphorylase 0.0404 0.2621 0.2619
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0636 0.4196 0.4194
Loa Loa (eye worm) RGC/RGC protein kinase 0.0207 0.1278 0.1278
Trypanosoma brucei DNA repair and recombination helicase protein PIF7 0.0103 0.0574 0.1191
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1059 0.7071 0.707
Schistosoma mansoni hypothetical protein 0.0275 0.1746 0.1744
Onchocerca volvulus 0.0048 0.0203 0.0774
Echinococcus multilocularis tyrosine kinase 0.0207 0.1278 0.1276
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.1019 0.6799 0.5
Loa Loa (eye worm) hypothetical protein 0.0045 0.018 0.018
Echinococcus granulosus thymidylate synthase 0.0097 0.0532 0.0529
Schistosoma mansoni cercarial elastase (S01 family) 0.0024 0.0036 0.0033
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0034 0.0105 0.0248
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0077 0.0396 0.1376
Echinococcus granulosus enteropeptidase 0.0024 0.0036 0.0033
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0077 0.0396 0.1376
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0207 0.1278 0.1278
Trichomonas vaginalis conserved hypothetical protein 0.0067 0.0332 0.1128
Loa Loa (eye worm) SET domain-containing protein 0.094 0.6259 0.6259
Echinococcus granulosus glycoprotein Antigen 5 0.0024 0.0036 0.0033
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0077 0.0396 0.1376
Schistosoma mansoni cercarial elastase (S01 family) 0.0024 0.0036 0.0033
Mycobacterium ulcerans putative regulatory protein 0.0024 0.0041 0.0041
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0031 0.0084 0.0081
Loa Loa (eye worm) glycogen phosphorylase 0.0404 0.2621 0.2621
Leishmania major hypothetical protein, conserved 0.0027 0.0056 0.0128
Onchocerca volvulus 0.0045 0.018 0.0686
Echinococcus multilocularis neuropeptide s receptor 0.1022 0.6818 0.6817
Onchocerca volvulus 0.0024 0.0036 0.0138
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0077 0.0396 0.1376
Trypanosoma brucei DNA repair and recombination helicase protein PIF6 0.0103 0.0574 0.1191
Echinococcus granulosus metabotropic glutamate receptor 2 0.0207 0.1278 0.1276
Loa Loa (eye worm) hypothetical protein 0.0144 0.0851 0.0851
Echinococcus granulosus glycogen phosphorylase 0.0404 0.2621 0.2619
Echinococcus granulosus transmembrane protease serine 3 0.0024 0.0036 0.0033
Schistosoma mansoni glutamate receptor kainate 0.0429 0.2793 0.279
Entamoeba histolytica hypothetical protein 0.0019 0.0003 0.0013
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0306 0.1952 0.4361
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0103 0.0574 0.1191
Schistosoma mansoni glutamate receptor kainate 0.0412 0.2673 0.2671
Schistosoma mansoni dihydrofolate reductase 0.149 1 1
Brugia malayi latrophilin 2 splice variant baaae 0.0093 0.0505 0.0505
Schistosoma mansoni cercarial elastase (S01 family) 0.0024 0.0036 0.0033
Echinococcus multilocularis Mastin 0.0024 0.0036 0.0033
Loa Loa (eye worm) hypothetical protein 0.0024 0.0036 0.0036
Echinococcus multilocularis carbonic anhydrase 0.0144 0.0851 0.0848
Loa Loa (eye worm) glutamate receptor 2 0.0412 0.2673 0.2673
Loa Loa (eye worm) glutamate receptor 1 0.0412 0.2673 0.2673
Giardia lamblia Glycogen phosphorylase 0.0404 0.2621 1
Schistosoma mansoni hypothetical protein 0.0048 0.0203 0.02
Loa Loa (eye worm) hypothetical protein 0.0207 0.1278 0.1278
Schistosoma mansoni cercarial elastase (S01 family) 0.0024 0.0036 0.0033
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0306 0.1952 0.1952
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0052 0.023 0.0733
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0077 0.0396 0.0783
Echinococcus granulosus receptor type guanylyl cyclase 0.0207 0.1278 0.1276
Brugia malayi Trypsin family protein 0.0287 0.1828 0.1828
Schistosoma mansoni hypothetical protein 0.0093 0.0505 0.0501
Schistosoma mansoni hypothetical protein 0.0043 0.0167 0.0163
Echinococcus granulosus tyrosine kinase 0.0207 0.1278 0.1276
Echinococcus multilocularis enteropeptidase 0.0024 0.0036 0.0033
Echinococcus granulosus geminin 0.0275 0.1746 0.1744
Mycobacterium ulcerans thymidylate synthase 0.0097 0.0532 0.0532
Schistosoma mansoni metabotropic glutamate receptor 0.0207 0.1278 0.1276
Brugia malayi hypothetical protein 0.0048 0.0203 0.0203
Echinococcus granulosus carbonic anhydrase 0.0144 0.0851 0.0848
Loa Loa (eye worm) glutamate receptor 0.0207 0.1278 0.1278
Loa Loa (eye worm) TK/ALK protein kinase 0.0048 0.0203 0.0203
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0144 0.0851 0.0851
Onchocerca volvulus 0.0045 0.018 0.0686
Echinococcus multilocularis GPCR, family 2 0.0043 0.0167 0.0163
Schistosoma mansoni hypothetical protein 0.0103 0.0574 0.0571
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0034 0.0105 0.0105
Brugia malayi Guanylyl cyclase protein 23 0.0207 0.1278 0.1278
Schistosoma mansoni metabotropic glutamate receptor 0.0207 0.1278 0.1276
Echinococcus multilocularis dihydrofolate reductase 0.149 1 1
Brugia malayi hypothetical protein 0.0027 0.0056 0.0056
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0306 0.1952 0.1949
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0618 0.4076 0.4074
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.144 0.9655 0.9655
Trichomonas vaginalis conserved hypothetical protein 0.0067 0.0332 0.1128
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0074 0.038 0.0377
Entamoeba histolytica hypothetical protein 0.0019 0.0003 0.0013
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0024 0.0036 0.0033
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0077 0.0396 0.1376
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0077 0.0396 0.1376
Loa Loa (eye worm) hypothetical protein 0.0024 0.0036 0.0036
Echinococcus granulosus Mastin 0.0024 0.0036 0.0033
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0077 0.0396 0.1376
Echinococcus multilocularis glycogen phosphorylase 0.0404 0.2621 0.2619
Echinococcus multilocularis glutamate receptor 2 0.0618 0.4076 0.4074
Schistosoma mansoni glycogen phosphorylase 0.0404 0.2621 0.2619
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0287 0.1828 0.1825
Loa Loa (eye worm) hypothetical protein 0.0207 0.1278 0.1278
Loa Loa (eye worm) hypothetical protein 0.0144 0.0851 0.0851
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.149 1 1
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0034 0.0105 0.0102
Mycobacterium leprae conserved hypothetical protein 0.0024 0.0041 0.0041
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0168 0.102 0.102
Echinococcus granulosus glycogen phosphorylase 0.0404 0.2621 0.2619
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0144 0.0851 0.0851
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0306 0.1952 0.1949
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0024 0.0036 0.0033
Loa Loa (eye worm) hypothetical protein 0.0024 0.0036 0.0036
Toxoplasma gondii hypothetical protein 0.0144 0.0851 0.1856
Entamoeba histolytica glycogen phosphorylase, putative 0.0175 0.1063 0.4054
Schistosoma mansoni hypothetical protein 0.0048 0.0203 0.02
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0144 0.0851 0.0851
Schistosoma mansoni carbonic anhydrase-related 0.0144 0.0851 0.0848
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0207 0.1278 0.4878
Loa Loa (eye worm) hypothetical protein 0.0207 0.1278 0.1278
Schistosoma mansoni hypothetical protein 0.0045 0.018 0.0177
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0667 0.4403 1
Brugia malayi jmjC domain containing protein 0.0031 0.0084 0.0084
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0403 0.2612 0.261
Schistosoma mansoni hypothetical protein 0.0403 0.2612 0.261
Schistosoma mansoni glutamate receptor AMPA 0.0412 0.2673 0.2671
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0074 0.038 0.0377
Loa Loa (eye worm) transcription factor SMAD2 0.0064 0.0308 0.0308
Loa Loa (eye worm) RGC/RGC protein kinase 0.0207 0.1278 0.1278
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0056 0.0034
Brugia malayi MH2 domain containing protein 0.0064 0.0308 0.0308
Schistosoma mansoni jumonji/arid domain-containing protein 0.0031 0.0084 0.0081
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0403 0.2612 0.261
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0077 0.0396 0.1376
Loa Loa (eye worm) hypothetical protein 0.0093 0.0505 0.0505
Onchocerca volvulus 0.0264 0.1667 0.6361
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0207 0.1278 0.1276
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0667 0.4403 1
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0636 0.4196 0.4194
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0077 0.0396 0.1376
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0181 0.1106 0.1106
Brugia malayi Receptor family ligand binding region containing protein 0.0207 0.1278 0.1278
Loa Loa (eye worm) hypothetical protein 0.0048 0.0203 0.0203
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0043 0.0167 0.0163
Echinococcus granulosus glutamate receptor 2 0.0216 0.1339 0.1337
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0306 0.1952 0.1952
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0304 0.194 0.1938
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0103 0.0574 0.1303
Echinococcus granulosus glutamate receptor ionotropic kainate 0.042 0.2732 0.2729
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0207 0.1278 0.1278
Loa Loa (eye worm) hypothetical protein 0.0135 0.0796 0.0796
Onchocerca volvulus 0.0079 0.0412 0.1573
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.149 1 1
Trichomonas vaginalis glycogen phosphorylase, putative 0.0404 0.2621 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0167 0.0167
Schistosoma mansoni cercarial elastase (S01 family) 0.0024 0.0036 0.0033
Schistosoma mansoni hypothetical protein 0.0144 0.0851 0.0848
Echinococcus granulosus neuropeptide s receptor 0.1022 0.6818 0.6817
Brugia malayi Latrophilin receptor protein 2 0.0043 0.0167 0.0167
Echinococcus granulosus nmda type glutamate receptor 0.1422 0.9536 0.9536
Schistosoma mansoni enhancer of zeste ezh 0.094 0.6259 0.6258
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0135 0.0796 0.0796
Trichomonas vaginalis glycogen phosphorylase, putative 0.0404 0.2621 1
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0206 0.1272 0.4852
Brugia malayi Trypsin-like protease protein 5 0.0024 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0206 0.1272 0.1272
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0077 0.0396 0.1376
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.1019 0.6799 0.6799
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0077 0.0396 0.1376
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0043 0.0167 0.0167
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.1019 0.6799 0.5662
Schistosoma mansoni hypothetical protein 0.0024 0.0036 0.0033
Loa Loa (eye worm) hypothetical protein 0.0024 0.0036 0.0036
Echinococcus granulosus nmda type glutamate receptor 0.0207 0.1278 0.1276
Echinococcus granulosus ATP dependent DNA helicase PIF1 0.0103 0.0574 0.0571
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0077 0.0396 0.0393
Loa Loa (eye worm) dihydrofolate reductase 0.149 1 1
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0034 0.0105 0.0102
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0077 0.0396 0.0783
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0077 0.0396 0.1376
Onchocerca volvulus 0.0048 0.0203 0.0774
Loa Loa (eye worm) hypothetical protein 0.0207 0.1278 0.1278
Loa Loa (eye worm) RGC/RGC protein kinase 0.0207 0.1278 0.1278
Brugia malayi Protein kinase domain containing protein 0.0048 0.0203 0.0203
Echinococcus granulosus carbonic anhydrase 0.0144 0.0851 0.0848
Echinococcus granulosus tm gpcr rhodopsin 0.0271 0.1715 0.1712
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0043 0.0167 0.0163
Echinococcus multilocularis lysine specific demethylase 5A 0.0031 0.0084 0.0081
Loa Loa (eye worm) hypothetical protein 0.0048 0.0203 0.0203
Brugia malayi thymidylate synthase 0.0097 0.0532 0.0532
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0077 0.0396 0.1376
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.1019 0.6799 0.5
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0135 0.0796 0.0796
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0046 0.0188 0.0303
Brugia malayi hypothetical protein 0.0019 0.0003 0.0003
Schistosoma mansoni cercarial elastase (S01 family) 0.0024 0.0036 0.0033
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0667 0.4403 1
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0207 0.1278 0.1278
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0271 0.1715 0.1712
Echinococcus multilocularis nmda type glutamate receptor 0.0207 0.1278 0.1276
Brugia malayi carbohydrate phosphorylase 0.0404 0.2621 0.2621
Mycobacterium ulcerans putative regulatory protein 0.0024 0.0041 0.0041
Onchocerca volvulus 0.0024 0.0036 0.0138
Onchocerca volvulus Glycogen phosphorylase homolog 0.0404 0.2621 1
Mycobacterium tuberculosis Hypothetical protein 0.0046 0.0188 0.0188
Entamoeba histolytica hypothetical protein 0.0207 0.1278 0.4878
Onchocerca volvulus 0.0045 0.018 0.0686
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0144 0.0851 0.0851
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0077 0.0396 0.1376
Echinococcus multilocularis glutamate receptor 2 0.0216 0.1339 0.1337
Echinococcus granulosus carbonic anhydrase 0.0144 0.0851 0.0848
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0667 0.4403 1
Echinococcus granulosus metabotropic glutamate receptor 5 0.0207 0.1278 0.1276
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0024 0.0036 0.0033
Echinococcus granulosus histone lysine N methyltransferase Ez 0.094 0.6259 0.6258
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0077 0.0396 0.1376
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0144 0.0851 0.0851
Schistosoma mansoni carbonic anhydrase-related 0.0144 0.0851 0.0848
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0074 0.038 0.0377
Loa Loa (eye worm) hypothetical protein 0.0079 0.0412 0.0412
Schistosoma mansoni hypothetical protein 0.0043 0.0167 0.0163
Brugia malayi Dihydrofolate reductase 0.149 1 1
Echinococcus granulosus Glycosyl transferase family 35 0.0404 0.2621 0.2619
Schistosoma mansoni carbonic anhydrase-related 0.0144 0.0851 0.0848
Echinococcus multilocularis thymidylate synthase 0.0097 0.0532 0.0529
Schistosoma mansoni glutamate receptor NMDA 0.0412 0.2673 0.2671
Brugia malayi Trypsin family protein 0.0024 0.0036 0.0036
Brugia malayi Receptor family ligand binding region containing protein 0.0207 0.1278 0.1278
Schistosoma mansoni cercarial elastase (S01 family) 0.0024 0.0036 0.0033
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0077 0.0396 0.0783
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0031 0.0084 0.0081
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0403 0.2612 0.261
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0103 0.0574 0.1303
Echinococcus multilocularis receptor type guanylyl cyclase 0.0207 0.1278 0.1276
Schistosoma mansoni glutamate receptor kainate 0.0429 0.2793 0.279
Loa Loa (eye worm) hypothetical protein 0.0027 0.0056 0.0056
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0077 0.0396 0.1376
Echinococcus multilocularis glycoprotein Antigen 5 0.0024 0.0036 0.0033
Schistosoma mansoni ATP-binding cassette transporter 0.0412 0.2673 0.2671
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0097 0.0532 0.0532
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0024 0.0041 0.0041
Brugia malayi SET domain containing protein 0.094 0.6259 0.6259
Trichomonas vaginalis conserved hypothetical protein 0.0067 0.0332 0.1128
Entamoeba histolytica glycogen phosphorylase, putative 0.0175 0.1063 0.4054
Brugia malayi jmjC domain containing protein 0.0031 0.0084 0.0084
Toxoplasma gondii hypothetical protein 0.0067 0.0332 0.0667
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0306 0.1952 0.4361
Entamoeba histolytica hypothetical protein 0.0019 0.0003 0.0013
Loa Loa (eye worm) thymidylate synthase 0.0097 0.0532 0.0532
Entamoeba histolytica glycogenphosphorylase, putative 0.0175 0.1063 0.4054
Schistosoma mansoni cercarial elastase (S01 family) 0.0024 0.0036 0.0033
Echinococcus granulosus atrial natriuretic peptide receptor 0.0207 0.1278 0.1276
Loa Loa (eye worm) hypothetical protein 0.0287 0.1828 0.1828
Schistosoma mansoni carbonic anhydrase 0.0144 0.0851 0.0848
Echinococcus multilocularis neuropeptide receptor A26 0.1022 0.6818 0.6817
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0077 0.0396 0.1376
Loa Loa (eye worm) hypothetical protein 0.0024 0.0041 0.0041
Leishmania major extracellular receptor, putative 0.0207 0.1278 0.2903
Onchocerca volvulus 0.0024 0.0036 0.0138
Echinococcus granulosus MAM 0.0048 0.0203 0.02
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0181 0.1106 0.1106
Schistosoma mansoni tyrosine kinase 0.0207 0.1278 0.1276
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.042 0.2732 0.2729
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0103 0.0574 0.1191
Echinococcus granulosus lysine specific demethylase 5A 0.0031 0.0084 0.0081
Schistosoma mansoni cercarial elastase (S01 family) 0.0024 0.0036 0.0033
Chlamydia trachomatis dihydrofolate reductase 0.149 1 1
Chlamydia trachomatis glutamine binding protein 0.1019 0.6799 0.5662
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0412 0.2673 0.2671
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0074 0.038 0.0377
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0077 0.0396 0.0393
Entamoeba histolytica hypothetical protein, conserved 0.0103 0.0574 0.2189
Loa Loa (eye worm) hypothetical protein 0.0287 0.1828 0.1828
Echinococcus multilocularis carbonic anhydrase II 0.0306 0.1952 0.1949
Loa Loa (eye worm) hypothetical protein 0.0034 0.0105 0.0105
Schistosoma mansoni tyrosine kinase 0.0207 0.1278 0.1276
Entamoeba histolytica hypothetical protein 0.0019 0.0003 0.0013
Brugia malayi hypothetical protein 0.0079 0.0412 0.0412
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0636 0.4196 0.4194
Brugia malayi hypothetical protein 0.0046 0.0188 0.0188
Trypanosoma brucei carbonic anhydrase-like protein 0.0306 0.1952 0.4361
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0024 0.0041 0.0041
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0636 0.4196 0.4194
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0077 0.0396 0.1376
Loa Loa (eye worm) hypothetical protein 0.0207 0.1278 0.1278
Loa Loa (eye worm) hypothetical protein 0.0144 0.0851 0.0851
Schistosoma mansoni glutamate receptor AMPA 0.0412 0.2673 0.2671
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0034 0.0105 0.0248
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0077 0.0396 0.1376
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0052 0.023 0.0401
Mycobacterium ulcerans glycogen phosphorylase GlgP 0.0175 0.1063 0.1063
Brugia malayi Trypsin family protein 0.0024 0.0036 0.0036
Echinococcus multilocularis Glycosyl transferase, family 35 0.0404 0.2621 0.2619
Mycobacterium ulcerans hypothetical protein 0.0024 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0207 0.1278 0.1278
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0144 0.0851 0.0851
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0077 0.0396 0.1376
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.042 0.2732 0.2729
Schistosoma mansoni hypothetical protein 0.0043 0.0167 0.0163
Echinococcus multilocularis MAM 0.0048 0.0203 0.02
Loa Loa (eye worm) trypsin family protein 0.0024 0.0036 0.0036
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0667 0.4403 1
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0024 0.0041 0.0041
Schistosoma mansoni protein kinase 0.0207 0.1278 0.1276
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0034 0.0105 0.0102
Onchocerca volvulus 0.0024 0.0036 0.0138
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0024 0.0036 0.0033
Echinococcus granulosus GPCR family 2 0.0043 0.0167 0.0163
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0306 0.1952 0.1952
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0077 0.0396 0.0393
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.149 1 1
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0097 0.0532 0.0529
Echinococcus multilocularis glycogen phosphorylase 0.0404 0.2621 0.2619
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0024 0.0036 0.0033
Echinococcus granulosus glutamate receptor 2 0.0618 0.4076 0.4074
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0074 0.038 0.0377
Echinococcus granulosus carbonic anhydrase II 0.0306 0.1952 0.1949
Echinococcus granulosus glutamate receptor subunit protein glur 0.0403 0.2612 0.261
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0077 0.0396 0.1376

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) = 19.6 umol/min/mg Activity at human recombinant NQO1 assessed as average rate of irreversible NADH oxidation after 30 to 40 mins by HPLC analysis ChEMBL. 23635904
Activity (binding) = 55.3 umol/min/mg Activity at human recombinant NQO1 assessed as initial rate of cytochrome c reduction after 30 to 40 mins by spectrophotometry ChEMBL. 23635904

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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