Detailed information for compound 1777222

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 481.625 | Formula: C23H31NO6S2
  • H donors: 2 H acceptors: 5 LogP: 0.94 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCC[C@@]1(CC)N[C@H](c2ccccc2)c2c(S(=O)(=O)C1)cc(c(c2)OC)CS(=O)(=O)O
  • InChi: 1S/C23H31NO6S2/c1-4-6-12-23(5-2)16-31(25,26)21-13-18(15-32(27,28)29)20(30-3)14-19(21)22(24-23)17-10-8-7-9-11-17/h7-11,13-14,22,24H,4-6,12,15-16H2,1-3H3,(H,27,28,29)/t22-,23-/m1/s1
  • InChiKey: BFWPUQURSUWSSX-DHIUTWEWSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens solute carrier family 10 (sodium/bile acid cotransporter), member 2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis sodium bile acid cotransporter Get druggable targets OG5_128996 All targets in OG5_128996
Echinococcus granulosus sodium bile acid cotransporter Get druggable targets OG5_128996 All targets in OG5_128996
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128996 All targets in OG5_128996
Schistosoma japonicum IPR002657,Bile acid:sodium symporter,domain-containing Get druggable targets OG5_128996 All targets in OG5_128996
Echinococcus granulosus sodium bile acid cotransporter Get druggable targets OG5_128996 All targets in OG5_128996
Schistosoma mansoni sodium-bile acid cotransporter Get druggable targets OG5_128996 All targets in OG5_128996
Brugia malayi Sodium Bile acid symporter family protein Get druggable targets OG5_128996 All targets in OG5_128996
Onchocerca volvulus Get druggable targets OG5_128996 All targets in OG5_128996
Schistosoma mansoni sodium-bile acid cotransporter related Get druggable targets OG5_128996 All targets in OG5_128996
Schistosoma japonicum ko:K03453 bile acid:Na+ symporter, BASS family, putative Get druggable targets OG5_128996 All targets in OG5_128996
Echinococcus granulosus sodium bile acid cotransporter Get druggable targets OG5_128996 All targets in OG5_128996
Echinococcus multilocularis sodium bile acid cotransporter Get druggable targets OG5_128996 All targets in OG5_128996
Echinococcus multilocularis sodium bile acid cotransporter Get druggable targets OG5_128996 All targets in OG5_128996
Schistosoma japonicum Conserved hypothetical protein Get druggable targets OG5_128996 All targets in OG5_128996
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0032 0.0504 0.0454
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0083 0.1664 1
Brugia malayi Receptor family ligand binding region containing protein 0.0017 0.0142 0.0142
Echinococcus multilocularis muscleblind protein 1 0.0448 1 1
Loa Loa (eye worm) RGC/RGC protein kinase 0.0017 0.0142 0.0101
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0631 0.0592
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0115 0.2384 1
Echinococcus multilocularis receptor type guanylyl cyclase 0.0017 0.0142 0.009
Onchocerca volvulus 0.0026 0.0364 0.0421
Loa Loa (eye worm) hypothetical protein 0.0448 1 1
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0017 0.0142 0.0142
Chlamydia trachomatis glutamine binding protein 0.0083 0.1664 1
Entamoeba histolytica phosphofructokinase, putative 0.0115 0.2384 1
Entamoeba histolytica phosphofructokinase, putative 0.0115 0.2384 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0285 0.0593
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0032 0.0504 0.0454
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0285 0.0285
Echinococcus multilocularis lamin dm0 0.0026 0.0364 0.0313
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0031 0.047 0.2099
Loa Loa (eye worm) hypothetical protein 0.0039 0.0661 0.0622
Onchocerca volvulus 0.0023 0.0285 0.0271
Schistosoma mansoni intermediate filament proteins 0.0026 0.0364 0.03
Schistosoma mansoni glutamate receptor AMPA 0.0032 0.0504 0.046
Schistosoma mansoni lamin 0.0026 0.0364 0.03
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0152 0.006
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0285 0.0682
Brugia malayi PHD-finger family protein 0.0026 0.0348 0.0348
Loa Loa (eye worm) hypothetical protein 0.0041 0.07 0.0661
Echinococcus granulosus tyrosine kinase 0.0017 0.0142 0.009
Schistosoma mansoni 6-phosphofructokinase 0.0115 0.2384 0.2595
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0017 0.0142 0.0101
Trichomonas vaginalis phosphofructokinase, putative 0.0115 0.2384 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0142 0.0101
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0364 0.0324
Trypanosoma cruzi extracellular receptor, putative 0.0017 0.0142 0.0187
Loa Loa (eye worm) glutamate receptor 0.0017 0.0142 0.0101
Loa Loa (eye worm) RGC/RGC protein kinase 0.0017 0.0142 0.0101
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0285 0.0593
Schistosoma mansoni ap endonuclease 0.0038 0.0631 0.0603
Echinococcus granulosus geminin 0.0329 0.7289 0.7274
Treponema pallidum exodeoxyribonuclease (exoA) 0.0038 0.0631 0.0839
Schistosoma mansoni cpg binding protein 0.0028 0.0404 0.0345
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.047 0.6641
Brugia malayi Bromodomain containing protein 0.0037 0.0607 0.0607
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0032 0.0504 0.0454
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.1123 0.1163
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0016 0.0138 0.0086
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0074 0.1442 0.1397
Echinococcus multilocularis muscleblind protein 0.0448 1 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0059 0.1116 0.1069
Loa Loa (eye worm) hypothetical protein 0.0013 0.0052 0.0011
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0285 0.0593
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0115 0.2384 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0017 0.0152 0.01
Leishmania major extracellular receptor, putative 0.0017 0.0142 0.0187
Loa Loa (eye worm) phosphofructokinase 0.0115 0.2384 0.2352
Loa Loa (eye worm) hypothetical protein 0.0041 0.07 0.0661
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0031 0.047 0.1463
Loa Loa (eye worm) hypothetical protein 0.0017 0.0142 0.0101
Echinococcus multilocularis lamin 0.0026 0.0364 0.0313
Brugia malayi CXXC zinc finger family protein 0.0028 0.0404 0.0404
Echinococcus multilocularis 6 phosphofructokinase 0.0115 0.2384 0.2343
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0555 0.0505
Schistosoma mansoni glutamate receptor kainate 0.0032 0.0504 0.046
Schistosoma mansoni hypothetical protein 0.002 0.0217 0.0134
Trichomonas vaginalis phosphofructokinase, putative 0.0115 0.2384 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0631 0.0581
Echinococcus multilocularis glutamate receptor 2 0.009 0.1823 0.178
Brugia malayi Metabotropic glutamate receptor precursor. 0.0017 0.0142 0.0142
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0017 0.0142 0.0101
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.047 0.6641
Brugia malayi Probable ATP-dependent helicase DHX35 0.0171 0.3678 0.3678
Echinococcus multilocularis sodium bile acid cotransporter 0.0247 0.5413 0.5388
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0083 0.1664 0.6241
Schistosoma mansoni glutamate receptor NMDA 0.0032 0.0504 0.046
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0631 0.0631
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0285 0.0285
Schistosoma mansoni glutamate receptor AMPA 0.0032 0.0504 0.046
Echinococcus granulosus atrial natriuretic peptide receptor 0.0017 0.0142 0.009
Schistosoma mansoni ATP-binding cassette transporter 0.0032 0.0504 0.046
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0152 0.006
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0285 0.0593
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0296 0.0245
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.0631 0.2178
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0285 0.0593
Schistosoma mansoni methyl-cpg binding protein mbd 0.0016 0.0138 0.0044
Loa Loa (eye worm) hypothetical protein 0.0017 0.0153 0.0112
Mycobacterium ulcerans 6-phosphofructokinase 0.0115 0.2384 1
Brugia malayi Glutamate receptor 2 precursor 0.0074 0.1442 0.1442
Echinococcus granulosus lamin 0.0026 0.0364 0.0313
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.047 0.6641
Trichomonas vaginalis phosphofructokinase, putative 0.0115 0.2384 1
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0032 0.0504 0.0454
Loa Loa (eye worm) hypothetical protein 0.0041 0.07 0.0661
Loa Loa (eye worm) hypothetical protein 0.0023 0.0285 0.0245
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0285 0.0637
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0631 0.0581
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.103 1
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.047 0.6641
Echinococcus multilocularis nmda type glutamate receptor 0.0116 0.2407 0.2367
Schistosoma mansoni 6-phosphofructokinase 0.0115 0.2384 0.2595
Loa Loa (eye worm) hypothetical protein 0.0017 0.0153 0.0112
Echinococcus granulosus glutamate receptor 4 0.0041 0.07 0.0651
Loa Loa (eye worm) hypothetical protein 0.0017 0.0152 0.0111
Loa Loa (eye worm) hypothetical protein 0.0017 0.0142 0.0101
Echinococcus granulosus glutamate NMDA receptor subunit 0.0032 0.0504 0.0454
Schistosoma mansoni cpg binding protein 0.0032 0.0482 0.0435
Loa Loa (eye worm) hypothetical protein 0.0017 0.0153 0.0112
Echinococcus multilocularis glutamate receptor 2 0.0058 0.1081 0.1034
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0285 0.0813
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0364 0.0364
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0555 0.0505
Schistosoma mansoni glutamate receptor NMDA 0.0049 0.0885 0.0892
Echinococcus granulosus glutamate receptor 1 0.0041 0.07 0.0651
Loa Loa (eye worm) glutamate receptor 2 0.0032 0.0504 0.0465
Loa Loa (eye worm) hypothetical protein 0.0048 0.0866 0.0828
Echinococcus granulosus methyl CpG binding domain protein 2 0.0016 0.0138 0.0086
Echinococcus multilocularis cpg binding protein 0.0032 0.0482 0.0432
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0115 0.2384 1
Loa Loa (eye worm) 6-phosphofructokinase 0.0115 0.2384 0.2352
Loa Loa (eye worm) hypothetical protein 0.0068 0.1323 0.1287
Entamoeba histolytica phosphofructokinase, putative 0.0115 0.2384 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0142 0.0101
Brugia malayi hypothetical protein 0.0017 0.0142 0.0142
Echinococcus granulosus nmda type glutamate receptor 0.0116 0.2407 0.2367
Loa Loa (eye worm) hypothetical protein 0.0017 0.0142 0.0101
Loa Loa (eye worm) hypothetical protein 0.0017 0.0142 0.0101
Loa Loa (eye worm) hypothetical protein 0.0247 0.5413 0.5393
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0285 0.0682
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0032 0.0504 0.0454
Schistosoma mansoni hypothetical protein 0.0329 0.7289 0.8168
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0631 0.2325
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0049 0.0885 0.0837
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0017 0.0142 0.009
Onchocerca volvulus 0.0026 0.0364 0.0421
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0631 0.0839
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0083 0.1664 0.6775
Echinococcus granulosus metabotropic glutamate receptor 5 0.0017 0.0142 0.009
Schistosoma mansoni hypothetical protein 0.04 0.8901 1
Echinococcus granulosus cpg binding protein 0.0032 0.0482 0.0432
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0049 0.0885 0.0837
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0049 0.0885 0.0837
Loa Loa (eye worm) hypothetical protein 0.0448 1 1
Brugia malayi Bromodomain containing protein 0.0074 0.1454 0.1454
Brugia malayi Glutamate receptor 1 precursor 0.0074 0.1442 0.1442
Schistosoma mansoni methyl-cpg binding protein mbd 0.0016 0.0138 0.0044
Schistosoma mansoni lamin 0.0026 0.0364 0.03
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0032 0.0504 0.0454
Schistosoma mansoni ap endonuclease 0.0038 0.0631 0.0603
Echinococcus granulosus nmda type glutamate receptor 0.0017 0.0142 0.009
Schistosoma mansoni protein kinase 0.0017 0.0142 0.0049
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0031 0.047 0.2099
Echinococcus multilocularis zinc finger protein 0.0021 0.0231 0.0179
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.2423 0.2392
Echinococcus granulosus muscleblind protein 0.0448 1 1
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0049 0.0885 0.0837
Loa Loa (eye worm) hypothetical protein 0.0026 0.0353 0.0313
Loa Loa (eye worm) hypothetical protein 0.0017 0.0142 0.0101
Brugia malayi Sodium Bile acid symporter family protein 0.0247 0.5413 0.5413
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0116 0.2407 0.2367
Schistosoma mansoni bromodomain containing protein 0.0063 0.1195 0.1245
Leishmania major ATP-dependent phosphofructokinase 0.0115 0.2384 1
Schistosoma mansoni hypothetical protein 0.0329 0.7289 0.8168
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0017 0.0142 0.0101
Trichomonas vaginalis phosphofructokinase, putative 0.0115 0.2384 1
Echinococcus granulosus tumor protein p63 0.033 0.7306 0.7292
Schistosoma mansoni sodium-bile acid cotransporter 0.0147 0.3121 0.3433
Loa Loa (eye worm) hypothetical protein 0.0017 0.0153 0.0112
Echinococcus granulosus sodium bile acid cotransporter 0.0247 0.5413 0.5388
Loa Loa (eye worm) hypothetical protein 0.0026 0.0364 0.0324
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0038 0.0631 1
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0296 0.0223
Echinococcus granulosus 6 phosphofructokinase 0.0115 0.2384 0.2343
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.009 0.1823 0.178
Brugia malayi metabotropic glutamate receptor type 2 0.0017 0.0142 0.0142
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0059 0.1116 0.1069
Mycobacterium ulcerans hypothetical protein 0.0023 0.0285 0.0593
Onchocerca volvulus 0.0028 0.0404 0.0496
Loa Loa (eye worm) DEAH box polypeptide 35 0.0171 0.3678 0.3652
Echinococcus multilocularis glutamate receptor 4 0.0041 0.07 0.0651
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0285 0.0637
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0115 0.2384 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.2423 0.2392
Loa Loa (eye worm) hypothetical protein 0.0017 0.0142 0.0101
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0049 0.0885 0.0837
Loa Loa (eye worm) hypothetical protein 0.0171 0.3678 0.3652
Echinococcus granulosus receptor type guanylyl cyclase 0.0017 0.0142 0.009
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0084 0.0084
Toxoplasma gondii exonuclease III APE 0.0038 0.0631 0.2867
Echinococcus multilocularis glutamate receptor 2 0.0074 0.1442 0.1397
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0285 0.0813
Brugia malayi 6-phosphofructokinase 0.0115 0.2384 0.2384
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0631 0.2325
Loa Loa (eye worm) 6-phosphofructokinase 0.0115 0.2384 0.2352
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0404 0.0364
Schistosoma mansoni zinc finger protein 0.0021 0.0231 0.0149
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.009 0.1823 0.178
Echinococcus multilocularis dnaJ subfamily B 0.04 0.8901 0.8896
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0285 0.0637
Schistosoma mansoni glutamate receptor kainate 0.0032 0.0504 0.046
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0285 0.0813
Echinococcus granulosus histone lysine methyltransferase setb 0.0017 0.0152 0.01
Loa Loa (eye worm) hypothetical protein 0.0017 0.0142 0.0101
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0017 0.0142 0.009
Schistosoma mansoni tyrosine kinase 0.0017 0.0142 0.0049
Loa Loa (eye worm) hypothetical protein 0.0017 0.0153 0.0112
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0296 0.0245
Echinococcus granulosus glutamate receptor 2 0.0058 0.1081 0.1034
Echinococcus multilocularis sodium bile acid cotransporter 0.0247 0.5413 0.5388
Echinococcus multilocularis musashi 0.0026 0.0364 0.0313
Echinococcus multilocularis nmda type glutamate receptor 0.0017 0.0142 0.009
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0083 0.1664 0.6241
Schistosoma mansoni tyrosine kinase 0.0017 0.0142 0.0049
Echinococcus granulosus lamin dm0 0.0026 0.0364 0.0313
Loa Loa (eye worm) hypothetical protein 0.0023 0.0285 0.0245
Schistosoma mansoni sodium-bile acid cotransporter related 0.01 0.2053 0.222
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0285 0.0285
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0364 0.0324
Echinococcus multilocularis tyrosine kinase 0.0017 0.0142 0.009
Brugia malayi phosphofructokinase 0.0115 0.2384 0.2384
Schistosoma mansoni metabotropic glutamate receptor 0.0017 0.0142 0.0049
Echinococcus granulosus dnaJ subfamily B 0.04 0.8901 0.8896
Brugia malayi 6-phosphofructokinase 0.0115 0.2384 0.2384
Echinococcus granulosus sodium bile acid cotransporter 0.0247 0.5413 0.5388
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0049 0.0885 0.0837
Schistosoma mansoni glutamate receptor kainate 0.0032 0.0504 0.046
Echinococcus granulosus glutamate receptor subunit protein glur 0.0074 0.1442 0.1397
Echinococcus multilocularis tumor protein p63 0.033 0.7306 0.7292
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.0152 0.0111
Echinococcus granulosus sodium bile acid cotransporter 0.0247 0.5413 0.5388
Loa Loa (eye worm) hypothetical protein 0.0037 0.0609 0.057
Brugia malayi intermediate filament protein 0.0026 0.0364 0.0364
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0115 0.2384 1
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0083 0.1664 0.6806
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0631 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0631 0.2325
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0631 1
Brugia malayi Receptor family ligand binding region containing protein 0.0017 0.0142 0.0142
Onchocerca volvulus 0.0048 0.0866 0.1373
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0285 0.0593
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0017 0.0142 0.009
Echinococcus multilocularis geminin 0.0329 0.7289 0.7274
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0631 0.2325
Loa Loa (eye worm) hypothetical protein 0.0023 0.0285 0.0245
Brugia malayi Guanylyl cyclase protein 23 0.0017 0.0142 0.0142
Echinococcus granulosus intermediate filament protein 0.0026 0.0364 0.0313
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0285 0.0593
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.0631 0.2142
Schistosoma mansoni cpg binding protein 0.0032 0.0482 0.0435
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0038 0.0631 0.2216
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0038 0.0631 0.5
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0866 0.0871
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0631 0.0839
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0217 0.0177
Schistosoma mansoni sodium-bile acid cotransporter related 0.0247 0.5413 0.6036
Echinococcus granulosus zinc finger protein 0.0021 0.0231 0.0179
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0084 0.0043
Brugia malayi MH2 domain containing protein 0.0116 0.2423 0.2423
Loa Loa (eye worm) glutamate receptor 1 0.0074 0.1442 0.1407
Loa Loa (eye worm) hypothetical protein 0.0043 0.074 0.0701
Onchocerca volvulus 0.0247 0.5413 1
Schistosoma mansoni metabotropic glutamate receptor 0.0017 0.0142 0.0049
Schistosoma mansoni hypothetical protein 0.0032 0.0504 0.046
Loa Loa (eye worm) RGC/RGC protein kinase 0.0017 0.0142 0.0101
Echinococcus multilocularis NMDA receptor 0.0032 0.0504 0.0454
Echinococcus granulosus metabotropic glutamate receptor 2 0.0017 0.0142 0.009
Echinococcus multilocularis sodium bile acid cotransporter 0.0247 0.5413 0.5388
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0153 0.0095
Echinococcus granulosus glutamate receptor 2 0.009 0.1823 0.178

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 4 nM Inhibition of human ASBT expressed in HEK293 cells assessed as inhibition of [3H]-taurocholate uptake after 90 mins by scintillation counting analysis ChEMBL. 23678871

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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