TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 550.674 | Formula: C31H30N6O2S
H donors: 4 H acceptors: 5 LogP: 5.35 Rotable bonds: 10
Rule of 5 violations (Lipinski): 2
SMILES: OC[C@H](c1ccccc1)NC(=O)c1ccc(c(c1)Nc1ncnc2c1ccc(n2)C(C)C)Sc1ccc(cc1)N
InChi: 1S/C31H30N6O2S/c1-19(2)25-14-13-24-29(35-25)33-18-34-30(24)36-26-16-21(8-15-28(26)40-23-11-9-22(32)10-12-23)31(39)37-27(17-38)20-6-4-3-5-7-20/h3-16,18-19,27,38H,17,32H2,1-2H3,(H,37,39)(H,33,34,35,36)/t27-/m1/s1
InChiKey: FPIDRFVVLBHBQV-HHHXNRCGSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0852	0.3873	0.3873
Plasmodium falciparum	pyruvate kinase	0.1967	0.9307	1
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0852	0.3873	0.3873
Loa Loa (eye worm)	ShTK domain-containing protein	0.0096	0.019	0.019
Schistosoma mansoni	protein kinase	0.0852	0.3873	0.3754
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0852	0.3873	0.3873
Echinococcus multilocularis		0.1257	0.5849	0.5849
Schistosoma mansoni	signal transduction protein lnk-related	0.1257	0.5849	0.5769
Schistosoma mansoni	tyrosine kinase	0.0852	0.3873	0.3754
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0852	0.3873	0.3873
Echinococcus granulosus	pyruvate kinase	0.1967	0.9307	0.9307
Schistosoma mansoni	tensin-related	0.1257	0.5849	0.5769
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0852	0.3873	0.3754
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.2109	1	1
Brugia malayi	Protein kinase domain containing protein	0.0852	0.3873	0.3754
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0852	0.3873	0.3873
Loa Loa (eye worm)	TK/FER protein kinase	0.2109	1	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0852	0.3873	0.3873
Loa Loa (eye worm)	TK/FER protein kinase	0.0852	0.3873	0.3873
Brugia malayi	Protein kinase domain containing protein	0.0852	0.3873	0.3754
Onchocerca volvulus		0.1257	0.5849	0.5769
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.2109	1	1
Brugia malayi	tRNA modification GTPase TrmE family protein	0.1257	0.5849	0.5769
Echinococcus granulosus	tyrosine protein kinase Fyn	0.2109	1	1
Schistosoma mansoni	tyrosine protein kinase	0.0852	0.3873	0.3754
Schistosoma mansoni	protein tyrosine kinase	0.0852	0.3873	0.3754
Loa Loa (eye worm)	hypothetical protein	0.0852	0.3873	0.3873
Brugia malayi	Protein kinase domain containing protein	0.0852	0.3873	0.3754
Echinococcus multilocularis	c src tyrosine kinase	0.2109	1	1
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0852	0.3873	0.3873
Onchocerca volvulus		0.0852	0.3873	0.3754
Trypanosoma brucei	pyruvate kinase 1	0.1967	0.9307	1
Loa Loa (eye worm)	TK/EGFR protein kinase	0.1361	0.6357	0.6357
Loa Loa (eye worm)	pyruvate kinase	0.0414	0.1741	0.1741
Echinococcus granulosus	pyruvate kinase	0.1967	0.9307	0.9307
Loa Loa (eye worm)	hypothetical protein	0.1257	0.5849	0.5849
Echinococcus granulosus	suppressor of cytokine signaling 7	0.1257	0.5849	0.5849
Schistosoma mansoni	hypothetical protein	0.0566	0.2481	0.2335
Echinococcus granulosus	tyrosine protein kinase Src42A	0.2109	1	1
Loa Loa (eye worm)	indoleamine 2,3-dioxygenase	0.0566	0.2481	0.2481
Brugia malayi	Variant SH3 domain containing protein	0.1257	0.5849	0.5769
Echinococcus multilocularis	tyrosine kinase	0.0852	0.3873	0.3873
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.2109	1	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0852	0.3873	0.3873
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0852	0.3873	0.3873
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0852	0.3873	0.3873
Onchocerca volvulus		0.2109	1	1
Schistosoma mansoni	tyrosine kinase	0.2109	1	1
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0852	0.3873	0.3754
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0852	0.3873	0.3754
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0852	0.3873	0.3873
Schistosoma mansoni	ephrin receptor	0.0852	0.3873	0.3754
Trypanosoma cruzi	pyruvate kinase 2, putative	0.1967	0.9307	1
Schistosoma mansoni	nck2/grb4	0.1257	0.5849	0.5769
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0852	0.3873	0.3873
Brugia malayi	Protein kinase domain containing protein	0.0852	0.3873	0.3754
Echinococcus granulosus	tyrosine protein kinase csk	0.0852	0.3873	0.3873
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0852	0.3873	0.3873
Brugia malayi	Protein kinase domain containing protein	0.0852	0.3873	0.3754
Brugia malayi	Protein kinase domain containing protein	0.2109	1	1
Echinococcus granulosus	protein kinase	0.0852	0.3873	0.3873
Giardia lamblia	Pyruvate kinase	0.1009	0.4642	0.1415
Echinococcus multilocularis	transfer RNA-Thr	0.0852	0.3873	0.3873
Schistosoma mansoni	lipoxygenase	0.0108	0.0247	0.0057
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0852	0.3873	0.3873
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.2109	1	1
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.1257	0.5849	0.5849
Echinococcus multilocularis	NCK adaptor protein	0.1257	0.5849	0.5849
Loa Loa (eye worm)	hypothetical protein	0.0852	0.3873	0.3873
Echinococcus granulosus	tyrosine protein kinase pr2	0.0852	0.3873	0.3873
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.2109	1	1
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.2109	1	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0852	0.3873	0.3754
Brugia malayi	Protein kinase domain containing protein	0.2109	1	1
Onchocerca volvulus	Tyrosine kinase receptor Cad96Ca homolog	0.0852	0.3873	0.3754
Schistosoma mansoni	protein kinase	0.0852	0.3873	0.3754
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.2109	1	1
Brugia malayi	Protein kinase domain containing protein	0.0852	0.3873	0.3754
Onchocerca volvulus		0.1257	0.5849	0.5769
Loa Loa (eye worm)	hypothetical protein	0.1967	0.9307	0.9307
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0852	0.3873	0.3754
Loa Loa (eye worm)	hypothetical protein	0.0852	0.3873	0.3873
Schistosoma mansoni	tyrosine kinase	0.0852	0.3873	0.3754
Schistosoma mansoni	SH2A	0.1257	0.5849	0.5769
Loa Loa (eye worm)	TK/FER protein kinase	0.2109	1	1
Brugia malayi	Variant SH3 domain containing protein	0.1257	0.5849	0.5769
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.1257	0.5849	0.5769
Schistosoma mansoni	tyrosine kinase	0.0852	0.3873	0.3754
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0852	0.3873	0.3873
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.1257	0.5849	0.5849
Loa Loa (eye worm)	SRC-1	0.2109	1	1
Loa Loa (eye worm)	pyruvate kinase-PB	0.1372	0.6407	0.6407
Schistosoma mansoni	tyrosine kinase	0.1361	0.6357	0.6286
Schistosoma mansoni	tyrosine kinase	0.2109	1	1
Schistosoma mansoni	tyrosine kinase	0.0852	0.3873	0.3754
Schistosoma mansoni	tyrosine kinase	0.2109	1	1
Schistosoma mansoni	growth factor receptor-bound protein	0.1257	0.5849	0.5769
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0852	0.3873	0.3754
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0871	0.3967	0.3967
Loa Loa (eye worm)	STAT protein	0.1257	0.5849	0.5849
Echinococcus multilocularis	integrin linked protein kinase	0.0852	0.3873	0.3873
Loa Loa (eye worm)	TK protein kinase	0.0852	0.3873	0.3873
Brugia malayi	SH2 domain containing protein	0.2109	1	1
Echinococcus granulosus	indoleamine 23 dioxygenase 2	0.0566	0.2481	0.2481
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.2109	1	1
Echinococcus granulosus	pyruvate kinase	0.1009	0.4642	0.4642
Trichomonas vaginalis	pyruvate kinase, putative	0.1967	0.9307	1
Echinococcus granulosus	SH2 motif	0.1257	0.5849	0.5849
Echinococcus granulosus	SH2 domain containing protein 7	0.1257	0.5849	0.5849
Loa Loa (eye worm)	pyruvate kinase	0.1967	0.9307	0.9307
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0852	0.3873	0.3873
Echinococcus granulosus	tyrosine protein kinase shark	0.2109	1	1
Onchocerca volvulus		0.0852	0.3873	0.3754
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.1257	0.5849	0.5849
Onchocerca volvulus		0.0852	0.3873	0.3754
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0852	0.3873	0.3754
Schistosoma mansoni	tyrosine kinase	0.0852	0.3873	0.3754
Schistosoma mansoni	hypothetical protein	0.0566	0.2481	0.2335
Schistosoma mansoni	tyrosine kinase	0.0852	0.3873	0.3754
Schistosoma mansoni	tensin	0.1257	0.5849	0.5769
Schistosoma mansoni	tyrosine kinase	0.0852	0.3873	0.3754
Echinococcus multilocularis	epidermal growth factor receptor	0.1124	0.5201	0.5201
Loa Loa (eye worm)	SH2 domain-containing protein	0.1257	0.5849	0.5849
Echinococcus granulosus	ephrin type A receptor 4 A	0.0852	0.3873	0.3873
Brugia malayi	Pyruvate kinase, alpha/beta domain containing protein	0.0595	0.2622	0.2479
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.1257	0.5849	0.5769
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0852	0.3873	0.3873
Brugia malayi	Guanylyl cyclase protein 23	0.0852	0.3873	0.3754
Brugia malayi	cytokine inducible SH2-containing protein 5	0.1257	0.5849	0.5769
Echinococcus multilocularis	epidermal growth factor receptor	0.1361	0.6357	0.6357
Echinococcus granulosus	tyrosine protein kinase Srms	0.2109	1	1
Schistosoma mansoni	tyrosine kinase	0.1013	0.4657	0.4553
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.2109	1	1
Echinococcus granulosus	kinase suppressor of Ras 1	0.0852	0.3873	0.3873
Loa Loa (eye worm)	TK protein kinase	0.2109	1	1
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.1257	0.5849	0.5849
Schistosoma mansoni	tensin-related	0.1257	0.5849	0.5769
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.1257	0.5849	0.5849
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.1013	0.4657	0.4657
Loa Loa (eye worm)	TK/FAK protein kinase	0.0852	0.3873	0.3873
Echinococcus granulosus	tyrosine protein kinase Lyn	0.2109	1	1
Echinococcus granulosus	suppressor of cytokine signaling 6	0.1257	0.5849	0.5849
Echinococcus granulosus	tyrosine protein kinase Blk	0.2109	1	1
Schistosoma mansoni	tyrosine kinase	0.0852	0.3873	0.3754
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0852	0.3873	0.3873
Loa Loa (eye worm)	hypothetical protein	0.1257	0.5849	0.5849
Echinococcus multilocularis	FL cytokine receptor	0.0852	0.3873	0.3873
Onchocerca volvulus	Pyruvate kinase homolog	0.1967	0.9307	0.9294
Schistosoma mansoni	tyrosine kinase	0.1124	0.5201	0.5108
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0852	0.3873	0.3873
Brugia malayi	SH2 domain containing protein	0.1257	0.5849	0.5769
Echinococcus multilocularis	insulin receptor	0.1013	0.4657	0.4657
Mycobacterium tuberculosis	Probable pyruvate kinase PykA	0.1967	0.9307	0.5
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.2109	1	1
Loa Loa (eye worm)	TK/ABL protein kinase	0.2109	1	1
Loa Loa (eye worm)	pyruvate kinase	0.1967	0.9307	0.9307
Echinococcus multilocularis	pyruvate kinase	0.1967	0.9307	0.9307
Brugia malayi	Variant SH3 domain containing protein	0.1257	0.5849	0.5769
Loa Loa (eye worm)	TK/CSK protein kinase	0.0852	0.3873	0.3873
Echinococcus multilocularis	tensin	0.1257	0.5849	0.5849
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0108	0.0247	0.0247
Loa Loa (eye worm)	TK/FER protein kinase	0.0852	0.3873	0.3873
Echinococcus multilocularis	SH2 motif	0.1257	0.5849	0.5849
Brugia malayi	Protein kinase domain containing protein	0.0852	0.3873	0.3754
Loa Loa (eye worm)	pyruvate kinase	0.1967	0.9307	0.9307
Brugia malayi	Raf kinase	0.0852	0.3873	0.3754
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0852	0.3873	0.3873
Brugia malayi	SH2 domain containing protein	0.1257	0.5849	0.5769
Loa Loa (eye worm)	TK protein kinase	0.0852	0.3873	0.3873
Brugia malayi	pyruvate kinase	0.0414	0.1741	0.1581
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.1257	0.5849	0.5849
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.1124	0.5201	0.5201
Loa Loa (eye worm)	TK/FER protein kinase	0.2109	1	1
Onchocerca volvulus		0.0852	0.3873	0.3754
Brugia malayi	SH2 domain containing protein	0.1257	0.5849	0.5769
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.1257	0.5849	0.5849
Schistosoma mansoni	suppressor of cytokine signaling	0.1257	0.5849	0.5769
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0852	0.3873	0.3873
Brugia malayi	Protein kinase domain containing protein	0.0852	0.3873	0.3754
Schistosoma mansoni	protein kinase	0.0852	0.3873	0.3754
Schistosoma mansoni	serine/threonine protein kinase	0.0852	0.3873	0.3754
Brugia malayi	Receptor family ligand binding region containing protein	0.0852	0.3873	0.3754
Loa Loa (eye worm)	hypothetical protein	0.1257	0.5849	0.5849
Echinococcus multilocularis	tyrosine protein kinase Abl	0.2109	1	1
Echinococcus granulosus	integrin linked protein kinase	0.0852	0.3873	0.3873
Echinococcus multilocularis	pyruvate kinase	0.1552	0.7288	0.7288
Loa Loa (eye worm)	hypothetical protein	0.0096	0.019	0.019
Echinococcus multilocularis	tyrosine kinase	0.2109	1	1
Echinococcus granulosus	SHC transforming protein 3	0.1257	0.5849	0.5849
Brugia malayi	integrin-linked kinase	0.0852	0.3873	0.3754
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.1257	0.5849	0.5769
Echinococcus granulosus	N chimaerin	0.1257	0.5849	0.5849
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.1257	0.5849	0.5769
Brugia malayi	Protein kinase domain containing protein	0.0852	0.3873	0.3754
Echinococcus granulosus	natriuretic peptide receptor 1	0.0852	0.3873	0.3873
Schistosoma mansoni	pyruvate kinase	0.1967	0.9307	0.9294
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.2109	1	1
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.1257	0.5849	0.5769
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.1257	0.5849	0.5849
Brugia malayi	Protein kinase domain containing protein	0.0852	0.3873	0.3754
Echinococcus granulosus	tyrosine kinase	0.2109	1	1
Schistosoma mansoni	adapter molecule crk	0.1257	0.5849	0.5769
Brugia malayi	Protein kinase domain containing protein	0.0852	0.3873	0.3754
Loa Loa (eye worm)	hypothetical protein	0.2109	1	1
Schistosoma mansoni	protein kinase	0.0852	0.3873	0.3754
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.1257	0.5849	0.5849
Echinococcus granulosus	tyrosine protein kinase Fyn	0.2109	1	1
Echinococcus multilocularis	pyruvate kinase	0.1009	0.4642	0.4642
Schistosoma mansoni	protein kinase	0.0852	0.3873	0.3754
Trypanosoma brucei	pyruvate kinase 1, putative	0.1967	0.9307	1
Toxoplasma gondii	pyruvate kinase PyKII	0.1009	0.4642	0.1415
Echinococcus granulosus	epidermal growth factor receptor	0.1361	0.6357	0.6357
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0852	0.3873	0.3873
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0852	0.3873	0.3873
Schistosoma mansoni	tensin	0.1257	0.5849	0.5769
Brugia malayi	Sex muscle abnormal protein 5	0.1257	0.5849	0.5769
Echinococcus multilocularis	pyruvate kinase	0.1009	0.4642	0.4642
Loa Loa (eye worm)	hypothetical protein	0.1257	0.5849	0.5849
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0852	0.3873	0.3754
Echinococcus multilocularis	indoleamine 2,3 dioxygenase 2	0.0566	0.2481	0.2481
Loa Loa (eye worm)	SH2 domain-containing protein	0.1257	0.5849	0.5849
Brugia malayi	Protein kinase domain containing protein	0.0852	0.3873	0.3754
Echinococcus granulosus	epidermal growth factor receptor	0.1124	0.5201	0.5201
Echinococcus granulosus	tyrosine protein kinase csk	0.0852	0.3873	0.3873
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.1257	0.5849	0.5769
Schistosoma mansoni	serine/threonine protein kinase	0.0852	0.3873	0.3754
Echinococcus granulosus	SH2 motif	0.1257	0.5849	0.5849
Loa Loa (eye worm)	TK/FER protein kinase	0.0852	0.3873	0.3873
Loa Loa (eye worm)	TK/ALK protein kinase	0.0852	0.3873	0.3873
Chlamydia trachomatis	pyruvate kinase	0.1967	0.9307	0.5
Schistosoma mansoni	tensin	0.1257	0.5849	0.5769
Brugia malayi	pyruvate kinase, muscle isozyme	0.0414	0.1741	0.1581
Loa Loa (eye worm)	serine/threonine protein kinase	0.0852	0.3873	0.3873
Echinococcus multilocularis	SH2 domain containing protein 7	0.1257	0.5849	0.5849
Schistosoma mansoni	tyrosine kinase	0.1124	0.5201	0.5108
Echinococcus multilocularis	heat shock protein 70	0.0852	0.3873	0.3873
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0871	0.3967	0.385
Loa Loa (eye worm)	TK protein kinase	0.0852	0.3873	0.3873
Loa Loa (eye worm)	TK protein kinase	0.0871	0.3967	0.3967
Onchocerca volvulus	Pyruvate kinase homolog	0.1967	0.9307	0.9294
Onchocerca volvulus		0.1257	0.5849	0.5769
Echinococcus multilocularis	protein kinase	0.0852	0.3873	0.3873
Loa Loa (eye worm)	TK/FER protein kinase	0.2109	1	1
Echinococcus granulosus	c src tyrosine kinase	0.2109	1	1
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0108	0.0247	0.0247
Loa Loa (eye worm)	TK/FER protein kinase	0.0852	0.3873	0.3873
Onchocerca volvulus		0.0852	0.3873	0.3754
Loa Loa (eye worm)	hypothetical protein	0.1257	0.5849	0.5849
Schistosoma mansoni	tyrosine kinase	0.2109	1	1
Echinococcus granulosus	signal transduction protein lnk realted	0.1257	0.5849	0.5849
Loa Loa (eye worm)	hypothetical protein	0.1257	0.5849	0.5849
Schistosoma mansoni	ephrin receptor	0.0852	0.3873	0.3754
Brugia malayi	Protein kinase domain containing protein	0.0852	0.3873	0.3754
Echinococcus multilocularis	signal transduction protein lnk realted	0.1257	0.5849	0.5849
Loa Loa (eye worm)	TK/RYK protein kinase	0.0852	0.3873	0.3873
Loa Loa (eye worm)	TK/DDR protein kinase	0.0852	0.3873	0.3873
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.2109	1	1
Schistosoma mansoni	tyrosine kinase	0.0852	0.3873	0.3754
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.1257	0.5849	0.5849
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0852	0.3873	0.3873
Loa Loa (eye worm)	TK/ROR protein kinase	0.0871	0.3967	0.3967
Plasmodium falciparum	pyruvate kinase 2	0.1009	0.4642	0.1415
Brugia malayi	Protein kinase domain containing protein	0.0852	0.3873	0.3754
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.1257	0.5849	0.5849
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.2109	1	1
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0852	0.3873	0.3873
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0852	0.3873	0.3873
Toxoplasma gondii	pyruvate kinase PyK1	0.1967	0.9307	1
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0852	0.3873	0.3873
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.1257	0.5849	0.5849
Echinococcus granulosus	insulin receptor	0.1013	0.4657	0.4657
Loa Loa (eye worm)	TK protein kinase	0.0852	0.3873	0.3873
Brugia malayi	RhoGAP domain containing protein	0.1257	0.5849	0.5769
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0852	0.3873	0.3873
Loa Loa (eye worm)	hypothetical protein	0.0096	0.019	0.019
Brugia malayi	Tyrosine-protein kinase abl-1	0.2109	1	1
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0852	0.3873	0.3873
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.1257	0.5849	0.5849
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0852	0.3873	0.3754
Brugia malayi	Protein kinase domain containing protein	0.0852	0.3873	0.3754
Echinococcus multilocularis	tyrosine protein kinase csk	0.0852	0.3873	0.3873
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0852	0.3873	0.3754
Entamoeba histolytica	SH2 domain containing protein	0.1257	0.5849	0.3226
Loa Loa (eye worm)	TK/ACK protein kinase	0.0852	0.3873	0.3873
Brugia malayi	Protein kinase domain containing protein	0.0852	0.3873	0.3754
Loa Loa (eye worm)	TK/FER protein kinase	0.2109	1	1
Giardia lamblia	Pyruvate kinase	0.1967	0.9307	1
Loa Loa (eye worm)	hypothetical protein	0.0852	0.3873	0.3873
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.1257	0.5849	0.5849
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.2109	1	1
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0852	0.3873	0.3873
Echinococcus multilocularis	SH2 motif	0.1257	0.5849	0.5849
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0852	0.3873	0.3873
Brugia malayi	Protein kinase domain containing protein	0.0852	0.3873	0.3754
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.1257	0.5849	0.5849
Leishmania major	pyruvate kinase	0.1967	0.9307	1
Echinococcus multilocularis	N chimaerin	0.1257	0.5849	0.5849
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0852	0.3873	0.3873
Echinococcus multilocularis	tyrosine protein kinase Blk	0.2109	1	1
Brugia malayi	hypothetical protein	0.0852	0.3873	0.3754
Schistosoma mansoni	tyrosine kinase	0.0852	0.3873	0.3754
Entamoeba histolytica	protein kinase, putative	0.1257	0.5849	0.3226
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.1257	0.5849	0.3226
Loa Loa (eye worm)	hypothetical protein	0.0852	0.3873	0.3873
Loa Loa (eye worm)	hypothetical protein	0.0852	0.3873	0.3873
Brugia malayi	Protein kinase domain containing protein	0.0852	0.3873	0.3754
Loa Loa (eye worm)	hypothetical protein	0.1257	0.5849	0.5849
Brugia malayi	hypothetical protein	0.0852	0.3873	0.3754
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.1257	0.5849	0.5849
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0852	0.3873	0.3873
Loa Loa (eye worm)	TK/FER protein kinase	0.2109	1	1
Schistosoma mansoni	tyrosine kinase	0.2109	1	1
Schistosoma mansoni	tyrosine kinase	0.0852	0.3873	0.3754
Echinococcus granulosus	tyrosine protein kinase Fyn	0.2109	1	1
Loa Loa (eye worm)	TK protein kinase	0.0852	0.3873	0.3873
Echinococcus granulosus	raf serine:threonine protein kinase	0.0852	0.3873	0.3873
Onchocerca volvulus		0.2109	1	1
Echinococcus multilocularis	pyruvate kinase	0.1967	0.9307	0.9307
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0852	0.3873	0.3754
Schistosoma mansoni	growth factor receptor-bound protein	0.1257	0.5849	0.5769
Schistosoma mansoni	shc transforming protein	0.1257	0.5849	0.5769
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0852	0.3873	0.3873
Trichomonas vaginalis	pyruvate kinase, putative	0.1967	0.9307	1
Schistosoma mansoni	tyrosine kinase	0.2109	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.2109	1	1
Echinococcus granulosus	expressed conserved protein	0.1257	0.5849	0.5849
Brugia malayi	Protein kinase domain containing protein	0.2109	1	1
Schistosoma mansoni	pyruvate kinase	0.1967	0.9307	0.9294
Loa Loa (eye worm)	TK/EPH protein kinase	0.0852	0.3873	0.3873
Schistosoma mansoni	hypothetical protein	0.1257	0.5849	0.5769
Loa Loa (eye worm)	hypothetical protein	0.0852	0.3873	0.3873
Brugia malayi	protein-tyrosine kinase	0.2109	1	1
Brugia malayi	Pyruvate kinase, muscle isozyme	0.1967	0.9307	0.9294
Schistosoma mansoni	hypothetical protein	0.0852	0.3873	0.3754
Echinococcus multilocularis	protein kinase	0.0852	0.3873	0.3873
Mycobacterium leprae	Probable pyruvate kinase PykA	0.1967	0.9307	0.5
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0852	0.3873	0.3873
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0852	0.3873	0.3754
Brugia malayi	Protein kinase domain containing protein	0.0852	0.3873	0.3754
Schistosoma mansoni	protein kinase	0.0852	0.3873	0.3754
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.1257	0.5849	0.5769
Echinococcus granulosus	SH2 domain containing adapter protein F	0.1257	0.5849	0.5849
Echinococcus multilocularis	tyrosine protein kinase Srms	0.2109	1	1
Loa Loa (eye worm)	TK protein kinase	0.0852	0.3873	0.3873
Schistosoma mansoni	pyruvate kinase	0.1009	0.4642	0.4538
Onchocerca volvulus		0.0852	0.3873	0.3754
Echinococcus granulosus	tyrosine protein kinase HCK	0.0852	0.3873	0.3873
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.1257	0.5849	0.5849
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0852	0.3873	0.3873
Echinococcus multilocularis	growth factor receptor bound protein 2	0.1257	0.5849	0.5849
Loa Loa (eye worm)	hypothetical protein	0.1257	0.5849	0.5849
Trypanosoma cruzi	pyruvate kinase 2, putative	0.1967	0.9307	1
Brugia malayi	Protein kinase domain containing protein	0.1013	0.4657	0.4553
Brugia malayi	hypothetical protein	0.1257	0.5849	0.5769
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0852	0.3873	0.3873
Echinococcus granulosus	tensin	0.1257	0.5849	0.5849
Brugia malayi	SH2 domain containing protein	0.1257	0.5849	0.5769
Loa Loa (eye worm)	tyrosinase 1	0.0096	0.019	0.019
Loa Loa (eye worm)	TK/FER protein kinase	0.0852	0.3873	0.3873
Onchocerca volvulus		0.1257	0.5849	0.5769
Schistosoma mansoni	tyrosine kinase	0.0852	0.3873	0.3754
Onchocerca volvulus		0.1257	0.5849	0.5769
Brugia malayi	Protein kinase domain containing protein	0.0852	0.3873	0.3754
Echinococcus multilocularis	protein tyrosine kinase	0.0852	0.3873	0.3873
Echinococcus multilocularis	SHC transforming protein 3	0.1257	0.5849	0.5849
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0889	0.4056	0.4056
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.0852	0.3873	0.3754
Brugia malayi	Furin-like cysteine rich region family protein	0.1361	0.6357	0.6286
Echinococcus granulosus	tyrosine protein kinase	0.0852	0.3873	0.3873
Brugia malayi	ephrin receptor 1 precursor	0.0852	0.3873	0.3754
Plasmodium vivax	pyruvate kinase, putative	0.1967	0.9307	1
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0852	0.3873	0.3873
Loa Loa (eye worm)	hypothetical protein	0.1257	0.5849	0.5849
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.1013	0.4657	0.4657
Schistosoma mansoni	serine/threonine RGC	0.0852	0.3873	0.3754
Loa Loa (eye worm)	TK/Met protein kinase	0.0852	0.3873	0.3873
Schistosoma mansoni	protein kinase	0.0852	0.3873	0.3754
Brugia malayi	STAT protein, DNA binding domain containing protein	0.1257	0.5849	0.5769
Echinococcus granulosus	tyrosine kinase	0.0852	0.3873	0.3873
Loa Loa (eye worm)	TK/INSR protein kinase	0.1013	0.4657	0.4657
Echinococcus multilocularis	tyrosine protein kinase csk	0.0852	0.3873	0.3873
Schistosoma mansoni	tyrosine kinase	0.088	0.4012	0.3896
Echinococcus granulosus	growth factor receptor bound protein 2	0.1257	0.5849	0.5849
Echinococcus multilocularis	tensin	0.1257	0.5849	0.5849
Leishmania major	pyruvate kinase	0.1967	0.9307	1
Mycobacterium ulcerans	pyruvate kinase	0.1967	0.9307	0.5
Schistosoma mansoni	tyrosine kinase	0.0273	0.105	0.0876
Echinococcus granulosus	tyrosine kinase	0.2109	1	1
Echinococcus granulosus	NCK adaptor protein	0.1257	0.5849	0.5849
Plasmodium vivax	pyruvate kinase 2, putative	0.1009	0.4642	0.1415
Brugia malayi	Tensin	0.1257	0.5849	0.5769
Echinococcus multilocularis		0.0159	0.0495	0.0495
Onchocerca volvulus		0.0852	0.3873	0.3754
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0852	0.3873	0.3873
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.2109	1	1
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.2109	1	1
Schistosoma mansoni	tyrosine kinase	0.1013	0.4657	0.4553
Echinococcus multilocularis	activated cdc42 kinase 1	0.0852	0.3873	0.3873
Loa Loa (eye worm)	TK/FER protein kinase	0.2109	1	1
Brugia malayi	Protein kinase domain containing protein	0.0852	0.3873	0.3754
Loa Loa (eye worm)	ShTK domain-containing protein	0.0096	0.019	0.019
Loa Loa (eye worm)	hypothetical protein	0.0852	0.3873	0.3873
Loa Loa (eye worm)	hypothetical protein	0.1257	0.5849	0.5849
Loa Loa (eye worm)	hypothetical protein	0.1257	0.5849	0.5849
Onchocerca volvulus		0.2109	1	1
Loa Loa (eye worm)	hypothetical protein	0.0852	0.3873	0.3873
Onchocerca volvulus		0.2109	1	1
Schistosoma mansoni	serine/threonine protein kinase	0.0852	0.3873	0.3754
Loa Loa (eye worm)	TK/FER protein kinase	0.2109	1	1
Loa Loa (eye worm)	hypothetical protein	0.1257	0.5849	0.5849
Onchocerca volvulus	Tyrosine kinase homolog	0.0871	0.3967	0.385
Loa Loa (eye worm)	hypothetical protein	0.1257	0.5849	0.5849
Brugia malayi	SRC-1	0.2109	1	1
Onchocerca volvulus		0.2109	1	1
Echinococcus granulosus	pyruvate kinase	0.1009	0.4642	0.4642
Loa Loa (eye worm)	hypothetical protein	0.0852	0.3873	0.3873
Loa Loa (eye worm)	hypothetical protein	0.0852	0.3873	0.3873
Echinococcus granulosus	activated cdc42 kinase 1	0.0852	0.3873	0.3873
Echinococcus granulosus	protein tyrosine kinase	0.0852	0.3873	0.3873
Brugia malayi	Tyrosine-protein kinase PR2	0.0852	0.3873	0.3754
Echinococcus granulosus	receptor type guanylyl cyclase	0.0852	0.3873	0.3873
Loa Loa (eye worm)	hypothetical protein	0.1257	0.5849	0.5849
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.1257	0.5849	0.5769
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0889	0.4056	0.3941
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0871	0.3967	0.3967
Echinococcus multilocularis	activin receptor type	0.0852	0.3873	0.3873
Brugia malayi	hypothetical protein	0.2109	1	1
Schistosoma mansoni	tyrosine kinase	0.0852	0.3873	0.3754
Brugia malayi	indoleamine 2,3-dioxygenase	0.0566	0.2481	0.2335
Onchocerca volvulus		0.1257	0.5849	0.5769
Schistosoma mansoni	suppressor of cytokine signaling	0.1257	0.5849	0.5769
Loa Loa (eye worm)	TK/FER protein kinase	0.0852	0.3873	0.3873
Schistosoma mansoni	protein kinase	0.0852	0.3873	0.3754
Echinococcus granulosus	hypothetical protein	0.1257	0.5849	0.5849
Brugia malayi	Variant SH3 domain containing protein	0.1257	0.5849	0.5769
Onchocerca volvulus	Pyruvate kinase homolog	0.1967	0.9307	0.9294
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0852	0.3873	0.3873
Brugia malayi	Protein kinase domain containing protein	0.0852	0.3873	0.3754
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.1257	0.5849	0.5849
Echinococcus granulosus	tyrosine protein kinase Src42A	0.1257	0.5849	0.5849
Schistosoma mansoni	tyrosine kinase	0.0852	0.3873	0.3754
Echinococcus multilocularis	tyrosine protein kinase	0.0852	0.3873	0.3873
Loa Loa (eye worm)	TK/FER protein kinase	0.2109	1	1
Echinococcus multilocularis	SH2 motif	0.1257	0.5849	0.5849
Loa Loa (eye worm)	hypothetical protein	0.0852	0.3873	0.3873
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0852	0.3873	0.3754
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0852	0.3873	0.3873
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0852	0.3873	0.3873
Loa Loa (eye worm)	TK/FER protein kinase	0.0852	0.3873	0.3873
Schistosoma mansoni	hypothetical protein	0.1257	0.5849	0.5769
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.2109	1	1
Schistosoma mansoni	tyrosine kinase	0.0852	0.3873	0.3754
Echinococcus granulosus	tyrosine protein kinase Src64B	0.2109	1	1
Schistosoma mansoni	protein kinase	0.0852	0.3873	0.3754
Schistosoma mansoni	vav2	0.1257	0.5849	0.5769
Echinococcus multilocularis	tyrosine protein kinase csk	0.0852	0.3873	0.3873
Brugia malayi	Protein kinase domain containing protein	0.0852	0.3873	0.3754
Schistosoma mansoni	tyrosine kinase	0.0273	0.105	0.0876
Echinococcus granulosus	activated cdc42 kinase 1	0.0852	0.3873	0.3873
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.2109	1	1
Echinococcus granulosus	tyrosine protein kinase csk	0.0852	0.3873	0.3873
Loa Loa (eye worm)	SH2 domain-containing protein	0.1257	0.5849	0.5849
Onchocerca volvulus		0.0852	0.3873	0.3754
Schistosoma mansoni	protein kinase	0.0852	0.3873	0.3754
Schistosoma mansoni	GTPase activating protein	0.1257	0.5849	0.5769
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0852	0.3873	0.3873
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.2109	1	1
Echinococcus granulosus	activin receptor type	0.0852	0.3873	0.3873
Echinococcus multilocularis	tyrosine protein kinase shark	0.2109	1	1
Onchocerca volvulus		0.0852	0.3873	0.3754
Brugia malayi	Pyruvate kinase, M2 isozyme	0.1967	0.9307	0.9294
Schistosoma mansoni	tyrosine kinase	0.0852	0.3873	0.3754
Schistosoma mansoni	tyrosine kinase	0.0273	0.105	0.0876
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.2109	1	1
Echinococcus granulosus	pyruvate kinase	0.1009	0.4642	0.4642
Brugia malayi	Protein kinase domain containing protein	0.0852	0.3873	0.3754
Brugia malayi	SH2 domain containing protein	0.2109	1	1
Loa Loa (eye worm)	hypothetical protein	0.1257	0.5849	0.5849
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.1257	0.5849	0.5849
Brugia malayi	SH2 domain containing protein	0.1257	0.5849	0.5769
Schistosoma mansoni	tyrosine kinase	0.0852	0.3873	0.3754
Brugia malayi	SH2 domain containing protein	0.1257	0.5849	0.5769
Entamoeba histolytica	pyruvate kinase, putative	0.1372	0.6407	0.4136
Loa Loa (eye worm)	TK protein kinase	0.0852	0.3873	0.3873
Brugia malayi	Protein kinase domain containing protein	0.2109	1	1
Loa Loa (eye worm)	hypothetical protein	0.1372	0.6407	0.6407
Onchocerca volvulus		0.2109	1	1
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0852	0.3873	0.3873
Echinococcus multilocularis	tyrosine protein kinase csk	0.0852	0.3873	0.3873
Brugia malayi	C-terminal src kinase protein 1	0.0852	0.3873	0.3754
Schistosoma mansoni	serine/threonine protein kinase	0.0852	0.3873	0.3754
Schistosoma mansoni	protein kinase	0.0852	0.3873	0.3754
Schistosoma mansoni	tyrosine kinase	0.0852	0.3873	0.3754
Echinococcus multilocularis	pyruvate kinase	0.1009	0.4642	0.4642
Brugia malayi	SH2 domain containing protein	0.1257	0.5849	0.5769
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.1257	0.5849	0.5849
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0852	0.3873	0.3873
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0852	0.3873	0.3873
Loa Loa (eye worm)	TK protein kinase	0.0852	0.3873	0.3873
Echinococcus granulosus	tyrosine protein kinase ABL1	0.2109	1	1
Schistosoma mansoni	tyrosine kinase	0.0852	0.3873	0.3754

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2392640

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1777347