Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) | Starlite/ChEMBL | References |
Homo sapiens | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | CMGC family protein kinase | 0.1035 | 1 | 0.5 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0028 | 0.0155 | 0.5 |
Brugia malayi | AMP-binding enzyme family protein | 0.0028 | 0.0155 | 0.0155 |
Onchocerca volvulus | Matrilysin homolog | 0.0042 | 0.0297 | 0.3717 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0297 | 0.0297 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0028 | 0.0155 | 0.2277 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.1035 | 1 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0028 | 0.0155 | 0.2277 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0028 | 0.0155 | 0.5 |
Brugia malayi | Matrixin family protein | 0.0042 | 0.0297 | 0.0297 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0155 | 0.0155 |
Trypanosoma brucei | protein kinase, putative | 0.1035 | 1 | 0.5 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.1035 | 1 | 0.5 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0021 | 0.0087 | 0.0355 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.1035 | 1 | 1 |
Loa Loa (eye worm) | matrixin family protein | 0.0093 | 0.0798 | 0.0798 |
Echinococcus granulosus | mitogen activated protein kinase | 0.1035 | 1 | 1 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0093 | 0.0798 | 1 |
Giardia lamblia | Kinase, CMGC MAPK | 0.1035 | 1 | 0.5 |
Brugia malayi | Matrixin family protein | 0.0042 | 0.0297 | 0.0297 |
Brugia malayi | AMP-binding enzyme family protein | 0.0028 | 0.0155 | 0.0155 |
Brugia malayi | Matrixin family protein | 0.0042 | 0.0297 | 0.0297 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0386 | 0.0386 |
Brugia malayi | Hemopexin family protein | 0.006 | 0.0468 | 0.0468 |
Onchocerca volvulus | 0.0028 | 0.0155 | 0.1941 | |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0028 | 0.0155 | 0.2551 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.0051 | 0.0386 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.1035 | 1 | 0.5 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0028 | 0.0155 | 0.2277 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0028 | 0.0155 | 0.2277 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0021 | 0.0087 | 0.5 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0021 | 0.0087 | 0.5 |
Schistosoma mansoni | matrix metallopeptidase-9 (M10 family) | 0.01 | 0.0862 | 0.0862 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.1035 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0155 | 0.0155 |
Brugia malayi | AMP-binding enzyme family protein | 0.0028 | 0.0155 | 0.0155 |
Loa Loa (eye worm) | matrix metalloproteinase | 0.0042 | 0.0297 | 0.0297 |
Onchocerca volvulus | Matrilysin homolog | 0.0093 | 0.0798 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0087 | 0.0087 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0028 | 0.0155 | 0.2277 |
Brugia malayi | Matrixin family protein | 0.0042 | 0.0297 | 0.0297 |
Onchocerca volvulus | 0.006 | 0.0468 | 0.5873 | |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.1035 | 1 | 0.5 |
Mycobacterium ulcerans | hydrolase | 0.0051 | 0.0386 | 1 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0028 | 0.0155 | 0.2277 |
Brugia malayi | Matrixin family protein | 0.0102 | 0.088 | 0.088 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0087 | 0.0087 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1035 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0297 | 0.0297 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1035 | 1 | 1 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.1035 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1035 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1035 | 1 | 0.5 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.1035 | 1 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0028 | 0.0155 | 0.2551 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.0051 | 0.0386 | 0.0386 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0087 | 0.0087 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0297 | 0.0297 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.1035 | 1 | 1 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0028 | 0.0155 | 0.5 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0028 | 0.0155 | 0.2277 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0155 | 0.0155 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.1035 | 1 | 1 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0153 | 0.1381 | 0.1381 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0087 | 0.0087 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.1035 | 1 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0028 | 0.0155 | 0.2277 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0087 | 0.0087 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.1035 | 1 | 0.5 |
Onchocerca volvulus | 0.0042 | 0.0297 | 0.3717 | |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.0042 | 0.0297 | 0.0297 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0153 | 0.1381 | 0.1381 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.0051 | 0.0386 | 1 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0021 | 0.0087 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.006 | 0.0468 | 0.0468 |
Loa Loa (eye worm) | matrixin family protein | 0.0102 | 0.088 | 0.088 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | < 1 nM | Inhibition of human full length MMP2 using Mca-Pro-Leu-Gly-Leu-Dpa(Dnp)-Ala-Arg-NH2 as substrate measured up to 120 mins by fluorescence assay | ChEMBL. | 23688254 |
IC50 (binding) | = 460 nM | Inhibition of human full length MMP9 using Mca-Pro-Leu-Gly-Leu-Dpa(Dnp)-Ala-Arg-NH2 as substrate measured up to 120 mins by fluorescence assay | ChEMBL. | 23688254 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.