Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | epoxide hydrolase 2, cytoplasmic | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium tuberculosis | Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase) | Get druggable targets OG5_129061 | All targets in OG5_129061 |
Mycobacterium ulcerans | epoxide hydrolase EphA | Get druggable targets OG5_129061 | All targets in OG5_129061 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | thymidylate synthase | 0.0504 | 0.2004 | 0.1245 |
Trichomonas vaginalis | conserved hypothetical protein | 0.024 | 0.0276 | 0.5 |
Onchocerca volvulus | 0.0504 | 0.2004 | 0.5 | |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0504 | 0.2004 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0504 | 0.2004 | 1 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.1726 | 1 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.033 | 0.0866 | 0.4323 |
Brugia malayi | dihydrofolate reductase family protein | 0.033 | 0.0866 | 0.3415 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0709 | 0.3347 | 0.5 |
Mycobacterium ulcerans | thymidylate synthase | 0.0504 | 0.2004 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.0504 | 0.2004 | 0.1245 |
Mycobacterium tuberculosis | Hypothetical protein | 0.024 | 0.0276 | 0.1379 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0709 | 0.3347 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.033 | 0.0866 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0709 | 0.3347 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 0.033 | 0.0866 | 0.3415 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0504 | 0.2004 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.033 | 0.0866 | 0.4323 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0709 | 0.3347 | 0.5 |
Brugia malayi | thymidylate synthase | 0.0504 | 0.2004 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0709 | 0.3347 | 0.5 |
Loa Loa (eye worm) | thymidylate synthase | 0.0504 | 0.2004 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0709 | 0.3347 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 113 nM | Inhibition of recombinant human soluble epoxide hydrolase using CMNPC as substrate preincubated for 5 mins before substrate addition measured after 10 mins by fluorescence assay | ChEMBL. | 23498915 |
MIC (functional) | = 12.5 ug ml-1 | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv after 7 days by microbroth dilution method | ChEMBL. | 23498915 |
MIC (functional) | > 200 ug ml-1 | Antibacterial against Escherichia coli K-12 | ChEMBL. | 23498915 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.