TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 739.533 | Formula: C32H34Cl2F6N4O5
H donors: 5 H acceptors: 5 LogP: 8.76 Rotable bonds: 2
Rule of 5 violations (Lipinski): 2
SMILES: [O-]C(=O)C(F)(F)F.[O-]C(=O)C(F)(F)F.Clc1ccc2c(c1)[n+]1CCCCC[n+]3ccc(NCCCCCNc2cc1)c1c3cc(Cl)cc1.O
InChi: 1S/C28H30Cl2N4.2C2HF3O2.H2O/c29-21-7-9-23-25-11-17-33(27(23)19-21)15-5-2-6-16-34-18-12-26(32-14-4-1-3-13-31-25)24-10-8-22(30)20-28(24)34;2*3-2(4,5)1(6)7;/h7-12,17-20H,1-6,13-16H2;2*(H,6,7);1H2/b31-25+,32-26+;;;
InChiKey: VMYMFCSOBWBZQC-DHWQIPLESA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Small conductance calcium-activated potassium channel protein 3	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	Small conductance calcium-activated potassium channel protein, putative	Get druggable targets OG5_130097	All targets in OG5_130097
Schistosoma mansoni	hypothetical protein	Get druggable targets OG5_130097	All targets in OG5_130097
Schistosoma japonicum	Small conductance calcium-activated potassium channel protein, putative	Get druggable targets OG5_130097	All targets in OG5_130097
Schistosoma mansoni	calcium-activated potassium channel	Get druggable targets OG5_130097	All targets in OG5_130097
Schistosoma japonicum	ko:K01047 phospholipase A2 [EC3.1.1.4], putative	Get druggable targets OG5_130097	All targets in OG5_130097
Echinococcus granulosus	small conductance calcium activated potassium	Get druggable targets OG5_130097	All targets in OG5_130097
Echinococcus multilocularis	small conductance calcium activated potassium	Get druggable targets OG5_130097	All targets in OG5_130097
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_130097	All targets in OG5_130097
Schistosoma japonicum	expressed protein	Get druggable targets OG5_130097	All targets in OG5_130097
Schistosoma japonicum	IPR011996,SK channel region,domain-containing	Get druggable targets OG5_130097	All targets in OG5_130097
Schistosoma japonicum	ko:K04942 potassium intermediate/small conductance calcium-activated channel,, putative	Get druggable targets OG5_130097	All targets in OG5_130097
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_130097	All targets in OG5_130097

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	SH2 domain containing protein	0.0278	0.5316	0.3223
Giardia lamblia	Kinase, NEK	0.0188	0.3089	0.5
Brugia malayi	SH2 domain containing protein	0.0466	1	1
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.0278	0.5316	0.3223
Loa Loa (eye worm)	TK/CSK protein kinase	0.0188	0.3089	0.3089
Schistosoma mansoni	tyrosine kinase	0.0188	0.3089	0.1595
Trichomonas vaginalis	TKL family protein kinase	0.0188	0.3089	0.5
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0466	1	1
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0466	1	1
Onchocerca volvulus		0.0466	1	1
Schistosoma mansoni	tyrosine kinase	0.0188	0.3089	0.1595
Trichomonas vaginalis	TKL family protein kinase	0.0188	0.3089	0.5
Echinococcus granulosus	SH2 motif	0.0278	0.5316	0.3223
Schistosoma mansoni	tyrosine kinase	0.0188	0.3089	0.1595
Trichomonas vaginalis	TKL family protein kinase	0.0188	0.3089	0.5
Onchocerca volvulus		0.0278	0.5316	0.3223
Loa Loa (eye worm)	TK/FER protein kinase	0.0188	0.3089	0.3089
Schistosoma mansoni	suppressor of cytokine signaling	0.0278	0.5316	0.4304
Loa Loa (eye worm)	hypothetical protein	0.0278	0.5316	0.5316
Schistosoma mansoni	tensin	0.0278	0.5316	0.4304
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0466	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0188	0.3089	0.5
Loa Loa (eye worm)	TK protein kinase	0.0188	0.3089	0.3089
Trichomonas vaginalis	TKL family protein kinase	0.0188	0.3089	0.5
Brugia malayi	hypothetical protein	0.0278	0.5316	0.3223
Loa Loa (eye worm)	hypothetical protein	0.0188	0.3089	0.3089
Trichomonas vaginalis	TKL family protein kinase	0.0188	0.3089	0.5
Loa Loa (eye worm)	TK/RYK protein kinase	0.0188	0.3089	0.3089
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0278	0.5316	0.3223
Loa Loa (eye worm)	TK/FER protein kinase	0.0466	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0188	0.3089	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0188	0.3089	0.5
Brugia malayi	Protein kinase domain containing protein	0.0466	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0466	1	1
Schistosoma mansoni	tyrosine kinase	0.0188	0.3089	0.1595
Trichomonas vaginalis	TKL family protein kinase	0.0188	0.3089	0.5
Brugia malayi	RhoGAP domain containing protein	0.0278	0.5316	0.3223
Toxoplasma gondii	protein kinase domain-containing protein	0.0188	0.3089	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0466	1	1
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0466	1	1
Echinococcus multilocularis	SH2 motif	0.0278	0.5316	0.3223
Trichomonas vaginalis	TKL family protein kinase	0.0188	0.3089	0.5
Loa Loa (eye worm)	TK/FAK protein kinase	0.0188	0.3089	0.3089
Brugia malayi	Protein kinase domain containing protein	0.0466	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0188	0.3089	0.5
Brugia malayi	SH2 domain containing protein	0.0278	0.5316	0.3223
Trichomonas vaginalis	conserved hypothetical protein	0.0188	0.3089	0.5
Schistosoma mansoni	tyrosine kinase	0.0188	0.3089	0.1595
Loa Loa (eye worm)	hypothetical protein	0.0188	0.3089	0.3089
Echinococcus granulosus	SH2 domain containing protein 7	0.0278	0.5316	0.3223
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0188	0.3089	0.3089
Loa Loa (eye worm)	hypothetical protein	0.0278	0.5316	0.5316
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0188	0.3089	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0188	0.3089	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0188	0.3089	0.5
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0466	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0188	0.3089	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0188	0.3089	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0188	0.3089	0.5
Schistosoma mansoni	tyrosine kinase	0.0466	1	1
Onchocerca volvulus		0.0466	1	1
Loa Loa (eye worm)	hypothetical protein	0.0278	0.5316	0.5316
Trichomonas vaginalis	TKL family protein kinase	0.0188	0.3089	0.5
Loa Loa (eye worm)	hypothetical protein	0.0188	0.3089	0.3089
Schistosoma mansoni	adapter molecule crk	0.0278	0.5316	0.4304
Loa Loa (eye worm)	TK protein kinase	0.0188	0.3089	0.3089
Loa Loa (eye worm)	TK/FER protein kinase	0.0466	1	1
Plasmodium falciparum	protein kinase, putative	0.0188	0.3089	0.5
Schistosoma mansoni	tyrosine kinase	0.0188	0.3089	0.1595
Trichomonas vaginalis	conserved hypothetical protein	0.0188	0.3089	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0188	0.3089	0.5
Entamoeba histolytica	SH2 domain containing protein	0.0278	0.5316	0.3223
Schistosoma mansoni	tyrosine kinase	0.0466	1	1
Schistosoma mansoni	tyrosine kinase	0.0188	0.3089	0.1595
Trichomonas vaginalis	TKL family protein kinase	0.0188	0.3089	0.5
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0278	0.5316	0.4304
Toxoplasma gondii	protein kinase	0.0188	0.3089	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0466	1	1
Loa Loa (eye worm)	TK/Met protein kinase	0.0188	0.3089	0.3089
Brugia malayi	Sex muscle abnormal protein 5	0.0278	0.5316	0.3223
Schistosoma mansoni	tyrosine kinase	0.0188	0.3089	0.1595
Trichomonas vaginalis	TKL family protein kinase	0.0188	0.3089	0.5
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0278	0.5316	0.3223
Echinococcus multilocularis	SH2 domain containing protein 7	0.0278	0.5316	0.3223
Trichomonas vaginalis	TKL family protein kinase	0.0188	0.3089	0.5
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0278	0.5316	0.4304
Echinococcus granulosus	small conductance calcium activated potassium	0.021	0.3631	0.0785
Loa Loa (eye worm)	TK/FER protein kinase	0.0188	0.3089	0.3089
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0188	0.3089	0.1595
Loa Loa (eye worm)	SH2 domain-containing protein	0.0278	0.5316	0.5316
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0278	0.5316	0.5316
Trichomonas vaginalis	TKL family protein kinase	0.0188	0.3089	0.5
Onchocerca volvulus		0.0278	0.5316	0.3223
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0466	1	1
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0188	0.3089	0.5
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0188	0.3089	0.3089
Schistosoma mansoni	tyrosine protein kinase	0.0188	0.3089	0.1595
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0278	0.5316	0.3223
Trichomonas vaginalis	TKL family protein kinase	0.0188	0.3089	0.5
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0466	1	1
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0188	0.3089	0.3089
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0278	0.5316	0.3223
Onchocerca volvulus		0.0466	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0188	0.3089	0.3089
Loa Loa (eye worm)	TK/FER protein kinase	0.0466	1	1
Echinococcus multilocularis	tyrosine kinase	0.0466	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0188	0.3089	0.5
Echinococcus multilocularis	NCK adaptor protein	0.0278	0.5316	0.3223
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0278	0.5316	0.3223
Schistosoma mansoni	growth factor receptor-bound protein	0.0278	0.5316	0.4304
Trypanosoma brucei	protein kinase, putative	0.0188	0.3089	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0188	0.3089	0.5
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0466	1	1
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0188	0.3089	0.5
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0466	1	1
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0466	1	1
Brugia malayi	SH2 domain containing protein	0.0278	0.5316	0.3223
Schistosoma mansoni	signal transduction protein lnk-related	0.0278	0.5316	0.4304
Loa Loa (eye worm)	hypothetical protein	0.0466	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0188	0.3089	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0188	0.3089	0.5
Brugia malayi	SH2 domain containing protein	0.0278	0.5316	0.3223
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0466	1	1
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0182	0.0182
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0278	0.5316	0.3223
Onchocerca volvulus		0.0278	0.5316	0.3223
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0188	0.3089	0.3089
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0188	0.3089	0.1595
Plasmodium falciparum	tyrosine kinase-like protein	0.0188	0.3089	0.5
Loa Loa (eye worm)	hypothetical protein	0.0278	0.5316	0.5316
Echinococcus granulosus	NCK adaptor protein	0.0278	0.5316	0.3223
Echinococcus granulosus	expressed conserved protein	0.0278	0.5316	0.3223
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0278	0.5316	0.3223
Echinococcus granulosus	hypothetical protein	0.0278	0.5316	0.3223
Plasmodium falciparum	protein kinase, putative	0.0188	0.3089	0.5
Schistosoma mansoni	protein kinase	0.0188	0.3089	0.1595
Schistosoma mansoni	tyrosine kinase	0.0466	1	1
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0466	1	1
Schistosoma mansoni	ephrin receptor	0.0188	0.3089	0.1595
Echinococcus granulosus	SH2 motif	0.0278	0.5316	0.3223
Loa Loa (eye worm)	hypothetical protein	0.0278	0.5316	0.5316
Echinococcus multilocularis		0.0278	0.5316	0.3223
Schistosoma mansoni	tyrosine kinase	0.0188	0.3089	0.1595
Schistosoma mansoni	protein kinase	0.0188	0.3089	0.1595
Trichomonas vaginalis	TKL family protein kinase	0.0188	0.3089	0.5
Schistosoma mansoni	protein tyrosine kinase	0.0188	0.3089	0.1595
Loa Loa (eye worm)	SH2 domain-containing protein	0.0278	0.5316	0.5316
Loa Loa (eye worm)	hypothetical protein	0.0188	0.3089	0.3089
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0278	0.5316	0.3223
Loa Loa (eye worm)	TK/EPH protein kinase	0.0188	0.3089	0.3089
Trichomonas vaginalis	TKL family protein kinase	0.0188	0.3089	0.5
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0466	1	1
Echinococcus multilocularis	signal transduction protein lnk realted	0.0278	0.5316	0.3223
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0466	1	1
Schistosoma mansoni	protein kinase	0.0188	0.3089	0.1595
Echinococcus granulosus	c src tyrosine kinase	0.0466	1	1
Brugia malayi	SH2 domain containing protein	0.0278	0.5316	0.3223
Loa Loa (eye worm)	hypothetical protein	0.0278	0.5316	0.5316
Loa Loa (eye worm)	TK/FER protein kinase	0.0466	1	1
Schistosoma mansoni	vav2	0.0278	0.5316	0.4304
Echinococcus multilocularis	SH2 motif	0.0278	0.5316	0.3223
Trichomonas vaginalis	TKL family protein kinase	0.0188	0.3089	0.5
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0278	0.5316	0.3223
Trichomonas vaginalis	TKL family protein kinase	0.0188	0.3089	0.5
Schistosoma mansoni	growth factor receptor-bound protein	0.0278	0.5316	0.4304
Giardia lamblia	Kinase	0.0188	0.3089	0.5
Schistosoma mansoni	tyrosine kinase	0.0188	0.3089	0.1595
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0278	0.5316	0.3223
Brugia malayi	SH2 domain containing protein	0.0278	0.5316	0.3223
Echinococcus multilocularis	SHC transforming protein 3	0.0278	0.5316	0.3223
Echinococcus granulosus	tyrosine protein kinase shark	0.0466	1	1
Schistosoma mansoni	tensin-related	0.0278	0.5316	0.4304
Loa Loa (eye worm)	hypothetical protein	0.0278	0.5316	0.5316
Loa Loa (eye worm)	hypothetical protein	0.0188	0.3089	0.3089
Schistosoma mansoni	hypothetical protein	0.0278	0.5316	0.4304
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0466	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0188	0.3089	0.5
Schistosoma mansoni	suppressor of cytokine signaling	0.0278	0.5316	0.4304
Loa Loa (eye worm)	hypothetical protein	0.0188	0.3089	0.3089
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0188	0.3089	0.1595
Leishmania major	protein kinase, putative	0.0188	0.3089	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0188	0.3089	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0466	1	1
Schistosoma mansoni	tyrosine kinase	0.0188	0.3089	0.1595
Echinococcus multilocularis	tyrosine protein kinase shark	0.0466	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0188	0.3089	0.5
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0278	0.5316	0.3223
Schistosoma mansoni	hypothetical protein	0.0278	0.5316	0.4304
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0188	0.3089	0.1595
Loa Loa (eye worm)	hypothetical protein	0.0188	0.3089	0.3089
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0278	0.5316	0.3223
Schistosoma mansoni	tyrosine kinase	0.0188	0.3089	0.1595
Plasmodium vivax	protein kinase, putative	0.0188	0.3089	0.5
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0188	0.3089	0.3089
Trichomonas vaginalis	TKL family protein kinase	0.0188	0.3089	0.5
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0466	1	1
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0278	0.5316	0.4304
Trichomonas vaginalis	TKL family protein kinase	0.0188	0.3089	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0188	0.3089	0.5
Schistosoma mansoni	tyrosine kinase	0.0188	0.3089	0.1595
Echinococcus granulosus	tyrosine protein kinase Srms	0.0466	1	1
Brugia malayi	Variant SH3 domain containing protein	0.0278	0.5316	0.3223
Echinococcus granulosus	growth factor receptor bound protein 2	0.0278	0.5316	0.3223
Entamoeba histolytica	protein kinase, putative	0.0278	0.5316	0.3223
Plasmodium falciparum	tyrosine kinase-like protein	0.0188	0.3089	0.5
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0188	0.3089	0.3089
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0466	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0188	0.3089	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0188	0.3089	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0188	0.3089	0.1595
Loa Loa (eye worm)	TK/ROR protein kinase	0.0188	0.3089	0.3089
Loa Loa (eye worm)	hypothetical protein	0.0278	0.5316	0.5316
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0466	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0188	0.3089	0.3089
Loa Loa (eye worm)	TK/ACK protein kinase	0.0188	0.3089	0.3089
Schistosoma mansoni	protein kinase	0.0188	0.3089	0.1595
Loa Loa (eye worm)	TK protein kinase	0.0188	0.3089	0.3089
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0278	0.5316	0.3223
Schistosoma mansoni	protein kinase	0.0188	0.3089	0.1595
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0278	0.5316	0.3223
Leishmania major	hypothetical protein, conserved	0.0188	0.3089	0.5
Loa Loa (eye worm)	hypothetical protein	0.0278	0.5316	0.5316
Schistosoma mansoni	tensin	0.0278	0.5316	0.4304
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0278	0.5316	0.4304
Loa Loa (eye worm)	TK protein kinase	0.0188	0.3089	0.3089
Brugia malayi	protein-tyrosine kinase	0.0466	1	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0188	0.3089	0.3089
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0466	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0188	0.3089	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0188	0.3089	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0188	0.3089	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0188	0.3089	0.5
Echinococcus granulosus	N chimaerin	0.0278	0.5316	0.3223
Schistosoma mansoni	serine/threonine protein kinase	0.0188	0.3089	0.1595
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0466	1	1
Trichomonas vaginalis	protein kinase atn1, putative	0.0188	0.3089	0.5
Loa Loa (eye worm)	hypothetical protein	0.0188	0.3089	0.3089
Loa Loa (eye worm)	hypothetical protein	0.0278	0.5316	0.5316
Loa Loa (eye worm)	hypothetical protein	0.0188	0.3089	0.3089
Schistosoma mansoni	SH2A	0.0278	0.5316	0.4304
Onchocerca volvulus		0.0466	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0188	0.3089	0.5
Brugia malayi	SRC-1	0.0466	1	1
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0188	0.3089	0.5
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0188	0.3089	0.5
Loa Loa (eye worm)	TK/DDR protein kinase	0.0188	0.3089	0.3089
Trichomonas vaginalis	TKL family protein kinase	0.0188	0.3089	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0188	0.3089	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0188	0.3089	0.3089
Onchocerca volvulus		0.0278	0.5316	0.3223
Schistosoma mansoni	tyrosine kinase	0.0188	0.3089	0.1595
Loa Loa (eye worm)	TK protein kinase	0.0188	0.3089	0.3089
Schistosoma mansoni	protein kinase	0.0188	0.3089	0.1595
Echinococcus granulosus	tyrosine kinase	0.0466	1	1
Giardia lamblia	Protein 21.1	0.0188	0.3089	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0188	0.3089	0.5
Loa Loa (eye worm)	TK/ALK protein kinase	0.0188	0.3089	0.3089
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0188	0.3089	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0188	0.3089	0.5
Schistosoma mansoni	tyrosine kinase	0.0188	0.3089	0.1595
Trichomonas vaginalis	TKL family protein kinase	0.0188	0.3089	0.5
Schistosoma mansoni	protein kinase	0.0188	0.3089	0.1595
Brugia malayi	Protein kinase domain containing protein	0.0466	1	1
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0188	0.3089	0.5
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0466	1	1
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0466	1	1
Echinococcus multilocularis	small conductance calcium activated potassium	0.021	0.3631	0.0785
Trichomonas vaginalis	TKL family protein kinase	0.0188	0.3089	0.5
Echinococcus multilocularis	tensin	0.0278	0.5316	0.3223
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0278	0.5316	0.5316
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0466	1	1
Schistosoma mansoni	hypothetical protein	0.0188	0.3089	0.1595
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0278	0.5316	0.5316
Echinococcus granulosus	tyrosine protein kinase Blk	0.0466	1	1
Loa Loa (eye worm)	TK/ABL protein kinase	0.0466	1	1
Schistosoma mansoni	serine/threonine protein kinase	0.0188	0.3089	0.1595
Trichomonas vaginalis	TKL family protein kinase	0.0188	0.3089	0.5
Schistosoma mansoni	tyrosine kinase	0.0188	0.3089	0.1595
Loa Loa (eye worm)	hypothetical protein	0.0188	0.3089	0.3089
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0188	0.3089	0.5
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0188	0.3089	0.3089
Brugia malayi	SH2 domain containing protein	0.0466	1	1
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0466	1	1
Loa Loa (eye worm)	serine/threonine protein kinase	0.0188	0.3089	0.3089
Trichomonas vaginalis	conserved hypothetical protein	0.0188	0.3089	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0188	0.3089	0.5
Loa Loa (eye worm)	STAT protein	0.0278	0.5316	0.5316
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0278	0.5316	0.5316
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0278	0.5316	0.3223
Schistosoma mansoni	tyrosine kinase	0.0188	0.3089	0.1595
Loa Loa (eye worm)	hypothetical protein	0.0278	0.5316	0.5316
Schistosoma mansoni	protein kinase	0.0188	0.3089	0.1595
Trypanosoma cruzi	protein kinase, putative	0.0188	0.3089	0.5
Schistosoma mansoni	tensin	0.0278	0.5316	0.4304
Trichomonas vaginalis	TKL family protein kinase	0.0188	0.3089	0.5
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0188	0.3089	0.5
Loa Loa (eye worm)	hypothetical protein	0.0188	0.3089	0.3089
Onchocerca volvulus		0.0278	0.5316	0.3223
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.0278	0.5316	0.3223
Schistosoma mansoni	tyrosine kinase	0.0188	0.3089	0.1595
Schistosoma mansoni	GTPase activating protein	0.0278	0.5316	0.4304
Trichomonas vaginalis	TKL family protein kinase	0.0188	0.3089	0.5
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0466	1	1
Loa Loa (eye worm)	hypothetical protein	0.0278	0.5316	0.5316
Trichomonas vaginalis	TKL family protein kinase	0.0188	0.3089	0.5
Schistosoma mansoni	tyrosine kinase	0.0188	0.3089	0.1595
Loa Loa (eye worm)	TK protein kinase	0.0188	0.3089	0.3089
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0278	0.5316	0.3223
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0188	0.3089	0.5
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0188	0.3089	0.3089
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0278	0.5316	0.5316
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0278	0.5316	0.3223
Trichomonas vaginalis	TKL family protein kinase	0.0188	0.3089	0.5
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0278	0.5316	0.3223
Trichomonas vaginalis	STE family protein kinase	0.0188	0.3089	0.5
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0278	0.5316	0.3223
Loa Loa (eye worm)	TK/FER protein kinase	0.0466	1	1
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0278	0.5316	0.5316
Brugia malayi	hypothetical protein	0.0466	1	1
Schistosoma mansoni	tyrosine kinase	0.0188	0.3089	0.1595
Schistosoma mansoni	tensin-related	0.0278	0.5316	0.4304
Echinococcus multilocularis	tensin	0.0278	0.5316	0.3223
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0086	0.0086
Trichomonas vaginalis	conserved hypothetical protein	0.0188	0.3089	0.5
Loa Loa (eye worm)	TK protein kinase	0.0466	1	1
Schistosoma mansoni	shc transforming protein	0.0278	0.5316	0.4304
Giardia lamblia	Kinase, NEK	0.0188	0.3089	0.5
Loa Loa (eye worm)	TK/INSR protein kinase	0.0188	0.3089	0.3089
Trichomonas vaginalis	TKL family protein kinase	0.0188	0.3089	0.5
Toxoplasma gondii	STE kinase	0.0188	0.3089	0.5
Onchocerca volvulus		0.0278	0.5316	0.3223
Trichomonas vaginalis	TKL family protein kinase	0.0188	0.3089	0.5
Trichomonas vaginalis	TK family protein kinase	0.0188	0.3089	0.5
Loa Loa (eye worm)	hypothetical protein	0.0188	0.3089	0.3089
Echinococcus multilocularis	SH2 motif	0.0278	0.5316	0.3223
Schistosoma mansoni	serine/threonine RGC	0.0188	0.3089	0.1595
Schistosoma mansoni	tyrosine kinase	0.0466	1	1
Schistosoma mansoni	calcium-activated potassium channel	0.021	0.3631	0.2255
Loa Loa (eye worm)	SRC-1	0.0466	1	1
Schistosoma mansoni	nck2/grb4	0.0278	0.5316	0.4304
Trichomonas vaginalis	conserved hypothetical protein	0.0188	0.3089	0.5
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0278	0.5316	0.4304
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0188	0.3089	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0188	0.3089	0.1595
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0278	0.5316	0.3223
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0188	0.3089	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0188	0.3089	0.3089
Brugia malayi	SH2 domain containing protein	0.0278	0.5316	0.3223
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0278	0.5316	0.3223
Onchocerca volvulus		0.0466	1	1
Schistosoma mansoni	tyrosine kinase	0.0188	0.3089	0.1595
Trichomonas vaginalis	TKL family protein kinase	0.0188	0.3089	0.5
Trichomonas vaginalis	CAMK family protein kinase	0.0188	0.3089	0.5
Schistosoma mansoni	protein kinase	0.0188	0.3089	0.1595
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0188	0.3089	0.5
Loa Loa (eye worm)	TK protein kinase	0.0188	0.3089	0.3089
Schistosoma mansoni	tyrosine kinase	0.0466	1	1
Echinococcus granulosus	tyrosine kinase	0.0466	1	1
Echinococcus multilocularis	c src tyrosine kinase	0.0466	1	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0278	0.5316	0.3223
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0466	1	1
Schistosoma mansoni	hypothetical protein	0.021	0.3631	0.2255
Loa Loa (eye worm)	TK/FER protein kinase	0.0466	1	1
Brugia malayi	Variant SH3 domain containing protein	0.0278	0.5316	0.3223
Loa Loa (eye worm)	TK protein kinase	0.0188	0.3089	0.3089
Schistosoma mansoni	tyrosine kinase	0.0188	0.3089	0.1595
Loa Loa (eye worm)	hypothetical protein	0.0278	0.5316	0.5316
Trichomonas vaginalis	TKL family protein kinase	0.0188	0.3089	0.5
Onchocerca volvulus		0.0466	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0188	0.3089	0.5
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0466	1	1
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0188	0.3089	0.1595
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0278	0.5316	0.3223
Schistosoma mansoni	protein kinase	0.0188	0.3089	0.1595
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0466	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0188	0.3089	0.5
Schistosoma mansoni	tyrosine kinase	0.0188	0.3089	0.1595
Trichomonas vaginalis	TKL family protein kinase	0.0188	0.3089	0.5
Schistosoma mansoni	tyrosine kinase	0.0188	0.3089	0.1595
Schistosoma mansoni	ephrin receptor	0.0188	0.3089	0.1595
Loa Loa (eye worm)	hypothetical protein	0.0278	0.5316	0.5316
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0188	0.3089	0.3089
Leishmania major	protein kinase, putative	0.0188	0.3089	0.5
Brugia malayi	Protein kinase domain containing protein	0.0466	1	1
Echinococcus granulosus	SHC transforming protein 3	0.0278	0.5316	0.3223
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0188	0.3089	0.1595
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0466	1	1
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0188	0.3089	0.3089
Echinococcus multilocularis	N chimaerin	0.0278	0.5316	0.3223
Brugia malayi	Variant SH3 domain containing protein	0.0278	0.5316	0.3223
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0188	0.3089	0.3089
Trichomonas vaginalis	AGC family protein kinase	0.0188	0.3089	0.5
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0278	0.5316	0.3223
Brugia malayi	Variant SH3 domain containing protein	0.0278	0.5316	0.3223
Loa Loa (eye worm)	hypothetical protein	0.021	0.3631	0.3631
Trichomonas vaginalis	TKL family protein kinase	0.0188	0.3089	0.5
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0188	0.3089	0.3089
Trichomonas vaginalis	TKL family protein kinase	0.0188	0.3089	0.5
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0188	0.3089	0.5
Trypanosoma brucei	Pseudokinase, putative	0.0188	0.3089	0.5
Schistosoma mansoni	protein kinase	0.0188	0.3089	0.1595
Brugia malayi	Tensin	0.0278	0.5316	0.3223
Loa Loa (eye worm)	SH2 domain-containing protein	0.0278	0.5316	0.5316
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0466	1	1
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0188	0.3089	0.3089
Plasmodium falciparum	protein kinase, putative	0.0188	0.3089	0.5
Schistosoma mansoni	tyrosine kinase	0.0466	1	1
Loa Loa (eye worm)	TK protein kinase	0.0188	0.3089	0.3089
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0188	0.3089	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0188	0.3089	0.5
Trypanosoma cruzi	protein kinase, putative	0.0188	0.3089	0.5
Echinococcus granulosus	tensin	0.0278	0.5316	0.3223
Trichomonas vaginalis	TKL family protein kinase	0.0188	0.3089	0.5
Loa Loa (eye worm)	hypothetical protein	0.0278	0.5316	0.5316
Schistosoma mansoni	tyrosine kinase	0.0188	0.3089	0.1595
Trichomonas vaginalis	TKL family protein kinase	0.0188	0.3089	0.5
Echinococcus granulosus	signal transduction protein lnk realted	0.0278	0.5316	0.3223
Brugia malayi	Tyrosine-protein kinase abl-1	0.0466	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0188	0.3089	0.3089

Activities

Activity type	Activity value	Assay description	Source	Reference
EMR (binding)	= 0.53	Inhibition of KCa2.3 in Sprague-Dawley rat superior cervical ganglion neurons assessed as inhibition of afterhyperpolarization by electrophysiological assay relative to UCL1848	ChEMBL.	23685886
IC50 (binding)	= 2.6 nM	Inhibition of KCa2.3 in Sprague-Dawley rat superior cervical ganglion neurons assessed as inhibition of afterhyperpolarization by electrophysiological assay	ChEMBL.	23685886

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL2391673

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1777945