Detailed information for compound 1777953

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 748.713 | Formula: C40H34F6N4O4
  • H donors: 4 H acceptors: 4 LogP: 9.49 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 2
  • SMILES: [O-]C(=O)C(F)(F)F.[O-]C(=O)C(F)(F)F.Cc1ccc2c(c1)c1NCc3ccc(cc3)CNc3cc[n+](Cc4cc(C[n+]2cc1)ccc4)c1ccc(cc31)C
  • InChi: 1S/C36H32N4.2C2HF3O2/c1-25-6-12-35-31(18-25)33-14-16-39(35)23-29-4-3-5-30(20-29)24-40-17-15-34(32-19-26(2)7-13-36(32)40)38-22-28-10-8-27(9-11-28)21-37-33;2*3-2(4,5)1(6)7/h3-20H,21-24H2,1-2H3;2*(H,6,7)/b37-33+,38-34+;;
  • InChiKey: TVCARSXGAQAFJE-PNRDVOISSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Small conductance calcium-activated potassium channel protein 3 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K04942 potassium intermediate/small conductance calcium-activated channel,, putative Get druggable targets OG5_130097 All targets in OG5_130097
Schistosoma mansoni hypothetical protein Get druggable targets OG5_130097 All targets in OG5_130097
Schistosoma japonicum IPR011996,SK channel region,domain-containing Get druggable targets OG5_130097 All targets in OG5_130097
Schistosoma mansoni calcium-activated potassium channel Get druggable targets OG5_130097 All targets in OG5_130097
Schistosoma japonicum ko:K01047 phospholipase A2 [EC3.1.1.4], putative Get druggable targets OG5_130097 All targets in OG5_130097
Schistosoma japonicum expressed protein Get druggable targets OG5_130097 All targets in OG5_130097
Schistosoma japonicum Small conductance calcium-activated potassium channel protein, putative Get druggable targets OG5_130097 All targets in OG5_130097
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_130097 All targets in OG5_130097
Schistosoma japonicum Small conductance calcium-activated potassium channel protein, putative Get druggable targets OG5_130097 All targets in OG5_130097
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_130097 All targets in OG5_130097
Echinococcus multilocularis small conductance calcium activated potassium Get druggable targets OG5_130097 All targets in OG5_130097
Echinococcus granulosus small conductance calcium activated potassium Get druggable targets OG5_130097 All targets in OG5_130097
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni voltage-gated potassium channel 0.0509 0.9629 0.9629
Echinococcus granulosus potassium voltage gated channel protein 0.0509 0.9629 0.9629
Schistosoma mansoni voltage-gated potassium channel 0.0509 0.9629 0.9629
Echinococcus granulosus voltage gated potassium channel 0.0509 0.9629 0.9629
Echinococcus granulosus short transient receptor potential channel 6 0.0528 1 1
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0509 0.9629 0.9629
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0509 0.9629 0.9629
Schistosoma mansoni hypothetical protein 0.021 0.3753 0.3753
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0062 0.0844 0.5
Echinococcus granulosus transient receptor potential cation channel 0.0509 0.9629 0.9629
Schistosoma mansoni voltage-gated potassium channel 0.0509 0.9629 0.9629
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0509 0.9629 0.9629
Echinococcus granulosus two pore calcium channel protein 1 0.0509 0.9629 0.9629
Brugia malayi Cyclic-nucleotide gated cation channel 0.0509 0.9629 0.9609
Echinococcus multilocularis ATP dependent DNA helicase PIF1 0.0036 0.033 0.033
Echinococcus granulosus TRP transient receptor potential channel 0.0509 0.9629 0.9629
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0509 0.9629 0.9629
Loa Loa (eye worm) hypothetical protein 0.0509 0.9629 0.9593
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0062 0.0844 0.0553
Brugia malayi ion channel NompC 0.0509 0.9629 0.9609
Echinococcus multilocularis short transient receptor potential channel 6 0.0509 0.9629 0.9629
Loa Loa (eye worm) voltage-dependent calcium channel 0.0509 0.9629 0.9593
Schistosoma mansoni voltage-gated potassium channel 0.0509 0.9629 0.9629
Loa Loa (eye worm) hypothetical protein 0.0509 0.9629 0.9593
Loa Loa (eye worm) thioredoxin reductase 0.0179 0.314 0.2473
Schistosoma mansoni voltage-gated ion channel 0.0509 0.9629 0.9629
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0062 0.0844 0.0553
Echinococcus multilocularis transient receptor potential gamma protein 0.0509 0.9629 0.9629
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0509 0.9629 0.9629
Schistosoma mansoni voltage-gated potassium channel 0.0509 0.9629 0.9629
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0062 0.0844 0.5
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0509 0.9629 0.9609
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0062 0.0844 0.5
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0062 0.0844 0.0553
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0509 0.9629 0.9629
Schistosoma mansoni voltage-gated potassium channel 0.0509 0.9629 0.9629
Loa Loa (eye worm) hypothetical protein 0.0509 0.9629 0.9593
Leishmania major trypanothione reductase 0.0179 0.314 0.3021
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0509 0.9629 0.9629
Schistosoma mansoni two-pore calcium channel 0.0509 0.9629 0.9629
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.0509 0.9629 1
Trypanosoma cruzi trypanothione reductase, putative 0.0062 0.0844 0.0553
Loa Loa (eye worm) glutathione reductase 0.0179 0.314 0.2473
Echinococcus granulosus voltage dependent calcium channel 0.0509 0.9629 0.9629
Echinococcus multilocularis voltage dependent calcium channel 0.0509 0.9629 0.9629
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0509 0.9629 0.9629
Echinococcus multilocularis hyperpolarization activated cyclic 0.0509 0.9629 0.9629
Plasmodium vivax thioredoxin reductase, putative 0.0179 0.314 1
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0509 0.9629 0.9629
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0509 0.9629 0.9629
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0509 0.9629 0.9629
Plasmodium vivax glutathione reductase, putative 0.0179 0.314 1
Loa Loa (eye worm) hypothetical protein 0.0509 0.9629 0.9593
Echinococcus granulosus thioredoxin glutathione reductase 0.0179 0.314 0.314
Schistosoma mansoni transient receptor potential channel 4 0.0509 0.9629 0.9629
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.0509 0.9629 0.9629
Echinococcus multilocularis calcium activated potassium channel 0.0509 0.9629 0.9629
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0062 0.0844 0.5
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0509 0.9629 1
Brugia malayi cation channel family protein 0.0509 0.9629 0.9609
Echinococcus granulosus ryanodine receptor 44f 0.0509 0.9629 0.9629
Echinococcus granulosus potassium voltage gated channel protein 0.0509 0.9629 0.9629
Plasmodium falciparum glutathione reductase 0.0179 0.314 1
Loa Loa (eye worm) hypothetical protein 0.0509 0.9629 0.9593
Trypanosoma cruzi trypanothione reductase, putative 0.0179 0.314 0.3021
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0062 0.0844 0.0553
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0509 0.9629 0.9609
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0062 0.0844 0.0844
Schistosoma mansoni voltage-gated cation channel 0.0509 0.9629 0.9629
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0509 0.9629 0.9629
Loa Loa (eye worm) hypothetical protein 0.0509 0.9629 0.9593
Loa Loa (eye worm) hypothetical protein 0.0509 0.9629 0.9593
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0509 0.9629 0.9609
Schistosoma mansoni voltage-gated potassium channel 0.0509 0.9629 0.9629
Echinococcus granulosus voltage gated hydrogen channel 1 0.0509 0.9629 0.9629
Echinococcus granulosus calcium activated potassium channel 0.0509 0.9629 0.9629
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0509 0.9629 0.9629
Echinococcus granulosus two pore calcium channel protein 2 0.0509 0.9629 0.9629
Schistosoma mansoni calcium-activated potassium channel 0.021 0.3753 0.3753
Echinococcus multilocularis transient receptor potential cation channel 0.0528 1 1
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0509 0.9629 0.9629
Echinococcus multilocularis transient receptor potential cation channel 0.0509 0.9629 0.9629
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0509 0.9629 0.5
Echinococcus granulosus transient receptor potential cation channel 0.0509 0.9629 0.9629
Schistosoma mansoni voltage-gated potassium channel 0.0509 0.9629 0.9629
Schistosoma mansoni vesicular amine transporter 0.0509 0.9629 0.9629
Schistosoma mansoni voltage-gated potassium channel 0.0509 0.9629 0.9629
Loa Loa (eye worm) hypothetical protein 0.0071 0.103 0.0158
Echinococcus granulosus hypothetical protein 0.0509 0.9629 0.9629
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0509 0.9629 0.9629
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0509 0.9629 0.9629
Loa Loa (eye worm) hypothetical protein 0.0509 0.9629 0.9593
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0509 0.9629 0.9629
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0509 0.9629 0.9609
Echinococcus granulosus small conductance calcium activated potassium 0.021 0.3753 0.3753
Loa Loa (eye worm) hypothetical protein 0.0509 0.9629 0.9593
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0509 0.9629 0.9629
Giardia lamblia NADH oxidase lateral transfer candidate 0.0062 0.0844 1
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.033 0.0343
Echinococcus multilocularis voltage dependent calcium channel 0.0509 0.9629 0.9629
Loa Loa (eye worm) hypothetical protein 0.0509 0.9629 0.9593
Echinococcus multilocularis voltage gated hydrogen channel 1 0.0509 0.9629 0.9629
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0509 0.9629 0.9629
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.0509 0.9629 0.9609
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0509 0.9629 0.9629
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0509 0.9629 0.9629
Loa Loa (eye worm) hypothetical protein 0.0509 0.9629 0.9593
Echinococcus multilocularis potassium voltage gated channel protein 0.0509 0.9629 0.9629
Echinococcus granulosus hyperpolarization activated cyclic 0.0509 0.9629 0.9629
Brugia malayi glutathione reductase 0.0179 0.314 0.2763
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0062 0.0844 0.0553
Brugia malayi Thioredoxin reductase 0.0179 0.314 0.2763
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0062 0.0844 0.5
Entamoeba histolytica DNA repair and recombination protein, putative 0.0036 0.033 0.5
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0509 0.9629 0.9629
Echinococcus granulosus short transient receptor potential channel 6 0.0509 0.9629 0.9629
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0509 0.9629 1
Echinococcus multilocularis transient receptor potential cation channel 0.0509 0.9629 0.9629
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0509 0.9629 0.9609
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0509 0.9629 0.9609
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0509 0.9629 0.9629
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0509 0.9629 0.9629
Schistosoma mansoni voltage-gated potassium channel 0.0509 0.9629 0.9629
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0509 0.9629 0.9629
Loa Loa (eye worm) hypothetical protein 0.0509 0.9629 0.9593
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0509 0.9629 0.9629
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0509 0.9629 0.9629
Schistosoma mansoni calcium-activated potassium channel 0.0136 0.2289 0.2289
Echinococcus multilocularis small conductance calcium activated potassium 0.021 0.3753 0.3753
Loa Loa (eye worm) hypothetical protein 0.0509 0.9629 0.9593
Echinococcus multilocularis potassium voltage gated channel protein 0.0509 0.9629 0.9629
Echinococcus granulosus ATP dependent DNA helicase PIF1 0.0036 0.033 0.033
Echinococcus granulosus potassium voltage gated channel protein 0.0509 0.9629 0.9629
Giardia lamblia Rrm3p helicase 0.0036 0.033 0.391
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0509 0.9629 0.5
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0509 0.9629 0.9629
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0509 0.9629 0.9629
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0062 0.0844 0.0341
Loa Loa (eye worm) calcium channel 0.0509 0.9629 0.9593
Echinococcus multilocularis sodium channel protein 0.0509 0.9629 0.9629
Toxoplasma gondii hypothetical protein 0.0509 0.9629 1
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0509 0.9629 0.9629
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0509 0.9629 0.9629
Brugia malayi cation channel family protein 0.0509 0.9629 0.9609
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0509 0.9629 1
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0509 0.9629 0.9629
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0509 0.9629 0.9609
Brugia malayi voltage-dependent calcium channel 0.0509 0.9629 0.9609
Echinococcus multilocularis transient receptor potential cation channel 0.0509 0.9629 0.9629
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0509 0.9629 0.9609
Toxoplasma gondii hypothetical protein 0.0509 0.9629 1
Schistosoma mansoni transient receptor potential channel 0.0528 1 1
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0509 0.9629 0.9593
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0509 0.9629 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0179 0.314 0.314
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0509 0.9629 0.9629
Echinococcus multilocularis transfer RNA-Gly 0.0509 0.9629 0.9629
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0509 0.9629 1
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0509 0.9629 0.9629
Loa Loa (eye worm) hypothetical protein 0.0509 0.9629 0.9593
Echinococcus granulosus voltage gated potassium channel 0.0509 0.9629 0.9629
Schistosoma mansoni ryanodine receptor related 0.0509 0.9629 0.9629
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0509 0.9629 0.9629
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0509 0.9629 0.9629
Echinococcus granulosus transient receptor potential cation channel 0.0528 1 1
Echinococcus multilocularis transient receptor potential cation channel 0.0509 0.9629 0.9629
Trypanosoma brucei trypanothione reductase 0.0179 0.314 0.3021
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0509 0.9629 0.9629
Echinococcus granulosus transient receptor potential gamma protein 0.0509 0.9629 0.9629
Loa Loa (eye worm) ion channel NompC 0.0509 0.9629 0.9593
Echinococcus multilocularis two pore calcium channel protein 1 0.0509 0.9629 0.9629
Echinococcus multilocularis potassium large conductance calcium activated 0.0509 0.9629 0.9629
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0062 0.0844 0.0844
Leishmania major hypothetical protein, conserved 0.0509 0.9629 1
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0509 0.9629 0.9629
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0509 0.9629 0.9593
Echinococcus multilocularis voltage gated potassium channel 0.0509 0.9629 0.9629
Toxoplasma gondii transporter, cation channel family protein 0.0509 0.9629 1
Loa Loa (eye worm) hypothetical protein 0.0509 0.9629 0.9593
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0509 0.9629 0.9629
Loa Loa (eye worm) hypothetical protein 0.0509 0.9629 0.9593
Schistosoma mansoni voltage-gated potassium channel 0.0509 0.9629 0.9629
Loa Loa (eye worm) hypothetical protein 0.0068 0.0954 0.0075
Schistosoma mansoni voltage-gated potassium channel 0.0509 0.9629 0.9629
Loa Loa (eye worm) ryanodine receptor 0.0509 0.9629 0.9593
Toxoplasma gondii transporter, cation channel family protein 0.0509 0.9629 1
Schistosoma mansoni voltage-gated potassium channel 0.0509 0.9629 0.9629
Trichomonas vaginalis mercuric reductase, putative 0.0062 0.0844 0.0877
Echinococcus multilocularis transient receptor potential cation channel 0.0528 1 1
Toxoplasma gondii transporter, cation channel family protein 0.0509 0.9629 1
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0062 0.0844 0.0553
Echinococcus multilocularis potassium voltage gated channel protein 0.0509 0.9629 0.9629
Treponema pallidum NADH oxidase 0.0062 0.0844 0.5
Loa Loa (eye worm) voltage-gated potassium channel 0.0509 0.9629 0.9593
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0062 0.0844 0.0553
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0062 0.0844 0.0553
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0179 0.314 1
Schistosoma mansoni voltage-gated potassium channel 0.0509 0.9629 0.9629
Loa Loa (eye worm) hypothetical protein 0.0509 0.9629 0.9593
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0062 0.0844 0.0553
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0509 0.9629 0.9629
Echinococcus multilocularis voltage gated potassium channel 0.0509 0.9629 0.9629
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.0509 0.9629 0.9609
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0509 0.9629 0.9629
Loa Loa (eye worm) hypothetical protein 0.0509 0.9629 0.9593
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0062 0.0844 0.0553
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.0509 0.9629 0.9609
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0509 0.9629 1
Echinococcus granulosus voltage dependent calcium channel 0.0509 0.9629 0.9629
Echinococcus multilocularis sodium leak channel non selective protein 0.0509 0.9629 0.9629
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.0509 0.9629 0.9609
Schistosoma mansoni hypothetical protein 0.0036 0.033 0.033
Loa Loa (eye worm) voltage-gated calcium channel 0.0509 0.9629 0.9593
Echinococcus granulosus sodium channel protein 0.0509 0.9629 0.9629
Loa Loa (eye worm) hypothetical protein 0.021 0.3753 0.3145
Echinococcus granulosus shaker cognate 0.0509 0.9629 0.9629
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0509 0.9629 0.9629
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0062 0.0844 0.5
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0509 0.9629 0.9629
Onchocerca volvulus 0.0509 0.9629 0.5
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0062 0.0844 0.0553
Brugia malayi hypothetical protein 0.0509 0.9629 0.9609
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0509 0.9629 0.9629
Schistosoma mansoni transient receptor potential channel 0.0509 0.9629 0.9629
Schistosoma mansoni voltage-dependent calcium channel 0.0509 0.9629 0.9629
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0509 0.9629 1
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0509 0.9629 0.9629
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0062 0.0844 0.0553
Echinococcus granulosus potassium voltage gated channel protein 0.0509 0.9629 0.9629
Echinococcus multilocularis short transient receptor potential channel 6 0.0528 1 1
Loa Loa (eye worm) hypothetical protein 0.0509 0.9629 0.9593
Echinococcus granulosus hyperpolarization activated cyclic 0.0509 0.9629 0.9629
Schistosoma mansoni voltage-gated potassium channel 0.0509 0.9629 0.9629
Echinococcus granulosus potassium voltage gated channel protein 0.0509 0.9629 0.9629
Leishmania major hypothetical protein, unknown function 0.0509 0.9629 1
Schistosoma mansoni calcium-activated potassium channel 0.0509 0.9629 0.9629
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0062 0.0844 0.0553
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0509 0.9629 0.9593
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0509 0.9629 0.9629
Schistosoma mansoni 60S ribosomal protein L21 0.0509 0.9629 0.9629
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0509 0.9629 0.9609
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.0509 0.9629 0.9609
Schistosoma mansoni voltage-gated potassium channel 0.0509 0.9629 0.9629
Entamoeba histolytica hypothetical protein, conserved 0.0036 0.033 0.5
Echinococcus multilocularis potassium voltage gated channel protein 0.0509 0.9629 0.9629
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0509 0.9629 0.9609
Schistosoma mansoni transient receptor potential channel 0.0509 0.9629 0.9629
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0509 0.9629 0.9629
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.0509 0.9629 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0062 0.0844 0.0553
Echinococcus granulosus potassium large conductance calcium activated 0.0509 0.9629 0.9629
Brugia malayi Transient-receptor-potential like protein 0.0509 0.9629 0.9609
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0062 0.0844 0.0553
Schistosoma mansoni hypothetical protein 0.0509 0.9629 0.9629
Echinococcus granulosus sodium leak channel non selective protein 0.0509 0.9629 0.9629
Echinococcus multilocularis shaker cognate 0.0509 0.9629 0.9629
Plasmodium falciparum thioredoxin reductase 0.0179 0.314 1
Echinococcus granulosus transient receptor potential cation channel 0.0509 0.9629 0.9629
Schistosoma mansoni voltage-gated potassium channel 0.0509 0.9629 0.9629
Echinococcus multilocularis ryanodine receptor 44f 0.0509 0.9629 0.9629
Loa Loa (eye worm) voltage-gated potassium channel 0.0509 0.9629 0.9593
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0062 0.0844 0.0553
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0509 0.9629 0.9629
Echinococcus multilocularis two pore calcium channel protein 2 0.0509 0.9629 0.9629
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0062 0.0844 0.0844
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0062 0.0844 0.5
Echinococcus multilocularis hyperpolarization activated cyclic 0.0509 0.9629 0.9629
Loa Loa (eye worm) hypothetical protein 0.0509 0.9629 0.9593
Echinococcus granulosus transient receptor potential cation channel 0.0509 0.9629 0.9629
Loa Loa (eye worm) hypothetical protein 0.0528 1 1
Schistosoma mansoni voltage-gated potassium channel 0.0509 0.9629 0.9629
Echinococcus multilocularis conserved hypothetical protein 0.0509 0.9629 0.9629
Toxoplasma gondii thioredoxin reductase 0.0179 0.314 0.2613
Loa Loa (eye worm) hypothetical protein 0.0509 0.9629 0.9593
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0509 0.9629 0.9629
Echinococcus granulosus transient receptor potential cation channel 0.0509 0.9629 0.9629
Trichomonas vaginalis glutathione reductase, putative 0.0062 0.0844 0.0877

Activities

Activity type Activity value Assay description Source Reference
EMR (binding) = 7.6 Inhibition of KCa2.3 in Sprague-Dawley rat superior cervical ganglion neurons assessed as inhibition of afterhyperpolarization by electrophysiological assay relative to UCL1848 ChEMBL. 23685886
IC50 (binding) = 19 nM Inhibition of KCa2.3 in Sprague-Dawley rat superior cervical ganglion neurons assessed as inhibition of afterhyperpolarization by electrophysiological assay ChEMBL. 23685886

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.