TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 526.666 | Formula: C33H38N2O4
H donors: 2 H acceptors: 3 LogP: 6.96 Rotable bonds: 13
Rule of 5 violations (Lipinski): 2
SMILES: CC[C@@H]([C@@H]1C(=O)O[C@H]1C(=O)N[C@H]1C[C@H]1[C@H]([C@H](NC(=O)c1ccc2c(c1)cccc2)CCc1ccccc1)C)C
InChi: 1S/C33H38N2O4/c1-4-20(2)29-30(39-33(29)38)32(37)35-28-19-26(28)21(3)27(17-14-22-10-6-5-7-11-22)34-31(36)25-16-15-23-12-8-9-13-24(23)18-25/h5-13,15-16,18,20-21,26-30H,4,14,17,19H2,1-3H3,(H,34,36)(H,35,37)/t20-,21+,26-,27+,28-,29-,30+/m0/s1
InChiKey: QBWIRPCJSVFFIL-HAJIRACMSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus		0.035	0.1352	0.0908
Brugia malayi	SRC-1	0.06	0.3368	0.3093
Onchocerca volvulus		0.06	0.3368	0.318
Plasmodium vivax	protein kinase, putative	0.025	0.0546	0.3845
Echinococcus multilocularis	growth factor receptor bound protein 2	0.035	0.1352	0.0852
Echinococcus granulosus	SH2 motif	0.035	0.1352	0.0852
Echinococcus multilocularis	SH2 domain containing protein 7	0.035	0.1352	0.0852
Loa Loa (eye worm)	TK/FER protein kinase	0.06	0.3368	0.318
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.035	0.1352	0.0852
Trichomonas vaginalis	TKL family protein kinase	0.025	0.0546	0.0000010197
Entamoeba histolytica	protein farnesyltransferase beta subunit, putative	0.025	0.0547	0.0001
Brugia malayi	Tensin	0.035	0.1352	0.0883
Schistosoma mansoni	tyrosine kinase	0.06	0.3368	0.2985
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.035	0.1352	0.0883
Loa Loa (eye worm)	prenyltransferase and squalene oxidase repeat family protein	0.025	0.0547	0.0001
Echinococcus multilocularis	tensin	0.035	0.1352	0.0852
Giardia lamblia	Kinase, NEK	0.025	0.0546	0.0000010197
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.035	0.1352	0.0852
Schistosoma mansoni	serine/threonine protein kinase	0.1423	1	1
Plasmodium falciparum	protein farnesyltransferase subunit beta	0.025	0.0547	0.0007
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.06	0.3368	0.2985
Echinococcus multilocularis	SH2 motif	0.035	0.1352	0.0852
Echinococcus multilocularis	protein farnesyltransferase alpha subunit	0.0359	0.1421	0.0925
Brugia malayi	Variant SH3 domain containing protein	0.035	0.1352	0.0883
Schistosoma mansoni	protein kinase	0.025	0.0546	0.000000094367
Loa Loa (eye worm)	hypothetical protein	0.035	0.1352	0.0908
Giardia lamblia	Prenyltransferase	0.025	0.0547	0.0007
Echinococcus granulosus	SH2 domain containing adapter protein F	0.035	0.1352	0.0852
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.06	0.3368	0.2985
Loa Loa (eye worm)	hypothetical protein	0.035	0.1352	0.0908
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.035	0.1352	0.0908
Loa Loa (eye worm)	prenyltransferase alpha subunit repeat containing protein	0.0359	0.1421	0.0986
Echinococcus granulosus	tyrosine protein kinase Srms	0.06	0.3368	0.2985
Brugia malayi	Variant SH3 domain containing protein	0.035	0.1352	0.0883
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.035	0.1352	0.0852
Schistosoma mansoni	tensin-related	0.035	0.1352	0.0852
Giardia lamblia	Rab geranylgeranyltransferase	0.0359	0.1421	1
Echinococcus multilocularis	signal transduction protein lnk realted	0.035	0.1352	0.0852
Echinococcus multilocularis	N chimaerin	0.0391	0.1683	0.1203
Brugia malayi	SH2 domain containing protein	0.035	0.1352	0.0883
Echinococcus granulosus	tyrosine protein kinase shark	0.06	0.3368	0.2985
Echinococcus granulosus	tyrosine protein kinase ABL1	0.06	0.3368	0.2985
Echinococcus granulosus	tensin	0.035	0.1352	0.0852
Leishmania major	farnesyltransferase beta subunit	0.025	0.0547	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.06	0.3368	0.2985
Onchocerca volvulus		0.1351	0.942	1
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.035	0.1352	0.0908
Brugia malayi	cytokine inducible SH2-containing protein 5	0.035	0.1352	0.0883
Brugia malayi	Variant SH3 domain containing protein	0.035	0.1352	0.0883
Schistosoma mansoni	tyrosine kinase	0.06	0.3368	0.2985
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.025	0.0546	0.0000010197
Echinococcus multilocularis	tyrosine protein kinase Srms	0.06	0.3368	0.2985
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.06	0.3368	0.2985
Schistosoma mansoni	hypothetical protein	0.035	0.1352	0.0852
Brugia malayi	SH2 domain containing protein	0.06	0.3368	0.3093
Schistosoma mansoni	nck2/grb4	0.035	0.1352	0.0852
Schistosoma mansoni	vav2	0.0391	0.1683	0.1203
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.035	0.1352	0.0908
Brugia malayi	Raf kinase	0.1382	0.9669	1
Schistosoma mansoni	shc transforming protein	0.035	0.1352	0.0852
Schistosoma mansoni	tensin-related	0.035	0.1352	0.0852
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.06	0.3368	0.2985
Echinococcus granulosus	expressed conserved protein	0.035	0.1352	0.0852
Brugia malayi	SH2 domain containing protein	0.035	0.1352	0.0883
Schistosoma mansoni	tensin	0.035	0.1352	0.0852
Schistosoma mansoni	suppressor of cytokine signaling	0.035	0.1352	0.0852
Schistosoma mansoni	tensin	0.035	0.1352	0.0852
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.06	0.3368	0.2985
Brugia malayi	Protein kinase domain containing protein	0.06	0.3368	0.3093
Onchocerca volvulus		0.06	0.3368	0.318
Loa Loa (eye worm)	hypothetical protein	0.035	0.1352	0.0908
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.035	0.1352	0.0908
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.035	0.1352	0.0852
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.06	0.3368	0.2985
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.035	0.1352	0.0852
Toxoplasma gondii	hypothetical protein	0.0266	0.0672	1
Trichomonas vaginalis	geranylgeranyl transferase type II beta subunit, putative	0.025	0.0547	0.0007
Loa Loa (eye worm)	TK/FER protein kinase	0.06	0.3368	0.318
Echinococcus granulosus	tyrosine kinase	0.06	0.3368	0.2985
Echinococcus multilocularis	NCK adaptor protein	0.035	0.1352	0.0852
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.06	0.3368	0.2985
Echinococcus granulosus	protein farnesyltransferase subunit beta	0.025	0.0547	0.0001
Onchocerca volvulus		0.035	0.1352	0.0908
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.06	0.3368	0.2985
Loa Loa (eye worm)	SRC-1	0.06	0.3368	0.318
Trichomonas vaginalis	type I geranylgeranyltransferase beta subunit, putative	0.025	0.0547	0.0007
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0391	0.1683	0.1203
Echinococcus granulosus	NCK adaptor protein	0.035	0.1352	0.0852
Entamoeba histolytica	protein kinase, putative	0.1351	0.942	1
Schistosoma mansoni	tyrosine kinase	0.06	0.3368	0.2985
Loa Loa (eye worm)	TK/FER protein kinase	0.06	0.3368	0.318
Onchocerca volvulus		0.06	0.3368	0.318
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	0.0359	0.1421	1
Entamoeba histolytica	protein farnesyltransferase alpha subunit, putative	0.0359	0.1421	0.0986
Brugia malayi	Protein kinase domain containing protein	0.06	0.3368	0.3093
Loa Loa (eye worm)	hypothetical protein	0.035	0.1352	0.0908
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.035	0.1352	0.0852
Plasmodium vivax	tyrosine kinase-like protein, putative	0.025	0.0546	0.3845
Loa Loa (eye worm)	TK/FER protein kinase	0.06	0.3368	0.318
Loa Loa (eye worm)	hypothetical protein	0.035	0.1352	0.0908
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.025	0.0546	0.00000010054
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.06	0.3368	0.318
Trichomonas vaginalis	geranylgeranyl transferase type I beta subunit, putative	0.025	0.0547	0.0007
Brugia malayi	RhoGAP domain containing protein	0.0391	0.1683	0.1246
Schistosoma mansoni	protein farnesyltransferase subunit beta	0.025	0.0547	0.0001
Schistosoma mansoni	hypothetical protein	0.035	0.1352	0.0852
Echinococcus granulosus	SHC transforming protein 3	0.035	0.1352	0.0852
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.06	0.3368	0.2985
Schistosoma mansoni	adapter molecule crk	0.035	0.1352	0.0852
Schistosoma mansoni	tyrosine kinase	0.06	0.3368	0.2985
Loa Loa (eye worm)	hypothetical protein	0.035	0.1352	0.0908
Echinococcus granulosus	growth factor receptor bound protein 2	0.035	0.1352	0.0852
Schistosoma mansoni	growth factor receptor-bound protein	0.035	0.1352	0.0852
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0391	0.1683	0.1203
Entamoeba histolytica	protein kinase, putative	0.025	0.0546	0.00000010054
Echinococcus multilocularis		0.035	0.1352	0.0852
Loa Loa (eye worm)	hypothetical protein	0.035	0.1352	0.0908
Plasmodium falciparum	protein farnesyltransferase subunit alpha	0.0359	0.1421	1
Echinococcus granulosus	tyrosine kinase	0.06	0.3368	0.2985
Brugia malayi	SH2 domain containing protein	0.035	0.1352	0.0883
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.035	0.1352	0.0908
Schistosoma mansoni	suppressor of cytokine signaling	0.035	0.1352	0.0852
Echinococcus granulosus	tyrosine protein kinase Blk	0.06	0.3368	0.2985
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.035	0.1352	0.0852
Echinococcus granulosus	tyrosine protein kinase Lyn	0.06	0.3368	0.2985
Schistosoma mansoni	tyrosine kinase	0.06	0.3368	0.2985
Brugia malayi	Protein kinase domain containing protein	0.1351	0.942	0.9727
Echinococcus granulosus	signal transduction protein lnk realted	0.035	0.1352	0.0852
Brugia malayi	hypothetical protein	0.06	0.3368	0.3093
Onchocerca volvulus		0.06	0.3368	0.318
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0913	0.5886	0.6018
Brugia malayi	SH2 domain containing protein	0.035	0.1352	0.0883
Echinococcus granulosus	integrin linked protein kinase	0.025	0.0546	0.000000094367
Brugia malayi	protein-tyrosine kinase	0.06	0.3368	0.3093
Onchocerca volvulus		0.035	0.1352	0.0908
Echinococcus granulosus	SH2 motif	0.035	0.1352	0.0852
Echinococcus granulosus	tyrosine protein kinase Fyn	0.06	0.3368	0.2985
Entamoeba histolytica	SH2 domain containing protein	0.035	0.1352	0.0908
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.035	0.1352	0.0852
Loa Loa (eye worm)	TK/ABL protein kinase	0.06	0.3368	0.318
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.035	0.1352	0.0852
Schistosoma mansoni	tyrosine kinase	0.06	0.3368	0.2985
Loa Loa (eye worm)	hypothetical protein	0.035	0.1352	0.0908
Entamoeba histolytica	ankyrin repeat protein	0.025	0.0546	0.00000010054
Loa Loa (eye worm)	hypothetical protein	0.035	0.1352	0.0908
Onchocerca volvulus		0.06	0.3368	0.318
Echinococcus granulosus	hypothetical protein	0.035	0.1352	0.0852
Trichomonas vaginalis	geranylgeranyl transferase type II beta subunit, putative	0.025	0.0547	0.0007
Loa Loa (eye worm)	SH2 domain-containing protein	0.035	0.1352	0.0908
Echinococcus multilocularis	SHC transforming protein 3	0.035	0.1352	0.0852
Brugia malayi	SH2 domain containing protein	0.035	0.1352	0.0883
Echinococcus multilocularis	tyrosine protein kinase shark	0.06	0.3368	0.2985
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0391	0.1683	0.1203
Trichomonas vaginalis	protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative	0.0359	0.1421	1
Trypanosoma cruzi	protein farnesyltransferase, putative	0.025	0.0547	1
Loa Loa (eye worm)	hypothetical protein	0.035	0.1352	0.0908
Loa Loa (eye worm)	TK/FER protein kinase	0.06	0.3368	0.318
Trichomonas vaginalis	TKL family protein kinase	0.025	0.0546	0.0000010197
Onchocerca volvulus		0.035	0.1352	0.0908
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.06	0.3368	0.2985
Toxoplasma gondii	prenyltransferase and squalene oxidase repeat-containing protein	0.025	0.0547	0.005
Loa Loa (eye worm)	hypothetical protein	0.035	0.1352	0.0908
Loa Loa (eye worm)	SH2 domain-containing protein	0.035	0.1352	0.0908
Loa Loa (eye worm)	hypothetical protein	0.06	0.3368	0.318
Brugia malayi	SH2 domain containing protein	0.035	0.1352	0.0883
Trichomonas vaginalis	TKL family protein kinase	0.025	0.0546	0.0000010197
Brugia malayi	tRNA modification GTPase TrmE family protein	0.035	0.1352	0.0883
Brugia malayi	STAT protein, DNA binding domain containing protein	0.035	0.1352	0.0883
Echinococcus granulosus	tyrosine protein kinase Src64B	0.06	0.3368	0.2985
Plasmodium vivax	tyrosine kinase-like protein, putative	0.025	0.0546	0.3845
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.035	0.1352	0.0852
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.035	0.1352	0.0908
Schistosoma mansoni	tensin	0.035	0.1352	0.0852
Loa Loa (eye worm)	TK/FER protein kinase	0.06	0.3368	0.318
Schistosoma mansoni	protein kinase	0.025	0.0546	0.000000094367
Echinococcus granulosus	N chimaerin	0.0391	0.1683	0.1203
Brugia malayi	hypothetical protein	0.035	0.1352	0.0883
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.06	0.3368	0.2985
Trypanosoma brucei	protein farnesyltransferase beta subunit	0.025	0.0547	1
Echinococcus granulosus	protein farnesyltransferase alpha subunit	0.0359	0.1421	0.0925
Loa Loa (eye worm)	hypothetical protein	0.0359	0.1421	0.0986
Loa Loa (eye worm)	TK/FER protein kinase	0.06	0.3368	0.318
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.06	0.3368	0.2985
Onchocerca volvulus		0.035	0.1352	0.0908
Trichomonas vaginalis	TKL family protein kinase	0.025	0.0546	0.0000010197
Loa Loa (eye worm)	TK protein kinase	0.06	0.3368	0.318
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.06	0.3368	0.2985
Schistosoma mansoni	signal transduction protein lnk-related	0.035	0.1352	0.0852
Brugia malayi	Protein kinase domain containing protein	0.06	0.3368	0.3093
Loa Loa (eye worm)	hypothetical protein	0.035	0.1352	0.0908
Onchocerca volvulus		0.035	0.1352	0.0908
Echinococcus multilocularis	SH2 motif	0.035	0.1352	0.0852
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.06	0.3368	0.2985
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.1351	0.942	1
Schistosoma mansoni	growth factor receptor-bound protein	0.035	0.1352	0.0852
Echinococcus granulosus	suppressor of cytokine signaling 7	0.035	0.1352	0.0852
Loa Loa (eye worm)	TK/FER protein kinase	0.06	0.3368	0.318
Loa Loa (eye worm)	TK/FER protein kinase	0.06	0.3368	0.318
Echinococcus granulosus	tyrosine protein kinase Src42A	0.035	0.1352	0.0852
Brugia malayi	Sex muscle abnormal protein 5	0.035	0.1352	0.0883
Loa Loa (eye worm)	hypothetical protein	0.035	0.1352	0.0908
Schistosoma mansoni	SH2A	0.035	0.1352	0.0852
Echinococcus multilocularis	SH2 motif	0.035	0.1352	0.0852
Echinococcus multilocularis	tensin	0.035	0.1352	0.0852
Brugia malayi	Variant SH3 domain containing protein	0.0391	0.1683	0.1246
Loa Loa (eye worm)	raf kinase	0.1173	0.7984	0.8382
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.035	0.1352	0.0908
Echinococcus multilocularis	c src tyrosine kinase	0.06	0.3368	0.2985
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.06	0.3368	0.2985
Trypanosoma cruzi	protein farnesyltransferase, putative	0.025	0.0547	1
Brugia malayi	Tyrosine-protein kinase abl-1	0.06	0.3368	0.3093
Echinococcus granulosus	tyrosine protein kinase Fyn	0.06	0.3368	0.2985
Plasmodium vivax	prenyltransferase alpha subunit, putative	0.0359	0.1421	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.06	0.3368	0.2985
Brugia malayi	integrin-linked kinase	0.025	0.0546	0.000000097794
Echinococcus multilocularis	protein farnesyltransferase subunit beta	0.025	0.0547	0.0001
Echinococcus multilocularis	tyrosine protein kinase Blk	0.06	0.3368	0.2985
Schistosoma mansoni	GTPase activating protein	0.035	0.1352	0.0852
Echinococcus granulosus	c src tyrosine kinase	0.06	0.3368	0.2985
Onchocerca volvulus		0.06	0.3368	0.318
Loa Loa (eye worm)	STAT protein	0.035	0.1352	0.0908
Giardia lamblia	Protein 21.1	0.025	0.0546	0.0000010197
Loa Loa (eye worm)	hypothetical protein	0.035	0.1352	0.0908
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0391	0.1683	0.1281
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.035	0.1352	0.0852
Brugia malayi	Protein prenyltransferase alpha subunit repeat containing protein	0.0359	0.1421	0.0959
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.035	0.1352	0.0852
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	0.0359	0.1421	1
Trichomonas vaginalis	protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative	0.0266	0.0672	0.1433
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.035	0.1352	0.0852
Echinococcus granulosus	tyrosine protein kinase Fyn	0.06	0.3368	0.2985
Plasmodium vivax	farnesyltransferase beta subunit, putative	0.025	0.0547	0.3849
Brugia malayi	Protein kinase domain containing protein	0.06	0.3368	0.3093
Brugia malayi	SH2 domain containing protein	0.035	0.1352	0.0883
Echinococcus granulosus	suppressor of cytokine signaling 6	0.035	0.1352	0.0852
Loa Loa (eye worm)	SH2 domain-containing protein	0.035	0.1352	0.0908
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.06	0.3368	0.2985
Brugia malayi	Protein kinase domain containing protein	0.06	0.3368	0.3093
Brugia malayi	SH2 domain containing protein	0.06	0.3368	0.3093
Trichomonas vaginalis	geranylgeranyl transferase type II beta subunit, putative	0.025	0.0547	0.0007
Echinococcus multilocularis	raf serine:threonine protein kinase	0.1423	1	1
Entamoeba histolytica	protein kinase, putative	0.035	0.1352	0.0908
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0391	0.1683	0.1203
Echinococcus multilocularis	tyrosine protein kinase Abl	0.06	0.3368	0.2985
Loa Loa (eye worm)	TK/FER protein kinase	0.06	0.3368	0.318
Schistosoma mansoni	protein farnesyltransferase alpha subunit	0.0359	0.1421	0.0925
Echinococcus multilocularis	tyrosine kinase	0.06	0.3368	0.2985
Loa Loa (eye worm)	hypothetical protein	0.035	0.1352	0.0908
Echinococcus granulosus	tyrosine protein kinase Src42A	0.06	0.3368	0.2985
Echinococcus granulosus	SH2 domain containing protein 7	0.035	0.1352	0.0852
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.035	0.1352	0.0908
Echinococcus multilocularis	integrin linked protein kinase	0.025	0.0546	0.000000094367
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.035	0.1352	0.0852
Trichomonas vaginalis	geranylgeranyl transferase type beta subunit, putative	0.025	0.0547	0.0007
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.035	0.1352	0.0852
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.06	0.3368	0.2985
Brugia malayi	Prenyltransferase and squalene oxidase repeat family protein	0.025	0.0547	0.0001

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL2403102

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1778244