Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | dihydroorotate dehydrogenase (quinone) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | dihydroorotate dehydrogenase (quinone) | 395 aa | 361 aa | 24.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | 6 phosphofructo 2 kinase:fructose 2 | 0.0114 | 0.3603 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.02 | 1 | 1 |
Schistosoma mansoni | dihydroorotate dehydrogenase | 0.02 | 1 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.0112 | 0.3461 | 0.2771 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0078 | 0.0954 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.3461 | 0.9604 |
Trypanosoma cruzi | dihydroorotate dehydrogenase (fumarate), putative | 0.02 | 1 | 1 |
Echinococcus granulosus | 6 phosphofructo 2 kinase:fructose 2 | 0.0114 | 0.3603 | 1 |
Mycobacterium tuberculosis | Probable dihydroorotate dehydrogenase PyrD | 0.02 | 1 | 0.5 |
Mycobacterium ulcerans | dihydroorotate dehydrogenase 2 | 0.02 | 1 | 1 |
Toxoplasma gondii | dihydroorotate dehydrogenase reveal, putative | 0.02 | 1 | 0.5 |
Entamoeba histolytica | dihydropyrimidine dehydrogenase, putative | 0.0078 | 0.0954 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydroorotate dehydrogenase 2 | 0.02 | 1 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0078 | 0.0954 | 0.5 |
Plasmodium vivax | dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.02 | 1 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0114 | 0.3603 | 0.2928 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.3603 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.0112 | 0.3461 | 0.2771 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0114 | 0.3603 | 0.0218 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0114 | 0.3603 | 0.2928 |
Giardia lamblia | Hypothetical protein | 0.0067 | 0.0143 | 0.5 |
Trypanosoma brucei | dihydroorotate dehydrogenase (fumarate) | 0.02 | 1 | 1 |
Onchocerca volvulus | 0.0114 | 0.3603 | 0.5 | |
Trichomonas vaginalis | dihydropyrimidine dehydrogenase, putative | 0.0078 | 0.0954 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.02 | 1 | 1 |
Plasmodium falciparum | dihydroorotate dehydrogenase | 0.02 | 1 | 0.5 |
Mycobacterium leprae | Probable dihydroorotate dehydrogenase PyrD | 0.02 | 1 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0078 | 0.0954 | 0.5 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0114 | 0.3603 | 0.0218 |
Giardia lamblia | Hypothetical protein | 0.0067 | 0.0143 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0078 | 0.0954 | 0.5 |
Leishmania major | dihydroorotate dehydrogenase | 0.02 | 1 | 1 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.02 | 1 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0078 | 0.0954 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 95 nM | Inhibition of human DHODH | ChEMBL. | 23930152 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.