Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | prostaglandin D2 receptor 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | flavodoxin domain-containing protein | 0.017 | 0 | 0.5 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0342 | 1 | 1 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0342 | 1 | 1 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0342 | 1 | 1 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0342 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0342 | 1 | 0.5 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0342 | 1 | 0.5 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0172 | 0.0151 | 0.0151 |
Brugia malayi | FAD binding domain containing protein | 0.0342 | 1 | 1 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.017 | 0 | 0.5 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0303 | 0.7743 | 0.5 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0342 | 1 | 1 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0342 | 1 | 0.5 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0211 | 0.2407 | 0.2407 |
Chlamydia trachomatis | sulfite reductase | 0.0211 | 0.2407 | 0.5 |
Trypanosoma cruzi | p450 reductase, putative | 0.0342 | 1 | 0.5 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0342 | 1 | 1 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0342 | 1 | 1 |
Giardia lamblia | Hypothetical protein | 0.0303 | 0.7743 | 0.5 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0342 | 1 | 0.5 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0342 | 1 | 1 |
Leishmania major | p450 reductase, putative | 0.0342 | 1 | 1 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0342 | 1 | 1 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0342 | 1 | 0.5 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0342 | 1 | 0.5 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0342 | 1 | 0.5 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0342 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0342 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0342 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 36 nM | Antagonist activity at CRTh2 receptor (unknown origin) overexpressed in CHOK1 cell membranes assessed as inhibition of [35S]-GTPgammaS binding preincubated for 1 hr followed by 50 nM PGD2 and 0.1 nM [35S]-GTPgammaS addition measured after 2 hrs by liquid scintillation counting analysis | ChEMBL. | 23601708 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.