Detailed information for compound 1778738

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 496.65 | Formula: C29H36N8
  • H donors: 4 H acceptors: 3 LogP: 4.69 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: NC1CCC(CC1)Nc1nc(NCc2ccc(cc2)c2ccccc2N)c2c(n1)n(cn2)C1CCCC1
  • InChi: 1S/C29H36N8/c30-21-13-15-22(16-14-21)34-29-35-27(26-28(36-29)37(18-33-26)23-5-1-2-6-23)32-17-19-9-11-20(12-10-19)24-7-3-4-8-25(24)31/h3-4,7-12,18,21-23H,1-2,5-6,13-17,30-31H2,(H2,32,34,35,36)
  • InChiKey: MTRJBUWLBZZPJJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cyclin-dependent kinase 3 Starlite/ChEMBL References
Homo sapiens cyclin E1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei gambiense cell division related protein kinase 2, putative,CDC2-related protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium yoelii cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Theileria parva cell division control protein 2 related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense cdc2-related kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania donovani cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi Cyclin, N-terminal domain containing protein Get druggable targets OG5_133273 All targets in OG5_133273
Echinococcus granulosus cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum ko:K02087 cyclin-dependent kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium berghei cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium parvum Cdc2-like CDK2/CDC28 like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum ko:K02090 cyclin-dependent kinase 5, putative Get druggable targets OG5_126712 All targets in OG5_126712
Babesia bovis cell division control protein 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) cyclin domain-containing protein Get druggable targets OG5_133273 All targets in OG5_133273
Leishmania infantum cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium knowlesi Cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania donovani cell division protein kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Neospora caninum CMGC kinase, CDK family TgPK2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium falciparum protein kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium hominis cdc2-like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei gambiense cell division protein kinase 2 homolog 1,cdc2- like protein kinase, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium vivax protein kinase Crk2 Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 cyclin-dependent kinase 3 305 aa 303 aa 32.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) CAMK/CAMKL/MELK protein kinase 0.0214 0.104 0.1009
Onchocerca volvulus 0.0099 0.0204 0.0808
Echinococcus multilocularis twitchin 0.0106 0.0257 0.0269
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0481 0.2975 0.3101
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0122 0.0374 0.0372
Echinococcus granulosus protein tyrosine kinase 0.0536 0.3381 0.3539
Echinococcus multilocularis activin receptor type 0.0082 0.0082 0.0086
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0151 0.0584 0.0552
Entamoeba histolytica protein kinase, putative 0.0145 0.0537 0.109
Giardia lamblia Kinase, STE STE20 0.0086 0.011 0.0038
Plasmodium vivax NIMA-related protein kinase (Pfnek-1), putative 0.0136 0.0472 0.0409
Echinococcus multilocularis notch 0.014 0.0504 0.0528
Echinococcus multilocularis mitogen activated protein kinase 14 0.0158 0.0633 0.0663
Brugia malayi Protein kinase domain containing protein 0.0436 0.2652 0.2652
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0156 0.0616 0.0563
Trichomonas vaginalis CAMK family protein kinase 0.0214 0.104 0.3298
Echinococcus granulosus protein jagged 1 0.014 0.0504 0.0528
Trypanosoma cruzi casein kinase, putative 0.0109 0.0278 0.0272
Entamoeba histolytica protein kinase domain containing protein 0.0138 0.0492 0.0995
Trichomonas vaginalis CMGC family protein kinase 0.0101 0.0218 0.0454
Brugia malayi putative serine/threonine kinase SADA gamma 0.009 0.0143 0.0143
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0113 0.0309 0.0304
Echinococcus multilocularis serine threonine protein kinase 0.0206 0.0983 0.1029
Brugia malayi hypothetical protein 0.0289 0.1587 0.1587
Brugia malayi Peroxidasin 0.0151 0.0586 0.0586
Schistosoma mansoni protein kinase 0.0233 0.1175 0.1175
Loa Loa (eye worm) hypothetical protein 0.014 0.0504 0.0472
Mycobacterium ulcerans glutamate synthase subunit beta 0.0128 0.0413 0.0763
Schistosoma mansoni serine/threonine protein kinase 0.0166 0.0695 0.0695
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0122 0.0374 0.0341
Entamoeba histolytica casein kinase, putative 0.0109 0.0278 0.0552
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0186 0.0839 0.0808
Echinococcus multilocularis mitogen activated protein kinase 3 0.0085 0.0103 0.0108
Echinococcus granulosus tyrosine protein kinase shark 0.0306 0.1705 0.1785
Loa Loa (eye worm) hypothetical protein 0.0099 0.0203 0.017
Loa Loa (eye worm) hypothetical protein 0.0225 0.1117 0.1087
Schistosoma mansoni slit 0.014 0.0506 0.0506
Echinococcus multilocularis N chimaerin 0.0093 0.0162 0.017
Loa Loa (eye worm) hypothetical protein 0.014 0.0504 0.0472
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0481 0.2975 1
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0128 0.0413 0.0763
Schistosoma mansoni protein kinase 0.0087 0.0119 0.0119
Loa Loa (eye worm) AGC/AKT protein kinase 0.0295 0.1627 0.1599
Brugia malayi EGF-like domain containing protein 0.014 0.0504 0.0504
Onchocerca volvulus Neurogenic locus notch homolog 0.014 0.0504 0.1993
Echinococcus granulosus epidermal growth factor receptor 0.0594 0.3795 0.3972
Onchocerca volvulus 0.0073 0.0019 0.0075
Loa Loa (eye worm) hypothetical protein 0.0166 0.0694 0.0662
Schistosoma mansoni serine/threonine protein kinase 0.0247 0.1277 0.1277
Loa Loa (eye worm) hypothetical protein 0.0346 0.2001 0.1974
Leishmania major casein kinase, putative 0.0109 0.0278 0.0207
Schistosoma mansoni protein kinase 0.0191 0.087 0.087
Schistosoma mansoni notch 0.014 0.0504 0.0504
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0481 0.2975 0.3101
Echinococcus multilocularis mitogen activated protein kinase 11 0.0158 0.0633 0.0663
Echinococcus granulosus serine:threonine protein kinase mig 15 0.0225 0.1117 0.1169
Echinococcus granulosus oligomeric golgi complex subunit 3 0.0725 0.475 0.4971
Loa Loa (eye worm) AGC/PKG protein kinase 0.0134 0.0461 0.0428
Plasmodium falciparum protein serine/threonine kinase-1 0.0153 0.0595 0.0541
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0089 0.0136 0.0136
Trichomonas vaginalis mercuric reductase, putative 0.0481 0.2975 1
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0231 0.1167 0.1221
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0128 0.0413 0.0763
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0481 0.2975 0.3054
Echinococcus multilocularis cyclin dependent kinase 5 0.0129 0.0422 0.0442
Schistosoma mansoni hypothetical protein 0.014 0.0504 0.0504
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0128 0.0413 0.1127
Schistosoma mansoni serine/threonine protein kinase 0.009 0.0143 0.0143
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0221 0.1091 0.1142
Trichomonas vaginalis CMGC family protein kinase 0.0101 0.0218 0.0454
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0083 0.0087 0.0054
Schistosoma mansoni hypothetical protein 0.014 0.0504 0.0504
Schistosoma mansoni protein kinase 0.0101 0.0218 0.0218
Loa Loa (eye worm) hypothetical protein 0.0115 0.0323 0.029
Brugia malayi STE20-like kinase MST 0.0253 0.132 0.132
Schistosoma mansoni serine/threonine kinase 0.0222 0.1101 0.1101
Brugia malayi SH2 domain containing protein 0.0099 0.0204 0.0204
Brugia malayi Immunoglobulin I-set domain containing protein 0.0081 0.0075 0.0075
Loa Loa (eye worm) casein kinase 0.0175 0.0754 0.0723
Schistosoma mansoni tyrosine kinase 0.0392 0.2331 0.2331
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0481 0.2975 0.3101
Loa Loa (eye worm) hypothetical protein 0.014 0.0504 0.0472
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.012 0.0356 0.0373
Schistosoma mansoni septate junction protein 0.0081 0.0073 0.0073
Trichomonas vaginalis CAMK family protein kinase 0.0115 0.0324 0.0818
Brugia malayi Tyrosine-protein kinase abl-1 0.0136 0.0472 0.0472
Trichomonas vaginalis CMGC family protein kinase 0.0085 0.0103 0.0055
Echinococcus multilocularis 0.0152 0.0591 0.0619
Loa Loa (eye worm) hypothetical protein 0.0259 0.1365 0.1336
Brugia malayi Protein kinase domain containing protein 0.0166 0.0695 0.0695
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0081 0.0073 0.0077
Onchocerca volvulus 0.0099 0.0204 0.0808
Trypanosoma cruzi cdc2-related kinase 1 0.0129 0.0422 0.0423
Giardia lamblia Kinase, CMGC GSK 0.0128 0.0419 0.1114
Echinococcus multilocularis peroxidasin 0.0151 0.0586 0.0614
Loa Loa (eye worm) TK protein kinase 0.0184 0.0823 0.0791
Trichomonas vaginalis CAMK family protein kinase 0.009 0.0143 0.0193
Schistosoma mansoni notch 0.014 0.0504 0.0504
Loa Loa (eye worm) CAMK/CAMKL/AMPK protein kinase 0.0184 0.0821 0.0789
Loa Loa (eye worm) TK/FER protein kinase 0.0099 0.0204 0.0171
Loa Loa (eye worm) TK protein kinase 0.0309 0.1728 0.1699
Trichomonas vaginalis CAMK family protein kinase 0.009 0.0143 0.0193
Brugia malayi serine/threonine protein kinase 6 0.0145 0.0537 0.0537
Brugia malayi Protein kinase domain containing protein 0.0129 0.0422 0.0422
Schistosoma mansoni serine/threonine protein kinase 0.0466 0.2867 0.2867
Giardia lamblia Kinase, AGC PKA 0.0156 0.0616 0.1797
Echinococcus multilocularis dual specificity protein kinase clk2 0.0153 0.0595 0.0622
Echinococcus multilocularis casein kinase I alpha 0.0109 0.0278 0.0291
Echinococcus granulosus protein kinase shaggy 0.0128 0.0419 0.0439
Giardia lamblia Kinase, CDC7 0.0091 0.0146 0.0163
Echinococcus granulosus basement membrane specific heparan sulfate 0.0081 0.0073 0.0077
Echinococcus multilocularis oligomeric golgi complex subunit 3 0.0725 0.475 0.4971
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0481 0.2975 0.3054
Onchocerca volvulus 0.0128 0.0419 0.1657
Brugia malayi hypothetical protein 0.0259 0.1365 0.1365
Onchocerca volvulus 0.0259 0.1365 0.5398
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0286 0.1564 0.1536
Trichomonas vaginalis STE family protein kinase 0.0087 0.0119 0.011
Brugia malayi Cyclin, N-terminal domain containing protein 0.0297 0.1643 0.1643
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0221 0.1091 0.1142
Plasmodium vivax glutathione reductase, putative 0.1387 0.9554 1
Schistosoma mansoni tyrosine kinase 0.0238 0.1217 0.1217
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0113 0.0309 0.0239
Echinococcus multilocularis tyrosine protein kinase HCK 0.0132 0.0441 0.0462
Schistosoma mansoni protein kinase 0.0359 0.2093 0.2093
Schistosoma mansoni serine/threonine protein kinase 0.0138 0.0492 0.0492
Echinococcus granulosus C type lectin domian containing protein 0.0259 0.1365 0.1429
Trypanosoma brucei protein kinase, putative 0.0093 0.0164 0.0086
Trichomonas vaginalis CMGC family protein kinase 0.0091 0.0146 0.0202
Echinococcus granulosus low density lipoprotein receptor ldl 0.0081 0.0073 0.0077
Trichomonas vaginalis AGC family protein kinase 0.0186 0.0839 0.2602
Trypanosoma brucei casein kinase I, isoform 2 0.0109 0.0278 0.0207
Echinococcus granulosus epidermal growth factor receptor 0.0392 0.2331 0.244
Leishmania major hypothetical protein, conserved 0.0128 0.0413 0.0349
Trypanosoma brucei cdc2-related kinase 1 0.0129 0.0422 0.0359
Brugia malayi Fibronectin type III domain containing protein 0.0289 0.1587 0.1587
Loa Loa (eye worm) STE/STE20/KHS protein kinase 0.0359 0.2093 0.2066
Brugia malayi Immunoglobulin I-set domain containing protein 0.0151 0.0584 0.0584
Plasmodium falciparum thioredoxin reductase 0.0481 0.2975 0.3054
Echinococcus multilocularis Down syndrome cell adhesion molecule 0.0096 0.0183 0.0192
Echinococcus granulosus GTPase activating Rap:RanGAP domain 3 0.0108 0.0272 0.0285
Schistosoma mansoni disulfide oxidoreductase 0.0128 0.0413 0.0413
Echinococcus multilocularis cyclin dependent kinase 19 0.0952 0.6398 0.6696
Echinococcus multilocularis maternal embryonic leucine zipper kinase 0.0115 0.0324 0.0339
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0323 0.1828 0.18
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0129 0.0422 0.0359
Brugia malayi Cadherin domain containing protein 0.014 0.0504 0.0504
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0323 0.1828 0.1828
Trichomonas vaginalis STE family protein kinase 0.0087 0.0119 0.011
Echinococcus granulosus tyrosine protein kinase Lyn 0.0257 0.135 0.1413
Echinococcus granulosus mitogen activated protein kinase 3 0.0085 0.0103 0.0108
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0086 0.011 0.0095
Schistosoma mansoni hypothetical protein 0.0099 0.0203 0.0203
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0113 0.0309 0.0304
Brugia malayi EGF-like domain containing protein 0.014 0.0504 0.0504
Echinococcus multilocularis roundabout 2 0.0441 0.2684 0.2809
Plasmodium falciparum glutathione reductase 0.1387 0.9554 1
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0128 0.0413 0.0349
Echinococcus multilocularis titin 0.0121 0.0367 0.0385
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0128 0.0413 0.0763
Loa Loa (eye worm) hypothetical protein 0.0274 0.1477 0.1448
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0128 0.0413 0.0832
Loa Loa (eye worm) programmed cell death 8 0.0128 0.0413 0.038
Echinococcus granulosus homeodomain interacting protein kinase 3 0.02 0.0939 0.0983
Onchocerca volvulus 0.0179 0.0785 0.3104
Echinococcus granulosus twitchin 0.038 0.2247 0.2352
Echinococcus multilocularis low density lipoprotein receptor (ldl) 0.0081 0.0073 0.0077
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0081 0.0073 0.0073
Schistosoma mansoni roundabout 0.0151 0.0584 0.0584
Loa Loa (eye worm) STE/STE20/TAO protein kinase 0.0219 0.1077 0.1046
Mycobacterium ulcerans dehydrogenase 0.0128 0.0413 0.0763
Schistosoma mansoni hypothetical protein 0.0081 0.0073 0.0073
Echinococcus granulosus cyclin dependent kinase 0.0129 0.0422 0.0442
Schistosoma mansoni septate junction protein 0.0151 0.0584 0.0584
Trichomonas vaginalis CMGC family protein kinase 0.0091 0.0146 0.0202
Brugia malayi Immunoglobulin I-set domain containing protein 0.0166 0.0694 0.0694
Schistosoma mansoni tyrosine kinase 0.0392 0.2331 0.2331
Trichomonas vaginalis AGC family protein kinase 0.0091 0.0148 0.0212
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0128 0.0413 0.0432
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0221 0.1091 0.1142
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0156 0.0616 0.0644
Loa Loa (eye worm) TK protein kinase 0.034 0.1956 0.1928
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0153 0.0595 0.0604
Echinococcus granulosus tyrosine protein kinase Srms 0.0494 0.307 0.3214
Echinococcus granulosus hypothetical protein 0.0117 0.0335 0.0351
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0128 0.0413 0.0432
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0086 0.0108 0.0074
Trichomonas vaginalis CMGC family protein kinase 0.0129 0.0422 0.1159
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0089 0.0136 0.0103
Echinococcus multilocularis cell adhesion molecule:down regulated by 0.0081 0.0073 0.0077
Echinococcus granulosus casein kinase i 0.0109 0.0278 0.0291
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0128 0.0413 0.1127
Echinococcus multilocularis nervana 2 0.012 0.0356 0.0373
Trichomonas vaginalis glutathione reductase, putative 0.0481 0.2975 1
Schistosoma mansoni growth factor receptor-bound protein 0.0089 0.0136 0.0136
Plasmodium vivax ferrodoxin reductase, putative 0.0128 0.0413 0.0347
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0082 0.0082 0.0067
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0128 0.0413 0.0349
Loa Loa (eye worm) hypothetical protein 0.0086 0.0114 0.0081
Trypanosoma brucei Casein kinase II 0.0101 0.0218 0.0143
Schistosoma mansoni sulfide quinone reductase 0.0128 0.0413 0.0413
Brugia malayi Protein kinase domain containing protein 0.0099 0.0204 0.0204
Leishmania major protein kinase, putative 0.0145 0.0537 0.048
Echinococcus multilocularis dual specificity 0.0138 0.0492 0.0515
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.0916 0.6136 0.6123
Trichomonas vaginalis CAMK family protein kinase 0.009 0.0143 0.0193
Echinococcus multilocularis tyrosine protein kinase Srms 0.0184 0.0823 0.0861
Brugia malayi Protein kinase domain containing protein 0.0091 0.0146 0.0146
Schistosoma mansoni serine/threonine protein kinase 0.0213 0.1033 0.1033
Trypanosoma brucei serine/arginine-rich protein specific kinase SRPK, putative 0.0084 0.0099 0.0017
Echinococcus multilocularis lachesin 0.0151 0.0584 0.0611
Loa Loa (eye worm) hypothetical protein 0.0168 0.0705 0.0674
Loa Loa (eye worm) CMGC/CDK/CDK9 protein kinase 0.0084 0.0095 0.0061
Trichomonas vaginalis CAMK family protein kinase 0.0266 0.1414 0.4595
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0221 0.1091 0.1142
Toxoplasma gondii cell-cycle-associated protein kinase SRPK, putative 0.0084 0.0099 0.0017
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0128 0.0413 0.0349
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0128 0.0413 0.0349
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0213 0.1033 0.1081
Toxoplasma gondii thioredoxin reductase 0.1387 0.9554 1
Echinococcus granulosus roundabout 2 0.0441 0.2684 0.2809
Toxoplasma gondii CMGC kinase, CK2 family 0.0101 0.0218 0.0143
Echinococcus granulosus glutamate synthase 0.0128 0.0413 0.0432
Trichomonas vaginalis AGC family protein kinase 0.0295 0.1627 0.5332
Toxoplasma gondii AGC kinase 0.0113 0.0309 0.0239
Schistosoma mansoni serine/threonine protein kinase 0.0084 0.0099 0.0099
Trypanosoma brucei polo-like protein kinase 0.0266 0.1414 0.1406
Loa Loa (eye worm) CAMK/PHK protein kinase 0.0163 0.0668 0.0636
Brugia malayi casein kinase I 0.0109 0.0278 0.0278
Brugia malayi Prion-like- 0.0151 0.0584 0.0584
Echinococcus multilocularis casein kinase I alpha 0.0109 0.0278 0.0291
Echinococcus granulosus neurogenic locus notch protein 0.014 0.0504 0.0528
Plasmodium falciparum ferrodoxin reductase-like protein 0.0128 0.0413 0.0349
Echinococcus granulosus serine:threonine protein kinase N2 0.0292 0.1607 0.1682
Echinococcus granulosus protein jagged 2 0.014 0.0504 0.0528
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0101 0.0223 0.0149
Echinococcus granulosus tyrosine protein kinase Blk 0.0184 0.0823 0.0861
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0184 0.0823 0.0861
Echinococcus multilocularis mitogen activated protein kinase 14 0.0158 0.0633 0.0663
Brugia malayi hypothetical protein 0.0259 0.1365 0.1365
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0345 0.1993 0.1966
Plasmodium vivax protein kinase Crk2 0.0129 0.0422 0.0357
Schistosoma mansoni tyrosine kinase 0.0221 0.1091 0.1091
Echinococcus granulosus N chimaerin 0.0093 0.0162 0.017
Loa Loa (eye worm) TK/EGFR protein kinase 0.0594 0.3795 0.3774
Entamoeba histolytica protein kinase domain containing protein 0.0145 0.0537 0.109
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0274 0.1477 0.1546
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0085 0.0103 0.0022
Schistosoma mansoni glutamate synthase 0.0128 0.0413 0.0413
Trichomonas vaginalis CK1 family protein kinase 0.0109 0.0278 0.0662
Echinococcus multilocularis leucine rich repeat containing protein 4 0.0081 0.0073 0.0077
Trypanosoma cruzi aurora B kinase, putative 0.0145 0.0537 0.0544
Onchocerca volvulus 0.0259 0.1365 0.5398
Giardia lamblia Kinase, STE STE20 0.0087 0.0119 0.0071
Loa Loa (eye worm) AGC/NDR protein kinase 0.0166 0.0695 0.0663
Onchocerca volvulus 0.0259 0.1365 0.5398
Trichomonas vaginalis STE family protein kinase 0.0136 0.0472 0.1331
Onchocerca volvulus 0.0086 0.0108 0.0427
Schistosoma mansoni tyrosine kinase 0.0594 0.3795 0.3795
Loa Loa (eye worm) hypothetical protein 0.014 0.0504 0.0472
Brugia malayi EGF-like domain containing protein 0.014 0.0504 0.0504
Echinococcus granulosus neuroglian 0.0345 0.1988 0.2081
Schistosoma mansoni cell adhesion molecule 0.037 0.2173 0.2173
Echinococcus granulosus slit 2 protein 0.0168 0.0705 0.0738
Echinococcus granulosus titin 0.0121 0.0367 0.0385
Trichomonas vaginalis CMGC family protein kinase 0.0138 0.0492 0.14
Brugia malayi Cadherin domain containing protein 0.014 0.0504 0.0504
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0128 0.0413 0.0432
Giardia lamblia Glutamate synthase 0.0128 0.0413 0.1092
Echinococcus granulosus cyclin dependent kinase 9 0.0092 0.0156 0.0163
Echinococcus multilocularis pro neuregulin 2, membrane bound 0.0081 0.0073 0.0077
Trypanosoma cruzi NADH dehydrogenase, putative 0.0128 0.0413 0.0413
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0153 0.0595 0.0541
Echinococcus granulosus casein kinase I alpha 0.0109 0.0278 0.0291
Schistosoma mansoni sulfide quinone reductase 0.0128 0.0413 0.0413
Schistosoma mansoni titin 0.0121 0.0367 0.0367
Loa Loa (eye worm) hypothetical protein 0.0086 0.0108 0.0074
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0128 0.0413 0.1092
Schistosoma mansoni tyrosine kinase 0.0253 0.1324 0.1324
Brugia malayi hypothetical protein 0.0259 0.1365 0.1365
Loa Loa (eye worm) CAMK/TSSK protein kinase 0.0585 0.3732 0.3711
Trichomonas vaginalis AGC family protein kinase 0.0145 0.0537 0.1558
Loa Loa (eye worm) TK protein kinase 0.0132 0.0441 0.0409
Onchocerca volvulus Serine\/threonine kinase homolog 0.0163 0.0668 0.2642
Brugia malayi Protein kinase domain containing protein 0.0153 0.0595 0.0595
Trichomonas vaginalis CAMK family protein kinase 0.009 0.0143 0.0193
Loa Loa (eye worm) hypothetical protein 0.0202 0.095 0.0919
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0081 0.0073 0.0073
Echinococcus granulosus insulin receptor 0.0436 0.2652 0.2776
Brugia malayi GCC2 and GCC3 family protein 0.0399 0.2382 0.2382
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0109 0.0278 0.0272
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0129 0.0422 0.039
Echinococcus multilocularis Glutaredoxin protein 5 0.012 0.0356 0.0373
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0481 0.2975 0.3054
Echinococcus granulosus cyclin dependent kinase 9 0.0084 0.0095 0.0099
Echinococcus multilocularis cyclin dependent kinase 9 0.0084 0.0095 0.0099
Loa Loa (eye worm) AGC/PKA protein kinase 0.0113 0.0309 0.0276
Loa Loa (eye worm) hypothetical protein 0.014 0.0504 0.0472
Brugia malayi hypothetical protein 0.0219 0.1077 0.1077
Onchocerca volvulus 0.0091 0.0146 0.0576
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0085 0.0103 0.0088
Trichomonas vaginalis CAMK family protein kinase 0.0266 0.1414 0.4595
Echinococcus granulosus casein kinase I alpha 0.0109 0.0278 0.0291
Echinococcus granulosus mitogen activated protein kinase 14 0.0158 0.0633 0.0663
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0129 0.0422 0.039
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0128 0.0413 0.0347
Trypanosoma brucei cdc2-related kinase 3 0.0129 0.0422 0.0359
Loa Loa (eye worm) hypothetical protein 0.0081 0.0073 0.0039
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0145 0.0537 0.0562
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0128 0.0413 0.0349
Echinococcus granulosus pro neuregulin 2 membrane bound 0.0081 0.0073 0.0077
Brugia malayi Immunoglobulin I-set domain containing protein 0.0151 0.0584 0.0584
Echinococcus multilocularis fat cadherin tumor suppressor 0.014 0.0504 0.0528
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0359 0.2093 0.219
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0088 0.0128 0.0239
Schistosoma mansoni kinase 0.0283 0.1544 0.1544
Schistosoma mansoni serine/threonine protein kinase 0.009 0.0143 0.0143
Loa Loa (eye worm) hypothetical protein 0.0081 0.0073 0.0039
Echinococcus granulosus calcium activated potassium channel 0.0134 0.0463 0.0484
Entamoeba histolytica hypothetical protein 0.0122 0.0374 0.0751
Loa Loa (eye worm) hypothetical protein 0.0113 0.0309 0.0276
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0166 0.0694 0.0727
Schistosoma mansoni serine/threonine protein kinase 0.0072 0.0013 0.0013
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0151 0.0584 0.0584
Schistosoma mansoni growth factor receptor-bound protein 0.0091 0.015 0.015
Schistosoma mansoni serine/threonine protein kinase 0.0292 0.1607 0.1607
Echinococcus multilocularis serine:threonine protein kinase N2 0.0292 0.1607 0.1682
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0481 0.2975 0.3053
Loa Loa (eye worm) hypothetical protein 0.0134 0.0462 0.043
Echinococcus granulosus cGMP dependent protein kinase 0.0134 0.0461 0.0482
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0093 0.0162 0.0162
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0221 0.1091 0.1142
Loa Loa (eye worm) hypothetical protein 0.0289 0.1587 0.1558
Trichomonas vaginalis CMGC family protein kinase 0.0085 0.0103 0.0055
Echinococcus multilocularis protein jagged 2 0.014 0.0504 0.0528
Echinococcus granulosus tyrosine protein kinase ABL1 0.0099 0.0204 0.0214
Brugia malayi Protein kinase domain containing protein 0.0916 0.6136 0.6136
Entamoeba histolytica serine/threonine protein kinase, putative 0.009 0.0143 0.0271
Trypanosoma cruzi NADH dehydrogenase, putative 0.0128 0.0413 0.0413
Echinococcus granulosus mitogen activated protein kinase 0.0085 0.0103 0.0108
Echinococcus multilocularis Immunoglobulin 0.0081 0.0073 0.0077
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0128 0.0413 0.0349
Schistosoma mansoni protein kinase 0.0087 0.0119 0.0119
Echinococcus multilocularis neurogenic locus notch protein 0.014 0.0504 0.0528
Echinococcus multilocularis nervana 2 0.012 0.0356 0.0373
Plasmodium vivax thioredoxin reductase, putative 0.1387 0.9554 1
Loa Loa (eye worm) hypothetical protein 0.0108 0.0272 0.0239
Trichomonas vaginalis AGC family protein kinase 0.0136 0.0472 0.1331
Echinococcus multilocularis cyclin dependent kinase 9 0.0092 0.0156 0.0163
Echinococcus granulosus cyclin 0.0725 0.475 0.4971
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0113 0.0309 0.0239
Loa Loa (eye worm) CMGC/CDK/CDK8 protein kinase 0.0952 0.6398 0.6385
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0128 0.0413 0.0763
Echinococcus granulosus NCK adaptor protein 0.0089 0.0136 0.0143
Trichomonas vaginalis STE family protein kinase 0.0087 0.0119 0.011
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0274 0.1477 0.1477
Echinococcus granulosus CDC7 cell division cycle 7 0.0091 0.0146 0.0152
Loa Loa (eye worm) hypothetical protein 0.014 0.0504 0.0472
Trichomonas vaginalis CAMK family protein kinase 0.009 0.0143 0.0193
Schistosoma mansoni protein kinase 0.0424 0.2565 0.2565
Trypanosoma brucei hypothetical protein, conserved 0.0128 0.0413 0.0349
Trichomonas vaginalis CMGC family protein kinase 0.0128 0.0419 0.1149
Echinococcus multilocularis Serine:threonine protein kinase PLK4 0.0144 0.0533 0.0558
Entamoeba histolytica cell division protein kinase 2, putative 0.0129 0.0422 0.0851
Onchocerca volvulus 0.0259 0.1365 0.5398
Trichomonas vaginalis CMGC family protein kinase 0.0091 0.0146 0.0202
Loa Loa (eye worm) hypothetical protein 0.0355 0.2063 0.2036
Brugia malayi cyclin-dependent kinase 9 0.0084 0.0095 0.0095
Entamoeba histolytica protein kinase domain containing protein 0.0122 0.0374 0.0751
Leishmania major protein kinase A catalytic subunit isoform 1 0.0113 0.0309 0.0239
Brugia malayi Variant SH3 domain containing protein 0.0089 0.0136 0.0136
Trypanosoma brucei aurora B kinase 0.0145 0.0537 0.048
Schistosoma mansoni notch 0.014 0.0504 0.0504
Echinococcus granulosus tyrosine protein kinase Src64B 0.0221 0.1091 0.1142
Brugia malayi Calcium binding EGF domain containing protein 0.014 0.0504 0.0504
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0481 0.2975 0.2803
Loa Loa (eye worm) AUR protein kinase 0.0145 0.0537 0.0505
Loa Loa (eye worm) hypothetical protein 0.0187 0.0848 0.0817
Schistosoma mansoni tyrosine kinase 0.0346 0.1995 0.1995
Onchocerca volvulus 0.0099 0.0204 0.0808
Trichomonas vaginalis AGC family protein kinase 0.0295 0.1627 0.5332
Schistosoma mansoni hypothetical protein 0.014 0.0504 0.0504
Schistosoma mansoni basigin related 0.0081 0.0073 0.0073
Echinococcus multilocularis 5' AMP activated protein kinase catalytic 0.0184 0.0821 0.0859
Brugia malayi Protein kinase domain containing protein 0.0185 0.0832 0.0832
Trypanosoma cruzi casein kinase, putative 0.0109 0.0278 0.0272
Echinococcus multilocularis protein tyrosine kinase 0.0536 0.3381 0.3539
Echinococcus multilocularis epidermal growth factor receptor 0.0392 0.2331 0.244
Schistosoma mansoni hypothetical protein 0.0099 0.0203 0.0203
Echinococcus granulosus casein kinase I delta 0.0109 0.0278 0.0291
Giardia lamblia Kinase, NEK 0.0136 0.0472 0.1296
Brugia malayi Protein kinase domain containing protein 0.0191 0.087 0.087
Brugia malayi Protein kinase domain containing protein 0.0114 0.0317 0.0317
Onchocerca volvulus 0.0091 0.0146 0.0576
Trypanosoma cruzi trypanothione reductase, putative 0.1387 0.9554 1
Schistosoma mansoni kinase 0.0084 0.0095 0.0095
Brugia malayi Immunoglobulin I-set domain containing protein 0.0086 0.0108 0.0108
Echinococcus granulosus tyrosine protein kinase Fyn 0.0221 0.1091 0.1142
Trichomonas vaginalis STE family protein kinase 0.0087 0.0119 0.011
Schistosoma mansoni titin 0.0086 0.0108 0.0108
Echinococcus multilocularis mitogen activated protein kinase 0.0085 0.0103 0.0108
Schistosoma mansoni serine/threonine protein kinase 0.0219 0.1077 0.1077
Loa Loa (eye worm) hypothetical protein 0.0179 0.0785 0.0754
Loa Loa (eye worm) hypothetical protein 0.014 0.0504 0.0472
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0128 0.0413 0.1127
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0166 0.0694 0.0662
Schistosoma mansoni serine/threonine protein kinase 0.0145 0.0537 0.0537
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0084 0.0099 0.0017
Schistosoma mansoni serine/threonine protein kinase 0.0091 0.0146 0.0146
Echinococcus granulosus tyrosine kinase 0.0184 0.0823 0.0861
Loa Loa (eye worm) CAMK/TSSK protein kinase 0.0585 0.3732 0.3711
Echinococcus granulosus Glutaredoxin protein 5 0.012 0.0356 0.0373
Loa Loa (eye worm) SRC-1 0.0221 0.1091 0.106
Brugia malayi Immunoglobulin I-set domain containing protein 0.0109 0.0276 0.0276
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0481 0.2975 0.3054
Entamoeba histolytica protein kinase domain containing protein 0.0082 0.0082 0.0145
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0392 0.2331 0.244
Onchocerca volvulus Putative cubilin 0.014 0.0504 0.1993
Loa Loa (eye worm) cyclin domain-containing protein 0.0725 0.475 0.4732
Giardia lamblia Kinase, CMGC CDK 0.0129 0.0422 0.1124
Brugia malayi Protein kinase domain 0.0087 0.0119 0.0119
Echinococcus granulosus Immunoglobulin 0.0081 0.0073 0.0077
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0481 0.2975 1
Schistosoma mansoni nephrin 0.0166 0.0694 0.0694
Schistosoma mansoni serine/threonine protein kinase 0.0319 0.18 0.18
Onchocerca volvulus 0.0187 0.0848 0.3352
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0166 0.0694 0.0727
Loa Loa (eye worm) hypothetical protein 0.014 0.0504 0.0472
Trichomonas vaginalis apoptosis inducing factor, putative 0.0128 0.0413 0.1127
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0101 0.0223 0.0234
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0126 0.04 0.0336
Giardia lamblia Kinase, CAMK CAMKL 0.0099 0.0204 0.0366
Trichomonas vaginalis AGC family protein kinase 0.0145 0.0537 0.1558
Trichomonas vaginalis CMGC family protein kinase 0.0085 0.0103 0.0055
Brugia malayi phosphoinositide-dependent protein kinase I 0.0083 0.0087 0.0087
Mycobacterium ulcerans monoxygenase 0.0128 0.0413 0.0763
Echinococcus multilocularis epidermal growth factor receptor 0.0594 0.3795 0.3972
Brugia malayi Immunoglobulin I-set domain containing protein 0.0081 0.0073 0.0073
Onchocerca volvulus 0.0302 0.1682 0.665
Entamoeba histolytica hypothetical protein 0.0368 0.2158 0.4459
Toxoplasma gondii AGC kinase 0.0286 0.1564 0.1565
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0158 0.0633 0.0644
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0156 0.0616 0.0644
Brugia malayi p70 ribosomal S6 kinase beta 0.0286 0.1564 0.1564
Loa Loa (eye worm) hypothetical protein 0.0274 0.1477 0.1448
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0153 0.0595 0.0604
Trichomonas vaginalis glutamate synthase, putative 0.0128 0.0413 0.1127
Echinococcus granulosus dual specificity 0.0138 0.0492 0.0515
Schistosoma mansoni notch 0.014 0.0504 0.0504
Loa Loa (eye worm) CAMK protein kinase 0.0121 0.0367 0.0335
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0213 0.1033 0.1081
Leishmania major hypothetical protein, conserved 0.0128 0.0413 0.0349
Loa Loa (eye worm) hypothetical protein 0.0288 0.1576 0.1547
Brugia malayi intracellular kinase 0.0128 0.0419 0.0419
Loa Loa (eye worm) hypothetical protein 0.014 0.0504 0.0472
Brugia malayi Protein kinase domain containing protein 0.0585 0.3732 0.3732
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0122 0.0374 0.0372
Trichomonas vaginalis CAMK family protein kinase 0.0266 0.1414 0.4595
Loa Loa (eye worm) CAMK/CAMKL/MARK protein kinase 0.0114 0.0317 0.0284
Trichomonas vaginalis CAMK family protein kinase 0.0115 0.0324 0.0818
Giardia lamblia Kinase, CMGC CK2 0.0101 0.0218 0.0416
Entamoeba histolytica PH domain containing protein kinase, putative 0.0122 0.0372 0.0747
Brugia malayi Immunoglobulin domain containing protein 0.0081 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0289 0.1587 0.1558
Schistosoma mansoni cell adhesion molecule 0.0166 0.0694 0.0694
Onchocerca volvulus 0.0099 0.0204 0.0808
Giardia lamblia Kinase, NEK 0.0136 0.0472 0.1296
Onchocerca volvulus 0.014 0.0504 0.1993
Schistosoma mansoni cell polarity protein 0.014 0.0504 0.0504
Echinococcus multilocularis growth factor receptor bound protein 2 0.0089 0.0136 0.0143
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0082 0.0084 0.0002
Toxoplasma gondii AGC kinase 0.0113 0.0309 0.0239
Brugia malayi Immunoglobulin I-set domain containing protein 0.0086 0.0108 0.0108
Schistosoma mansoni nephrin related 0.0081 0.0073 0.0073
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.0083 0.0087 0.0091
Brugia malayi Protein kinase domain containing protein 0.0163 0.0668 0.0668
Schistosoma mansoni vesicular amine transporter 0.0274 0.1477 0.1477
Loa Loa (eye worm) hypothetical protein 0.0081 0.0073 0.0039
Brugia malayi Immunoglobulin I-set domain containing protein 0.0289 0.1587 0.1587
Plasmodium falciparum cGMP-dependent protein kinase 0.0134 0.0461 0.0399
Onchocerca volvulus 0.0108 0.0272 0.1077
Giardia lamblia Kinase, AGC PKA 0.0113 0.0309 0.0731
Echinococcus granulosus raf serine:threonine protein kinase 0.0087 0.0117 0.0123
Brugia malayi glutathione reductase 0.1387 0.9554 0.9554
Mycobacterium tuberculosis Probable oxidoreductase 0.0481 0.2975 0.2803
Trichomonas vaginalis CMGC family protein kinase 0.0129 0.0422 0.1159
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0198 0.0926 0.0895
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0128 0.0413 0.0832
Brugia malayi EGF-like domain containing protein 0.014 0.0504 0.0504
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0156 0.0616 0.0626
Schistosoma mansoni cell adhesion molecule 0.0081 0.0073 0.0073
Schistosoma mansoni serine/threonine protein kinase 0.0085 0.0103 0.0103
Plasmodium falciparum casein kinase 2, alpha subunit 0.0101 0.0218 0.0143
Brugia malayi Heparan sulfate 0.0081 0.0073 0.0073
Echinococcus granulosus serine:threonine protein kinase 3 0.0253 0.132 0.1382
Giardia lamblia NADH oxidase lateral transfer candidate 0.0481 0.2975 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0424 0.2565 0.2685
Loa Loa (eye worm) hypothetical protein 0.0089 0.0136 0.0103
Brugia malayi Immunoglobulin I-set domain containing protein 0.0096 0.0183 0.0183
Echinococcus multilocularis c src tyrosine kinase 0.0136 0.0472 0.0495
Echinococcus granulosus lachesin 0.0151 0.0584 0.0611
Brugia malayi Immunoglobulin I-set domain containing protein 0.0086 0.0108 0.0108
Schistosoma mansoni hypothetical protein 0.014 0.0504 0.0504
Loa Loa (eye worm) hypothetical protein 0.0151 0.0586 0.0554
Loa Loa (eye worm) hypothetical protein 0.0399 0.2382 0.2356
Leishmania major protein kinase A catalytic subunit 0.0113 0.0309 0.0239
Echinococcus granulosus 5' AMP activated protein kinase catalytic 0.0184 0.0821 0.0859
Loa Loa (eye worm) hypothetical protein 0.0259 0.1365 0.1336
Entamoeba histolytica protein kinase domain containing protein 0.0084 0.0095 0.0171
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0162 0.0666 0.0634
Brugia malayi Furin-like cysteine rich region family protein 0.0594 0.3795 0.3795
Onchocerca volvulus 0.0086 0.0108 0.0427
Echinococcus multilocularis insulin receptor 0.0436 0.2652 0.2776
Plasmodium falciparum thioredoxin reductase 0.1387 0.9554 1
Echinococcus multilocularis casein kinase ii subunit alpha 0.0101 0.0218 0.0229
Toxoplasma gondii rhoptry neck protein RON1 0.0259 0.1365 0.1354
Onchocerca volvulus 0.0259 0.1365 0.5398
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0481 0.2975 0.3054
Entamoeba histolytica protein kinase, putative 0.0101 0.0223 0.0438
Giardia lamblia Kinase, CMGC CLK 0.0153 0.0595 0.1724
Echinococcus granulosus serine:threonine protein kinase Chk2 0.0072 0.0013 0.0013
Trichomonas vaginalis AGC family protein kinase 0.0195 0.0902 0.282
Echinococcus granulosus cGMP dependent protein kinase 1 0.0134 0.0461 0.0482
Toxoplasma gondii NADPH-glutathione reductase 0.0481 0.2975 0.3054
Echinococcus granulosus expressed protein 0.0084 0.0099 0.0103
Trichomonas vaginalis CMGC family protein kinase 0.0101 0.0218 0.0454
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0134 0.0461 0.0482
Plasmodium falciparum apical sushi protein 0.0259 0.1365 0.1354
Schistosoma mansoni tyrosine kinase 0.0436 0.2652 0.2652
Brugia malayi pregnancy-associated plasma protein-A 0.0259 0.1365 0.1365
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0386 0.2286 0.2259
Loa Loa (eye worm) hypothetical protein 0.0151 0.0584 0.0552
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0128 0.0413 0.1127
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0113 0.0309 0.0239
Schistosoma mansoni c4b-binding protein beta chain 0.0259 0.1365 0.1365
Echinococcus granulosus growth factor receptor bound protein 2 0.0091 0.015 0.0157
Trypanosoma cruzi Protein kinase B 0.0164 0.0678 0.0692
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0233 0.1175 0.123
Mycobacterium ulcerans hypothetical protein 0.0128 0.0413 0.0763
Trichomonas vaginalis CAMK family protein kinase 0.009 0.0143 0.0193
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0481 0.2975 1
Echinococcus multilocularis fibropellin Ia 0.014 0.0504 0.0528
Loa Loa (eye worm) STE/STE20/MSN protein kinase 0.0152 0.0591 0.0559
Brugia malayi probable protein kinase 0.026 0.1377 0.1377
Brugia malayi Hr1 repeat family protein 0.0292 0.1607 0.1607
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0128 0.0413 0.0349
Entamoeba histolytica protein kinase, putative 0.0295 0.1627 0.3355
Loa Loa (eye worm) hypothetical protein 0.0151 0.0584 0.0552
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0266 0.1414 0.1481
Echinococcus multilocularis rho associated protein kinase 0.0319 0.18 0.1884
Entamoeba histolytica protein kinase, putative 0.0132 0.0441 0.0891
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0108 0.0272 0.0266
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0093 0.0162 0.017
Trichomonas vaginalis glutamate synthase, putative 0.0128 0.0413 0.1127
Entamoeba histolytica casein kinase 1, putative 0.0109 0.0278 0.0552
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.0198 0.0926 0.0969
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0393 0.2337 0.2446
Schistosoma mansoni serine/threonine protein kinase 0.021 0.1014 0.1014
Trypanosoma cruzi dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0138 0.0492 0.0496
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0128 0.0413 0.0432
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0174 0.075 0.0719
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0113 0.0309 0.0239
Brugia malayi Protein kinase domain containing protein 0.0191 0.0876 0.0876
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0101 0.0218 0.0185
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0166 0.0694 0.0727
Schistosoma mansoni serine/threonine kinase 0.0166 0.0695 0.0695
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0145 0.0537 0.0562
Trypanosoma cruzi casein kinase, putative 0.0109 0.0278 0.0272
Brugia malayi Protein kinase domain containing protein 0.021 0.1014 0.1014
Toxoplasma gondii casein kinase I 0.0109 0.0278 0.0207
Echinococcus granulosus tyrosine protein kinase otk 0.0151 0.0584 0.0611
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0274 0.1477 0.1477
Echinococcus multilocularis calcium:calmodulin dependent protein kinase I 0.0072 0.0013 0.0013
Echinococcus multilocularis hypothetical protein 0.0099 0.0203 0.0213
Brugia malayi Protein kinase domain containing protein 0.0345 0.1993 0.1993
Echinococcus multilocularis tyrosine protein kinase 0.0279 0.1508 0.1579
Schistosoma mansoni nck2/grb4 0.0089 0.0136 0.0136
Schistosoma mansoni cell adhesion molecule 0.0086 0.0108 0.0108
Plasmodium vivax serine/threonine protein kinase, putative 0.0084 0.0099 0.0016
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0481 0.2975 0.3101
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0128 0.0413 0.1127
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0128 0.0413 0.0347
Echinococcus granulosus serine:threonine protein kinase TAO1 0.0219 0.1077 0.1127
Schistosoma mansoni hypothetical protein 0.0081 0.0073 0.0073
Trypanosoma cruzi casein kinase, putative 0.0109 0.0278 0.0272
Loa Loa (eye worm) TK/FER protein kinase 0.0099 0.0204 0.0171
Loa Loa (eye worm) hypothetical protein 0.0425 0.2574 0.2549
Entamoeba histolytica protein kinase, putative 0.0128 0.0419 0.0845
Schistosoma mansoni hypothetical protein 0.014 0.0504 0.0504
Echinococcus multilocularis serine:threonine protein kinase 38 0.0166 0.0695 0.0728
Toxoplasma gondii EGF family domain-containing protein 0.014 0.0504 0.0445
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.0312 0.0312
Entamoeba histolytica protein kinase , putative 0.0145 0.0537 0.109
Loa Loa (eye worm) hypothetical protein 0.014 0.0504 0.0472
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0221 0.1091 0.1142
Schistosoma mansoni laminin gamma-3 chain 0.014 0.0504 0.0504
Echinococcus granulosus roundabout 2 0.0166 0.0694 0.0727
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0113 0.0309 0.0324
Brugia malayi Variant SH3 domain containing protein 0.0089 0.0136 0.0136
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0082 0.0082 0.0067
Trichomonas vaginalis AGC family protein kinase 0.0295 0.1627 0.5332
Plasmodium falciparum serine/threonine protein kinase 0.0084 0.0099 0.0017
Brugia malayi protein kinase C3,putative 0.0157 0.0623 0.0623
Schistosoma mansoni serine/threonine protein kinase 0.0129 0.0422 0.0422
Echinococcus multilocularis raf serine:threonine protein kinase 0.0087 0.0117 0.0123
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0481 0.2975 1
Brugia malayi hypothetical protein 0.0081 0.0073 0.0073
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0087 0.0119 0.0125
Trichomonas vaginalis CAMK family protein kinase 0.009 0.0143 0.0193
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0145 0.0537 0.109
Loa Loa (eye worm) hypothetical protein 0.0274 0.1479 0.145
Schistosoma mansoni serine/threonine protein kinase 0.0106 0.0257 0.0257
Trypanosoma cruzi cdc2-related kinase 3 0.0129 0.0422 0.0423
Onchocerca volvulus Serine\/threonine kinase homolog 0.0266 0.1414 0.5593
Trichomonas vaginalis CAMK family protein kinase 0.0274 0.1476 0.4807
Brugia malayi EGF-like domain containing protein 0.014 0.0504 0.0504
Plasmodium vivax casein kinase 1, putative 0.0109 0.0278 0.0205
Schistosoma mansoni netrin receptor unc5 0.0081 0.0073 0.0073
Echinococcus multilocularis cyclin dependent kinase 1 0.0129 0.0422 0.0442
Loa Loa (eye worm) hypothetical protein 0.0081 0.0073 0.0039
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.0083 0.0087 0.0091
Plasmodium falciparum calcium-dependent protein kinase 4 0.0101 0.0223 0.0149
Echinococcus granulosus cyclin dependent kinase 1 0.0129 0.0422 0.0442
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0128 0.0419 0.0439
Brugia malayi Protein kinase domain containing protein 0.0083 0.0087 0.0087
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0238 0.1217 0.1273
Leishmania major protein kinase, putative 0.0086 0.011 0.0029
Echinococcus multilocularis cyclin dependent kinase 0.0129 0.0422 0.0442
Loa Loa (eye worm) hypothetical protein 0.0108 0.0272 0.0239
Echinococcus multilocularis serine:threonine kinase SAD 1 0.009 0.0143 0.015
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0129 0.0422 0.0359
Schistosoma mansoni tyrosine kinase 0.0436 0.2652 0.2652
Echinococcus multilocularis roundabout 2 0.0166 0.0694 0.0727
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0101 0.0223 0.0234
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0081 0.0073 0.0073
Plasmodium falciparum NIMA related kinase 1 0.0136 0.0472 0.0411
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0145 0.0537 0.0479
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0158 0.0633 0.0644
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0128 0.0413 0.038
Echinococcus granulosus fibropellin Ia 0.014 0.0504 0.0528
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0481 0.2975 0.3101
Brugia malayi Protein kinase domain containing protein 0.0275 0.1486 0.1486
Loa Loa (eye worm) TK/FER protein kinase 0.0099 0.0204 0.0171
Loa Loa (eye worm) AUR protein kinase 0.0145 0.0537 0.0505
Giardia lamblia Kinase, CMGC CDK 0.0129 0.0422 0.1124
Echinococcus multilocularis hemicentin 1 0.0151 0.0584 0.0611
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0128 0.0413 0.0432
Trichomonas vaginalis CAMK family protein kinase 0.009 0.0143 0.0193
Brugia malayi hypothetical protein 0.0259 0.1365 0.1365
Trichomonas vaginalis CMGC family protein kinase 0.0128 0.0419 0.1149
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0128 0.0413 0.0432
Echinococcus multilocularis dual specificity 0.0138 0.0492 0.0515
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0158 0.0633 0.0601
Brugia malayi Protein kinase domain containing protein 0.0099 0.0204 0.0204
Schistosoma mansoni serine/threonine protein kinase 0.0134 0.0461 0.0461
Loa Loa (eye worm) hypothetical protein 0.014 0.0504 0.0472
Loa Loa (eye worm) hypothetical protein 0.0128 0.0413 0.038
Brugia malayi Immunoglobulin I-set domain containing protein 0.0151 0.0584 0.0584
Brugia malayi Protein kinase domain containing protein 0.0084 0.0099 0.0099
Echinococcus granulosus Protein kinase C brain isozyme 0.0247 0.1277 0.1336
Schistosoma mansoni serine/threonine-protein kinase 0.0164 0.0678 0.0678
Trichomonas vaginalis AGC family protein kinase 0.0295 0.1627 0.5332
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0098 0.0199 0.0166
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0101 0.0223 0.019
Echinococcus multilocularis C type lectin domian containing protein 0.0259 0.1365 0.1429
Loa Loa (eye worm) hypothetical protein 0.0151 0.0584 0.0552
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.012 0.0356 0.0373
Brugia malayi Immunoglobulin domain containing protein 0.0081 0.0073 0.0073
Echinococcus granulosus serine threonine protein kinase nrc 0.0156 0.0616 0.0644
Schistosoma mansoni serine/threonine protein kinase 0.0247 0.1277 0.1277
Echinococcus multilocularis c4b binding protein beta chain 0.0259 0.1365 0.1429
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0117 0.0334 0.035
Echinococcus multilocularis phosphorylase kinase gamma subunit 0.0163 0.0668 0.0699
Echinococcus granulosus phosphorylase kinase gamma subunit 0.0163 0.0668 0.0699
Plasmodium falciparum glutathione reductase 0.0481 0.2975 0.3054
Schistosoma mansoni serine/threonine protein kinase 0.0134 0.0463 0.0463
Brugia malayi protein kinase C II. 0.0208 0.0998 0.0998
Trypanosoma cruzi hypothetical protein, conserved 0.0128 0.0413 0.0413
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0215 0.1044 0.1044
Trypanosoma cruzi cdc2-related kinase 1 0.0129 0.0422 0.0423
Brugia malayi MAP kinase sur-1 0.0085 0.0103 0.0103
Trypanosoma brucei 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.009 0.0143 0.0064
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0704 0.4594 0.4576
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0481 0.2975 0.3101
Loa Loa (eye worm) hypothetical protein 0.0151 0.0584 0.0552
Trypanosoma cruzi cdc2-related kinase 3 0.0129 0.0422 0.0423
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0089 0.0136 0.0103
Schistosoma mansoni hypothetical protein 0.0081 0.0073 0.0073
Echinococcus multilocularis aurora kinase A 0.0145 0.0537 0.0562
Trichomonas vaginalis CAMK family protein kinase 0.009 0.0143 0.0193
Echinococcus multilocularis neurogenic locus notch protein 4 0.014 0.0504 0.0528
Echinococcus multilocularis rac serine:threonine kinase 0.0164 0.0678 0.071
Brugia malayi Protein kinase domain containing protein 0.0186 0.0839 0.0839
Echinococcus multilocularis thioredoxin glutathione reductase 0.1387 0.9554 1
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0101 0.0223 0.0147
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0353 0.2049 0.2049
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0101 0.0223 0.0234
Entamoeba histolytica protein kinase domain containing protein 0.0128 0.0419 0.0845
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0345 0.1993 0.1966
Leishmania major serine/threonine protein kinase, putative,protein kinase, putative 0.009 0.0143 0.0064
Loa Loa (eye worm) AUR protein kinase 0.0145 0.0537 0.0505
Toxoplasma gondii NIMA-related protein kinase NIMA1 0.0136 0.0472 0.0411
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0128 0.0413 0.0413
Loa Loa (eye worm) hypothetical protein 0.0138 0.0491 0.0459
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0128 0.0413 0.0432
Entamoeba histolytica protein kinase, putative 0.0088 0.0128 0.0239
Echinococcus granulosus NDR protein kinase 0.0166 0.0695 0.0728
Echinococcus granulosus nephrin 0.0086 0.0108 0.0113
Leishmania major hypothetical protein, conserved 0.0128 0.0413 0.0349
Echinococcus multilocularis tyrosine protein kinase Blk 0.0184 0.0823 0.0861
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0101 0.0223 0.0147
Echinococcus granulosus casein kinase I alpha 0.0109 0.0278 0.0291
Brugia malayi Immunoglobulin I-set domain containing protein 0.0166 0.0694 0.0694
Schistosoma mansoni myosin-binding protein-related 0.0086 0.0108 0.0108
Trichomonas vaginalis CAMK family protein kinase 0.009 0.0143 0.0193
Schistosoma mansoni cell adhesion molecule 0.0151 0.0584 0.0584
Trichomonas vaginalis AGC family protein kinase 0.0295 0.1627 0.5332
Schistosoma mansoni serine/threonine protein kinase 0.0083 0.0087 0.0087
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.0223 0.0471
Loa Loa (eye worm) hypothetical protein 0.0259 0.1365 0.1336
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0481 0.2975 0.2975
Schistosoma mansoni glutamate synthase 0.0128 0.0413 0.0413
Loa Loa (eye worm) hypothetical protein 0.0101 0.0223 0.019
Schistosoma mansoni protein kinase 0.0424 0.2565 0.2565
Leishmania major casein kinase II, putative 0.0101 0.0218 0.0143
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0151 0.0584 0.0552
Echinococcus granulosus serine:threonine protein kinase 0.0114 0.0317 0.0332
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0481 0.2975 0.3101
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0153 0.0595 0.0563
Trichomonas vaginalis STE family protein kinase 0.0086 0.011 0.0077
Brugia malayi Protein kinase domain containing protein 0.0438 0.2668 0.2668
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0128 0.0413 0.0413
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.0229 0.1146 0.1116
Entamoeba histolytica protein kinase, putative 0.0075 0.003 0.0035
Schistosoma mansoni cell adhesion molecule 0.0166 0.0694 0.0694
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0481 0.2975 0.2975
Echinococcus granulosus cGMP dependent protein kinase 1 0.0134 0.0461 0.0482
Loa Loa (eye worm) hypothetical protein 0.0259 0.1365 0.1336
Entamoeba histolytica serine/threonine-protein kinase 3, putative 0.0086 0.011 0.0202
Brugia malayi Protein kinase domain containing protein 0.0099 0.0204 0.0204
Trichomonas vaginalis AGC family protein kinase 0.0186 0.0839 0.2602
Entamoeba histolytica protein kinase, putative 0.0083 0.0087 0.0155
Trichomonas vaginalis CAMK family protein kinase 0.0266 0.1414 0.4595
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0345 0.1993 0.788
Brugia malayi C1-like domain containing protein 0.0215 0.1044 0.1044
Brugia malayi Protein kinase domain containing protein 0.0295 0.1627 0.1627
Echinococcus granulosus dual specificity 0.0122 0.0374 0.0391
Brugia malayi Protein kinase domain containing protein 0.0279 0.1508 0.1508
Trichomonas vaginalis AGC family protein kinase 0.0295 0.1627 0.5332
Onchocerca volvulus 0.014 0.0504 0.1993
Brugia malayi Stress-activated protein kinase jnk-1 0.026 0.1372 0.1372
Echinococcus multilocularis serine:threonine protein kinase 0.0114 0.0317 0.0332
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0101 0.0223 0.0149
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0128 0.0413 0.0763
Schistosoma mansoni serine/threonine protein kinase 0.0184 0.0821 0.0821
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.1387 0.9554 1
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0166 0.0695 0.0728
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0128 0.0413 0.0413
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0215 0.1044 0.1014
Brugia malayi Protein kinase domain containing protein 0.0198 0.0926 0.0926
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0128 0.0413 0.0413
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0101 0.0223 0.0234
Brugia malayi SRC-1 0.0221 0.1091 0.1091
Brugia malayi cell division control protein 2 homolog 0.0129 0.0422 0.0422
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0481 0.2975 1
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0099 0.0204 0.0214
Brugia malayi serine/threonine kinase 12 0.0145 0.0537 0.0537
Echinococcus multilocularis ephrin type A receptor 4 A 0.0108 0.0273 0.0286
Loa Loa (eye worm) TK/EPH protein kinase 0.0125 0.0396 0.0364
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0156 0.0616 0.0561
Brugia malayi Sex muscle abnormal protein 5 0.0089 0.0136 0.0136
Echinococcus granulosus maternal embryonic leucine zipper kinase 0.0115 0.0324 0.0339
Brugia malayi Temporarily assigned gene name protein 59 0.0108 0.0272 0.0272
Schistosoma mansoni hypothetical protein 0.0128 0.0413 0.0413
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0134 0.0461 0.0399
Brugia malayi hypothetical protein 0.0099 0.0204 0.0204
Trichomonas vaginalis CAMK family protein kinase 0.009 0.0143 0.0193
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0128 0.0413 0.0413
Trypanosoma cruzi 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.009 0.0143 0.013
Onchocerca volvulus 0.0259 0.1365 0.5398
Brugia malayi Immunoglobulin I-set domain containing protein 0.0151 0.0584 0.0584
Loa Loa (eye worm) TK/INSR protein kinase 0.0436 0.2652 0.2627
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0113 0.0309 0.0324
Echinococcus multilocularis CDC7 cell division cycle 7 0.0091 0.0146 0.0152
Brugia malayi Homeodomain interacting protein kinase protein 1 0.02 0.0939 0.0939
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0128 0.0419 0.0355
Echinococcus multilocularis cyclin dependent kinase 1 0.0129 0.0422 0.0442
Loa Loa (eye worm) TK/ALK protein kinase 0.0275 0.1485 0.1456
Echinococcus multilocularis neuroglian 0.0166 0.0694 0.0727
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0158 0.0633 0.0581
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.014 0.0504 0.0504
Schistosoma mansoni netrin receptor unc5 0.0109 0.0276 0.0276
Echinococcus granulosus calcium:calmodulin dependent protein kinase I 0.0072 0.0013 0.0013
Echinococcus granulosus activin receptor type 0.0082 0.0082 0.0086
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0113 0.0309 0.0324
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0128 0.0419 0.0419
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0208 0.0998 0.0967
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0153 0.0595 0.0604
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase 0.0109 0.0278 0.0245
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0129 0.0422 0.0442
Loa Loa (eye worm) CMGC/DYRK/DYRK2 protein kinase 0.0138 0.0492 0.0459
Schistosoma mansoni cell adhesion molecule 0.0081 0.0073 0.0073
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0451 0.2762 0.2891
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0086 0.011 0.0095
Echinococcus multilocularis serine:threonine protein kinase 3 0.0253 0.132 0.1382
Loa Loa (eye worm) hypothetical protein 0.0081 0.0073 0.0039
Brugia malayi Variant SH3 domain containing protein 0.0093 0.0162 0.0162
Echinococcus granulosus neurogenic locus notch protein 0.014 0.0504 0.0528
Loa Loa (eye worm) protein kinase domain-containing protein 0.021 0.1014 0.0983
Brugia malayi Dual-specificity tyrosine-phosphorylation regulated kinase 2 0.0138 0.0492 0.0492
Echinococcus granulosus neurogenic locus protein delta 0.014 0.0504 0.0528
Loa Loa (eye worm) TK/FER protein kinase 0.0099 0.0204 0.0171
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0153 0.0595 0.0541
Loa Loa (eye worm) CDC7 protein kinase 0.0091 0.0146 0.0112
Echinococcus multilocularis Immunoglobulin 0.0274 0.1477 0.1546
Echinococcus multilocularis hemicentin 1 0.0151 0.0584 0.0611
Onchocerca volvulus 0.0283 0.1541 0.6092
Echinococcus granulosus netrin receptor unc 5 0.0109 0.0276 0.0289
Trichomonas vaginalis CMGC family protein kinase 0.0085 0.0103 0.0055
Loa Loa (eye worm) CMGC/SRPK protein kinase 0.0084 0.0099 0.0065
Entamoeba histolytica protein kinase, putative 0.0084 0.0099 0.0179
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0128 0.0413 0.0349
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0128 0.0413 0.0349
Toxoplasma gondii rhoptry neck protein RON9 0.0259 0.1365 0.1354
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0213 0.1033 0.1081
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0128 0.0419 0.0386
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0096 0.0183 0.015
Loa Loa (eye worm) STE/STE20/MST protein kinase 0.0253 0.132 0.129
Trichomonas vaginalis CMGC family protein kinase 0.0101 0.0218 0.0454
Loa Loa (eye worm) hypothetical protein 0.0259 0.1365 0.1336
Brugia malayi Protein kinase domain containing protein 0.0099 0.0204 0.0204
Echinococcus granulosus hemicentin 1 0.0151 0.0584 0.0611
Echinococcus granulosus fibroblast growth factor receptor 4 0.0238 0.1217 0.1273
Schistosoma mansoni hypothetical protein 0.014 0.0504 0.0504
Toxoplasma gondii selenide, water dikinase 0.0128 0.0413 0.0349
Brugia malayi casein kinase 1, delta 0.0109 0.0278 0.0278
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0231 0.1167 0.1221
Echinococcus granulosus serine:threonine kinase SAD 1 0.009 0.0143 0.015
Echinococcus granulosus casein kinase I delta 0.0109 0.0278 0.0291
Giardia lamblia Kinase, CMGC DYRK 0.0138 0.0492 0.1365
Giardia lamblia Kinase, AGC AKT 0.0117 0.0338 0.083
Entamoeba histolytica protein kinase, putative 0.0138 0.0492 0.0995
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0128 0.0413 0.0432
Loa Loa (eye worm) hypothetical protein 0.014 0.0504 0.0472
Plasmodium vivax serine/threonine kinase-1, putative 0.0153 0.0595 0.0539
Trichomonas vaginalis CAMK family protein kinase 0.0126 0.0403 0.1093
Schistosoma mansoni notch 0.014 0.0504 0.0504
Echinococcus granulosus roundabout 2 0.0166 0.0694 0.0727
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0087 0.0119 0.0125
Echinococcus granulosus c src tyrosine kinase 0.0136 0.0472 0.0495
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0128 0.0413 0.1127
Loa Loa (eye worm) glutathione reductase 0.1387 0.9554 0.9552
Trypanosoma cruzi casein kinase II, putative 0.0101 0.0218 0.0209
Echinococcus granulosus nervana 2 0.012 0.0356 0.0373
Loa Loa (eye worm) hypothetical protein 0.0425 0.2574 0.2549
Echinococcus granulosus Immunoglobulin subtype 0.0081 0.0073 0.0077
Echinococcus multilocularis neurogenic locus protein delta 0.014 0.0504 0.0528
Trichomonas vaginalis AGC family protein kinase 0.0145 0.0537 0.1558
Loa Loa (eye worm) hypothetical protein 0.0139 0.0496 0.0464
Echinococcus multilocularis GTPase activating Rap:RanGAP domain 3 0.0108 0.0272 0.0285
Schistosoma mansoni serine/threonine protein kinase 0.0213 0.1033 0.1033
Echinococcus multilocularis cyclin 0.0725 0.475 0.4971
Loa Loa (eye worm) hypothetical protein 0.009 0.0143 0.011
Echinococcus granulosus delta-like protein 1 0.014 0.0504 0.0528
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0987 0.6652 0.6962
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0128 0.0413 0.0349
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0481 0.2975 0.3054
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0394 0.2348 0.2457
Schistosoma mansoni tyrosine kinase 0.0536 0.3381 0.3381
Brugia malayi protein unc-22 0.0121 0.0367 0.0367
Schistosoma mansoni serine/threonine protein kinase 0.0386 0.2286 0.2286
Echinococcus granulosus defective proboscis extension response 0.0274 0.1477 0.1546
Plasmodium falciparum serine/threonine protein kinase KIN 0.009 0.0143 0.0064
Trichomonas vaginalis CAMK family protein kinase 0.009 0.0143 0.0193
Trichomonas vaginalis CAMK family protein kinase 0.0266 0.1414 0.4595
Leishmania major protein kinase, putative,dual-specificity protein kinase, putative 0.0138 0.0492 0.0432
Schistosoma mansoni serine/threonine protein kinase 0.0198 0.0926 0.0926
Onchocerca volvulus 0.0134 0.0462 0.1829
Echinococcus granulosus peroxidasin 0.0151 0.0586 0.0614
Schistosoma mansoni notch 0.014 0.0504 0.0504
Echinococcus multilocularis glutamate synthase 0.0128 0.0413 0.0432
Loa Loa (eye worm) cyclin domain-containing protein 0.0297 0.1643 0.1615
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0128 0.0419 0.0439
Echinococcus multilocularis casein kinase I alpha 0.0109 0.0278 0.0291
Echinococcus multilocularis homeodomain interacting protein kinase 3 0.02 0.0939 0.0983
Brugia malayi map kinase activated protein kinase protein 2 0.0386 0.2286 0.2286
Echinococcus multilocularis serine:threonine protein kinase N2 0.0126 0.0398 0.0417
Schistosoma mansoni protein kinase 0.0233 0.1175 0.1175
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0481 0.2975 0.3054
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0086 0.0108 0.0113
Onchocerca volvulus Slit protein homolog 0.0168 0.0705 0.2789
Schistosoma mansoni tyrosine kinase 0.0346 0.1995 0.1995
Echinococcus multilocularis protein kinase c iota type 0.0287 0.1572 0.1645
Echinococcus granulosus Serine:threonine protein kinase PLK4 0.0144 0.0533 0.0558
Loa Loa (eye worm) TK/FER protein kinase 0.0099 0.0204 0.0171
Echinococcus multilocularis expressed protein 0.0084 0.0099 0.0103
Entamoeba histolytica protein kinase, putative 0.0286 0.1564 0.3225
Onchocerca volvulus Netrin receptor homolog 0.0098 0.0201 0.0795
Echinococcus multilocularis death associated protein kinase 1 0.0825 0.5478 0.5734
Giardia lamblia Kinase, CMGC GSK 0.0128 0.0419 0.1114
Echinococcus multilocularis Immunoglobulin 0.0081 0.0073 0.0077
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0386 0.2286 0.2392
Entamoeba histolytica protein kinase, putative 0.0295 0.1627 0.3355
Brugia malayi Egg laying defective protein 4 0.0134 0.0461 0.0461
Schistosoma mansoni serine/threonine protein kinase 0.0113 0.0309 0.0309
Schistosoma mansoni serine/threonine protein kinase 0.0231 0.1167 0.1167
Loa Loa (eye worm) gastrulation defective protein 1 0.0916 0.6138 0.6125
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0128 0.0413 0.0432
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0233 0.1175 0.123
Echinococcus multilocularis calcium activated potassium channel 0.0134 0.0463 0.0484
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0481 0.2975 0.3114
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0345 0.1993 0.1993
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0128 0.0413 0.0413
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0202 0.0954 0.0923
Echinococcus multilocularis transfer RNA-Phe 0.0086 0.0108 0.0113
Trichomonas vaginalis CMGC family protein kinase 0.0138 0.0492 0.14
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0353 0.2049 0.2049
Loa Loa (eye worm) hypothetical protein 0.0151 0.0584 0.0552
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0238 0.1217 0.1273
Echinococcus granulosus protein kinase 0.0152 0.0591 0.0619
Echinococcus multilocularis casein kinase I gamma 0.021 0.1014 0.1061
Schistosoma mansoni septate junction protein 0.014 0.0504 0.0504
Trichomonas vaginalis CAMK family protein kinase 0.0266 0.1414 0.4595
Brugia malayi Immunoglobulin I-set domain containing protein 0.0151 0.0584 0.0584
Plasmodium vivax calcium-dependent protein kinase, putative 0.0101 0.0223 0.0147
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0101 0.0218 0.0142
Schistosoma mansoni tyrosine kinase 0.0306 0.1705 0.1705
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0113 0.0309 0.0324
Trypanosoma brucei Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0108 0.0272 0.0201
Loa Loa (eye worm) hypothetical protein 0.0134 0.0462 0.043
Brugia malayi serine/threonine-protein kinase 6 0.0145 0.0537 0.0537
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0117 0.0334 0.035
Schistosoma mansoni tyrosine kinase 0.0077 0.0044 0.0044
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0481 0.2975 0.3054
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0078 0.005 0.0052
Echinococcus granulosus neuroglian 0.0166 0.0694 0.0727
Echinococcus multilocularis tyrosine protein kinase shark 0.0306 0.1705 0.1785
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0087 0.0119 0.0125
Giardia lamblia Kinase, CK1 Casein kinase 0.0109 0.0278 0.0624
Echinococcus multilocularis protein jagged 1 0.014 0.0504 0.0528
Echinococcus granulosus titin 0.0121 0.0367 0.0385
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0166 0.0694 0.0694
Loa Loa (eye worm) hypothetical protein 0.014 0.0504 0.0472
Giardia lamblia Thioredoxin reductase 0.0128 0.0413 0.1092
Schistosoma mansoni serine/threonine-protein kinase 0.0164 0.0678 0.0678
Trypanosoma cruzi polo-like protein kinase, putative 0.0266 0.1414 0.1464
Trichomonas vaginalis CMGC family protein kinase 0.0101 0.0218 0.0454
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0113 0.0309 0.0324
Schistosoma mansoni hypothetical protein 0.0081 0.0073 0.0073
Trichomonas vaginalis CAMK family protein kinase 0.009 0.0143 0.0193
Plasmodium falciparum calcium-dependent protein kinase 5 0.0101 0.0223 0.0149
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0266 0.1414 0.1481
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0128 0.0413 0.0432
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0221 0.1091 0.1142
Brugia malayi Protein kinase domain containing protein 0.0542 0.3423 0.3423
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0086 0.0108 0.0074
Loa Loa (eye worm) camk/dcamkl protein kinase 0.015 0.0575 0.0543
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0128 0.0413 0.0413
Brugia malayi Immunoglobulin I-set domain containing protein 0.0086 0.0108 0.0108
Echinococcus granulosus ephrin type A receptor 4 A 0.0108 0.0273 0.0286
Onchocerca volvulus 0.0138 0.0491 0.1941
Schistosoma mansoni septate junction protein 0.0081 0.0073 0.0073
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0166 0.0694 0.0727
Echinococcus granulosus tyrosine kinase 0.0099 0.0204 0.0214
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0128 0.0413 0.0832
Entamoeba histolytica protein kinase, putative 0.0087 0.0119 0.0222
Toxoplasma gondii cell-cycle-associated protein kinase DYRK2, putative 0.0138 0.0492 0.0432
Brugia malayi RhoGAP domain containing protein 0.0093 0.0162 0.0162
Schistosoma mansoni serine/threonine protein kinase 0.0345 0.1993 0.1993
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0128 0.0419 0.042
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0184 0.0823 0.0861
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0093 0.0162 0.0129
Trypanosoma cruzi trypanothione reductase, putative 0.0481 0.2975 0.3101
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0122 0.0374 0.0308
Loa Loa (eye worm) AGC/PKN protein kinase 0.0292 0.1607 0.1578
Loa Loa (eye worm) hypothetical protein 0.0301 0.1671 0.1642
Loa Loa (eye worm) hypothetical protein 0.0108 0.0272 0.0239
Loa Loa (eye worm) AGC/PKA protein kinase 0.0113 0.0309 0.0276
Entamoeba histolytica protein kinase, putative 0.0122 0.0374 0.0751
Schistosoma mansoni serine/threonine protein kinase 0.0113 0.0309 0.0309
Entamoeba histolytica cell division protein kinase 2, putative 0.0137 0.0483 0.0978
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0113 0.0309 0.0304
Schistosoma mansoni hypothetical protein 0.014 0.0504 0.0504
Brugia malayi SH2 domain containing protein 0.0393 0.2337 0.2337
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0101 0.0223 0.0223
Giardia lamblia Kinase, CMGC MAPK 0.0085 0.0103 0.0015
Loa Loa (eye worm) hypothetical protein 0.0278 0.1506 0.1477
Entamoeba histolytica protein kinase domain containing protein 0.02 0.0939 0.1925
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0221 0.1091 0.1142
Brugia malayi Fes/CIP4 homology domain containing protein 0.011 0.0288 0.0288
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0128 0.0413 0.0349
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0087 0.0119 0.0125
Schistosoma mansoni tyrosine kinase 0.0359 0.2094 0.2094
Echinococcus granulosus neural cadherin 0.014 0.0504 0.0528
Echinococcus multilocularis 0.0117 0.0335 0.0351
Trichomonas vaginalis CAMK family protein kinase 0.0126 0.0403 0.1093
Echinococcus granulosus tyrosine protein kinase Fyn 0.0221 0.1091 0.1142
Onchocerca volvulus 0.0121 0.0367 0.1453
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0093 0.0162 0.017
Plasmodium vivax glycogen synthase kinase 3, putative 0.0128 0.0419 0.0354
Schistosoma mansoni protein kinase C mu 0.0215 0.1044 0.1044
Echinococcus multilocularis NCK adaptor protein 0.0091 0.015 0.0157
Echinococcus granulosus serine:threonine protein kinase N2 0.0126 0.0398 0.0417
Brugia malayi Protein kinase domain containing protein 0.0952 0.6398 0.6398
Schistosoma mansoni serine/threonine protein kinase 0.009 0.0143 0.0143
Echinococcus granulosus Vam6:Vps39 protein 0.0108 0.0272 0.0285
Loa Loa (eye worm) hypothetical protein 0.014 0.0504 0.0472
Schistosoma mansoni peroxidasin 0.0081 0.0075 0.0075
Brugia malayi Immunoglobulin I-set domain containing protein 0.0086 0.0108 0.0108
Onchocerca volvulus 0.0259 0.1365 0.5398
Entamoeba histolytica cyclin C, putative 0.0735 0.4825 1
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0122 0.0374 0.0308
Plasmodium falciparum protein kinase 5 0.0129 0.0422 0.0359
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0081 0.0073 0.0073
Brugia malayi Immunoglobulin domain containing protein 0.0081 0.0073 0.0073
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0481 0.2975 0.3053
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0451 0.2762 0.2891
Echinococcus multilocularis mitogen activated protein kinase 11 0.0158 0.0633 0.0663
Loa Loa (eye worm) hypothetical protein 0.0086 0.0108 0.0074
Loa Loa (eye worm) TK protein kinase 0.0279 0.1508 0.1479
Schistosoma mansoni serine/threonine protein kinase 0.026 0.1372 0.1372
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0078 0.005 0.0052
Loa Loa (eye worm) hypothetical protein 0.014 0.0504 0.0472
Trichomonas vaginalis AGC family protein kinase 0.0295 0.1627 0.5332
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0128 0.0413 0.0432
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0481 0.2975 0.3054
Onchocerca volvulus 0.0075 0.0029 0.0113
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0128 0.0413 0.0832
Brugia malayi glutamate synthase 0.0128 0.0413 0.0413
Loa Loa (eye worm) hypothetical protein 0.014 0.0504 0.0472
Echinococcus granulosus serine:threonine protein kinase 0.0114 0.0317 0.0332
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0091 0.0148 0.0115
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0481 0.2975 0.3114
Schistosoma mansoni serine/threonine protein kinase 0.0109 0.0278 0.0278
Onchocerca volvulus 0.0259 0.1365 0.5398
Entamoeba histolytica casein kinase, putative 0.0101 0.0218 0.0428
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0166 0.0695 0.0728
Schistosoma mansoni vam6/vps39 related 0.0108 0.0272 0.0272
Schistosoma mansoni hypothetical protein 0.0081 0.0073 0.0073
Schistosoma mansoni serine/threonine protein kinase 0.0952 0.6398 0.6398
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0085 0.0103 0.0088
Echinococcus multilocularis expressed conserved protein 0.0134 0.0461 0.0482
Entamoeba histolytica protein kinase, putative 0.0084 0.0099 0.0179
Echinococcus multilocularis serine:threonine protein kinase 0.0114 0.0317 0.0332
Trypanosoma brucei rac serine-threonine kinase, putative 0.0295 0.1627 0.1631
Trypanosoma brucei protein kinase, putative 0.0128 0.0419 0.0355
Schistosoma mansoni serine/threonine protein kinase 0.0134 0.0463 0.0463
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0136 0.0472 0.0472
Schistosoma mansoni adapter molecule crk 0.0089 0.0136 0.0136
Echinococcus granulosus neurogenic locus notch protein 4 0.014 0.0504 0.0528
Toxoplasma gondii histone kinase SNF1, putative 0.009 0.0143 0.0064
Schistosoma mansoni tyrosine kinase 0.0136 0.0472 0.0472
Echinococcus granulosus dual specificity 0.0138 0.0492 0.0515
Echinococcus granulosus tyrosine protein kinase 0.0279 0.1508 0.1579
Echinococcus multilocularis protein kinase shaggy 0.0128 0.0419 0.0439
Schistosoma mansoni serine/threonine protein kinase 0.0231 0.1167 0.1167
Brugia malayi Protein kinase domain containing protein 0.0214 0.104 0.104
Brugia malayi Casein kinase II, alpha chain 0.0101 0.0218 0.0218
Echinococcus multilocularis roundabout 2 0.0166 0.0694 0.0727
Entamoeba histolytica protein kinase 2, putative 0.0156 0.0616 0.1253
Echinococcus multilocularis c Jun NH2 terminal kinase 0.026 0.1372 0.1436
Schistosoma mansoni serine/threonine protein kinase 0.0266 0.1414 0.1414
Brugia malayi Protein kinase c protein 2 0.0116 0.0328 0.0328
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0153 0.0595 0.0604
Trichomonas vaginalis CMGC family protein kinase 0.0138 0.0492 0.14
Echinococcus granulosus protein jagged 1 0.014 0.0504 0.0528
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0128 0.0413 0.0349
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0113 0.0309 0.0324
Echinococcus granulosus c4b binding protein beta chain 0.0259 0.1365 0.1429
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.0151 0.0584 0.0611
Echinococcus granulosus Down syndrome cell adhesion molecule 0.0096 0.0183 0.0192
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0393 0.2337 0.2446
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0221 0.1091 0.1142
Loa Loa (eye worm) camk/mapkapk/mnk protein kinase 0.0438 0.2668 0.2643
Trichomonas vaginalis CMGC family protein kinase 0.0153 0.0595 0.1756
Onchocerca volvulus 0.014 0.0504 0.1993
Echinococcus multilocularis neurogenic locus notch protein 0.014 0.0504 0.0528
Loa Loa (eye worm) thioredoxin reductase 0.1387 0.9554 0.9552
Loa Loa (eye worm) hypothetical protein 0.014 0.0504 0.0472
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0086 0.0108 0.0074
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0248 0.1286 0.1346
Loa Loa (eye worm) immunoglobulin domain-containing protein 0.0081 0.0073 0.0039
Echinococcus multilocularis Immunoglobulin subtype 0.0081 0.0073 0.0077
Trypanosoma brucei trypanothione reductase 0.1387 0.9554 1
Trichomonas vaginalis CAMK family protein kinase 0.009 0.0143 0.0193
Echinococcus granulosus cyclin dependent kinase 19 0.0952 0.6398 0.6696
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.0087 0.0119 0.0125
Entamoeba histolytica protein kinase, putative 0.0145 0.0537 0.109
Echinococcus multilocularis neuroglian 0.0345 0.1988 0.2081
Loa Loa (eye worm) hypothetical protein 0.0138 0.0491 0.0459
Schistosoma mansoni serine/threonine protein kinase 0.0087 0.0117 0.0117
Loa Loa (eye worm) hypothetical protein 0.0099 0.0204 0.0171
Trichomonas vaginalis AGC family protein kinase 0.0113 0.0309 0.0768
Loa Loa (eye worm) cyclin C 0.1448 1 1
Loa Loa (eye worm) hypothetical protein 0.0134 0.0462 0.043
Schistosoma mansoni protein kinase 0.0145 0.0537 0.0537
Schistosoma mansoni protein kinase 0.0424 0.2565 0.2565
Brugia malayi Temporarily assigned gene name protein 59 0.0125 0.0394 0.0394
Brugia malayi EST embl|AI107989|AI107989 comes from the 3' UTR, putative 0.0184 0.0821 0.0821
Schistosoma mansoni serine/threonine protein kinase 0.0113 0.0309 0.0309
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0238 0.1217 0.1273
Schistosoma mansoni hypothetical protein 0.0108 0.0272 0.0272
Trichomonas vaginalis CMGC family protein kinase 0.0129 0.0422 0.1159
Loa Loa (eye worm) TK/FER protein kinase 0.0099 0.0204 0.0171
Schistosoma mansoni titin 0.0151 0.0584 0.0584
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0108 0.0272 0.0272
Brugia malayi Immunoglobulin I-set domain containing protein 0.0166 0.0694 0.0694
Echinococcus granulosus thioredoxin glutathione reductase 0.1387 0.9554 1
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0345 0.1993 0.2086
Echinococcus multilocularis tyrosine protein kinase Abl 0.0136 0.0472 0.0495
Loa Loa (eye worm) hypothetical protein 0.0346 0.2001 0.1974
Trichomonas vaginalis CAMK family protein kinase 0.009 0.0143 0.0193
Loa Loa (eye worm) TK/FER protein kinase 0.0099 0.0204 0.0171
Brugia malayi EGF-like domain containing protein 0.014 0.0504 0.0504
Onchocerca volvulus 0.0109 0.0278 0.1101
Echinococcus multilocularis serine:threonine protein kinase TAO1 0.0219 0.1077 0.1127
Loa Loa (eye worm) TK/ROR protein kinase 0.0117 0.0334 0.0301
Echinococcus granulosus c-Jun N-terminal kinases 0.026 0.1372 0.1436
Echinococcus granulosus serine/threonine protein kinase 0.0164 0.0678 0.071
Entamoeba histolytica serine/threonine protein kinase STE20, putative 0.0086 0.011 0.0202
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0128 0.0413 0.0763
Schistosoma mansoni serine/threonine protein kinase 0.0153 0.0595 0.0595
Echinococcus granulosus casein kinase ii subunit alpha 0.0101 0.0218 0.0229
Echinococcus multilocularis myosin iiia 0.0086 0.011 0.0115
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0266 0.1414 0.1406
Leishmania major protein kinase A catalytic subunit isoform 2 0.0113 0.0309 0.0239
Giardia lamblia Aurora kinase 0.0145 0.0537 0.1524
Schistosoma mansoni tyrosine kinase 0.0197 0.092 0.092
Brugia malayi Protein kinase domain containing protein 0.0099 0.0204 0.0204
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0085 0.0103 0.0022
Brugia malayi Protein kinase domain containing protein 0.0585 0.3732 0.3732
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.026 0.1372 0.1343
Schistosoma mansoni serine/threonine protein kinase 0.0248 0.1286 0.1286
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0481 0.2975 0.3054
Echinococcus granulosus mitogen activated protein kinase 11 0.0158 0.0633 0.0663
Loa Loa (eye worm) hypothetical protein 0.0259 0.1365 0.1336
Loa Loa (eye worm) TK/FER protein kinase 0.0393 0.2337 0.2311
Loa Loa (eye worm) hypothetical protein 0.0114 0.0317 0.0284
Schistosoma mansoni rap gtpase-activating protein 0.0108 0.0272 0.0272
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0101 0.0223 0.0147
Brugia malayi Calcium binding EGF domain containing protein 0.014 0.0504 0.0504
Plasmodium vivax unspecified product 0.0101 0.0218 0.0142
Brugia malayi notch-like transmembrane receptor 0.014 0.0504 0.0504
Loa Loa (eye worm) hypothetical protein 0.0259 0.1365 0.1336
Schistosoma mansoni serine/threonine protein kinase 0.0208 0.0998 0.0998
Treponema pallidum NADH oxidase 0.0481 0.2975 1
Trypanosoma cruzi polo-like protein kinase, putative 0.0266 0.1414 0.1464
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0128 0.0413 0.0832
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0221 0.1091 0.1142
Brugia malayi hypothetical protein 0.0259 0.1365 0.1365
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0345 0.1993 0.2086
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0481 0.2975 1
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0128 0.0413 0.1127
Echinococcus multilocularis serine:threonine protein kinase N2 0.0166 0.0695 0.0728
Schistosoma mansoni tyrosine kinase 0.0346 0.1995 0.1995
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0145 0.0537 0.109
Loa Loa (eye worm) STE/STE20/SLK protein kinase 0.0191 0.087 0.0839
Brugia malayi Muscle positioning protein 4 0.014 0.0504 0.0504
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0317 0.0794
Schistosoma mansoni basigin related 0.0081 0.0073 0.0073
Giardia lamblia Kinase, NEK 0.0136 0.0472 0.1296
Echinococcus granulosus casein kinase I gamma 0.021 0.1014 0.1061
Echinococcus multilocularis casein kinase I delta 0.0109 0.0278 0.0291
Echinococcus granulosus protein jagged 2 0.014 0.0504 0.0528
Onchocerca volvulus 0.0099 0.0204 0.0808
Trichomonas vaginalis CMGC family protein kinase 0.0138 0.0492 0.14
Schistosoma mansoni g1/s-specific cyclin C 0.1448 1 1
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0128 0.0419 0.0355
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0128 0.0413 0.0432
Leishmania major protein kinase, putative 0.0153 0.0595 0.0541
Schistosoma mansoni tyrosine kinase 0.0136 0.0472 0.0472
Giardia lamblia Kinase, CAMK CAMKL 0.0099 0.0204 0.0366
Brugia malayi hypothetical protein 0.0108 0.0272 0.0272
Leishmania major NADH dehydrogenase, putative 0.0128 0.0413 0.0349
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0128 0.0413 0.0763
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0145 0.0537 0.109
Echinococcus granulosus aurora kinase A 0.0145 0.0537 0.0562
Schistosoma mansoni glutamate synthase 0.0128 0.0413 0.0413
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0101 0.0223 0.0149
Schistosoma mansoni septate junction protein 0.0151 0.0584 0.0584
Schistosoma mansoni protein kinase 0.0109 0.0278 0.0278
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0158 0.0633 0.0581
Brugia malayi Immunoglobulin I-set domain containing protein 0.0121 0.0367 0.0367
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0101 0.0223 0.0234
Echinococcus granulosus 3'partial|cell adhesion molecule:down regulated by 0.0081 0.0073 0.0077
Schistosoma mansoni serine/threonine protein kinase 0.0251 0.1307 0.1307
Echinococcus granulosus protein kinase c iota type 0.0287 0.1572 0.1645
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0481 0.2975 0.2803
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0128 0.0413 0.1127
Trichomonas vaginalis CMGC family protein kinase 0.0138 0.0492 0.14
Schistosoma mansoni hypothetical protein 0.0086 0.0108 0.0108
Entamoeba histolytica PH domain containing protein kinase, putative 0.0164 0.0678 0.1384
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0101 0.0223 0.019
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0101 0.0223 0.0234
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0109 0.0278 0.0245
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0113 0.0309 0.0239
Loa Loa (eye worm) LAD-2 short isoform 0.0081 0.0073 0.0039
Echinococcus granulosus protein kinase C gamma type 0.0206 0.0983 0.1029
Plasmodium falciparum glycogen synthase kinase 3 0.0128 0.0419 0.0355
Echinococcus granulosus nervana 2 0.012 0.0356 0.0373
Trypanosoma brucei STE20-like serine/threonine-protein kinase 1, putative 0.0086 0.011 0.0029
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0481 0.2975 0.2803
Brugia malayi Immunoglobulin I-set domain containing protein 0.0081 0.0073 0.0073
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0085 0.0103 0.007
Loa Loa (eye worm) TK/FAK protein kinase 0.0542 0.3423 0.3401
Brugia malayi Doublecortin family protein 0.015 0.0575 0.0575
Schistosoma mansoni vav2 0.0102 0.0225 0.0225
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0108 0.0272 0.0272
Trichomonas vaginalis CAMK family protein kinase 0.009 0.0143 0.0193
Schistosoma mansoni serine/threonine protein kinase 0.0134 0.0463 0.0463
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.0087 0.0119 0.0125
Schistosoma mansoni serine/threonine protein kinase 0.0166 0.0695 0.0695
Trypanosoma cruzi hypothetical protein, conserved 0.0128 0.0413 0.0413
Trichomonas vaginalis CK1 family protein kinase 0.0109 0.0278 0.0662
Schistosoma mansoni serine/threonine protein kinase 0.0163 0.0668 0.0668
Onchocerca volvulus 0.0099 0.0204 0.0808
Echinococcus multilocularis 0.0168 0.0708 0.0741
Echinococcus granulosus tyrosine protein kinase Src42A 0.0221 0.1091 0.1142
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0144 0.0532 0.0557
Trypanosoma brucei SNF1-related protein kinases, putative 0.009 0.0143 0.0064
Loa Loa (eye worm) hypothetical protein 0.0175 0.0756 0.0725
Echinococcus multilocularis casein kinase i 0.0109 0.0278 0.0291
Brugia malayi Thioredoxin reductase 0.1387 0.9554 0.9554
Entamoeba histolytica disulphide oxidoreductase, putative 0.0128 0.0413 0.0832
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0355 0.2063 0.2159
Echinococcus granulosus contactin 0.0166 0.0694 0.0727
Entamoeba histolytica PH domain containing protein kinase, putative 0.0122 0.0372 0.0747
Entamoeba histolytica protein kinase, putative 0.0075 0.003 0.0035
Schistosoma mansoni serine/threonine protein kinase 0.0153 0.0595 0.0595
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0394 0.2348 0.2457
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0128 0.0413 0.1127
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0164 0.0678 0.0692
Echinococcus granulosus rho-associated protein kinase 1 0.0319 0.18 0.1884
Brugia malayi Immunoglobulin I-set domain containing protein 0.0151 0.0584 0.0584
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0386 0.2286 0.2392
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0266 0.1414 0.1385
Echinococcus multilocularis tyrosine protein kinase Src42A 0.014 0.0501 0.0524
Brugia malayi basement membrane proteoglycan 0.0081 0.0073 0.0073
Echinococcus multilocularis serine:threonine protein kinase Chk2 0.0072 0.0013 0.0013
Onchocerca volvulus 0.0259 0.1365 0.5398
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0424 0.2565 0.2685
Onchocerca volvulus 0.0128 0.0413 0.1633
Schistosoma mansoni nephrin 0.036 0.2098 0.2098
Schistosoma mansoni ste20-related kinase 0.0202 0.0957 0.0957
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0085 0.0103 0.0022
Schistosoma mansoni hypothetical protein 0.0081 0.0073 0.0073
Loa Loa (eye worm) TK/ABL protein kinase 0.0099 0.0204 0.0171
Loa Loa (eye worm) hypothetical protein 0.0289 0.1587 0.1558
Brugia malayi hypothetical protein 0.0259 0.1365 0.1365
Brugia malayi Cam kinase protein 1 0.0101 0.0223 0.0223
Onchocerca volvulus Tyrosine kinase homolog 0.0419 0.2529 1
Echinococcus granulosus protein kinase c epsilon type 0.0208 0.0998 0.1045
Entamoeba histolytica serine/threonine protein kinase, putative 0.0266 0.1414 0.2913
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0101 0.0223 0.0149
Brugia malayi protein-tyrosine kinase 0.0184 0.0823 0.0823
Echinococcus multilocularis casein kinase I delta 0.0109 0.0278 0.0291
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0248 0.1286 0.1257
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0248 0.1286 0.1346
Brugia malayi Protein kinase domain containing protein 0.0359 0.2093 0.2093
Mycobacterium ulcerans NADH dehydrogenase 0.0128 0.0413 0.0763
Trypanosoma brucei dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0138 0.0492 0.0432
Echinococcus multilocularis dual specificity 0.0138 0.0492 0.0515
Echinococcus multilocularis protein jagged 1 0.014 0.0504 0.0528
Schistosoma mansoni serine/threonine protein kinase 0.02 0.0939 0.0939
Schistosoma mansoni protein kinase 0.0082 0.0082 0.0082
Brugia malayi EGF-like domain containing protein 0.0168 0.0705 0.0705
Echinococcus granulosus tyrosine protein kinase Src42A 0.014 0.0501 0.0524
Echinococcus granulosus Immunoglobulin 0.0274 0.1477 0.1546
Loa Loa (eye worm) notch protein 0.014 0.0504 0.0472
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0359 0.2093 0.219
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0134 0.0461 0.0482
Brugia malayi serine/threonine-protein kinase PAK 7 0.0229 0.1146 0.1146
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0151 0.0584 0.231
Brugia malayi Cyclin, N-terminal domain containing protein 0.0725 0.475 0.475
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0481 0.2975 1
Loa Loa (eye worm) hypothetical protein 0.014 0.0504 0.0472
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0085 0.0103 0.0088
Loa Loa (eye worm) CAMK/CAMKL/BRSK protein kinase 0.009 0.0143 0.011
Brugia malayi Immunoglobulin I-set domain containing protein 0.0086 0.0108 0.0108
Loa Loa (eye worm) hypothetical protein 0.0232 0.1172 0.1142
Echinococcus multilocularis protein kinase c epsilon type 0.0208 0.0998 0.1045
Echinococcus granulosus dual specificity 0.0138 0.0492 0.0515
Brugia malayi Calcium binding EGF domain containing protein 0.014 0.0504 0.0504
Plasmodium falciparum calcium-dependent protein kinase 1 0.0101 0.0223 0.0149
Schistosoma mansoni basigin related 0.0081 0.0073 0.0073
Brugia malayi serine/threonine-protein kinase plk-2 0.0266 0.1414 0.1414
Leishmania major protein kinase, putative,SNF1-related protein kinases, putative 0.009 0.0143 0.0064
Entamoeba histolytica p21-activated kinase 0.0096 0.0182 0.0352
Echinococcus multilocularis netrin receptor unc 5 0.0109 0.0276 0.0289
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0128 0.0413 0.0349
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0085 0.0103 0.0088
Schistosoma mansoni ephrin receptor 0.0108 0.0273 0.0273
Brugia malayi basement membrane proteoglycan precursor 0.0081 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0093 0.0163 0.0129
Schistosoma mansoni serine/threonine protein kinase 0.0121 0.0367 0.0367
Brugia malayi Immunoglobulin I-set domain containing protein 0.0309 0.1728 0.1728
Entamoeba histolytica PH domain containing protein kinase, putative 0.0164 0.0678 0.1384
Trichomonas vaginalis AGC family protein kinase 0.0175 0.0756 0.2316
Leishmania major protein kinase, putative 0.0101 0.0223 0.0149
Loa Loa (eye worm) CMGC/DYRK/HIPK protein kinase 0.02 0.0939 0.0908
Brugia malayi Immunoglobulin I-set domain containing protein 0.0704 0.4594 0.4594
Echinococcus multilocularis neural cadherin 0.014 0.0504 0.0528
Entamoeba histolytica protein kinase domain containing protein 0.0101 0.0218 0.0428
Plasmodium vivax apical sushi protein, putative 0.0259 0.1365 0.1353
Loa Loa (eye worm) hypothetical protein 0.0585 0.3732 0.3711
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0109 0.0278 0.0245
Echinococcus multilocularis STE20 serine:threonine protein kinase 0.0483 0.299 0.3129
Trypanosoma cruzi serine/arginine-rich protein specific kinase SRPK, putative 0.0084 0.0099 0.0084
Schistosoma mansoni neuroglian 0.0166 0.0694 0.0694
Echinococcus multilocularis tyrosine protein kinase otk 0.0151 0.0584 0.0611
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0129 0.0422 0.0359
Trichomonas vaginalis CAMK family protein kinase 0.009 0.0143 0.0193
Brugia malayi ribosomal protein S6 kinase alpha 3 0.0117 0.0338 0.0338
Echinococcus granulosus tyrosine protein kinase Fyn 0.0221 0.1091 0.1142
Toxoplasma gondii aurora kinase 0.0145 0.0537 0.048
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0113 0.0309 0.0324
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0144 0.0532 0.0557
Loa Loa (eye worm) thyroid receptor interactor 0.011 0.0288 0.0255
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0108 0.0272 0.0266
Brugia malayi Delta serrate ligand family protein 0.014 0.0504 0.0504
Entamoeba histolytica protein kinase domain containing protein 0.0128 0.0419 0.0845
Trichomonas vaginalis CMGC family protein kinase 0.0101 0.0218 0.0454
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0213 0.1033 0.1081
Brugia malayi Sushi domain 0.0259 0.1365 0.1365
Trichomonas vaginalis CMGC family protein kinase 0.0101 0.0218 0.0454
Echinococcus granulosus dual specificity protein kinase clk2 0.0153 0.0595 0.0622
Plasmodium falciparum serine/threonine protein kinase, putative 0.0145 0.0537 0.048
Echinococcus granulosus tyrosine protein kinase HCK 0.0132 0.0441 0.0462
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0153 0.0595 0.0541
Schistosoma mansoni serine/threonine protein kinase 0.0129 0.0422 0.0422
Schistosoma mansoni cell adhesion molecule 0.0086 0.0108 0.0108
Entamoeba histolytica protein kinase, putative 0.0103 0.0232 0.0457
Echinococcus multilocularis tyrosine kinase 0.0099 0.0204 0.0214
Plasmodium falciparum tyrosine kinase-like protein, putative 0.0082 0.0084 0.0002
Onchocerca volvulus 0.0259 0.1365 0.5398
Brugia malayi Serine/threonine-protein kinase SULU 0.0219 0.1077 0.1077
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0113 0.0309 0.0309
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.014 0.0504 0.0504
Schistosoma mansoni serine/threonine protein kinase 0.0122 0.0374 0.0374
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0221 0.1091 0.1142
Loa Loa (eye worm) TK/FER protein kinase 0.0099 0.0204 0.0171
Loa Loa (eye worm) hypothetical protein 0.0086 0.0114 0.0081
Loa Loa (eye worm) hypothetical protein 0.0079 0.006 0.0026
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0113 0.0309 0.0304
Onchocerca volvulus 0.0319 0.18 0.7118
Loa Loa (eye worm) hypothetical protein 0.0117 0.0335 0.0302
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0121 0.0367 0.0335
Onchocerca volvulus 0.014 0.0504 0.1993
Plasmodium falciparum calcium-dependent protein kinase 3 0.0101 0.0223 0.0149
Brugia malayi Kinase associated domain 1 family protein 0.0099 0.0203 0.0203
Loa Loa (eye worm) hypothetical protein 0.014 0.0504 0.0472
Entamoeba histolytica thioredoxin reductase, putative 0.0128 0.0413 0.0832
Echinococcus multilocularis slit 2 protein 0.0168 0.0705 0.0738
Trichomonas vaginalis CMGC family protein kinase 0.0138 0.0492 0.14
Loa Loa (eye worm) Notch2 0.014 0.0504 0.0472
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0099 0.0204 0.0398
Brugia malayi P38 map kinase family protein 2 0.0158 0.0633 0.0633
Onchocerca volvulus 0.014 0.0504 0.1993
Echinococcus multilocularis dual specificity 0.0122 0.0374 0.0391
Brugia malayi hypothetical protein 0.0259 0.1365 0.1365
Trypanosoma cruzi casein kinase, putative 0.0109 0.0278 0.0272
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0128 0.0413 0.1127
Schistosoma mansoni hemicentin 0.0086 0.0108 0.0108
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.0198 0.0926 0.0969
Onchocerca volvulus Neurogenic locus notch protein homolog 0.014 0.0504 0.1993
Leishmania major protein kinase, putative 0.0153 0.0595 0.0541
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0081 0.0073 0.0073
Loa Loa (eye worm) pregnancy-associated plasma protein-E 0.0259 0.1365 0.1336
Echinococcus multilocularis neurogenic locus protein delta 0.014 0.0504 0.0528
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0247 0.1277 0.1336
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0166 0.0694 0.0727
Echinococcus granulosus notch 0.014 0.0504 0.0528
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0166 0.0695 0.0728
Loa Loa (eye worm) hypothetical protein 0.014 0.0504 0.0472
Trichomonas vaginalis AGC family protein kinase 0.0145 0.0537 0.1558
Loa Loa (eye worm) hypothetical protein 0.0447 0.273 0.2706
Trichomonas vaginalis CK1 family protein kinase 0.0109 0.0278 0.0662
Echinococcus multilocularis Immunoglobulin 0.0274 0.1477 0.1546
Schistosoma mansoni tyrosine kinase 0.0221 0.1091 0.1091
Entamoeba histolytica protein kinase, putative 0.0122 0.0374 0.0751
Loa Loa (eye worm) TK/FER protein kinase 0.0099 0.0204 0.0171
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0085 0.0103 0.0022
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0128 0.0419 0.0386
Schistosoma mansoni serine/threonine protein kinase 0.0134 0.0461 0.0461
Plasmodium falciparum calcium-dependent protein kinase 2 0.0101 0.0223 0.0149
Schistosoma mansoni protein kinase 0.0152 0.0591 0.0591
Mycobacterium ulcerans ferredoxin reductase 0.0128 0.0413 0.0763
Plasmodium falciparum casein kinase 1 0.0109 0.0278 0.0207
Entamoeba histolytica protein kinase, putative 0.0166 0.0695 0.1418
Giardia lamblia Kinase, PLK 0.0266 0.1414 0.4574
Echinococcus granulosus Immunoglobulin 0.0081 0.0073 0.0077
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0113 0.0309 0.0238
Loa Loa (eye worm) hypothetical protein 0.0151 0.0584 0.0552
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0129 0.0422 0.039
Schistosoma mansoni serine/threonine protein kinase 0.0101 0.0223 0.0223
Schistosoma mansoni protein kinase 0.026 0.1377 0.1377
Schistosoma mansoni serine/threonine protein kinase 0.009 0.0143 0.0143
Echinococcus granulosus cyclin dependent kinase 5 0.0129 0.0422 0.0442
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0151 0.0579 0.1704
Plasmodium vivax serine/threonine protein kinase KIN, putative 0.0099 0.0204 0.0127
Brugia malayi ephrin receptor 1 precursor 0.0076 0.0035 0.0035
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0166 0.0695 0.0728
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0481 0.2975 0.3101
Trypanosoma brucei NADH dehydrogenase 0.0128 0.0413 0.0349
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0481 0.2975 0.3054
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0128 0.0413 0.0413
Schistosoma mansoni atypical protein kinase C 0.0293 0.1615 0.1615
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0093 0.0162 0.0162
Brugia malayi Immunoglobulin I-set domain containing protein 0.0098 0.0199 0.0199
Brugia malayi Protein kinase domain containing protein 0.0122 0.0374 0.0374
Trypanosoma cruzi SNF1-related protein kinases, putative 0.009 0.0143 0.013
Schistosoma mansoni serine/threonine protein kinase 0.0084 0.0095 0.0095
Leishmania major trypanothione reductase 0.1387 0.9554 1
Giardia lamblia High cysteine protein 0.014 0.0504 0.1409
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0338 0.1943 0.1915
Echinococcus granulosus STE20 serine:threonine protein kinase 0.0483 0.299 0.3129
Loa Loa (eye worm) projectin 0.0086 0.0108 0.0074

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 20.5 nM Inhibition of human recombinant CDK2/Cyclin E expressed in baculovirus infected sf9 cells using histone H1 as substrate ChEMBL. 23829517
IC50 (binding) = 152 nM Inhibition of human recombinant CDK1 ChEMBL. 23829517
IC50 (functional) = 1.013 uM Cytotoxicity against human HeLa cells assessed as growth inhibition after 72 hrs by calcein AM staining-based fluoroscence assay ChEMBL. 23829517

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 23829517

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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