Detailed information for compound 1778780

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 391.46 | Formula: C24H25NO4
  • H donors: 0 H acceptors: 1 LogP: 4.1 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1oc2c3c(OC[C@H]4[C@@H]3N(Cc3ccccc3)OC4(C)C)ccc2c(=O)c1C
  • InChi: 1S/C24H25NO4/c1-14-15(2)28-23-17(22(14)26)10-11-19-20(23)21-18(13-27-19)24(3,4)29-25(21)12-16-8-6-5-7-9-16/h5-11,18,21H,12-13H2,1-4H3/t18-,21-/m0/s1
  • InChiKey: RRYIITOXXCFPAY-RXVVDRJESA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni 60S ribosomal protein L21 0.0287 0.2705 0.3575
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0287 0.2705 0.3575
Echinococcus multilocularis sodium leak channel non selective protein 0.0287 0.2705 0.3011
Loa Loa (eye worm) hypothetical protein 0.0287 0.2705 0.3575
Echinococcus granulosus hyperpolarization activated cyclic 0.0287 0.2705 0.3575
Toxoplasma gondii hypothetical protein 0.0287 0.2705 0.2705
Schistosoma mansoni transient receptor potential channel 0.0287 0.2705 0.3575
Echinococcus multilocularis ryanodine receptor 44f 0.0287 0.2705 0.3011
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.003 0.009
Loa Loa (eye worm) ryanodine receptor 0.0287 0.2705 0.3575
Echinococcus multilocularis transient receptor potential gamma protein 0.0287 0.2705 0.3011
Echinococcus granulosus transient receptor potential cation channel 0.0287 0.2705 0.3575
Schistosoma mansoni voltage-gated potassium channel 0.0287 0.2705 0.3575
Schistosoma mansoni voltage-gated potassium channel 0.0287 0.2705 0.3575
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.003 0.009
Echinococcus granulosus geminin 0.0197 0.1844 0.2437
Echinococcus granulosus snurportin 1 0.0359 0.3384 0.4473
Echinococcus multilocularis geminin 0.0197 0.1844 0.2052
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0287 0.2705 0.3575
Loa Loa (eye worm) hypothetical protein 0.0287 0.2705 0.3575
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0287 0.2705 0.3575
Schistosoma mansoni hypothetical protein 0.0359 0.3384 0.4473
Echinococcus multilocularis potassium large conductance calcium activated 0.0287 0.2705 0.3011
Toxoplasma gondii transporter, cation channel family protein 0.0287 0.2705 0.2705
Echinococcus granulosus potassium large conductance calcium activated 0.0287 0.2705 0.3575
Echinococcus multilocularis potassium voltage gated channel protein 0.0287 0.2705 0.3011
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0074 0.0663 0.0876
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0287 0.2705 0.3575
Echinococcus multilocularis two pore calcium channel protein 1 0.0287 0.2705 0.3011
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0287 0.2705 0.3575
Echinococcus granulosus transient receptor potential gamma protein 0.0287 0.2705 0.3575
Loa Loa (eye worm) hypothetical protein 0.0287 0.2705 0.3575
Mycobacterium ulcerans thymidylate synthase 0.0747 0.7091 0.9359
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0287 0.2705 0.3011
Schistosoma mansoni voltage-gated potassium channel 0.0287 0.2705 0.3575
Toxoplasma gondii HEAT repeat-containing protein 0.0034 0.0279 0.0279
Echinococcus granulosus shaker cognate 0.0287 0.2705 0.3575
Leishmania major hypothetical protein, unknown function 0.0287 0.2705 0.2705
Loa Loa (eye worm) voltage-gated potassium channel 0.0287 0.2705 0.3575
Trypanosoma brucei Importin-beta N-terminal domain/HEAT-like repeat, putative 0.0006 0.0018 0.0018
Echinococcus granulosus potassium voltage gated channel protein 0.0287 0.2705 0.3575
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0022 0.0167 0.7664
Echinococcus multilocularis voltage dependent calcium channel 0.0287 0.2705 0.3011
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0037 0.0049
Echinococcus granulosus dihydrofolate reductase 0.0796 0.7565 1
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0287 0.2705 0.3011
Brugia malayi ion channel NompC 0.0287 0.2705 0.3575
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0287 0.2705 0.3575
Loa Loa (eye worm) hypothetical protein 0.0287 0.2705 0.3575
Loa Loa (eye worm) hypothetical protein 0.0287 0.2705 0.3575
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0022 0.0167 1
Loa Loa (eye worm) hypothetical protein 0.0287 0.2705 0.3575
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0022 0.0167 0.0221
Brugia malayi cation channel family protein 0.0287 0.2705 0.3575
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0287 0.2705 0.3011
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0287 0.2705 0.3575
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0287 0.2705 0.3575
Schistosoma mansoni voltage-gated potassium channel 0.0287 0.2705 0.3575
Echinococcus granulosus transient receptor potential cation channel 0.0287 0.2705 0.3575
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.1051 1 1
Echinococcus granulosus ryanodine receptor 44f 0.0287 0.2705 0.3575
Schistosoma mansoni cpg binding protein 0.0035 0.0296 0.0391
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.003 0.009
Echinococcus multilocularis tar DNA binding protein 0.0074 0.0663 0.0738
Leishmania major hypothetical protein, conserved 0.0287 0.2705 0.2705
Loa Loa (eye worm) hypothetical protein 0.0287 0.2705 0.3575
Echinococcus granulosus transportin 1 0.0006 0.0018 0.0024
Echinococcus multilocularis importin subunit beta 1 0.0034 0.0279 0.031
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0218 0.065
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.003 0.009
Loa Loa (eye worm) hypothetical protein 0.0287 0.2705 0.3575
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0747 0.7091 0.9373
Echinococcus multilocularis transient receptor potential cation channel 0.0287 0.2705 0.3011
Echinococcus multilocularis hyperpolarization activated cyclic 0.0287 0.2705 0.3011
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.003 0.009
Loa Loa (eye worm) hypothetical protein 0.0287 0.2705 0.3575
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0287 0.2705 0.3575
Echinococcus granulosus potassium voltage gated channel protein 0.0287 0.2705 0.3575
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0287 0.2705 0.3011
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0037 0.0049
Onchocerca volvulus 0.0287 0.2705 0.3814
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0022 0.0167 0.0167
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0287 0.2705 0.3575
Loa Loa (eye worm) hypothetical protein 0.0287 0.2705 0.3575
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.003 0.009
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0287 0.2705 0.3575
Echinococcus granulosus potassium voltage gated channel protein 0.0287 0.2705 0.3575
Loa Loa (eye worm) TAR-binding protein 0.0074 0.0663 0.0876
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.003 0.009
Brugia malayi Dihydrofolate reductase 0.0796 0.7565 1
Chlamydia trachomatis dihydrofolate reductase 0.0796 0.7565 0.5
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.1051 1 1
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0287 0.2705 0.3011
Echinococcus multilocularis transient receptor potential cation channel 0.0287 0.2705 0.3011
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.0287 0.2705 0.2705
Loa Loa (eye worm) voltage-gated potassium channel 0.0287 0.2705 0.3575
Schistosoma mansoni voltage-gated potassium channel 0.0287 0.2705 0.3575
Echinococcus multilocularis transfer RNA-Gly 0.0287 0.2705 0.3011
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0287 0.2705 0.3011
Loa Loa (eye worm) hypothetical protein 0.0287 0.2705 0.3575
Brugia malayi Transient-receptor-potential like protein 0.0287 0.2705 0.3575
Echinococcus multilocularis voltage gated potassium channel 0.0287 0.2705 0.3011
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0287 0.2705 0.3575
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.0287 0.2705 0.3575
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0287 0.2705 0.3575
Echinococcus multilocularis thymidylate synthase 0.0747 0.7091 0.7893
Echinococcus multilocularis cpg binding protein 0.0035 0.0296 0.0329
Echinococcus multilocularis transient receptor potential cation channel 0.0287 0.2705 0.3011
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0287 0.2705 0.3011
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.1051 1 1
Echinococcus granulosus importin 5 0.0006 0.0018 0.0024
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0359 0.3384 0.4473
Brugia malayi dihydrofolate reductase family protein 0.0796 0.7565 1
Brugia malayi olfactory channel protein osm-9 0.0287 0.2705 0.3575
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0287 0.2705 0.3575
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0287 0.2705 0.3575
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0287 0.2705 0.3575
Echinococcus multilocularis voltage gated potassium channel 0.0287 0.2705 0.3011
Loa Loa (eye worm) thymidylate synthase 0.0747 0.7091 0.9373
Echinococcus multilocularis importin 5 0.0006 0.0018 0.0021
Echinococcus granulosus voltage dependent calcium channel 0.0287 0.2705 0.3575
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.0287 0.2705 0.3575
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0287 0.2705 0.3575
Schistosoma mansoni voltage-dependent calcium channel 0.0287 0.2705 0.3575
Brugia malayi RNA, U transporter 1 0.0096 0.087 0.1151
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0287 0.2705 0.2705
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0055 0.0073
Loa Loa (eye worm) dihydrofolate reductase 0.0796 0.7565 1
Schistosoma mansoni voltage-gated potassium channel 0.0287 0.2705 0.3575
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.0287 0.2705 0.3575
Loa Loa (eye worm) hypothetical protein 0.0287 0.2705 0.3575
Echinococcus multilocularis voltage dependent calcium channel 0.0287 0.2705 0.3011
Echinococcus multilocularis transient receptor potential cation channel 0.0287 0.2705 0.3011
Echinococcus multilocularis translational activator gcn1 0.0006 0.0018 0.0021
Echinococcus multilocularis two pore calcium channel protein 2 0.0287 0.2705 0.3011
Schistosoma mansoni voltage-gated ion channel 0.0287 0.2705 0.3575
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.003 0.009
Echinococcus granulosus importin subunit beta 1 0.0034 0.0279 0.0368
Schistosoma mansoni ap endonuclease 0.0022 0.0167 0.0221
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0287 0.2705 0.3011
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0287 0.2705 0.3575
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0287 0.2705 0.3575
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0287 0.2705 0.3575
Schistosoma mansoni cpg binding protein 0.0033 0.0277 0.0367
Brugia malayi voltage-dependent calcium channel 0.0287 0.2705 0.3575
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0287 0.2705 0.3011
Trichomonas vaginalis conserved hypothetical protein 0.0355 0.3351 1
Loa Loa (eye worm) hypothetical protein 0.0287 0.2705 0.3575
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0287 0.2705 0.3575
Echinococcus granulosus translational activator gcn1 0.0006 0.0018 0.0024
Echinococcus granulosus tar DNA binding protein 0.0074 0.0663 0.0876
Schistosoma mansoni vesicular amine transporter 0.0287 0.2705 0.3575
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0022 0.0167 0.0221
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0287 0.2705 0.3011
Echinococcus granulosus cpg binding protein 0.0035 0.0296 0.0391
Loa Loa (eye worm) voltage-gated calcium channel 0.0287 0.2705 0.3575
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0287 0.2705 0.3575
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0167 0.0499
Schistosoma mansoni two-pore calcium channel 0.0287 0.2705 0.3575
Trichomonas vaginalis helicase, putative 0.0008 0.003 0.009
Schistosoma mansoni voltage-gated potassium channel 0.0287 0.2705 0.3575
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.003 0.009
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0287 0.2705 0.3575
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0287 0.2705 0.2705
Echinococcus multilocularis conserved hypothetical protein 0.0287 0.2705 0.3011
Toxoplasma gondii hypothetical protein 0.0287 0.2705 0.2705
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.1051 1 1
Brugia malayi Cyclic-nucleotide gated cation channel 0.0287 0.2705 0.3575
Echinococcus granulosus voltage gated potassium channel 0.0287 0.2705 0.3575
Echinococcus multilocularis potassium voltage gated channel protein 0.0287 0.2705 0.3011
Brugia malayi exodeoxyribonuclease III family protein 0.0022 0.0167 0.0221
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0287 0.2705 0.8071
Leishmania major importin beta-1 subunit, putative 0.0027 0.0218 0.0218
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0287 0.2705 0.3011
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0287 0.2705 0.3575
Toxoplasma gondii HEAT repeat-containing protein 0.0006 0.0018 0.0018
Echinococcus granulosus potassium voltage gated channel protein 0.0287 0.2705 0.3575
Toxoplasma gondii transporter, cation channel family protein 0.0287 0.2705 0.2705
Loa Loa (eye worm) CXXC zinc finger family protein 0.0033 0.0277 0.0367
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0663 0.0876
Schistosoma mansoni hypothetical protein 0.0197 0.1844 0.2437
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0663 0.0876
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0287 0.2705 0.3575
Loa Loa (eye worm) ion channel NompC 0.0287 0.2705 0.3575
Echinococcus multilocularis transportin 1 0.0006 0.0018 0.0021
Loa Loa (eye worm) RNA binding protein 0.0074 0.0663 0.0876
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0945 0.8984 1
Echinococcus multilocularis short transient receptor potential channel 6 0.0287 0.2705 0.3011
Echinococcus granulosus two pore calcium channel protein 1 0.0287 0.2705 0.3575
Schistosoma mansoni voltage-gated potassium channel 0.0287 0.2705 0.3575
Echinococcus granulosus voltage dependent calcium channel 0.0287 0.2705 0.3575
Echinococcus multilocularis dihydrofolate reductase 0.0796 0.7565 0.8421
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.0287 0.2705 0.3575
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.003 0.009
Mycobacterium tuberculosis Hypothetical protein 0.0355 0.3351 0.443
Loa Loa (eye worm) calcium channel 0.0287 0.2705 0.3575
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0796 0.7565 1
Schistosoma mansoni transient receptor potential channel 0.0287 0.2705 0.3575
Treponema pallidum exodeoxyribonuclease (exoA) 0.0022 0.0167 1
Schistosoma mansoni voltage-gated cation channel 0.0287 0.2705 0.3575
Plasmodium vivax importin-beta 2, putative 0.0034 0.0279 0.0279
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0287 0.2705 0.3575
Loa Loa (eye worm) importin-beta domain-containing protein 0.0006 0.0018 0.0024
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0037 0.0041
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.0287 0.2705 0.3575
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0287 0.2705 0.3575
Schistosoma mansoni importin beta-1 0.0034 0.0279 0.0368
Schistosoma mansoni voltage-gated potassium channel 0.0287 0.2705 0.3575
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0287 0.2705 0.3575
Brugia malayi Importin beta-1 subunit 0.0034 0.0279 0.0368
Loa Loa (eye worm) hypothetical protein 0.0287 0.2705 0.3575
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0022 0.0167 0.0167
Echinococcus granulosus potassium voltage gated channel protein 0.0287 0.2705 0.3575
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0287 0.2705 0.3575
Loa Loa (eye worm) hypothetical protein 0.0034 0.0279 0.0368
Schistosoma mansoni voltage-gated potassium channel 0.0287 0.2705 0.3575
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0287 0.2705 0.3011
Onchocerca volvulus 0.0747 0.7091 1
Plasmodium vivax transportin, putative 0.0006 0.0018 0.0018
Schistosoma mansoni calcium-activated potassium channel 0.0287 0.2705 0.3575
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0355 0.3351 0.3351
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0287 0.2705 0.3575
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0287 0.2705 0.3575
Echinococcus granulosus hypothetical protein 0.0287 0.2705 0.3575
Leishmania major hypothetical protein, conserved 0.0006 0.0018 0.0018
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0057 0.0063
Echinococcus multilocularis hyperpolarization activated cyclic 0.0287 0.2705 0.3011
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.003 0.009
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0796 0.7565 1
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.0287 0.2705 0.3575
Echinococcus granulosus voltage gated hydrogen channel 1 0.0287 0.2705 0.3575
Schistosoma mansoni dihydrofolate reductase 0.0796 0.7565 1
Brugia malayi kap beta 3 protein 0.0006 0.0018 0.0024
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0287 0.2705 0.3575
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0663 0.0876
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0167 0.0167
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0287 0.2705 0.3011
Loa Loa (eye worm) hypothetical protein 0.0287 0.2705 0.3575
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0663 0.0876
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0287 0.2705 0.3011
Echinococcus granulosus sodium leak channel non selective protein 0.0287 0.2705 0.3575
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0287 0.2705 0.3814
Schistosoma mansoni voltage-gated potassium channel 0.0287 0.2705 0.3575
Trypanosoma brucei importin beta-1 subunit, putative 0.0034 0.0279 0.0279
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0287 0.2705 0.3575
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0663 0.0876
Echinococcus multilocularis voltage gated hydrogen channel 1 0.0287 0.2705 0.3011
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0287 0.2705 0.3575
Brugia malayi RNA binding protein 0.0074 0.0663 0.0876
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0287 0.2705 0.3011
Echinococcus granulosus transient receptor potential cation channel 0.0287 0.2705 0.3575
Echinococcus multilocularis snurportin 1 0.0359 0.3384 0.3767
Brugia malayi CXXC zinc finger family protein 0.0033 0.0277 0.0367
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0287 0.2705 0.3814
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0287 0.2705 0.3575
Schistosoma mansoni transient receptor potential channel 0.0287 0.2705 0.3575
Plasmodium falciparum transportin 0.0006 0.0018 0.0018
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0037 0.0041
Echinococcus granulosus thymidylate synthase 0.0747 0.7091 0.9373
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0287 0.2705 0.3575
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0287 0.2705 0.2705
Loa Loa (eye worm) hypothetical protein 0.0287 0.2705 0.3575
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0022 0.0167 0.0167
Schistosoma mansoni voltage-gated potassium channel 0.0287 0.2705 0.3575
Toxoplasma gondii exonuclease III APE 0.0022 0.0167 0.0167
Echinococcus multilocularis calcium activated potassium channel 0.0287 0.2705 0.3011
Brugia malayi hypothetical protein 0.0287 0.2705 0.3575
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0287 0.2705 0.3575
Echinococcus granulosus two pore calcium channel protein 2 0.0287 0.2705 0.3575
Schistosoma mansoni voltage-gated potassium channel 0.0287 0.2705 0.3575
Loa Loa (eye worm) hypothetical protein 0.0287 0.2705 0.3575
Plasmodium falciparum importin beta, putative 0.0034 0.0279 0.0279
Onchocerca volvulus 0.0033 0.0277 0.0391
Echinococcus granulosus TRP transient receptor potential channel 0.0287 0.2705 0.3575
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.003 0.009
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0022 0.0167 0.0221
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0287 0.2705 0.3575
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0022 0.0167 0.5
Loa Loa (eye worm) hypothetical protein 0.0287 0.2705 0.3575
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.003 0.009
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.1051 1 1
Schistosoma mansoni cpg binding protein 0.0035 0.0296 0.0391
Brugia malayi TAR-binding protein 0.0074 0.0663 0.0876
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0167 0.0167
Schistosoma mansoni transient receptor potential channel 4 0.0287 0.2705 0.3575
Echinococcus multilocularis transient receptor potential cation channel 0.0287 0.2705 0.3011
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0287 0.2705 0.3575
Schistosoma mansoni hypothetical protein 0.0287 0.2705 0.3575
Schistosoma mansoni voltage-gated potassium channel 0.0287 0.2705 0.3575
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0747 0.7091 0.9373
Echinococcus multilocularis shaker cognate 0.0287 0.2705 0.3011
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.003 0.009
Trypanosoma brucei importin beta-1 subunit, putative 0.0034 0.0279 0.0279
Echinococcus multilocularis short transient receptor potential channel 6 0.0287 0.2705 0.3011
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0287 0.2705 0.3575
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.0287 0.2705 0.2705
Echinococcus granulosus calcium activated potassium channel 0.0287 0.2705 0.3575
Echinococcus granulosus short transient receptor potential channel 6 0.0287 0.2705 0.3575
Brugia malayi hypothetical protein 0.0355 0.3351 0.443
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.003 0.009
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0218 0.065
Brugia malayi cation channel family protein 0.0287 0.2705 0.3575
Echinococcus multilocularis sodium channel protein 0.0287 0.2705 0.3011
Loa Loa (eye worm) hypothetical protein 0.0287 0.2705 0.3575
Echinococcus multilocularis potassium voltage gated channel protein 0.0287 0.2705 0.3011
Schistosoma mansoni ap endonuclease 0.0022 0.0167 0.0221
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0287 0.2705 0.3575
Loa Loa (eye worm) histone methyltransferase 0.001 0.0057 0.0075
Toxoplasma gondii HEAT repeat-containing protein 0.0006 0.0018 0.0018
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0287 0.2705 0.3575
Echinococcus granulosus transient receptor potential cation channel 0.0287 0.2705 0.3575
Schistosoma mansoni ryanodine receptor related 0.0287 0.2705 0.3575
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0287 0.2705 0.2705
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0022 0.0167 0.0167
Toxoplasma gondii histone lysine methyltransferase SET1 0.0063 0.0563 0.0563
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.003 0.009
Schistosoma mansoni hypothetical protein 0.0197 0.1844 0.2437
Loa Loa (eye worm) voltage-dependent calcium channel 0.0287 0.2705 0.3575
Echinococcus granulosus hyperpolarization activated cyclic 0.0287 0.2705 0.3575
Echinococcus granulosus transient receptor potential cation channel 0.0287 0.2705 0.3575
Loa Loa (eye worm) kap beta 3 protein 0.0006 0.0018 0.0024
Echinococcus multilocularis transient receptor potential cation channel 0.0287 0.2705 0.3011
Schistosoma mansoni importin-beta 2 0.0006 0.0018 0.0024
Loa Loa (eye worm) hypothetical protein 0.0287 0.2705 0.3575
Echinococcus granulosus sodium channel protein 0.0287 0.2705 0.3575
Trichomonas vaginalis hypothetical protein 0.0006 0.0018 0.0055
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0287 0.2705 0.3575
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0071 0.0636 0.084
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0287 0.2705 0.2705
Trypanosoma cruzi importin beta-1 subunit, putative 0.0027 0.0218 0.0218
Loa Loa (eye worm) hypothetical protein 0.0287 0.2705 0.3575
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.003 0.009
Schistosoma mansoni voltage-gated potassium channel 0.0287 0.2705 0.3575
Brugia malayi thymidylate synthase 0.0747 0.7091 0.9373
Echinococcus granulosus voltage gated potassium channel 0.0287 0.2705 0.3575
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0287 0.2705 0.3575
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0057 0.0075
Entamoeba histolytica hypothetical protein 0.0027 0.0218 1
Schistosoma mansoni voltage-gated potassium channel 0.0287 0.2705 0.3575
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0005 0.0004 0.0005
Toxoplasma gondii transporter, cation channel family protein 0.0287 0.2705 0.2705
Echinococcus granulosus transient receptor potential cation channel 0.0287 0.2705 0.3575
Loa Loa (eye worm) hypothetical protein 0.0287 0.2705 0.3575
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0287 0.2705 0.3575
Echinococcus granulosus short transient receptor potential channel 6 0.0287 0.2705 0.3575
Trichomonas vaginalis importin beta-1, putative 0.0027 0.0218 0.065
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0022 0.0167 0.0186
Entamoeba histolytica HEAT repeat domain containing protein 0.0006 0.0018 0.0846
Echinococcus multilocularis potassium voltage gated channel protein 0.0287 0.2705 0.3011
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0287 0.2705 0.3011
Schistosoma mansoni voltage-gated potassium channel 0.0287 0.2705 0.3575
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0287 0.2705 0.8071
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0796 0.7565 1
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.0006 0.0018 0.0018
Brugia malayi RNA recognition motif domain containing protein 0.0074 0.0663 0.0876
Schistosoma mansoni voltage-gated potassium channel 0.0287 0.2705 0.3575
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0167 0.0499
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0037 0.0049
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0287 0.2705 0.3575

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 17.93 uM Cytotoxicity against human A549 cells by MTT assay ChEMBL. 23764302
IC50 (functional) > 100 uM Cytotoxicity against human HeLa cells by MTT assay ChEMBL. 23764302

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 23764302

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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