Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | conserved hypothetical protein | 0.0441 | 0.1046 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0441 | 0.1046 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0441 | 0.1046 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.128 | 0.9014 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0441 | 0.1046 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0441 | 0.1046 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0441 | 0.1046 | 1 |
Trichomonas vaginalis | NAD(P)H dehydrogenase, putative | 0.0441 | 0.1046 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.128 | 0.9014 | 0.5 |
Schistosoma mansoni | dihydrofolate reductase | 0.1384 | 1 | 1 |
Trichomonas vaginalis | NAD(P)H dehydrogenase, putative | 0.0441 | 0.1046 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0441 | 0.1046 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0441 | 0.1046 | 1 |
Giardia lamblia | NADPH oxidoreductase, putative | 0.0441 | 0.1046 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0441 | 0.1046 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0441 | 0.1046 | 1 |
Giardia lamblia | NADPH oxidoreductase, putative | 0.0441 | 0.1046 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.128 | 0.9014 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0441 | 0.1046 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.128 | 0.9014 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0441 | 0.1046 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.1384 | 1 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.128 | 0.9014 | 0.5 |
Trichomonas vaginalis | NAD(P)H dehydrogenase, putative | 0.0441 | 0.1046 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.128 | 0.9014 | 0.5 |
Onchocerca volvulus | 0.0461 | 0.1235 | 0.5 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.0441 | 0.1046 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.1384 | 1 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.1384 | 1 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.1384 | 1 | 0.5 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.1384 | 1 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.1384 | 1 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.1384 | 1 | 1 |
Giardia lamblia | NADPH oxidoreductase, putative | 0.0441 | 0.1046 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 0.1384 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Kd (binding) | > 10 mM | Dissociation constant after binding to human papillomavirus E2 DNA-binding domain (DBD) by observing the changes in [15N]-HSQC spectra. | ChEMBL. | 9379433 |
Kd (binding) | > 10 mM | Dissociation constant after binding to human papillomavirus E2 DNA-binding domain (DBD) by observing the changes in [15N]-HSQC spectra. | ChEMBL. | 9379433 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.