Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | phosphoglycerate mutase family protein, putative | 0.1913 | 0.2852 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.1913 | 0.2852 | 0.5 |
Trypanosoma brucei | 6-phosphofructo-2-kinase 2 | 0.3187 | 0.9706 | 0.9706 |
Loa Loa (eye worm) | raf kinase | 0.266 | 0.6866 | 0.6627 |
Loa Loa (eye worm) | hypothetical protein | 0.1859 | 0.2557 | 0.1988 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.3242 | 1 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.3187 | 0.9706 | 0.9706 |
Brugia malayi | Raf kinase | 0.2579 | 0.6435 | 0.5 |
Echinococcus multilocularis | 6 phosphofructo 2 kinase:fructose 2 | 0.3242 | 1 | 1 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.3187 | 0.9706 | 0.9706 |
Giardia lamblia | Hypothetical protein | 0.1913 | 0.2852 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.3242 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3187 | 0.9706 | 0.9683 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.3187 | 0.9706 | 0.9706 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.3242 | 1 | 1 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.3242 | 1 | 1 |
Mycobacterium ulcerans | fructose-2,6-bisphosphatase GpmB | 0.1913 | 0.2852 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.1913 | 0.2852 | 0.5 |
Onchocerca volvulus | 0.3242 | 1 | 0.5 | |
Schistosoma mansoni | 6-phosphofructokinase | 0.3242 | 1 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.3242 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.