TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 354.378 | Formula: C15H18N2O6S
H donors: 1 H acceptors: 4 LogP: -0.17 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: COC[C@@H]1C[C@H](CN1S(=O)(=O)c1ccc2c(c1)C(=O)C(=O)N2)OC
InChi: 1S/C15H18N2O6S/c1-22-8-9-5-10(23-2)7-17(9)24(20,21)11-3-4-13-12(6-11)14(18)15(19)16-13/h3-4,6,9-10H,5,7-8H2,1-2H3,(H,16,18,19)/t9-,10+/m0/s1
InChiKey: QPLAQLNMYMJMQA-VHSXEESVSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Toxoplasma gondii	Zn-finger in Ran binding protein and others domain-containing protein	0.0065	0.0141	0.2776
Trypanosoma brucei	mitochondrial RNA binding complex 1 subunit	0.0065	0.0141	0.0141
Toxoplasma gondii	DNA topoisomerase domain-containing protein	0.0183	0.0508	1
Onchocerca volvulus		0.0183	0.0508	0.0478
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0065	0.0141	0.2394
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0029	0.0028	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0108	0.0108
Trypanosoma cruzi	phosphoglycerate mutase, putative	0.0055	0.0108	0.0108
Entamoeba histolytica	phosphoglycerate mutase family protein, putative	0.191	0.5877	1
Schistosoma mansoni	zinc finger protein	0.0065	0.0141	0.0141
Leishmania major	phosphoglycerate mutase protein, putative	0.0055	0.0108	0.0108
Echinococcus granulosus	Nuclear pore complex protein Nup153	0.0065	0.0141	0.0141
Echinococcus multilocularis	zinc finger protein Ran binding	0.0065	0.0141	0.0141
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0141	0.0141
Trypanosoma cruzi	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatas, putative	0.0055	0.0108	0.0108
Echinococcus multilocularis	phosphoglycerate mutase	0.0055	0.0108	0.0108
Brugia malayi	YY1-associated factor 2	0.0065	0.0141	0.2394
Brugia malayi	brahma associated protein 60 kDa	0.0183	0.0508	0.8624
Trypanosoma cruzi	Histidine phosphatase superfamily (branch 1), putative	0.0055	0.0108	0.0108
Echinococcus granulosus	histone lysine methyltransferase setb	0.0048	0.0088	0.0088
Loa Loa (eye worm)	hypothetical protein	0.004	0.0064	0.0064
Schistosoma mansoni	hypothetical protein	0.0022	0.0006	0.0006
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0048	0.0088	0.0088
Chlamydia trachomatis	SWIB complex protein	0.0183	0.0508	1
Trypanosoma brucei	6-phosphofructo-2-kinase 2	0.3181	0.983	0.983
Mycobacterium leprae	Possible phosphoglycerate mutase	0.0055	0.0108	0.5
Echinococcus granulosus	phosphoglycerate mutase	0.0055	0.0108	0.0108
Toxoplasma gondii	phosphoglycerate mutase family protein	0.0055	0.0108	0.2132
Echinococcus multilocularis	SWI:SNF matrix associated	0.0183	0.0508	0.0508
Mycobacterium leprae	Probable phosphoglycerate mutase (phosphoglyceromutase) (phosphoglycerate phosphomutase)	0.0055	0.0108	0.5
Plasmodium falciparum	phosphoglucomutase-2	0.0055	0.0108	0.2132
Echinococcus multilocularis	Nuclear pore complex protein Nup153	0.0065	0.0141	0.0141
Trypanosoma cruzi	glycerolphosphate mutase, putative	0.0055	0.0108	0.0108
Plasmodium falciparum	phosphoglycerate mutase, putative	0.0055	0.0108	0.2132
Leishmania major	hypothetical protein, unknown function	0.0055	0.0108	0.0108
Entamoeba histolytica	phosphoglycerate mutase family protein, putative	0.0055	0.0108	0.0184
Mycobacterium ulcerans	phosphoglyceromutase	0.0055	0.0108	0.0184
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0038	0.0056	0.0056
Trypanosoma cruzi	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.1381	0.4232	0.4232
Echinococcus multilocularis	zinc finger protein	0.0021	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0088	0.0088
Onchocerca volvulus		0.0055	0.0108	0.0077
Trypanosoma brucei	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.3236	1	1
Mycobacterium leprae	conserved hypothetical protein	0.0055	0.0108	0.5
Mycobacterium ulcerans	hypothetical protein	0.0055	0.0108	0.0184
Brugia malayi	Bromodomain containing protein	0.0079	0.0184	0.3126
Trypanosoma brucei	glycerolphosphate mutase, putative	0.0055	0.0108	0.0108
Schistosoma mansoni	fusion	0.0065	0.0141	0.0141
Plasmodium vivax	SET domain protein, putative	0.003	0.0032	0.0624
Leishmania major	glycerolphosphate mutase, putative	0.0055	0.0108	0.0108
Leishmania major	hypothetical protein, conserved	0.0065	0.0141	0.0141
Leishmania major	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-1-like protein	0.1381	0.4232	0.4232
Trypanosoma cruzi	hypothetical protein, conserved	0.0065	0.0141	0.0141
Trypanosoma cruzi	Histidine phosphatase superfamily (branch 1), putative	0.0055	0.0108	0.0108
Trypanosoma cruzi	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatas, putative	0.0055	0.0108	0.0108
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0048	0.0088	0.0088
Toxoplasma gondii	phosphoglycerate mutase	0.0055	0.0108	0.2132
Leishmania major	hypothetical protein, conserved	0.0055	0.0108	0.0108
Schistosoma mansoni	hypothetical protein	0.0055	0.0108	0.0108
Loa Loa (eye worm)	hypothetical protein	0.0075	0.017	0.017
Mycobacterium tuberculosis	Conserved protein	0.0055	0.0108	1
Trichomonas vaginalis	phosphoglycerate mutase, putative	0.0055	0.0108	0.1595
Echinococcus multilocularis	SWI:SNF matrix associated	0.0183	0.0508	0.0508
Echinococcus multilocularis	ring and YY1 binding protein	0.0065	0.0141	0.0141
Trypanosoma brucei	Histidine phosphatase superfamily (branch 1), putative	0.0055	0.0108	0.0108
Brugia malayi	Pre-SET motif family protein	0.0209	0.0589	1
Trypanosoma cruzi	glycerolphosphate mutase, putative	0.0055	0.0108	0.0108
Trypanosoma cruzi	mitochondrial RNA binding complex 1 subunit, putative	0.0065	0.0141	0.0141
Mycobacterium leprae	PROBABLE PHOSPHOGLYCERATE MUTASE (PHOSPHOGLYCEROMUTASE)	0.0055	0.0108	0.5
Schistosoma mansoni	bromodomain containing protein	0.0067	0.0146	0.0146
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0038	0.0056	0.0056
Schistosoma mansoni	hypothetical protein	0.0183	0.0508	0.0508
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0141	0.0141
Trichomonas vaginalis	phosphoglycerate mutase, putative	0.0055	0.0108	0.1595
Echinococcus multilocularis	6 phosphofructo 2 kinase:fructose 2	0.3236	1	1
Mycobacterium tuberculosis	Conserved protein	0.0055	0.0108	1
Mycobacterium tuberculosis	Glucosyl-3-phosphoglycerate phosphatase GpgP	0.0055	0.0108	1
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0141	0.0141
Trypanosoma brucei	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.1381	0.4232	0.4232
Brugia malayi	phosphoglycerate mutase family protein	0.0055	0.0108	0.1839
Brugia malayi	SWIB/MDM2 domain containing protein	0.0183	0.0508	0.8624
Schistosoma mansoni	TRABID protein (C64 family)	0.0065	0.0141	0.0141
Echinococcus multilocularis	phosphoglycerate mutase	0.0055	0.0108	0.0108
Schistosoma mansoni	hypothetical protein	0.0183	0.0508	0.0508
Trichomonas vaginalis	conserved hypothetical protein	0.0055	0.0108	0.1595
Schistosoma mansoni	phosphoglycerate mutase	0.0055	0.0108	0.0108
Giardia lamblia	Hypothetical protein	0.191	0.5877	1
Echinococcus multilocularis	phosphoglycerate mutase	0.0055	0.0108	0.0108
Echinococcus granulosus	phosphoglycerate mutase	0.0055	0.0108	0.0108
Echinococcus multilocularis	phosphoglycerate mutase	0.0055	0.0108	0.0108
Leishmania major	hypothetical protein, conserved	0.0065	0.0141	0.0141
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0065	0.0141	0.2394
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0209	0.0589	0.0589
Onchocerca volvulus		0.0065	0.0141	0.011
Mycobacterium tuberculosis	Probable phosphoglycerate mutase (phosphoglyceromutase) (phosphoglycerate phosphomutase)	0.0055	0.0108	1
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.002	0	0.5
Leishmania major	hypothetical protein, conserved	0.0065	0.0141	0.0141
Echinococcus granulosus	ring and YY1 binding protein	0.0065	0.0141	0.0141
Leishmania major	hypothetical protein, conserved	0.0065	0.0141	0.0141
Trypanosoma cruzi	phosphoglycerate mutase family member 5, putative	0.0055	0.0108	0.0108
Trichomonas vaginalis	conserved hypothetical protein	0.0183	0.0508	0.7482
Trypanosoma brucei	hypothetical protein, conserved	0.0065	0.0141	0.0141
Mycobacterium ulcerans	acid phosphatase	0.0055	0.0108	0.0184
Treponema pallidum	phosphoglyceromutase	0.0055	0.0108	1
Plasmodium vivax	SWIB/MDM2 domain-containing protein, putative	0.0183	0.0508	1
Echinococcus granulosus	phosphoglycerate mutase	0.0055	0.0108	0.0108
Trypanosoma cruzi	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.3236	1	1
Echinococcus granulosus	zinc finger protein	0.0021	0.0003	0.0003
Loa Loa (eye worm)	PHD-finger family protein	0.0022	0.0006	0.0006
Plasmodium vivax	phosphoglucomutase-2, putative	0.0055	0.0108	0.2132
Mycobacterium ulcerans	hydrolase MutT1	0.0055	0.0108	0.0184
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0032	0.0032
Brugia malayi	PHD-finger family protein	0.0026	0.002	0.034
Echinococcus multilocularis	serine:threonine protein phosphatase PGAM5	0.0055	0.0108	0.0108
Schistosoma mansoni	hypothetical protein	0.0055	0.0108	0.0108
Toxoplasma gondii	SWIB/MDM2 domain-containing protein	0.0183	0.0508	1
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0072	0.0072
Trypanosoma cruzi	mitochondrial RNA binding complex 1 subunit, putative	0.0065	0.0141	0.0141
Loa Loa (eye worm)	hypothetical protein	0.3236	1	1
Onchocerca volvulus		0.0065	0.0141	0.011
Schistosoma mansoni	hypothetical protein	0.0065	0.0141	0.0141
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0048	0.0088	0.0088
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.003	0.0032	0.0032
Trypanosoma cruzi	Histidine phosphatase superfamily (branch 1), putative	0.0055	0.0108	0.0108
Loa Loa (eye worm)	brahma associated protein	0.0183	0.0508	0.0508
Trypanosoma cruzi	WLM domain containing protein, putative	0.0065	0.0141	0.0141
Trypanosoma cruzi	phosphoglycerate mutase family member 5, putative	0.0055	0.0108	0.0108
Brugia malayi	brahma associated protein 60 kDa	0.0183	0.0508	0.8624
Mycobacterium ulcerans	hypothetical protein	0.191	0.5877	1
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0113	0.0113
Mycobacterium ulcerans	lipoprotein LpqD	0.0055	0.0108	0.0184
Onchocerca volvulus	Protein UBASH3A homolog	0.0055	0.0108	0.0077
Mycobacterium tuberculosis	PE-PGRS family protein PE_PGRS11	0.0055	0.0108	1
Echinococcus granulosus	serine:threonine protein phosphatase PGAM5	0.0055	0.0108	0.0108
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0024	0.0012	0.0012
Schistosoma mansoni	hypothetical protein	0.0055	0.0108	0.0108
Leishmania major	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.3181	0.983	0.983
Mycobacterium ulcerans	fructose-2,6-bisphosphatase GpmB	0.191	0.5877	1
Toxoplasma gondii	phosphoglycerate mutase PGMII	0.0055	0.0108	0.2132
Toxoplasma gondii	ran binding protein	0.0065	0.0141	0.2776
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0055	0.0108	1
Trichomonas vaginalis	phosphoglycerate mutase, putative	0.0055	0.0108	0.1595
Mycobacterium leprae	conserved hypothetical protein	0.0055	0.0108	0.5
Echinococcus granulosus	zinc finger protein Ran binding	0.0065	0.0141	0.0141
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0078	0.0078
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0063	0.0134	0.0134
Trichomonas vaginalis	phosphoglycerate mutase, putative	0.0055	0.0108	0.1595
Leishmania major	hypothetical protein, conserved	0.0055	0.0108	0.0108
Loa Loa (eye worm)	phosphoglycerate mutase	0.0055	0.0108	0.0108
Brugia malayi	Bromodomain containing protein	0.004	0.0064	0.1084
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0108	0.0108
Onchocerca volvulus		0.0065	0.0141	0.011
Echinococcus multilocularis	SWI:SNF matrix associated	0.0183	0.0508	0.0508
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.003	0.0032	0.0032
Trypanosoma brucei	Serine/threonine-protein phosphatase PGAM5, mitochondrial, putative	0.0055	0.0108	0.0108
Trypanosoma cruzi	phosphoglycerate mutase, putative	0.0055	0.0108	0.0108
Onchocerca volvulus		0.3236	1	1
Mycobacterium leprae	PROBABLE PHOSPHOGLYCERATE MUTASE 1 GPM1 (PHOSPHOGLYCEROMUTASE) (PGAM) (BPG-DEPENDENT PGAM)	0.0055	0.0108	0.5
Trypanosoma cruzi	phosphoglycerate mutase protein, putative	0.0055	0.0108	0.0108
Echinococcus granulosus	serine:threonine protein phosphatase PGAM5	0.0055	0.0108	0.0108
Trypanosoma cruzi	hypothetical protein, conserved	0.0065	0.0141	0.0141
Toxoplasma gondii	phosphoglycerate mutase family protein	0.0055	0.0108	0.2132
Mycobacterium leprae	probable isochorismate synthase EntC	0.0055	0.0108	0.5
Schistosoma mansoni	hypothetical protein	0.0183	0.0508	0.0508
Trypanosoma brucei	hypothetical protein, conserved	0.0065	0.0141	0.0141
Trypanosoma cruzi	6-phosphofructo-2-kinase 1	0.3181	0.983	0.983
Giardia lamblia	Hypothetical protein	0.191	0.5877	1
Entamoeba histolytica	phosphoglycerate mutase family protein, putative	0.0055	0.0108	0.0184
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0141	0.0141
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0065	0.0141	0.2394
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0063	0.0134	0.0134
Trypanosoma brucei	Zn-finger in Ran binding protein and others/FYVE zinc finger, putative	0.0065	0.0141	0.0141
Brugia malayi	UBASH3A protein homolog	0.0055	0.0108	0.1839
Mycobacterium ulcerans	phosphoglycerate mutase	0.0055	0.0108	0.0184
Trichomonas vaginalis	conserved hypothetical protein	0.0055	0.0108	0.1595
Trypanosoma cruzi	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.3236	1	1
Trypanosoma cruzi	WLM domain containing protein, putative	0.0065	0.0141	0.0141
Trypanosoma brucei	Histidine phosphatase superfamily (branch 1), putative	0.0055	0.0108	0.0108
Trypanosoma cruzi	Zn-finger in Ran binding protein and others, putative	0.0065	0.0141	0.0141
Trypanosoma cruzi	Zn-finger in Ran binding protein and others/FYVE zinc finger, putative	0.0065	0.0141	0.0141
Leishmania major	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.3236	1	1
Brugia malayi	phosphoglycerate mutase family protein	0.0055	0.0108	0.1839
Trypanosoma cruzi	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.1381	0.4232	0.4232
Plasmodium vivax	phosphoglycerate mutase, putative	0.0055	0.0108	0.2132
Echinococcus multilocularis	phosphoglycerate mutase	0.0055	0.0108	0.0108
Mycobacterium ulcerans	hypothetical protein	0.0055	0.0108	0.0184
Mycobacterium leprae	conserved hypothetical protein	0.0055	0.0108	0.5
Echinococcus granulosus	phosphoglycerate mutase	0.0055	0.0108	0.0108
Trypanosoma cruzi	hypothetical protein, conserved	0.0065	0.0141	0.0141
Mycobacterium tuberculosis	Possible hydrolase MutT1	0.0055	0.0108	1
Trypanosoma brucei	Histidine phosphatase superfamily (branch 1), putative	0.0055	0.0108	0.0108
Schistosoma mansoni	hypothetical protein	0.0055	0.0108	0.0108
Toxoplasma gondii	phosphoglycerate mutase family protein	0.0055	0.0108	0.2132
Loa Loa (eye worm)	hypothetical protein	0.3181	0.983	0.983
Trypanosoma brucei	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatas, putative	0.0055	0.0108	0.0108
Echinococcus multilocularis	tumor protein p63	0.0384	0.1132	0.1132
Mycobacterium leprae	POSSIBLE HYDROLASE MUTT1	0.0055	0.0108	0.5
Trypanosoma cruzi	6-phosphofructo-2-kinase 1	0.3181	0.983	0.983
Trypanosoma brucei	phosphoglycerate mutase protein, putative	0.0055	0.0108	0.0108
Echinococcus multilocularis	Upstream activation factor subunit UAF30	0.0183	0.0508	0.0508
Trichomonas vaginalis	phosphoglycerate mutase, putative	0.0055	0.0108	0.1595
Echinococcus granulosus	Zinc finger RanBP2 type	0.0065	0.0141	0.0141
Onchocerca volvulus	Protein UBASH3A homolog	0.0055	0.0108	0.0077
Plasmodium falciparum	SWIB/MDM2 domain-containing protein	0.0183	0.0508	1
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0065	0.0141	0.2394
Trypanosoma cruzi	phosphoglycerate mutase protein, putative	0.0055	0.0108	0.0108
Trypanosoma brucei	phosphoglycerate mutase, putative	0.0055	0.0108	0.0108
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0108	0.0108
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0141	0.0141
Schistosoma mansoni	6-phosphofructokinase	0.3236	1	1
Mycobacterium tuberculosis	Probable conserved lipoprotein LpqD	0.0055	0.0108	1
Echinococcus multilocularis	serine:threonine protein phosphatase PGAM5	0.0055	0.0108	0.0108
Toxoplasma gondii	phosphoglycerate mutase family protein	0.0055	0.0108	0.2132
Leishmania major	phosphoglycerate mutase family member 5, putative	0.0055	0.0108	0.0108
Echinococcus granulosus	Upstream activation factor subunit UAF30	0.0183	0.0508	0.0508
Entamoeba histolytica	phosphoglycerate mutase family protein. putative	0.0055	0.0108	0.0184
Leishmania major	fructose-6-phosphate2-kinase/fructose-2,6-bisph os phatase-likeprotein	0.0055	0.0108	0.0108
Mycobacterium ulcerans	phosphoglycerate mutase	0.0055	0.0108	0.0184
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.003	0.0032	0.0624
Trypanosoma cruzi	Zn-finger in Ran binding protein and others, putative	0.0065	0.0141	0.0141
Mycobacterium ulcerans	phosphohistidine phosphatase SixA	0.0055	0.0108	0.0184
Plasmodium vivax	hypothetical protein, conserved	0.0183	0.0508	1
Plasmodium falciparum	SWIB/MDM2 domain-containing protein	0.0183	0.0508	1
Onchocerca volvulus		0.0055	0.0108	0.0077
Onchocerca volvulus	Ubiquitin thioesterase ZRANB1 homolog	0.0065	0.0141	0.011
Echinococcus granulosus	tumor protein p63	0.0384	0.1132	0.1132
Loa Loa (eye worm)	SWIB/MDM2 domain-containing protein	0.0183	0.0508	0.0508
Schistosoma mansoni	cellular tumor antigen P53	0.0056	0.0113	0.0113
Onchocerca volvulus		0.0056	0.0113	0.0082
Echinococcus multilocularis	phosphoglycerate mutase	0.0055	0.0108	0.0108
Schistosoma mansoni	brg-1 associated factor	0.0183	0.0508	0.0508
Trypanosoma cruzi	Histidine phosphatase superfamily (branch 1), putative	0.0055	0.0108	0.0108
Brugia malayi	Pre-SET motif family protein	0.003	0.0032	0.0538
Leishmania major	hypothetical protein, conserved	0.0055	0.0108	0.0108
Schistosoma mansoni	hypothetical protein	0.0055	0.0108	0.0108
Schistosoma mansoni	hypothetical protein	0.0055	0.0108	0.0108
Leishmania major	hypothetical protein, conserved	0.0065	0.0141	0.0141
Schistosoma mansoni	phosphoglycerate mutase	0.0055	0.0108	0.0108
Echinococcus granulosus	phosphoglycerate mutase	0.0055	0.0108	0.0108
Echinococcus multilocularis	Zinc finger, RanBP2 type	0.0065	0.0141	0.0141
Onchocerca volvulus		0.0238	0.0679	0.0649
Onchocerca volvulus	Protein UBASH3A homolog	0.0055	0.0108	0.0077
Leishmania major	phosphoglycerate mutase, putative	0.0055	0.0108	0.0108
Schistosoma mansoni	RNA binding protein	0.0065	0.0141	0.0141
Echinococcus granulosus	SWI:SNF matrix associated	0.0183	0.0508	0.0508
Onchocerca volvulus	Protein UBASH3A homolog	0.0055	0.0108	0.0077
Chlamydia trachomatis	DNA topoisomerase I	0.0183	0.0508	1
Trichomonas vaginalis	set domain proteins, putative	0.0238	0.0679	1
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0024	0.0012	0.0012
Echinococcus granulosus	fetal alzheimer antigen falz	0.0024	0.0012	0.0012
Loa Loa (eye worm)	hypothetical protein	0.1855	0.5707	0.5707
Onchocerca volvulus		0.0065	0.0141	0.011
Plasmodium falciparum	zinc finger Ran-binding domain-containing protein 2, putative	0.0065	0.0141	0.2776
Mycobacterium ulcerans	bifunctional RNase H/acid phosphatase	0.0055	0.0108	0.0184
Mycobacterium tuberculosis	Possible phosphoglycerate mutase Gpm2 (phosphoglyceromutase) (PGAM) (BPG-dependent PGAM)	0.0055	0.0108	1
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0108	0.0108
Schistosoma mansoni	zinc finger protein	0.0021	0.0003	0.0003
Trypanosoma cruzi	Histidine phosphatase superfamily (branch 1), putative	0.0055	0.0108	0.0108
Onchocerca volvulus		0.0055	0.0108	0.0077

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	> 500 uM	Inhibition of human recombinant caspase-7 using Ac-DEVD-AMC as substrate assessed as accumulation of AMC preincubated for 10 mins followed by substrate addition measured after 10 mins by fluorescence assay	ChEMBL.	23685941
IC50 (binding)	> 500 uM	Inhibition of human recombinant caspase-3 using Ac-DEVD-AMC as substrate assessed as accumulation of AMC preincubated for 10 mins followed by substrate addition measured after 10 mins by fluorescence assay	ChEMBL.	23685941

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2391850

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1779650