TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 516.562 | Formula: C22H32N2O10S
H donors: 2 H acceptors: 5 LogP: -1.29 Rotable bonds: 16
Rule of 5 violations (Lipinski): 2
SMILES: COC[C@@H]1C[C@@H](CN1S(=O)(=O)c1ccc2c(c1)C(=O)C(=O)N2)OCCOCCOCCOCCO
InChi: 1S/C22H32N2O10S/c1-30-15-16-12-17(34-11-10-33-9-8-32-7-6-31-5-4-25)14-24(16)35(28,29)18-2-3-20-19(13-18)21(26)22(27)23-20/h2-3,13,16-17,25H,4-12,14-15H2,1H3,(H,23,26,27)/t16-,17-/m0/s1
InChiKey: LFWWHMQTYPOGNR-IRXDYDNUSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Leishmania major	beta tubulin	0.0023	0.0026	0.0195
Loa Loa (eye worm)	tubulin beta chain	0.0023	0.0026	0.0024
Echinococcus multilocularis	orexin receptor type 2	0.0084	0.0254	0.0252
Loa Loa (eye worm)	hypothetical protein	0.0045	0.011	0.0107
Leishmania major	beta tubulin	0.0023	0.0026	0.0195
Echinococcus multilocularis	g protein coupled receptor	0.0084	0.0254	0.0252
Brugia malayi	Serotonin receptor	0.0084	0.0254	0.0252
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0254	0.0252
Plasmodium vivax	tubulin beta chain, putative	0.0023	0.0026	1
Onchocerca volvulus		0.0084	0.0254	0.1351
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0026	0.0037	0.0148
Schistosoma mansoni	neuropeptide F-like receptor	0.0084	0.0254	0.0254
Brugia malayi	Tubulin beta-1 chain	0.0023	0.0026	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0037	0.0035
Echinococcus granulosus	neuropeptides capa receptor	0.0084	0.0254	0.0252
Echinococcus granulosus	G protein coupled receptor 139	0.0084	0.0254	0.0252
Echinococcus multilocularis	Tubulin beta 2C chain	0.0023	0.0026	0.0024
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.046	0.1642	0.1642
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.046	0.1642	0.1642
Loa Loa (eye worm)	melatonin receptor type 1A	0.0084	0.0254	0.0252
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0084	0.0254	0.0254
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.006	0.0163	0.0163
Loa Loa (eye worm)	carboxylesterase	0.2725	1	1
Echinococcus granulosus	methyl CpG binding domain protein 2	0.0017	0.0007	0.0004
Onchocerca volvulus		0.0052	0.0136	0.0613
Schistosoma mansoni	hypothetical protein	0.0021	0.002	0.002
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0018	0.0009	0.0007
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0084	0.0254	0.0254
Trypanosoma brucei	beta tubulin	0.0023	0.0026	0.0195
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.046	0.1642	1
Echinococcus granulosus	sterol regulatory element binding protein	0.0042	0.0096	0.0093
Loa Loa (eye worm)	carboxylesterase	0.046	0.1642	0.164
Brugia malayi	G protein-coupled receptor F59B2.13	0.0084	0.0254	0.0252
Onchocerca volvulus		0.046	0.1642	1
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0062	0.0172	0.017
Schistosoma mansoni	hypothetical protein	0.0084	0.0254	0.0254
Brugia malayi	Bromodomain containing protein	0.0079	0.0232	0.023
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0018	0.0009	0.0009
Echinococcus granulosus	histone lysine methyltransferase setb	0.0018	0.0009	0.0007
Echinococcus multilocularis	G protein coupled receptor 139	0.0084	0.0254	0.0252
Loa Loa (eye worm)	hypothetical protein	0.2725	1	1
Trypanosoma cruzi	C-8 sterol isomerase, putative	0.0374	0.1321	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0037	0.0035
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0037	0.0078	0.0076
Echinococcus granulosus	tubulin beta 4A class IVa	0.0023	0.0026	0.0024
Schistosoma mansoni	hypothetical protein	0.0084	0.0254	0.0254
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0084	0.0254	0.0252
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.046	0.1642	0.164
Loa Loa (eye worm)	beta-tubulin	0.0023	0.0026	0.0024
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0042	0.0096	0.0093
Echinococcus multilocularis	beta tubulin	0.0023	0.0026	0.0024
Onchocerca volvulus		0.046	0.1642	1
Schistosoma mansoni	zinc finger protein	0.0022	0.0022	0.0022
Leishmania major	beta tubulin	0.0023	0.0026	0.0195
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0013	0.0011
Trichomonas vaginalis	conserved hypothetical protein	0.0042	0.0096	0.0432
Echinococcus multilocularis	neuropeptide s receptor	0.0084	0.0254	0.0252
Onchocerca volvulus		0.0084	0.0254	0.1351
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0254	0.0252
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0052	0.0132	0.013
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0084	0.0254	0.0252
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0084	0.0254	0.0254
Loa Loa (eye worm)	neuropeptide F receptor	0.0084	0.0254	0.0252
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0028	0.0046	0.0044
Echinococcus multilocularis	sterol regulatory element binding protein	0.0042	0.0096	0.0093
Echinococcus granulosus	Tubulin beta 2C chain	0.0023	0.0026	0.0024
Leishmania major	beta tubulin	0.0023	0.0026	0.0195
Brugia malayi	hypothetical protein	0.046	0.1642	0.164
Onchocerca volvulus		0.0084	0.0254	0.1351
Echinococcus granulosus	Tubulin beta 2C chain	0.0023	0.0026	0.0024
Echinococcus granulosus	neuropeptide FF receptor 2	0.0084	0.0254	0.0252
Echinococcus multilocularis	BC026374 protein (S09 family)	0.046	0.1642	0.164
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0084	0.0254	0.0254
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0056	0.0149	1
Giardia lamblia	Beta tubulin	0.0023	0.0026	0.5
Loa Loa (eye worm)	BEN-1 protein	0.0023	0.0026	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0254	0.0252
Leishmania major	beta tubulin	0.0023	0.0026	0.0195
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0084	0.0254	0.0252
Leishmania major	beta tubulin	0.0023	0.0026	0.0195
Onchocerca volvulus		0.0084	0.0254	0.1351
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0084	0.0254	0.0252
Echinococcus multilocularis	Tubulin beta 2C chain	0.0023	0.0026	0.0024
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0084	0.0254	0.0254
Leishmania major	C-8 sterol isomerase-like protein	0.0374	0.1321	1
Echinococcus multilocularis	Tubulin beta 2C chain	0.0023	0.0026	0.0024
Schistosoma mansoni	hypothetical protein	0.0016	0.0002	0.0002
Echinococcus granulosus	Tubulin beta 2C chain	0.0023	0.0026	0.0024
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0084	0.0254	0.0252
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0013	0.0011
Echinococcus granulosus	fmrfamide receptor	0.0084	0.0254	0.0252
Schistosoma mansoni	tubulin subunit beta	0.0023	0.0026	0.0026
Schistosoma mansoni	amine GPCR	0.0084	0.0254	0.0254
Echinococcus granulosus	g protein coupled receptor	0.0084	0.0254	0.0252
Brugia malayi	hypothetical protein	0.0084	0.0254	0.0252
Loa Loa (eye worm)	hypothetical protein	0.046	0.1642	0.164
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0254	0.0252
Echinococcus granulosus	rhodopsin orphan GPCR	0.0084	0.0254	0.0252
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0084	0.0254	0.0254
Trichomonas vaginalis	glucosylceramidase, putative	0.0168	0.0561	0.3311
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0084	0.0254	0.0254
Schistosoma mansoni	myosin xvIII	0.0084	0.0254	0.0254
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0084	0.0254	0.0252
Loa Loa (eye worm)	hypothetical protein	0.046	0.1642	0.164
Loa Loa (eye worm)	hypothetical protein	0.046	0.1642	0.164
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0254	0.0252
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0254	0.0252
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0084	0.0254	0.0252
Loa Loa (eye worm)	hypothetical protein	0.0257	0.0891	0.0889
Onchocerca volvulus		0.0084	0.0254	0.1351
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0172	0.0172
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0254	0.0252
Leishmania major	beta tubulin	0.0023	0.0026	0.0195
Leishmania major	beta tubulin	0.0023	0.0026	0.0195
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0084	0.0254	0.0252
Onchocerca volvulus		0.0084	0.0254	0.1351
Echinococcus multilocularis	neuropeptide receptor A26	0.0084	0.0254	0.0252
Echinococcus multilocularis	neuropeptide Y receptor	0.0084	0.0254	0.0252
Echinococcus granulosus	tm gpcr rhodopsin	0.0084	0.0254	0.0252
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0254	0.0252
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0084	0.0254	0.0252
Schistosoma mansoni	hypothetical protein	0.004	0.009	0.009
Brugia malayi	hypothetical protein	0.0084	0.0254	0.0252
Onchocerca volvulus		0.0084	0.0254	0.1351
Brugia malayi	Carboxylesterase family protein	0.046	0.1642	0.164
Echinococcus multilocularis	neuropeptide receptor	0.0084	0.0254	0.0252
Brugia malayi	AMP-binding enzyme family protein	0.0026	0.0037	0.0035
Schistosoma mansoni	hypothetical protein	0.004	0.009	0.009
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0084	0.0254	0.0252
Schistosoma mansoni	amine GPCR	0.0084	0.0254	0.0254
Leishmania major	beta tubulin	0.0023	0.0026	0.0195
Mycobacterium ulcerans	acyl-CoA synthetase	0.0026	0.0037	0.0148
Schistosoma mansoni	growth hormone secretagogue receptor	0.0084	0.0254	0.0254
Echinococcus multilocularis	Niemann Pick C1 protein	0.0097	0.03	0.0298
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0254	0.0252
Brugia malayi	hypothetical protein	0.0084	0.0254	0.0252
Echinococcus multilocularis	tar DNA binding protein	0.0062	0.0172	0.017
Schistosoma mansoni	opsin-like receptor	0.0084	0.0254	0.0254
Brugia malayi	AMP-binding enzyme family protein	0.0026	0.0037	0.0035
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0084	0.0254	0.0252
Echinococcus granulosus	tm gpcr rhodopsin	0.0084	0.0254	0.0252
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0084	0.0254	0.0252
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0132	0.013
Schistosoma mansoni	hypothetical protein	0.0403	0.1429	0.1429
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0026	0.0037	0.0171
Leishmania major	beta tubulin	0.0023	0.0026	0.0195
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0013	0.0011
Brugia malayi	AMP-binding enzyme family protein	0.0026	0.0037	0.0035
Onchocerca volvulus		0.046	0.1642	1
Brugia malayi	hypothetical protein	0.0084	0.0254	0.0252
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0084	0.0254	0.0254
Schistosoma mansoni	neuropeptide receptor	0.0084	0.0254	0.0254
Echinococcus multilocularis	fmrfamide receptor	0.0084	0.0254	0.0252
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0084	0.0254	0.0252
Trichomonas vaginalis	glucosylceramidase, putative	0.0255	0.0885	0.5318
Loa Loa (eye worm)	hypothetical protein	0.046	0.1642	0.164
Echinococcus multilocularis	dro:myosuppressin receptor	0.0084	0.0254	0.0252
Brugia malayi	RNA binding protein	0.0062	0.0172	0.017
Echinococcus granulosus	dro:myosuppressin receptor	0.0084	0.0254	0.0252
Onchocerca volvulus		0.0084	0.0254	0.1351
Brugia malayi	putative neuropeptide receptor	0.0084	0.0254	0.0252
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0037	0.0035
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0013	0.0011
Brugia malayi	G-protein coupled receptor	0.0084	0.0254	0.0252
Leishmania major	beta tubulin	0.0023	0.0026	0.0195
Loa Loa (eye worm)	hypothetical protein	0.0097	0.03	0.0298
Echinococcus multilocularis	acetylcholinesterase	0.2725	1	1
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0084	0.0254	0.0252
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0084	0.0254	0.0252
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0084	0.0254	0.0252
Echinococcus granulosus	g-protein coupled receptor	0.0084	0.0254	0.0252
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0254	0.0252
Schistosoma mansoni	hypothetical protein	0.0084	0.0254	0.0254
Echinococcus multilocularis	g-protein coupled receptor	0.0084	0.0254	0.0252
Brugia malayi	putative neuropeptide receptor NPR1	0.0084	0.0254	0.0252
Brugia malayi	Dopamine receptor protein 2	0.0084	0.0254	0.0252
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0254	0.0252
Echinococcus multilocularis	neuroligin	0.046	0.1642	0.164
Loa Loa (eye worm)	BEN-1 protein	0.0023	0.0026	0.0024
Brugia malayi	hypothetical protein	0.0084	0.0254	0.0252
Echinococcus multilocularis	protein dispatched 1	0.0047	0.0117	0.0115
Brugia malayi	hypothetical protein	0.0084	0.0254	0.0252
Loa Loa (eye worm)	hypothetical protein	0.046	0.1642	0.164
Trypanosoma brucei	beta tubulin	0.0023	0.0026	0.0195
Echinococcus granulosus	neuropeptide s receptor	0.0084	0.0254	0.0252
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0798	0.2889	0.2887
Echinococcus granulosus	g protein coupled receptor	0.0084	0.0254	0.0252
Leishmania major	4-coumarate:coa ligase-like protein	0.0026	0.0037	0.0282
Echinococcus granulosus	beta tubulin	0.0023	0.0026	0.0024
Echinococcus granulosus	Tubulin beta 2C chain	0.0023	0.0026	0.0024
Schistosoma mansoni	neuropeptide receptor	0.0084	0.0254	0.0254
Echinococcus granulosus	hypothetical protein	0.0084	0.0254	0.0252
Echinococcus granulosus	dnaJ subfamily B	0.0403	0.1429	0.1427
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0084	0.0254	0.0252
Leishmania major	beta tubulin	0.0023	0.0026	0.0195
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0172	0.0172
Brugia malayi	neuropeptide F receptor	0.0084	0.0254	0.0252
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0084	0.0254	0.0252
Schistosoma mansoni	cpg binding protein	0.0032	0.006	0.006
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0084	0.0254	0.0252
Loa Loa (eye worm)	G-protein coupled receptor	0.0084	0.0254	0.0252
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0254	0.0252
Giardia lamblia	Beta tubulin	0.0023	0.0026	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0084	0.0254	0.0254
Brugia malayi	ORL1-like opioid receptor	0.0084	0.0254	0.0252
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0084	0.0254	0.0252
Echinococcus multilocularis	serotonin receptor	0.0084	0.0254	0.0252
Echinococcus granulosus	rhodopsin orphan GPCR	0.0084	0.0254	0.0252
Brugia malayi	PHD-finger family protein	0.0027	0.0042	0.004
Echinococcus granulosus	tm gpcr rhodopsin	0.0084	0.0254	0.0252
Brugia malayi	Carboxylesterase family protein	0.046	0.1642	0.164
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0084	0.0254	0.0252
Schistosoma mansoni	histamine h1 receptor	0.0084	0.0254	0.0254
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0254	0.0252
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0254	0.0252
Schistosoma mansoni	biogenic amine receptor	0.0084	0.0254	0.0254
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0084	0.0254	0.0252
Echinococcus granulosus	neuropeptides capa receptor	0.0084	0.0254	0.0252
Echinococcus granulosus	somatostatin receptor	0.0084	0.0254	0.0252
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0026	0.0037	0.0171
Echinococcus granulosus	serotonin receptor	0.0084	0.0254	0.0252
Brugia malayi	RNA recognition motif domain containing protein	0.0062	0.0172	0.017
Schistosoma mansoni	survival motor neuron protein	0.0052	0.0136	0.0136
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0084	0.0254	0.0252
Brugia malayi	beta-tubulin, identical	0.0023	0.0026	0.0024
Echinococcus granulosus	neuropeptide receptor	0.0084	0.0254	0.0252
Brugia malayi	AKH receptor	0.0084	0.0254	0.0252
Echinococcus multilocularis	dnaJ subfamily B	0.0403	0.1429	0.1427
Echinococcus granulosus	g protein coupled receptor	0.0084	0.0254	0.0252
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0096	0.0093
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0254	0.0252
Echinococcus granulosus	acetylcholinesterase	0.2725	1	1
Echinococcus multilocularis	serotonin receptor	0.0084	0.0254	0.0252
Loa Loa (eye worm)	TYRA-2 protein	0.0084	0.0254	0.0252
Loa Loa (eye worm)	carboxylesterase	0.046	0.1642	0.164
Echinococcus granulosus	zinc finger protein	0.0022	0.0022	0.002
Schistosoma mansoni	opsin-like receptor	0.0084	0.0254	0.0254
Echinococcus granulosus	neuroligin	0.046	0.1642	0.164
Echinococcus granulosus	tar DNA binding protein	0.0062	0.0172	0.017
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0084	0.0254	0.0254
Schistosoma mansoni	biogenic amine receptor	0.0084	0.0254	0.0254
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0063	0.0174	0.0172
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0254	0.0252
Echinococcus granulosus	BC026374 protein S09 family	0.046	0.1642	0.164
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0084	0.0254	0.0252
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0254	0.0252
Schistosoma mansoni	bromodomain containing protein	0.0067	0.0188	0.0188
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0254	0.0252
Echinococcus granulosus	para nitrobenzyl esterase	0.046	0.1642	0.164
Mycobacterium ulcerans	hypothetical protein	0.0026	0.0037	0.0148
Schistosoma mansoni	neuroligin 3 (S09 family)	0.046	0.1642	0.1642
Onchocerca volvulus		0.0084	0.0254	0.1351
Onchocerca volvulus		0.0084	0.0254	0.1351
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0084	0.0254	0.0252
Trypanosoma brucei	beta tubulin	0.0023	0.0026	0.0195
Brugia malayi	Melatonin receptor type 1A	0.0084	0.0254	0.0252
Brugia malayi	follicle stimulating hormone receptor	0.0084	0.0254	0.0252
Echinococcus granulosus	7TM GPCR rhodopsin	0.0084	0.0254	0.0252
Brugia malayi	ERG2 and Sigma1 receptor like protein	0.0374	0.1321	0.1319
Echinococcus multilocularis	Tubulin beta 2C chain	0.0023	0.0026	0.0024
Schistosoma mansoni	biogenic amine receptor	0.0084	0.0254	0.0254
Loa Loa (eye worm)	hypothetical protein	0.0051	0.013	0.0128
Loa Loa (eye worm)	hypothetical protein	0.0191	0.0647	0.0645
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0254	0.0252
Echinococcus multilocularis	neuropeptides capa receptor	0.0084	0.0254	0.0252
Trichomonas vaginalis	glucosylceramidase, putative	0.0168	0.0561	0.3311
Schistosoma mansoni	tubulin subunit beta	0.0023	0.0026	0.0026
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0084	0.0254	0.0254
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0097	0.03	1
Schistosoma mansoni	tubulin subunit beta	0.0023	0.0026	0.0026
Onchocerca volvulus		0.0028	0.0046	0.0058
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0084	0.0254	0.0252
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0254	0.0252
Loa Loa (eye worm)	neuropeptide F receptor	0.0084	0.0254	0.0252
Echinococcus granulosus	neuropeptide receptor	0.0084	0.0254	0.0252
Echinococcus granulosus	Niemann Pick C1 protein	0.0139	0.0453	0.0451
Leishmania major	4-coumarate:coa ligase-like protein	0.0026	0.0037	0.0282
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0026	0.0037	0.0148
Echinococcus granulosus	expressed conserved protein	0.0091	0.0278	0.0276
Brugia malayi	hypothetical protein	0.0084	0.0254	0.0252
Loa Loa (eye worm)	hypothetical protein	0.046	0.1642	0.164
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0052	0.0132	0.013
Brugia malayi	hypothetical protein	0.0257	0.0891	0.0889
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0084	0.0254	0.0254
Trichomonas vaginalis	glucosylceramidase, putative	0.0168	0.0561	0.3311
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0019	0.0013	0.5
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0025	0.0033	0.0031
Schistosoma mansoni	adenoreceptor	0.0084	0.0254	0.0254
Schistosoma mansoni	cpg binding protein	0.0032	0.006	0.006
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0084	0.0254	0.0252
Brugia malayi	larval opioid receptor	0.0084	0.0254	0.0252
Loa Loa (eye worm)	TAR-binding protein	0.0062	0.0172	0.017
Echinococcus granulosus	neuropeptide Y receptor	0.0084	0.0254	0.0252
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0084	0.0254	0.0254
Brugia malayi	Carboxylesterase family protein	0.046	0.1642	0.164
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0254	0.0252
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0254	0.0252
Schistosoma mansoni	tubulin subunit beta	0.0023	0.0026	0.0026
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0084	0.0254	0.0252
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.046	0.1642	0.164
Brugia malayi	hypothetical protein	0.0084	0.0254	0.0252
Onchocerca volvulus		0.0084	0.0254	0.1351
Schistosoma mansoni	hypothetical protein	0.0016	0.0002	0.0002
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.0255	0.0885	0.0883
Brugia malayi	CHE-14 protein	0.0042	0.0096	0.0093
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0254	0.0252
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0084	0.0254	0.0252
Trichomonas vaginalis	glucosylceramidase, putative	0.0168	0.0561	0.3311
Schistosoma mansoni	hypothetical protein	0.0084	0.0254	0.0254
Onchocerca volvulus		0.046	0.1642	1
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0084	0.0254	0.0252
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0084	0.0254	0.0252
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0084	0.0254	0.0254
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0254	0.0252
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0026	0.0037	0.5
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.2725	1	1
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0084	0.0254	0.0254
Echinococcus granulosus	Niemann Pick C1 protein	0.0097	0.03	0.0298
Schistosoma mansoni	cpg binding protein	0.0028	0.0046	0.0046
Schistosoma mansoni	neuropeptide f receptor 76f	0.0084	0.0254	0.0254
Echinococcus granulosus	fetal alzheimer antigen falz	0.0025	0.0033	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0254	0.0252
Trypanosoma brucei	beta tubulin	0.0023	0.0026	0.0195
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0254	0.0252
Loa Loa (eye worm)	hypothetical protein	0.0494	0.1764	0.1762
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0254	0.0252
Echinococcus granulosus	beta tubulin	0.0023	0.0026	0.0024
Schistosoma mansoni	hypothetical protein	0.0052	0.0136	0.0136
Brugia malayi	hypothetical protein	0.0084	0.0254	0.0252
Echinococcus multilocularis	allatostatin A receptor	0.0084	0.0254	0.0252
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0084	0.0254	0.0254
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0254	0.0252
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0254	0.0252
Loa Loa (eye worm)	hypothetical protein	0.046	0.1642	0.164
Entamoeba histolytica	acyl-coA synthetase, putative	0.0026	0.0037	0.0415
Leishmania major	beta tubulin	0.0023	0.0026	0.0195
Brugia malayi	G-protein coupled receptor	0.0084	0.0254	0.0252
Schistosoma mansoni	opsin-like receptor	0.0084	0.0254	0.0254
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0084	0.0254	0.0252
Brugia malayi	neuropeptide F receptor	0.0084	0.0254	0.0252
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0254	0.0252
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0254	0.0252
Brugia malayi	Carboxylesterase family protein	0.2725	1	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0072	0.007
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0254	0.0252
Schistosoma mansoni	neuropeptide receptor	0.0084	0.0254	0.0254
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0084	0.0254	0.0254
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0084	0.0254	0.0252
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0084	0.0254	0.0252
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0084	0.0254	0.0254
Leishmania major	beta tubulin	0.0023	0.0026	0.0195
Schistosoma mansoni	BC026374 protein (S09 family)	0.046	0.1642	0.1642
Onchocerca volvulus		0.0084	0.0254	0.1351
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0254	0.0252
Onchocerca volvulus		0.0084	0.0254	0.1351
Echinococcus multilocularis	tubulin beta 1 chain	0.0023	0.0026	0.0024
Plasmodium falciparum	tubulin beta chain	0.0023	0.0026	1
Brugia malayi	Carboxylesterase family protein	0.046	0.1642	0.164
Echinococcus multilocularis	protein patched	0.0042	0.0096	0.0093
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0084	0.0254	0.0254
Echinococcus multilocularis	somatostatin receptor	0.0084	0.0254	0.0252
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0084	0.0254	0.0254
Brugia malayi	TAR-binding protein	0.0062	0.0172	0.017
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0096	0.0094
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.0255	0.0885	0.0883
Echinococcus granulosus	rhodopsin orphan GPCR	0.0084	0.0254	0.0252
Trypanosoma cruzi	beta tubulin, putative	0.0023	0.0026	0.0195
Echinococcus granulosus	neuropeptide receptor A26	0.0084	0.0254	0.0252
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0084	0.0254	0.0252
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0084	0.0254	0.0254
Trichomonas vaginalis	glucosylceramidase, putative	0.0168	0.0561	0.3311
Trypanosoma brucei	C-8 sterol isomerase, putative	0.0374	0.1321	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0168	0.0561	0.3311
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0084	0.0254	0.0252
Leishmania major	4-coumarate:coa ligase-like protein	0.0026	0.0037	0.0282
Loa Loa (eye worm)	tubulin beta-1 chain	0.0023	0.0026	0.0024
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0084	0.0254	0.0252
Loa Loa (eye worm)	tubulin beta-2A chain	0.0023	0.0026	0.0024
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0084	0.0254	0.0252
Giardia lamblia	Beta tubulin	0.0023	0.0026	0.5
Echinococcus multilocularis	neuropeptide Y receptor	0.0084	0.0254	0.0252
Loa Loa (eye worm)	hypothetical protein	0.2725	1	1
Brugia malayi	Bromodomain containing protein	0.0039	0.0087	0.0085
Brugia malayi	Niemann-Pick C1 protein precursor	0.0097	0.03	0.0298
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0084	0.0254	0.0254
Onchocerca volvulus		0.0084	0.0254	0.1351
Schistosoma mansoni	hypothetical protein	0.0016	0.0002	0.0002
Schistosoma mansoni	hypothetical protein	0.004	0.009	0.009
Echinococcus multilocularis	carboxylesterase 5A	0.2725	1	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0255	0.0885	0.5318
Onchocerca volvulus		0.0084	0.0254	0.1351
Mycobacterium tuberculosis	Carboxylesterase LipT	0.046	0.1642	1
Schistosoma mansoni	amine GPCR	0.0598	0.2149	0.2149
Echinococcus multilocularis	neuropeptide receptor	0.0084	0.0254	0.0252
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0084	0.0254	0.0252
Trichomonas vaginalis	glucosylceramidase, putative	0.0255	0.0885	0.5318
Echinococcus granulosus	tubulin beta 1 chain	0.0023	0.0026	0.0024
Echinococcus granulosus	acetylcholinesterase	0.2725	1	1
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0084	0.0254	0.0252
Schistosoma mansoni	gliotactin	0.046	0.1642	0.1642
Echinococcus multilocularis	tubulin subunit beta	0.0023	0.0026	0.0024
Loa Loa (eye worm)	tubulin beta-4 chain	0.0023	0.0026	0.0024
Schistosoma mansoni	tubulin subunit beta	0.0023	0.0026	0.0026
Echinococcus multilocularis	g protein coupled receptor	0.0084	0.0254	0.0252
Mycobacterium ulcerans	acyl-CoA synthetase	0.0026	0.0037	0.0148
Echinococcus multilocularis	expressed conserved protein	0.0091	0.0278	0.0276
Schistosoma mansoni	neuropeptide F-like receptor	0.0084	0.0254	0.0254
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0026	0.0037	0.0148
Trichomonas vaginalis	glucosylceramidase, putative	0.0168	0.0561	0.3311
Echinococcus granulosus	neuropeptide Y receptor	0.0084	0.0254	0.0252
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0254	0.0252
Echinococcus granulosus	biogenic amine 5HT receptor	0.0084	0.0254	0.0252
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0254	0.0252
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0254	0.0252
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.046	0.1642	1
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0084	0.0254	0.1351
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0013	0.0011
Echinococcus granulosus	biogenic amine 5HT receptor	0.0084	0.0254	0.0252
Trichomonas vaginalis	glucosylceramidase, putative	0.0177	0.0594	0.3517
Loa Loa (eye worm)	PHD-finger family protein	0.0021	0.002	0.0018
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0084	0.0254	0.0254
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0025	0.0033	0.0033
Loa Loa (eye worm)	acetylcholinesterase 1	0.2725	1	1
Echinococcus granulosus	cpg binding protein	0.0032	0.006	0.0057
Echinococcus granulosus	Protein patched homolog 1	0.0042	0.0096	0.0093
Echinococcus multilocularis	survival motor neuron protein 1	0.0257	0.0891	0.0889
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0172	0.0172
Schistosoma mansoni	amine GPCR	0.0084	0.0254	0.0254
Onchocerca volvulus		0.0084	0.0254	0.1351
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0026	0.0037	0.0415
Schistosoma mansoni	neuropeptide receptor	0.0084	0.0254	0.0254
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0254	0.0252
Echinococcus multilocularis	tubulin, beta 4A class IVa	0.0023	0.0026	0.0024
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0084	0.0254	0.0252
Echinococcus multilocularis	cpg binding protein	0.0032	0.006	0.0057
Echinococcus multilocularis	g protein coupled receptor	0.0084	0.0254	0.0252
Echinococcus multilocularis	methyl CpG binding domain protein 2	0.0017	0.0007	0.0004
Brugia malayi	latrophilin 2 splice variant baaae	0.0035	0.0072	0.007
Brugia malayi	GnHR receptor homolog	0.0084	0.0254	0.0252
Schistosoma mansoni	hypothetical protein	0.004	0.009	0.009
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0009	0.0007
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0084	0.0254	0.0252
Brugia malayi	CXXC zinc finger family protein	0.0028	0.0046	0.0044
Trichomonas vaginalis	glucosylceramidase, putative	0.0255	0.0885	0.5318
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0254	0.0252
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.046	0.1642	1
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0254	0.0252
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0018	0.0009	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0254	0.0252
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0098	0.0305	0.0305
Echinococcus granulosus	tubulin subunit beta	0.0023	0.0026	0.0024
Echinococcus granulosus	carboxylesterase 5A	0.2725	1	1
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0026	0.0037	0.0148
Mycobacterium ulcerans	acyl-CoA synthetase	0.0026	0.0037	0.0148
Leishmania major	beta tubulin	0.0023	0.0026	0.0195
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0172	0.0172
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0017	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0087	0.0085
Schistosoma mansoni	hypothetical protein	0.0016	0.0002	0.0002
Echinococcus granulosus	sex peptide receptor	0.0084	0.0254	0.0252
Trichomonas vaginalis	glucosylceramidase, putative	0.0177	0.0594	0.3517
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.046	0.1642	0.1642
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0172	0.0172
Onchocerca volvulus		0.046	0.1642	1
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0052	0.0136	0.0133
Echinococcus granulosus	survival motor neuron protein 1	0.0257	0.0891	0.0889
Echinococcus multilocularis	Tubulin beta 2C chain	0.0023	0.0026	0.0024
Leishmania major	beta tubulin	0.0023	0.0026	0.0195
Echinococcus granulosus	rhodopsin orphan GPCR	0.0084	0.0254	0.0252
Echinococcus multilocularis	neuropeptides capa receptor	0.0084	0.0254	0.0252
Mycobacterium ulcerans	carboxylesterase, LipT	0.046	0.1642	1
Onchocerca volvulus		0.0084	0.0254	0.1351
Loa Loa (eye worm)	RNA binding protein	0.0062	0.0172	0.017
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0084	0.0254	0.0252
Echinococcus multilocularis	beta tubulin	0.0023	0.0026	0.0024
Schistosoma mansoni	acetylcholinesterase	0.046	0.1642	0.1642
Echinococcus granulosus	rhodopsin orphan GPCR	0.0084	0.0254	0.0252
Brugia malayi	hypothetical protein	0.0084	0.0254	0.0252
Schistosoma mansoni	patched 1	0.0042	0.0096	0.0096
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0254	0.0252
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0084	0.0254	0.0252
Leishmania major	beta tubulin	0.0023	0.0026	0.0195
Loa Loa (eye worm)	hypothetical protein	0.0073	0.021	0.0208
Echinococcus multilocularis	zinc finger protein	0.0022	0.0022	0.002
Brugia malayi	Dopamine receptor	0.0084	0.0254	0.0252
Trichomonas vaginalis	glucosylceramidase, putative	0.0255	0.0885	0.5318
Loa Loa (eye worm)	bromodomain containing protein	0.0018	0.0009	0.0007
Echinococcus multilocularis	Niemann Pick C1 protein	0.0139	0.0453	0.0451
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0254	0.0252
Loa Loa (eye worm)	hypothetical protein	0.0374	0.1321	0.1319
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0052	0.0132	0.013
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0084	0.0254	0.0254
Leishmania major	beta tubulin	0.0023	0.0026	0.0195
Loa Loa (eye worm)	G-protein coupled receptor	0.0084	0.0254	0.0252
Echinococcus granulosus	rhodopsin orphan GPCR	0.0084	0.0254	0.0252
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0254	0.0252
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0019	0.0013	0.0024
Echinococcus granulosus	Tubulin beta 2C chain	0.0023	0.0026	0.0024
Echinococcus granulosus	allatostatin A receptor	0.0084	0.0254	0.0252
Echinococcus granulosus	7tm_1 domain containing protein	0.0084	0.0254	0.0252
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0026	0.0037	0.5
Trichomonas vaginalis	spcc417.12 protein, putative	0.046	0.1642	1
Echinococcus multilocularis	acetylcholinesterase	0.2725	1	1
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0254	0.0252
Echinococcus multilocularis	sex peptide receptor	0.0084	0.0254	0.0252
Schistosoma mansoni	amine GPCR	0.0084	0.0254	0.0254
Trichomonas vaginalis	glucosylceramidase, putative	0.0255	0.0885	0.5318
Schistosoma mansoni	tubulin subunit beta	0.0023	0.0026	0.0026
Echinococcus granulosus	orexin receptor type 2	0.0084	0.0254	0.0252
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0026	0.0037	0.0415
Brugia malayi	Dopamine receptor protein 1	0.0494	0.1764	0.1762
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0084	0.0254	0.1351
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0037	0.0078	0.0076
Echinococcus multilocularis	para nitrobenzyl esterase	0.046	0.1642	0.164
Onchocerca volvulus	Glucosylceramidase homolog	0.0168	0.0561	0.3263
Schistosoma mansoni	hypothetical protein	0.0035	0.0072	0.0072
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0084	0.0254	0.0254
Brugia malayi	sulfakinin receptor protein	0.0084	0.0254	0.0252
Echinococcus granulosus	rhodopsin orphan GPCR	0.0084	0.0254	0.0252
Echinococcus multilocularis	fmrfamide receptor	0.0084	0.0254	0.0252
Brugia malayi	RE15519p	0.0084	0.0254	0.0252
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0063	0.0174	0.0172
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0017	0.0007	0.0007
Brugia malayi	G protein-coupled receptor	0.0084	0.0254	0.0252
Brugia malayi	Serotonin receptor	0.0084	0.0254	0.0252

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	> 500 uM	Inhibition of human recombinant caspase-7 using Ac-DEVD-AMC as substrate assessed as accumulation of AMC preincubated for 10 mins followed by substrate addition measured after 10 mins by fluorescence assay	ChEMBL.	23685941
IC50 (binding)	> 500 uM	Inhibition of human recombinant caspase-3 using Ac-DEVD-AMC as substrate assessed as accumulation of AMC preincubated for 10 mins followed by substrate addition measured after 10 mins by fluorescence assay	ChEMBL.	23685941

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2391857

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1779657