Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0297 | 1 | 1 |
Trypanosoma brucei | 6-phosphofructo-2-kinase 2 | 0.0292 | 0.9706 | 0.9706 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0292 | 0.9706 | 0.9706 |
Mycobacterium ulcerans | hypothetical protein | 0.0175 | 0.2852 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.0292 | 0.9706 | 0.9706 |
Giardia lamblia | Hypothetical protein | 0.0175 | 0.2852 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0292 | 0.9706 | 0.9604 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.0292 | 0.9706 | 0.9706 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0297 | 1 | 1 |
Giardia lamblia | Hypothetical protein | 0.0175 | 0.2852 | 0.5 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0297 | 1 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0297 | 1 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0297 | 1 | 1 |
Onchocerca volvulus | 0.0297 | 1 | 0.5 | |
Echinococcus multilocularis | 6 phosphofructo 2 kinase:fructose 2 | 0.0297 | 1 | 0.5 |
Entamoeba histolytica | phosphoglycerate mutase family protein, putative | 0.0175 | 0.2852 | 0.5 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0297 | 1 | 0.5 |
Mycobacterium ulcerans | fructose-2,6-bisphosphatase GpmB | 0.0175 | 0.2852 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 128 uM | Cytotoxicity against human SMMC7721 cells after 72 hrs by MTT assay | ChEMBL. | 23644193 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.