Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.5729 | 1 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.5729 | 1 | 0.5 |
Onchocerca volvulus | 0.5729 | 1 | 0.5 | |
Brugia malayi | Furin-like cysteine rich region family protein | 0.4848 | 0.7918 | 0.7894 |
Echinococcus granulosus | thymidylate synthase | 0.5729 | 1 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.5729 | 1 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.5729 | 1 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.2578 | 0.2547 | 0.246 |
Trichomonas vaginalis | conserved hypothetical protein | 0.2725 | 0.2896 | 0.5 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.5729 | 1 | 1 |
Echinococcus granulosus | epidermal growth factor receptor | 0.2605 | 0.2612 | 0.2526 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.4848 | 0.7918 | 0.7918 |
Echinococcus granulosus | epidermal growth factor receptor | 0.4848 | 0.7918 | 0.7894 |
Schistosoma mansoni | tyrosine kinase | 0.2578 | 0.2547 | 0.246 |
Loa Loa (eye worm) | thymidylate synthase | 0.5729 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.4848 | 0.7918 | 0.7894 |
Schistosoma mansoni | tyrosine kinase | 0.2605 | 0.2612 | 0.2526 |
Brugia malayi | hypothetical protein | 0.2725 | 0.2896 | 0.2814 |
Schistosoma mansoni | tyrosine kinase | 0.2578 | 0.2547 | 0.246 |
Echinococcus multilocularis | thymidylate synthase | 0.5729 | 1 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.5729 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.2605 | 0.2612 | 0.2526 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.5729 | 1 | 0.5 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.4848 | 0.7918 | 0.7894 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.5729 | 1 | 0.5 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.2605 | 0.2612 | 0.2526 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.2605 | 0.2612 | 0.2612 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.5729 | 1 | 0.5 |
Echinococcus multilocularis | insulin receptor | 0.1549 | 0.0115 | 0.0115 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.1549 | 0.0115 | 0.0115 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.5729 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (ADMET) | = 33.3 ug ml-1 | Cytotoxicity against human Huh5-2 cells assessed as growth inhibition after 3 days by MTS assay | ChEMBL. | 23665801 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.