TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 343.291 | Formula: C17H24Cl2N2O
H donors: 1 H acceptors: 1 LogP: 4.93 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: O=C(C1CCCN1C1CCCCC1)Nc1ccccc1Cl.Cl
InChi: 1S/C17H23ClN2O.ClH/c18-14-9-4-5-10-15(14)19-17(21)16-11-6-12-20(16)13-7-2-1-3-8-13;/h4-5,9-10,13,16H,1-3,6-8,11-12H2,(H,19,21);1H
InChiKey: DUWQLOKLIWWVSU-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0079	0.0461	0.0447
Trichomonas vaginalis	D-aminoacylase, putative	0.0042	0.0179	1
Schistosoma mansoni	histamine h1 receptor	0.0079	0.0461	0.0447
Onchocerca volvulus		0.0079	0.0461	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0021	0.0014	0.0006
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0079	0.0461	0.0455
Echinococcus multilocularis	g protein coupled receptor	0.0079	0.0461	0.0455
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0079	0.0461	0.0455
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0014	0.0006
Mycobacterium tuberculosis	Conserved protein	0.0042	0.0179	0.0923
Echinococcus granulosus	beta LACTamase domain containing family member	0.0042	0.0179	0.0168
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0079	0.0461	0.0447
Schistosoma mansoni	neuropeptide F-like receptor	0.0079	0.0461	0.0447
Onchocerca volvulus		0.0079	0.0461	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0079	0.0461	0.0455
Echinococcus granulosus	neuropeptide receptor	0.0079	0.0461	0.0455
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0079	0.0461	0.0455
Loa Loa (eye worm)	TK/ALK protein kinase	0.0021	0.0014	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0461	0.046
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0027	0.0061	1
Brugia malayi	neuropeptide F receptor	0.0079	0.0461	0.0455
Echinococcus multilocularis	orexin receptor type 2	0.0079	0.0461	0.0455
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0079	0.0461	0.0455
Echinococcus granulosus	neuropeptide Y receptor	0.0079	0.0461	0.0455
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0179	0.0173
Trypanosoma cruzi	hypothetical protein, conserved	0.0042	0.0179	1
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0461	0.046
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0042	0.0179	0.0173
Plasmodium falciparum	tyrosine kinase-like protein	0.0021	0.0014	1
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0027	0.0061	0.3098
Trichomonas vaginalis	penicillin-binding protein, putative	0.0042	0.0179	1
Echinococcus granulosus	allatostatin A receptor	0.0079	0.0461	0.0455
Echinococcus granulosus	neuropeptides capa receptor	0.0079	0.0461	0.0455
Loa Loa (eye worm)	TK/FER protein kinase	0.0021	0.0014	0.0006
Echinococcus granulosus	neuropeptide s receptor	0.0079	0.0461	0.0455
Echinococcus granulosus	tm gpcr rhodopsin	0.0079	0.0461	0.0455
Loa Loa (eye worm)	TK/FER protein kinase	0.0021	0.0014	0.0006
Loa Loa (eye worm)	G-protein coupled receptor	0.0079	0.0461	0.046
Echinococcus granulosus	neuropeptide receptor A26	0.0079	0.0461	0.0455
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0461	0.046
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0027	0.0061	0.3098
Toxoplasma gondii	ABC1 family protein	0.0042	0.0179	1
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0461	0.046
Brugia malayi	G-protein coupled receptor	0.0079	0.0461	0.0455
Onchocerca volvulus		0.0027	0.0061	0.1054
Trichomonas vaginalis	esterase, putative	0.0042	0.0179	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0079	0.0461	0.0455
Schistosoma mansoni	hypothetical protein	0.0079	0.0461	0.0447
Schistosoma mansoni	amine GPCR	0.0079	0.0461	0.0447
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0079	0.0461	0.0455
Onchocerca volvulus		0.0079	0.0461	1
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0014	0.0006
Echinococcus multilocularis	g-protein coupled receptor	0.0079	0.0461	0.0455
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0461	0.046
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0061	0.0054
Echinococcus multilocularis	neuropeptides capa receptor	0.0079	0.0461	0.0455
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0079	0.0461	0.0455
Echinococcus granulosus	dro:myosuppressin receptor	0.0079	0.0461	0.0455
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0014	0.0006
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0021	0.0014	0.0006
Loa Loa (eye worm)	TK protein kinase	0.0021	0.0014	0.0006
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0079	0.0461	0.0447
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0079	0.0461	0.0447
Loa Loa (eye worm)	TK/FER protein kinase	0.0021	0.0014	0.0006
Echinococcus granulosus	neuropeptide receptor	0.0079	0.0461	0.0455
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0461	0.046
Mycobacterium tuberculosis	Probable esterase LipL	0.0042	0.0179	0.0923
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0461	0.046
Schistosoma mansoni	neuropeptide receptor	0.0079	0.0461	0.0447
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.0021	0.0015	0.0232
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0021	0.0014	0.0006
Loa Loa (eye worm)	TK/FER protein kinase	0.0021	0.0014	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0461	0.046
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0461	0.046
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0461	0.046
Echinococcus multilocularis	allatostatin A receptor	0.0079	0.0461	0.0455
Brugia malayi	AMP-binding enzyme family protein	0.0027	0.0061	0.0048
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0079	0.0461	0.046
Schistosoma mansoni	biogenic amine receptor	0.0079	0.0461	0.0447
Echinococcus granulosus	rhodopsin orphan GPCR	0.0079	0.0461	0.0455
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0021	0.0014	0.0006
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0079	0.0461	0.0447
Brugia malayi	beta-lactamase family protein	0.0042	0.0179	0.0168
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0079	0.0461	0.046
Loa Loa (eye worm)	SRC-1	0.0021	0.0014	0.0006
Plasmodium falciparum	protein kinase, putative	0.0021	0.0014	1
Loa Loa (eye worm)	TK protein kinase	0.0021	0.0014	0.0006
Loa Loa (eye worm)	TK protein kinase	0.0021	0.0014	0.0006
Schistosoma mansoni	hypothetical protein	0.0079	0.0461	0.0447
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0014	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0461	0.046
Echinococcus granulosus	g protein coupled receptor	0.0079	0.0461	0.0455
Mycobacterium leprae	Probable lipase LipE	0.0042	0.0179	1
Schistosoma mansoni	opsin-like receptor	0.0079	0.0461	0.0447
Echinococcus granulosus	biogenic amine 5HT receptor	0.0079	0.0461	0.0455
Brugia malayi	hypothetical protein	0.0079	0.0461	0.0455
Loa Loa (eye worm)	TK/ACK protein kinase	0.0021	0.0014	0.0006
Brugia malayi	hypothetical protein	0.0079	0.0461	0.0455
Mycobacterium tuberculosis	Conserved protein	0.0042	0.0179	0.0923
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0042	0.0179	0.0923
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0079	0.0461	0.0447
Mycobacterium ulcerans	acyl-CoA synthetase	0.0027	0.0061	0.3098
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0014	0.0006
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0079	0.0461	0.0455
Echinococcus multilocularis	neuropeptide receptor	0.0079	0.0461	0.0455
Loa Loa (eye worm)	TK/FER protein kinase	0.0021	0.0014	0.0006
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0079	0.0461	0.0447
Brugia malayi	hypothetical protein	0.0079	0.0461	0.0455
Onchocerca volvulus		0.0079	0.0461	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0079	0.0461	0.0447
Schistosoma mansoni	neuropeptide f receptor 76f	0.0079	0.0461	0.0447
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0461	0.046
Mycobacterium tuberculosis	Conserved protein	0.0042	0.0179	0.0923
Trypanosoma cruzi	hypothetical protein, conserved	0.0042	0.0179	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0079	0.0461	0.0455
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0179	0.0173
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0014	0.0006
Brugia malayi	hypothetical protein	0.0079	0.0461	0.0455
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0079	0.0461	0.0455
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0079	0.0461	0.0455
Echinococcus multilocularis	fmrfamide receptor	0.0079	0.0461	0.0455
Brugia malayi	hypothetical protein	0.0079	0.0461	0.0455
Echinococcus granulosus	7TM GPCR rhodopsin	0.0079	0.0461	0.0455
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0079	0.0461	0.0455
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0042	0.0179	0.0168
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0079	0.0461	0.0455
Plasmodium vivax	hypothetical protein, conserved	0.0042	0.0179	1
Echinococcus granulosus	g-protein coupled receptor	0.0079	0.0461	0.0455
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.002	0.0009	0.0044
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0021	0.0014	0.0338
Mycobacterium ulcerans	lipase LipD	0.0042	0.0179	1
Loa Loa (eye worm)	TK protein kinase	0.0021	0.0014	0.0006
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0079	0.0461	0.0455
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0042	0.0179	0.0165
Loa Loa (eye worm)	TKL/MLK/LZK protein kinase	0.1291	0.9838	1
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0079	0.0461	0.046
Schistosoma mansoni	amine GPCR	0.0079	0.0461	0.0447
Loa Loa (eye worm)	TYRA-2 protein	0.0079	0.0461	0.046
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0079	0.0461	0.0455
Mycobacterium tuberculosis	Probable lipase LipE	0.0042	0.0179	0.0923
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0014	0.0006
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0042	0.0179	0.0923
Echinococcus granulosus	tm gpcr rhodopsin	0.0079	0.0461	0.0455
Schistosoma mansoni	myosin xvIII	0.0079	0.0461	0.0447
Brugia malayi	hypothetical protein	0.0079	0.0461	0.0455
Onchocerca volvulus		0.0079	0.0461	1
Brugia malayi	larval opioid receptor	0.0079	0.0461	0.0455
Entamoeba histolytica	acyl-coA synthetase, putative	0.0027	0.0061	1
Echinococcus multilocularis	neuropeptide receptor	0.0079	0.0461	0.0455
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0014	0.0006
Loa Loa (eye worm)	TK protein kinase	0.0021	0.0014	0.0006
Mycobacterium ulcerans	esterase/lipase LipP	0.0042	0.0179	1
Trichomonas vaginalis	penicillin-binding protein, putative	0.0042	0.0179	1
Loa Loa (eye worm)	TK/ROR protein kinase	0.0021	0.0014	0.0006
Loa Loa (eye worm)	TK/EPH protein kinase	0.0021	0.0014	0.0006
Echinococcus granulosus	g protein coupled receptor	0.0079	0.0461	0.0455
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0461	0.046
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0079	0.0461	0.0455
Brugia malayi	sulfakinin receptor protein	0.0079	0.0461	0.0455
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0079	0.0461	0.0455
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0461	0.046
Trichomonas vaginalis	D-aminoacylase, putative	0.0042	0.0179	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0079	0.0461	0.0447
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0461	0.046
Loa Loa (eye worm)	TK/FER protein kinase	0.0021	0.0014	0.0006
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0079	0.0461	0.0447
Giardia lamblia	Protein 21.1	0.0021	0.0014	0.5
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0079	0.0461	0.0455
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0021	0.0014	0.0006
Onchocerca volvulus		0.0079	0.0461	1
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0461	0.046
Echinococcus multilocularis	dro:myosuppressin receptor	0.0079	0.0461	0.0455
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0021	0.0014	0.0006
Echinococcus granulosus	7tm_1 domain containing protein	0.0079	0.0461	0.0455
Loa Loa (eye worm)	TK/FER protein kinase	0.0021	0.0014	0.0006
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0079	0.0461	0.0447
Loa Loa (eye worm)	TK/FER protein kinase	0.0021	0.0014	0.0006
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0021	0.0014	0.0006
Brugia malayi	Protein kinase domain containing protein	0.1291	0.9838	1
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.1291	0.9838	1
Brugia malayi	Dopamine receptor	0.0079	0.0461	0.0455
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0021	0.0014	0.0006
Echinococcus granulosus	rhodopsin orphan GPCR	0.0079	0.0461	0.0455
Brugia malayi	ORL1-like opioid receptor	0.0079	0.0461	0.0455
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0079	0.0461	1
Brugia malayi	Dopamine receptor protein 1	0.0079	0.0461	0.0455
Loa Loa (eye worm)	TK protein kinase	0.0021	0.0014	0.0006
Echinococcus granulosus	hypothetical protein	0.0079	0.0461	0.0455
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0079	0.0461	0.0447
Onchocerca volvulus		0.0079	0.0461	1
Schistosoma mansoni	hypothetical protein	0.0079	0.0461	0.0447
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0461	0.046
Echinococcus granulosus	neuropeptides capa receptor	0.0079	0.0461	0.0455
Mycobacterium ulcerans	hypothetical protein	0.0042	0.0179	1
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0179	0.0173
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0079	0.0461	0.0455
Brugia malayi	putative neuropeptide receptor	0.0079	0.0461	0.0455
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0079	0.0461	0.0447
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0079	0.0461	0.0447
Schistosoma mansoni	hypothetical protein	0.0079	0.0461	0.0447
Entamoeba histolytica	hypothetical protein	0.0021	0.0015	0.0232
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0079	0.0461	0.0447
Echinococcus multilocularis	g protein coupled receptor	0.0079	0.0461	0.0455
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0461	0.046
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0014	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0014	0.0006
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0079	0.0461	0.0447
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0014	0.0006
Brugia malayi	RE15519p	0.0079	0.0461	0.0455
Schistosoma mansoni	biogenic amine receptor	0.0079	0.0461	0.0447
Onchocerca volvulus		0.0079	0.0461	1
Echinococcus multilocularis	neuropeptides capa receptor	0.0079	0.0461	0.0455
Plasmodium falciparum	protein kinase, putative	0.0021	0.0014	1
Mycobacterium leprae	conserved hypothetical protein	0.0042	0.0179	1
Onchocerca volvulus		0.0079	0.0461	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0079	0.0461	0.0455
Echinococcus multilocularis	serotonin receptor	0.0079	0.0461	0.0455
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0079	0.0461	0.0447
Onchocerca volvulus		0.0079	0.0461	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0027	0.0061	0.0316
Entamoeba histolytica	hypothetical protein	0.0021	0.0015	0.0232
Schistosoma mansoni	neuropeptide F-like receptor	0.0079	0.0461	0.0447
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0014	0.0006
Onchocerca volvulus		0.0042	0.0179	0.3688
Brugia malayi	AKH receptor	0.0079	0.0461	0.0455
Echinococcus multilocularis	serotonin receptor	0.0079	0.0461	0.0455
Loa Loa (eye worm)	beta-lactamase	0.0042	0.0179	0.0173
Echinococcus multilocularis	g protein coupled receptor	0.0079	0.0461	0.0455
Echinococcus granulosus	rhodopsin orphan GPCR	0.0079	0.0461	0.0455
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0027	0.0061	0.0316
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0079	0.0461	0.0447
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0461	0.046
Brugia malayi	AMP-binding enzyme family protein	0.0027	0.0061	0.0048
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0079	0.0461	0.0455
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0079	0.0461	0.0455
Loa Loa (eye worm)	TK/FER protein kinase	0.0021	0.0014	0.0006
Schistosoma mansoni	biogenic amine receptor	0.0079	0.0461	0.0447
Loa Loa (eye worm)	TK/FAK protein kinase	0.0021	0.0014	0.0006
Loa Loa (eye worm)	TK protein kinase	0.0021	0.0014	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0461	0.046
Onchocerca volvulus		0.0079	0.0461	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0042	0.0179	0.0165
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.002	0.0009	0.5
Brugia malayi	Serotonin receptor	0.0079	0.0461	0.0455
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0461	0.046
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0079	0.0461	0.0447
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0061	0.0054
Trichomonas vaginalis	D-aminoacylase, putative	0.0042	0.0179	1
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0461	0.046
Leishmania major	hypothetical protein, conserved	0.0042	0.0179	1
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0079	0.0461	0.046
Onchocerca volvulus		0.0079	0.0461	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0021	0.0014	0.0006
Loa Loa (eye worm)	TK/INSR protein kinase	0.0021	0.0014	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0461	0.046
Echinococcus granulosus	rhodopsin orphan GPCR	0.0079	0.0461	0.0455
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0079	0.0461	0.046
Plasmodium falciparum	protein kinase, putative	0.0021	0.0014	1
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0027	0.0061	0.3098
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0079	0.0461	0.0455
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0021	0.0014	0.0006
Schistosoma mansoni	amine GPCR	0.0079	0.0461	0.0447
Brugia malayi	hypothetical protein	0.0079	0.0461	0.0455
Schistosoma mansoni	neuropeptide receptor	0.0079	0.0461	0.0447
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0079	0.0461	0.0447
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0461	0.046
Brugia malayi	G protein-coupled receptor F59B2.13	0.0079	0.0461	0.0455
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0461	0.046
Leishmania major	4-coumarate:coa ligase-like protein	0.0027	0.0061	0.2857
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0079	0.0461	0.0455
Giardia lamblia	Kinase, NEK	0.0021	0.0014	0.5
Echinococcus granulosus	sex peptide receptor	0.0079	0.0461	0.0455
Echinococcus granulosus	tm gpcr rhodopsin	0.0079	0.0461	0.0455
Loa Loa (eye worm)	TK/RYK protein kinase	0.0021	0.0014	0.0006
Mycobacterium ulcerans	acyl-CoA synthetase	0.0027	0.0061	0.3098
Plasmodium vivax	protein kinase, putative	0.0021	0.0014	0.0338
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0079	0.0461	0.0455
Entamoeba histolytica	protein kinase, putative	0.0021	0.0015	0.0232
Brugia malayi	Melatonin receptor type 1A	0.0079	0.0461	0.0455
Loa Loa (eye worm)	G-protein coupled receptor	0.0079	0.0461	0.046
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0079	0.0461	0.0455
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0042	0.0179	0.0168
Brugia malayi	follicle stimulating hormone receptor	0.0079	0.0461	0.0455
Loa Loa (eye worm)	neuropeptide F receptor	0.0079	0.0461	0.046
Trypanosoma brucei	hypothetical protein, conserved	0.0042	0.0179	1
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0461	0.046
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0461	0.046
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0461	0.046
Loa Loa (eye worm)	TK/FER protein kinase	0.0021	0.0014	0.0006
Loa Loa (eye worm)	TK/FER protein kinase	0.0021	0.0014	0.0006
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0079	0.0461	0.0455
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0079	0.0461	0.0455
Loa Loa (eye worm)	TK protein kinase	0.0021	0.0014	0.0006
Loa Loa (eye worm)	hypothetical protein	0.1291	0.9838	1
Echinococcus granulosus	orexin receptor type 2	0.0079	0.0461	0.0455
Loa Loa (eye worm)	TK/Met protein kinase	0.0021	0.0014	0.0006
Mycobacterium tuberculosis	Probable hydrolase	0.0042	0.0179	0.0923
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0461	0.046
Echinococcus granulosus	biogenic amine 5HT receptor	0.0079	0.0461	0.0455
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0461	0.046
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0079	0.0461	0.0455
Onchocerca volvulus		0.0042	0.0179	0.3688
Echinococcus multilocularis	G protein coupled receptor 139	0.0079	0.0461	0.0455
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0079	0.0461	0.0455
Echinococcus granulosus	fmrfamide receptor	0.0079	0.0461	0.0455
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0021	0.0014	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0461	0.046
Echinococcus granulosus	somatostatin receptor	0.0079	0.0461	0.0455
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0014	0.0006
Loa Loa (eye worm)	TK/FER protein kinase	0.0021	0.0014	0.0006
Entamoeba histolytica	hypothetical protein	0.0021	0.0015	0.0232
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0079	0.0461	0.0447
Echinococcus multilocularis	neuropeptide receptor A26	0.0079	0.0461	0.0455
Brugia malayi	G protein-coupled receptor	0.0079	0.0461	0.0455
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0079	0.0461	0.0455
Mycobacterium ulcerans	beta-lactamase	0.0042	0.0179	1
Onchocerca volvulus		0.0079	0.0461	1
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0461	0.046
Brugia malayi	beta-lactamase	0.0042	0.0179	0.0168
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0179	0.0173
Echinococcus granulosus	rhodopsin orphan GPCR	0.0079	0.0461	0.0455
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0461	0.046
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0461	0.046
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0461	0.046
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0021	0.0014	0.0006
Brugia malayi	hypothetical protein	0.0079	0.0461	0.0455
Onchocerca volvulus		0.0079	0.0461	1
Schistosoma mansoni	neuropeptide receptor	0.0079	0.0461	0.0447
Echinococcus multilocularis	fmrfamide receptor	0.0079	0.0461	0.0455
Echinococcus granulosus	neuropeptide FF receptor 2	0.0079	0.0461	0.0455
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0079	0.0461	0.0447
Echinococcus granulosus	rhodopsin orphan GPCR	0.0079	0.0461	0.0455
Loa Loa (eye worm)	TK/DDR protein kinase	0.0021	0.0014	0.0006
Loa Loa (eye worm)	melatonin receptor type 1A	0.0079	0.0461	0.046
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0079	0.0461	0.0455
Brugia malayi	Dopamine receptor protein 2	0.0079	0.0461	0.0455
Brugia malayi	putative neuropeptide receptor NPR1	0.0079	0.0461	0.0455
Leishmania major	4-coumarate:coa ligase-like protein	0.0027	0.0061	0.2857
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.027	0.1939	1
Brugia malayi	hypothetical protein	0.0079	0.0461	0.0455
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0079	0.0461	0.0455
Schistosoma mansoni	amine GPCR	0.0079	0.0461	0.0447
Echinococcus multilocularis	neuropeptide s receptor	0.0079	0.0461	0.0455
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0079	0.0461	0.0447
Echinococcus granulosus	g protein coupled receptor	0.0079	0.0461	0.0455
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0461	0.046
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0079	0.0461	0.0447
Onchocerca volvulus		0.0042	0.0179	0.3688
Loa Loa (eye worm)	TK/ABL protein kinase	0.0021	0.0014	0.0006
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0079	0.0461	0.0455
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0021	0.0014	0.0338
Brugia malayi	G-protein coupled receptor	0.0079	0.0461	0.0455
Loa Loa (eye worm)	TK/FER protein kinase	0.0021	0.0014	0.0006
Schistosoma mansoni	amine GPCR	0.0079	0.0461	0.0447
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0042	0.0179	0.0923
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0461	0.046
Loa Loa (eye worm)	TK/FER protein kinase	0.0021	0.0014	0.0006
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0079	0.0461	0.0455
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.1291	0.9838	1
Giardia lamblia	Kinase, NEK	0.0021	0.0014	0.5
Echinococcus multilocularis	sex peptide receptor	0.0079	0.0461	0.0455
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0079	0.0461	0.0455
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0021	0.0014	0.0006
Loa Loa (eye worm)	TK/FER protein kinase	0.0021	0.0014	0.0006
Echinococcus granulosus	G protein coupled receptor 139	0.0079	0.0461	0.0455
Echinococcus granulosus	rhodopsin orphan GPCR	0.0079	0.0461	0.0455
Brugia malayi	AMP-binding enzyme family protein	0.0027	0.0061	0.0048
Loa Loa (eye worm)	serine/threonine protein kinase	0.0021	0.0014	0.0006
Brugia malayi	beta-lactamase family protein	0.0042	0.0179	0.0168
Onchocerca volvulus		0.0079	0.0461	1
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0042	0.0179	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0079	0.0461	0.0455
Brugia malayi	neuropeptide F receptor	0.0079	0.0461	0.0455
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0079	0.0461	0.0455
Onchocerca volvulus		0.0079	0.0461	1
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0461	0.046
Schistosoma mansoni	growth hormone secretagogue receptor	0.0079	0.0461	0.0447
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0461	0.046
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0021	0.0014	0.0006
Mycobacterium ulcerans	hypothetical protein	0.0027	0.0061	0.3098
Onchocerca volvulus		0.0079	0.0461	1
Brugia malayi	GnHR receptor homolog	0.0079	0.0461	0.0455
Schistosoma mansoni	adenoreceptor	0.0079	0.0461	0.0447
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0461	0.046
Schistosoma mansoni	opsin-like receptor	0.0079	0.0461	0.0447
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0461	0.046
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0021	0.0014	0.0006
Giardia lamblia	Kinase	0.0021	0.0014	0.5
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0079	0.0461	0.0455
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0027	0.0061	0.3098
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0179	0.0173
Loa Loa (eye worm)	TK protein kinase	0.0021	0.0014	0.0006
Loa Loa (eye worm)	TK/CSK protein kinase	0.0021	0.0014	0.0006
Loa Loa (eye worm)	TK/FER protein kinase	0.0021	0.0014	0.0006
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0027	0.0061	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0079	0.0461	0.0447
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0061	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0461	0.046
Leishmania major	4-coumarate:coa ligase-like protein	0.0027	0.0061	0.2857
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0179	0.0173
Mycobacterium tuberculosis	Probable lipase LipD	0.0042	0.0179	0.0923
Schistosoma mansoni	opsin-like receptor	0.0079	0.0461	0.0447
Brugia malayi	hypothetical protein	0.0079	0.0461	0.0455
Loa Loa (eye worm)	TK protein kinase	0.0021	0.0014	0.0006
Loa Loa (eye worm)	hypothetical protein	0.1291	0.9838	1
Plasmodium falciparum	tyrosine kinase-like protein	0.0021	0.0014	1
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0461	0.046
Echinococcus multilocularis	somatostatin receptor	0.0079	0.0461	0.0455
Brugia malayi	Serotonin receptor	0.0079	0.0461	0.0455
Schistosoma mansoni	neuropeptide receptor	0.0079	0.0461	0.0447
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0079	0.0461	0.0455
Mycobacterium ulcerans	acyl-CoA synthetase	0.0027	0.0061	0.3098
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0079	0.0461	1
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0461	0.046
Echinococcus granulosus	neuropeptide Y receptor	0.0079	0.0461	0.0455
Loa Loa (eye worm)	neuropeptide F receptor	0.0079	0.0461	0.046
Echinococcus granulosus	serotonin receptor	0.0079	0.0461	0.0455
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0461	0.046

Activities

Activity type	Activity value	Assay description	Source	Reference
LD50 (ADMET)	= 95 mg kg-1	Toxicity in iv dosed Swiss albino mouse after 72 hrs	ChEMBL.	23474900

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2386867

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1779848