Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Amyloid A4 extracellular domain containing protein | 0.0305 | 0.2444 | 0.229 |
Onchocerca volvulus | 0.0143 | 0.0199 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.0199 | 0.0199 |
Onchocerca volvulus | 0.0143 | 0.0199 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0848 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0848 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0848 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0143 | 0.0199 | 0.0199 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.0199 | 0.0199 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0143 | 0.0199 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.0199 | 0.0199 |
Echinococcus multilocularis | acetylcholinesterase | 0.0848 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0848 | 1 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0143 | 0.0199 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0143 | 0.0199 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.0199 | 0.0199 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0143 | 0.0199 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0848 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.0199 | 0.0199 |
Loa Loa (eye worm) | carboxylesterase | 0.0143 | 0.0199 | 0.0199 |
Onchocerca volvulus | 0.0143 | 0.0199 | 0.5 | |
Echinococcus granulosus | carboxylesterase 5A | 0.0848 | 1 | 1 |
Onchocerca volvulus | 0.0143 | 0.0199 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.0199 | 0.0199 |
Loa Loa (eye worm) | hypothetical protein | 0.0848 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.0199 | 0.0199 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0143 | 0.0199 | 0.5 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0143 | 0.0199 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0848 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0848 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0848 | 1 | 1 |
Onchocerca volvulus | 0.0143 | 0.0199 | 0.5 | |
Echinococcus multilocularis | carboxylesterase 5A | 0.0848 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.024 | 0.1545 | 0.1545 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 62 uM | Antimalarial activity against Plasmodium falciparum 3D7 infected in O positive erythrocytes assessed as parasite lactate dehydrogenase activity after 72 hrs | ChEMBL. | 23659857 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.